{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:24:32Z","timestamp":1792801472429,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004263","name":"FAPERGS","doi-asserted-by":"publisher","award":["16\/2551-0000526-5"],"award-info":[{"award-number":["16\/2551-0000526-5"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PRONUPEQ"},{"name":"ARD\/PPP","award":["16\/2251-0000183-9"],"award-info":[{"award-number":["16\/2251-0000183-9"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.cbi.2017.10.019","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T16:04:12Z","timestamp":1508342652000},"page":"111-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"special_numbering":"C","title":["Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins"],"prefix":"10.1016","volume":"279","author":[{"given":"Andr\u00e9 T.R.","family":"Goes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano R.","family":"Jesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando V.","family":"Lobo Ladd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliny A.B.","family":"Lobo Ladd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Luchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Paroul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana P.","family":"Boeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2017.10.019_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1353-8020(03)00063-4","article-title":"Organization of midbrain dopamine systems and the pathophysiology of Parkinson's disease","volume":"2","author":"Moore","year":"2003","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.cbi.2017.10.019_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.parkreldis.2017.02.011","article-title":"Effects of intracerebral neurotrophic factor application on motorsymptoms in Parkinson's disease: a systematic review and meta-analysis","volume":"38","author":"Hegarty","year":"2017","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.cbi.2017.10.019_bib3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/1381612822666151112151653","article-title":"Oxidative stress and Parkinson's disease: new hopes in treatment with herbal antioxidants","volume":"22","author":"Sarrafchi","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cbi.2017.10.019_bib4","article-title":"Role of gasotransmitters in oxidative stresses, neuroinflammation, and neuronal repair","volume":"1689341","author":"Shefa","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cbi.2017.10.019_bib5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000438701","article-title":"Advances in neurotrophic factor and cell-based therapies for Parkinson's disease: a mini-review","volume":"62","author":"Staudt","year":"2016","journal-title":"Gerontology"},{"key":"10.1016\/j.cbi.2017.10.019_bib6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1089\/hum.2015.065","article-title":"Prospects of neurotrophic factors for Parkinson's disease: comparison of protein and gene therapy","volume":"26","author":"Domanskyi","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.cbi.2017.10.019_bib7","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1742-4658.2012.08491.x","article-title":"Animal models of Parkinson's disease","volume":"279","author":"Blandini","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.cbi.2017.10.019_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.5813","article-title":"Supplementation with herbal extracts to promote behavioral and neuroprotective effects in experimental models of Parkinson's disease: a systematic review","author":"Da Costa","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.cbi.2017.10.019_bib9","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2174\/1570159X11311040005","article-title":"Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect","volume":"11","author":"Ansari","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.cbi.2017.10.019_bib10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/0748233711399324","article-title":"Protective effect of chrysin on carbon tetrachloride (CCl4)-induced tissue injury in male Wistar rats","volume":"27","author":"Anand","year":"2011","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.cbi.2017.10.019_bib11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cbi.2016.11.005","article-title":"Chrysin promotes attenuation of depressive-like behavior and hippocampal dysfunction resulting from olfactory bulbectomy in mice","volume":"25","author":"Filho","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.10.019_bib12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejphar.2016.09.005","article-title":"Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice","volume":"791","author":"Filho","year":"2016","journal-title":"Eur. J. Pharmcol"},{"key":"10.1016\/j.cbi.2017.10.019_bib13","first-page":"1","article-title":"Plant flavonoids in cancer chemoprevention: role in genome stability","volume":"28","author":"George","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.cbi.2017.10.019_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejphar.2012.01.025","article-title":"Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats","volume":"680","author":"He","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2017.10.019_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pbb.2015.04.010","article-title":"Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain","volume":"134","author":"Souza","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.cbi.2017.10.019_bib16","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/j.1471-4159.2011.07284.x","article-title":"Systemic administration of neuregulin-1\u03b21 protects dopaminergic neurons in a mouse model of Parkinson's disease","volume":"117","author":"Carlsson","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2017.10.019_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0165-0270(98)00078-8","article-title":"The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism","volume":"83","author":"Rozas","year":"1998","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.cbi.2017.10.019_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0166-4328(90)90099-Z","article-title":"Relation between motor asymmetry and direction of rotational behaviour under amphetamine and apomorphine in rats with unilateral degeneration of the nigrostriatal dopamine system","volume":"39","author":"Ziegler","year":"1990","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbi.2017.10.019_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2017.10.019_bib20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0891-5849(94)00117-3","article-title":"Evaluation of total antioxidant potential (TRAP) and total antioxidant reactivity from luminol-enhanced chemiluminescence measurements","volume":"18","author":"Lissi","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2017.10.019_bib21","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/s11064-007-9575-7","article-title":"Evaluation of estrogen neuroprotective effect on nigrostraital dopaminergic neurons following 6-OHDA injection into the substantia nigra pars compacta or medial forebrain bundle","volume":"33","author":"Ferraz","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbi.2017.10.019_bib22","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.cbi.2017.10.019_bib23","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/(SICI)1096-9861(19960318)366:4<580::AID-CNE3>3.0.CO;2-0","article-title":"Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: a stereological study using the cavalieri and optical disector methods","volume":"366","author":"Oorchot","year":"1996","journal-title":"J. Comp. Neur"},{"key":"10.1016\/j.cbi.2017.10.019_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-2818.2002.01054.x","article-title":"The smooth fractionator","volume":"207","author":"Gundersen","year":"2002","journal-title":"J. Microsc."