{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:56:00Z","timestamp":1791464160092,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472165"],"award-info":[{"award-number":["81472165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772450"],"award-info":[{"award-number":["81772450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572237"],"award-info":[{"award-number":["81572237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501953"],"award-info":[{"award-number":["81501953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Young Scholars","award":["81722028"],"award-info":[{"award-number":["81722028"]}]},{"name":"Zhejiang Provincial Natural Science","award":["LQ16H090007"],"award-info":[{"award-number":["LQ16H090007"]}]},{"name":"Traditional Chinese Medicine Health Science and Technology Program of Zhejiang Province","award":["2018ZA117"],"award-info":[{"award-number":["2018ZA117"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.cbi.2018.02.028","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T13:37:12Z","timestamp":1521466632000},"page":"96-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"special_numbering":"C","title":["NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K\/Akt\/mTOR signalling pathway to improve functional recovery after traumatic brain injury"],"prefix":"10.1016","volume":"286","author":[{"given":"Kebin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenzan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2018.02.028_bib1","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1038\/nature16035","article-title":"Global neurotrauma research challenges and opportunities","volume":"527","author":"Rubiano","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2018.02.028_bib2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tips.2010.09.005","article-title":"Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies","volume":"31","author":"Loane","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2018.02.028_bib3","doi-asserted-by":"crossref","first-page":"10747","DOI":"10.1073\/pnas.1308950110","article-title":"Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury","volume":"110","author":"Lu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cbi.2018.02.028_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1517\/14728210902769601","article-title":"Emerging treatments for traumatic brain injury","volume":"14","author":"Xiong","year":"2009","journal-title":"Expet Opin. Emerg. Drugs"},{"key":"10.1016\/j.cbi.2018.02.028_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.123","article-title":"Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death","volume":"5","author":"Lin","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2018.02.028_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.191","article-title":"ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS","volume":"5","author":"Koch","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2018.02.028_bib7","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1126\/science.1201148","article-title":"Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury","volume":"331","author":"Hellal","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cbi.2018.02.028_bib8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2174\/187152731304140702112805","article-title":"Mitochondrial neuroprotection in traumatic brain injury: rationale and therapeutic strategies","volume":"13","author":"Yokobori","year":"2014","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.cbi.2018.02.028_bib9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.mito.2004.07.021","article-title":"Mitochondrial damage and dysfunction in traumatic brain injury","volume":"4","author":"Lifshitz","year":"2004","journal-title":"Mitochondrion"},{"key":"10.1016\/j.cbi.2018.02.028_bib10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.gastro.2006.02.033","article-title":"The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver","volume":"131","author":"Fiorucci","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2018.02.028_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2014.05.014","article-title":"Hydrogen sulfide and nitric oxide interactions in inflammation","volume":"41","author":"Lo Faro","year":"2014","journal-title":"Nitric Oxide Biol. Chem."},{"key":"10.1016\/j.cbi.2018.02.028_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbi.2018.02.028_bib13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jnc.12695","article-title":"Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia","volume":"129","author":"Wang","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2018.02.028_bib14","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.neuint.2013.06.004","article-title":"Hydrogen sulfide prevents OGD\/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons","volume":"63","author":"Luo","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbi.2018.02.028_bib15","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.bbrc.2016.08.116","article-title":"Hydrogen sulfide protects against TNF-alpha induced neuronal cell apoptosis through miR-485-5p\/TRADD signaling","volume":"478","author":"Chen","year":"2016","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.cbi.2018.02.028_bib16","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.3892\/mmr.2015.4689","article-title":"Effects of hydrogen sulfide on myocardial fibrosis and PI3K\/AKT1-regulated autophagy in diabetic rats","volume":"13","author":"Xiao","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cbi.2018.02.028_bib17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ijcard.2016.06.200","article-title":"Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts","volume":"220","author":"Chen","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cbi.2018.02.028_bib18","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1523\/JNEUROSCI.3639-16.2017","article-title":"Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction","volume":"37","author":"Nakazato","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbi.2018.02.028_bib19","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2739","article-title":"Dendrobium