{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:42:44Z","timestamp":1784943764733,"version":"3.55.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.cbi.2018.05.015","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T23:18:58Z","timestamp":1527549538000},"page":"110-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Venlafaxine mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats"],"prefix":"10.1016","volume":"290","author":[{"given":"Dalia H.","family":"El-Kashef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha H.","family":"Sharawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2018.05.015_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5049\/EBP.2014.12.2.55","article-title":"Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies","volume":"12","author":"Oh","year":"2014","journal-title":"Electrolytes & Blood Pressure : BPP"},{"key":"10.1016\/j.cbi.2018.05.015_bib2","first-page":"47","article-title":"Cisplatin nephrotoxicity: molecular mechanisms","volume":"1","author":"Hanigan","year":"2003","journal-title":"Canc. Ther."},{"key":"10.1016\/j.cbi.2018.05.015_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.toxlet.2015.06.012","article-title":"An integrated view of cisplatin-induced nephrotoxicity and ototoxicity","volume":"237","author":"Karasawa","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2018.05.015_bib4","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/(SICI)1097-0215(19991210)83:6<866::AID-IJC34>3.0.CO;2-9","article-title":"Platinum organ toxicity and possible prevention in patients with testicular cancer","volume":"83","author":"Hartmann","year":"1999","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.cbi.2018.05.015_bib5","series-title":"Insights into Potential Cellular Mechanisms of Cisplatin Nephrotoxicity and Their Clinical Application, Nephrology, Dialysis, Transplantation","first-page":"2478","volume":"vol. 12","author":"Kuhlmann","year":"1997"},{"key":"10.1016\/j.cbi.2018.05.015_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MAJ.0b013e31812dfe1e","article-title":"Cisplatin nephrotoxicity: a review","volume":"334","author":"Yao","year":"2007","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.cbi.2018.05.015_bib7","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.cbi.2018.05.015_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1080\/13102818.2014.942489","article-title":"Protective effects of ethyl pyruvate in cisplatin-induced nephrotoxicity","volume":"28","author":"Kelle","year":"2014","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"10.1016\/j.cbi.2018.05.015_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000042803.28024.92","article-title":"Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells","volume":"14","author":"Townsend","year":"2003","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.cbi.2018.05.015_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/jat.1103","article-title":"Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods","volume":"26","author":"Cetin","year":"2006","journal-title":"J. Appl. Toxicol. : JAT (J. Appl. Toxicol.)"},{"key":"10.1016\/j.cbi.2018.05.015_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1523-1755.2003.00709.x","article-title":"Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death","volume":"63","author":"Tsuruya","year":"2003","journal-title":"Kidney International"},{"key":"10.1016\/j.cbi.2018.05.015_bib12","doi-asserted-by":"crossref","first-page":"F983","DOI":"10.1152\/ajprenal.90579.2008","article-title":"Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway","volume":"296","author":"Jiang","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cbi.2018.05.015_bib13","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1038\/sj.onc.1209440","article-title":"Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis","volume":"25","author":"Jiang","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.cbi.2018.05.015_bib14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ejphar.2014.04.046","article-title":"Antinociceptive effects of venlafaxine in a rat model of peripheral neuropathy: role of alpha2-adrenergic receptors","volume":"738","author":"Hajhashemi","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2018.05.015_bib15","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1590\/S1807-59322011000900017","article-title":"The effects of antidepressants and pilocarpine on rat parotid glands: an immunohistochemical study","volume":"66","author":"Mattioli","year":"2011","journal-title":"Clinics"},{"key":"10.1016\/j.cbi.2018.05.015_bib16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/0091270010394852","article-title":"Efficacy of antidepressants as analgesics: a review","volume":"52","author":"Dharmshaktu","year":"2012","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.cbi.2018.05.015_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.pharep.2014.11.004","article-title":"Ellagic acid enhances the antinociceptive action of venlafaxine in mouse acetic acid-induced pain: an isobolographic analysis","volume":"67","author":"Mansouri","year":"2015","journal-title":"Pharmacol. Rep. : PR"},{"key":"10.1016\/j.cbi.2018.05.015_bib18","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.pbb.2012.12.003","article-title":"Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration","volume":"103","author":"Ohgi","year":"2013","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.cbi.2018.05.015_bib19","first-page":"654","article-title":"The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema","volume":"18","author":"Hajhashemi","year":"2015","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.cbi.2018.05.015_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/hup.1177","article-title":"Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium","volume":"26","author":"Wang","year":"2011","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.cbi.2018.05.015_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pbb.2011.07.015","article-title":"Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice","volume":"100","author":"Abdel-Wahab","year":"2011","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.cbi.2018.05.015_bib22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000329529","article-title":"Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity","volume":"57","author":"Suddek","year":"2011","journal-title":"Chemotherapy"},{"key":"10.1016\/j.cbi.2018.05.015_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2018.05.015_bib24","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.cbi.2018.05.015_bib25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.cbi.2018.05.015_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0027-5107(85)90216-7","article-title":"Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB\/c mice","volume":"148","author":"Marklund","year":"1985","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cbi.2018.05.015_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/clinchem\/8.2.130","article-title":"Modified reagents for determination of urea and ammonia","volume":"8","author":"Chaney","year":"1962","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cbi.2018.05.015_bib28","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-5347(17)36621-1","article-title":"The alterations of norepinephrine and acetylcholine concentrations in immature rat urinary bladder caused by streptozotocin-induced diabetes","volume":"148","author":"Nakamura","year":"1992","journal-title":"J. Urol."