},{"key":"10.1016\/j.cbi.2017.10.019_bib25","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuroscience.2004.08.050","article-title":"Design-based stereology in neuroscience","volume":"130","author":"Schmitz","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbi.2017.10.019_bib26","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson's disease: clinical features and diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.cbi.2017.10.019_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.nbd.2016.04.008","article-title":"Protein kinase C\u03b4 upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease","volume":"93","author":"Gordon","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cbi.2017.10.019_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cbi.2014.06.022","article-title":"CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice","volume":"220","author":"Jayaraj","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.10.019_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbr.2015.09.025","article-title":"Differential pattern of motor impairments in neurotoxic, environmental and inflammation-driven rat models of Parkinson's disease","volume":"296","author":"Naughton","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbi.2017.10.019_bib30","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1523\/JNEUROSCI.1636-16.2016","article-title":"Anti-inflammatory modulation of microglia via CD163-targeted glucocorticoids protects dopaminergic neurons in the 6-OHDA Parkinson's disease model","volume":"36","author":"Tentillier","year":"2016","journal-title":"J. Neurosc"},{"key":"10.1016\/j.cbi.2017.10.019_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2015.04.014","article-title":"The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease","volume":"283","author":"Dursun","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cbi.2017.10.019_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbi.2013.07.007","article-title":"Cerebrospinal fluid inflammatory markers in Parkinson's disease\u2013associations with depression, fatigue, and cognitive impairment","volume":"33","author":"Lindqvist","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cbi.2017.10.019_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuropharm.2017.05.016","article-title":"Effects of L-DOPA\/benserazide co-treatment on colonic excitatory cholinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration","volume":"123","author":"Pellegrini","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cbi.2017.10.019_bib34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.phrs.2016.09.004","article-title":"Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: in vivo and in vitro evidence","volume":"113","author":"Avagliano","year":"2016","journal-title":"Pharmacolo. Res."},{"key":"10.1016\/j.cbi.2017.10.019_bib35","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/jamaneurol.2016.2742","article-title":"Aberrations in peripheral inflammatory cytokine levels in Parkinson disease: a systematic review and meta-analysis","volume":"73","author":"Quin","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.cbi.2017.10.019_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.123","article-title":"IFN-\u03b3 signaling, with the synergistic contribution of TNF-\u03b1, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease","volume":"3","author":"Barcia","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2017.10.019_bib37","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neulet.2008.06.040","article-title":"Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism","volume":"441","author":"Brodacki","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbi.2017.10.019_bib38","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.neuropharm.2012.01.028","article-title":"Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease","volume":"62","author":"Collins","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cbi.2017.10.019_bib39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cbi.2017.03.016","article-title":"Protective role of apigenin on rotenone induced rat model of Parkinson's disease: suppression of neuroinflammation and oxidative stress mediated apoptosis","volume":"269","author":"Anusha","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2017.10.019_bib40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejphar.2016.11.050","article-title":"D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation","volume":"797","author":"Li","year":"2017","journal-title":"Eur. J. Pharmcol"},{"key":"10.1016\/j.cbi.2017.10.019_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149776","article-title":"Comparative analysis of the effects of neurotrophic factors CDNF and GDNF in a nonhuman primate model of Parkinson's disease","volume":"11","author":"Garea-Rodriguez","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2017.10.019_bib42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejphar.2016.11.054","article-title":"Involvement of BDNF\/TrkB signaling in the effect of diphenyl diselenide on motor function in a Parkinson's disease rat model","volume":"795","author":"Sampaio","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2017.10.019_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17060904","article-title":"Neuroprotective and therapeutic strategies against parkinson's disease: recent perspectives","volume":"17","author":"Sarkar","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2017.10.019_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.263","article-title":"Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model","volume":"7","author":"Drinkut","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2017.10.019_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neulet.2015.10.010","article-title":"Overnight S100B in Parkinson's Disease: a glimpse into sleep-related neuroinflammation","volume":"608","author":"Carvalho","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbi.2017.10.019_bib46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes","volume":"49","author":"Niranjan","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cbi.2017.10.019_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/096368970000900107","article-title":"Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor","volume":"9","author":"Espejo","year":"2000","journal-title":"Cell Transpl."},{"key":"10.1016\/j.cbi.2017.10.019_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2010.12.017","article-title":"Tyrosine hydroxylase and regulation of dopamine synthesis","volume":"508","author":"Daubner","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2017.10.019_bib49","first-page":"162","article-title":"The 6-hydroxydopamine model and parkinsonian pathophysiology: novel findings in an older model","volume":"4853","author":"Hernandez-Baltazar","year":"2015","journal-title":"Neurologia"},{"key":"10.1016\/j.cbi.2017.10.019_bib50","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuroscience.2014.12.048","article-title":"Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin","volume":"289","author":"Filho","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbi.2017.10.019_bib51","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuint.2015.09.006","article-title":"Neuroprotective effect of chrysin: from Chemistry to medicine","volume":"90","author":"Nabavi","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbi.2017.10.019_bib52","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1211\/jpp.61.06.0015","article-title":"Hepatoprotective effect of chrysin of prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats","volume":"61","author":"Sathiavelu","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2017.10.019_bib53","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0896-6273(00)80650-9","article-title":"Topographic guidance labels in a sensory projection to the forebrain","volume":"21","author":"Feldheim","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.cbi.2017.10.019_bib54","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2014.01.044","article-title":"Neurogenesis in the striatum of the adult brain","volume":"156","author":"Ernst","year":"2014","journal-title":"Cell"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717306014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717306014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:46:15Z","timestamp":1757857575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279717306014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":54,"alternative-id":["S0009279717306014"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2017.10.019","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2017.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}