alkaloids prevent A beta(-)(25-35) induced neuronal and synaptic loss via promoting neurotrophic factors expression in mice","volume":"4","author":"Nie","year":"2016","journal-title":"Peer J"},{"key":"10.1016\/j.cbi.2018.02.028_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-015-0135-1","article-title":"Hydrogen sulfide protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord ischemia-reperfusion injury","volume":"22","author":"Li","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cbi.2018.02.028_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/jnc.12932","article-title":"Hydrogen sulfide is essential for Schwann cell responses to peripheral nerve injury","volume":"132","author":"Park","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2018.02.028_bib22","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.07.020","article-title":"Effect of the inhibition of hydrogen sulfide synthesis on ischemic injury and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats","volume":"24","author":"Hadadha","year":"2015","journal-title":"J. Stroke Cerebrovasc."},{"key":"10.1016\/j.cbi.2018.02.028_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/nature09513","article-title":"Pericytes are required for blood-brain barrier integrity during embryogenesis","volume":"468","author":"Daneman","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2018.02.028_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2018.02.028_bib25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/jnr.23732","article-title":"Chronic cerebrovascular dysfunction after traumatic brain injury","volume":"94","author":"Jullienne","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2018.02.028_bib26","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1002\/jnr.22453","article-title":"Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway","volume":"88","author":"Luo","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2018.02.028_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats","volume":"1491","author":"Yin","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2018.02.028_bib28","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1096\/fj.13-234716","article-title":"A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury","volume":"27","author":"Campolo","year":"2013","journal-title":"Faseb. J."},{"key":"10.1016\/j.cbi.2018.02.028_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.cbi.2018.02.028_bib30","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.4103\/1673-5374.147940","article-title":"Hydrogen sulfide controls peripheral nerve degeneration and regeneration: a novel therapeutic strategy for peripheral demyelinating disorders or nerve degenerative diseases","volume":"9","author":"Jung","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.cbi.2018.02.028_bib31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.aaa2958","article-title":"Systemic administration of epothilone B promotes axon regeneration after spinal cord injury","volume":"348","author":"Ruschel","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cbi.2018.02.028_bib32","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/sj.jcbfm.9600297","article-title":"Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy","volume":"26","author":"Singh","year":"2006","journal-title":"J. Cerebr. Blood F Met."},{"key":"10.1016\/j.cbi.2018.02.028_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8360738","article-title":"AP39, a mitochondria-targeted hydrogen sulfide donor, supports cellular bioenergetics and protects against Alzheimer's disease by preserving mitochondrial function in APP\/PS1 mice and neurons","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.cbi.2018.02.028_bib34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cbi.2018.02.028_bib35","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.4161\/15548627.2014.981787","article-title":"Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury","volume":"10","author":"Sarkar","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.cbi.2018.02.028_bib36","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03029","article-title":"The role of autophagy during the early neonatal starvation period","volume":"432","author":"Kuma","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2018.02.028_bib37","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1159\/000438597","article-title":"Hydrogen sulfide attenuates myocardial hypoxia-reoxygenation injury by inhibiting autophagy via mTOR activation","volume":"37","author":"Xiao","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cbi.2018.02.028_bib38","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.3892\/mmr.2017.7363","article-title":"Neuroprotective effects of hydrogen sulfide on sodium azide-induced autophagic cell death in PC12 cells","volume":"16","author":"Shan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cbi.2018.02.028_bib39","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.lfs.2012.07.026","article-title":"Hydrogen sulfide regulates cardiac sarcoplasmic reticulum Ca2+ uptake via K-ATP channel and PI3K\/Akt pathway","volume":"91","author":"Chen","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2018.02.028_bib40","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/HJH.0000000000001605","article-title":"Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta\/endothelial nitric oxide synthase signaling","volume":"36","author":"Xiao","year":"2017","journal-title":"J. Hypertens."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717313479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279717313479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:49:00Z","timestamp":1757857740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279717313479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":40,"alternative-id":["S0009279717313479"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2018.02.028","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K\/Akt\/mTOR signalling pathway to improve functional recovery after traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2018.02.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}