},{"key":"10.1016\/j.cbi.2018.05.015_bib29","first-page":"559","article-title":"Recent clinical trials using cisplatin, carboplatin and their combination chemotherapy drugs (review)","volume":"11","author":"Boulikas","year":"2004","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cbi.2018.05.015_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/phrs.2000.0724","article-title":"Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats","volume":"43","author":"Antunes","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2018.05.015_bib31","first-page":"121","article-title":"Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat","volume":"5","author":"Ahangarpour","year":"2014","journal-title":"Vet. Res. Forum : An International Quarterly Journal"},{"key":"10.1016\/j.cbi.2018.05.015_bib32","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.fct.2011.05.012","article-title":"Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkappaB, TNF-alpha and caspase-3 expression in wistar rats","volume":"49","author":"Arjumand","year":"2011","journal-title":"Food Chem. Toxicol. : Int. J. Publ. British Indus. Biol. Res. Assoc."},{"key":"10.1016\/j.cbi.2018.05.015_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.taap.2013.10.031","article-title":"Pre-treatment with cardamonin protects against cisplatin-induced nephrotoxicity in rats: impact on NOX-1, inflammation and apoptosis","volume":"274","author":"El-Naga","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2018.05.015_bib34","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.1021\/acs.jafc.5b00782","article-title":"Protective effects of processed ginseng and its active ginsenosides on cisplatin-induced nephrotoxicity: in vitro and in vivo studies","volume":"63","author":"Park","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2018.05.015_bib35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0305-7372(97)90012-8","article-title":"Free radicals and antioxidants in chemotherapy-induced toxicity","volume":"23","author":"Weijl","year":"1997","journal-title":"Canc. Treat Rev."},{"key":"10.1016\/j.cbi.2018.05.015_bib36","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1124\/jpet.108.147181","article-title":"Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative\/nitrosative stress, inflammation, and cell death","volume":"328","author":"Pan","year":"2009","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.cbi.2018.05.015_bib37","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1440-1681.2004.04127.x","article-title":"Role of non-selective adenosine receptor blockade and phosphodiesterase inhibition in cisplatin-induced nephrogonadal toxicity in rats","volume":"31","author":"Saad","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cbi.2018.05.015_bib38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phymed.2012.12.001","article-title":"Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage","volume":"20","author":"Sahu","year":"2013","journal-title":"Phytomedicine : International Journal of Phytotherapy and Phytopharmacology"},{"key":"10.1016\/j.cbi.2018.05.015_bib39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1742-7843.2005.pto_114.x","article-title":"Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide","volume":"97","author":"Saleh","year":"2005","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2018.05.015_bib40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1472-8206.2011.00996.x","article-title":"Montelukast ameliorates kidney function and urinary bladder sensitivity in experimentally induced renal dysfunction in rats","volume":"27","author":"Suddek","year":"2013","journal-title":"Fund. Clin. Pharmacol."},{"key":"10.1016\/j.cbi.2018.05.015_bib41","first-page":"373","article-title":"L-arginine ameliorates kidney function and urinary bladder sensitivity in experimentally-induced renal dysfunction in rats","volume":"36","author":"Mansour","year":"2003","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.cbi.2018.05.015_bib42","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1074\/jbc.M707568200","article-title":"ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis","volume":"283","author":"Pabla","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2018.05.015_bib43","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5935\/0101-2800.20130052","article-title":"Acute nephrotoxicity of cisplatin: molecular mechanisms","volume":"35","author":"Peres","year":"2013","journal-title":"J. Bras. Neurol. : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia"},{"key":"10.1016\/j.cbi.2018.05.015_bib44","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1183\/09031936.96.09081736","article-title":"Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation","volume":"9","author":"Drent","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cbi.2018.05.015_bib45","series-title":"Measurement of Cell Death in Mammalian Cells, Current Protocols in Pharmacology\/editorial Board","author":"Cummings","year":"2004"},{"key":"10.1016\/j.cbi.2018.05.015_bib46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00467-007-0606-z","article-title":"Urinary annexin V in children with nephrotic syndrome: a new prognostic marker?","volume":"23","author":"Simsek","year":"2008","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.cbi.2018.05.015_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R","article-title":"Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure","volume":"31","author":"van Engeland","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.cbi.2018.05.015_bib48","doi-asserted-by":"crossref","first-page":"F899","DOI":"10.1152\/ajprenal.00362.2014","article-title":"Signaling Rho-kinase mediates inflammation and apoptosis in T cells and renal tubules in cisplatin nephrotoxicity","volume":"308","author":"Nozaki","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cbi.2018.05.015_bib49","article-title":"The restrained expression of NF-kB in renal tissue ameliorates folic acid induced acute kidney injury in mice","volume":"10","author":"Kumar","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2018.05.015_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/967826","article-title":"Pathophysiology of cisplatin-induced acute kidney injury","volume":"2014","author":"Ozkok","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.cbi.2018.05.015_bib51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2018.03.033","article-title":"Protective effect of pristimerin against LPS-induced acute lung injury in mice","volume":"59","author":"Shaaban","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.cbi.2018.05.015_bib52","first-page":"1013","article-title":"Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells","volume":"62","author":"Lee","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2018.05.015_bib53","doi-asserted-by":"crossref","first-page":"F1140","DOI":"10.1152\/ajprenal.00262.2004","article-title":"Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity","volume":"287","author":"Jiang","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cbi.2018.05.015_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113662","article-title":"Transcriptional evidence for the role of chronic venlafaxine treatment in neurotrophic signaling and neuroplasticity including also Glutamatergic [corrected] - and insulin-mediated neuronal processes","volume":"9","author":"Tamasi","year":"2014","journal-title":"PLoS One"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971830293X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971830293X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:49:47Z","timestamp":1757857787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927971830293X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":54,"alternative-id":["S000927971830293X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2018.05.015","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venlafaxine mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2018.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}