{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:50:43Z","timestamp":1784944243253,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472844"],"award-info":[{"award-number":["81472844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["14ZZ114"],"award-info":[{"award-number":["14ZZ114"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.cbi.2018.06.014","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T06:23:05Z","timestamp":1528957385000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Biodistribution and toxicity assessment of intratumorally injected arginine\u2013glycine\u2013aspartic acid peptide conjugated to CdSe\/ZnS quantum dots in mice bearing pancreatic neoplasm"],"prefix":"10.1016","volume":"291","author":[{"given":"Ming-Ming","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ying","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.cbi.2018.06.014_bib1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.2174\/1389200216666150602145310","article-title":"Application of efficient nanoparticles for early diagnosis and treatment of cancer","volume":"16","author":"Alexiou","year":"2015","journal-title":"Curr. Drug Metabol."},{"issue":"1","key":"10.1016\/j.cbi.2018.06.014_bib2","first-page":"207","article-title":"The research and applications of quantum dots as nano-carriers for targeted drug delivery and cancer therapy","volume":"11","author":"Zhao","year":"2016","journal-title":"Chembiochem. Eur. J. Chem. Biol."},{"issue":"3","key":"10.1016\/j.cbi.2018.06.014_bib3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/cncr.22035","article-title":"Emerging implications of nanotechnology on cancer diagnostics and therapeutics","volume":"107","author":"Cuenca","year":"2006","journal-title":"Cancer"},{"issue":"24","key":"10.1016\/j.cbi.2018.06.014_bib4","doi-asserted-by":"crossref","first-page":"12018","DOI":"10.1039\/c3nr03949h","article-title":"Polymer-coated quantum dots","volume":"5","author":"Tomczak","year":"2013","journal-title":"Nanoscale"},{"key":"10.1016\/j.cbi.2018.06.014_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bios.2012.09.025","article-title":"Applications of quantum dots as probes in immunosensing of small-sized analytes","volume":"41","author":"Esteve-Turrillas","year":"2013","journal-title":"Biosens. Bioelectron."},{"issue":"22","key":"10.1016\/j.cbi.2018.06.014_bib6","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1002\/smll.201401508","article-title":"Conjugated polymer\/nanocrystal nanocomposites for renewable energy applications in photovoltaics and photocatalysis","volume":"10","author":"Su","year":"2014","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.cbi.2018.06.014_bib7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1166\/jnn.2014.9134","article-title":"Surface modified quantum dots as fluorescent probes for biomolecule recognition","volume":"14","author":"Mehta","year":"2014","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"7","key":"10.1016\/j.cbi.2018.06.014_bib8","doi-asserted-by":"crossref","first-page":"13447","DOI":"10.3390\/ijms140713447","article-title":"The functions and applications of RGD in tumor therapy and tissue engineering","volume":"14","author":"Wang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.cbi.2018.06.014_bib9","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2174\/1389557515666150909144606","article-title":"Molecular imaging of breast cancer: role of RGD peptides","volume":"15","author":"Chakravarty","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"issue":"5","key":"10.1016\/j.cbi.2018.06.014_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/jlcr.2999","article-title":"RGD-based PET tracers for imaging receptor integrin alphav beta3 expression","volume":"56","author":"Cai","year":"2013","journal-title":"J. Labelled Comp. Rad."},{"issue":"10","key":"10.1016\/j.cbi.2018.06.014_bib11","first-page":"1707","article-title":"microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide","volume":"46","author":"Wu","year":"2005","journal-title":"J. Nucl. Med. Official Publ. Soc. Nucl. Med."},{"issue":"1","key":"10.1016\/j.cbi.2018.06.014_bib12","first-page":"130","article-title":"Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene","volume":"47","author":"Xiong","year":"2006","journal-title":"J. Nucl. Med. Official Publ. Soc. Nucl. Med."},{"issue":"6","key":"10.1016\/j.cbi.2018.06.014_bib13","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1021\/acsnano.5b00406","article-title":"Fluorescence imaging assisted photodynamic therapy using photosensitizer-linked gold quantum clusters","volume":"9","author":"Nair","year":"2015","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.cbi.2018.06.014_bib14","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.3390\/ijerph121013435","article-title":"Threshold dose of three types of quantum dots (QDs) induces oxidative stress triggers DNA damage and apoptosis in mouse fibroblast L929 cells","volume":"12","author":"Zhang","year":"2015","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.cbi.2018.06.014_bib15","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.2147\/IJN.S138624","article-title":"Quantum dots in imaging, drug delivery and sensor applications","volume":"12","author":"Matea","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"10.1016\/j.cbi.2018.06.014_bib16","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1007\/s00253-017-8140-9","article-title":"Cadmium-containing quantum dots: properties, applications, and toxicity","volume":"101","author":"Mo","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"32","key":"10.1016\/j.cbi.2018.06.014_bib17","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1021\/jp8018606","article-title":"Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots","volume":"112","author":"Anas","year":"2008","journal-title":"J. Phys. Chem. B"},{"issue":"4","key":"10.1016\/j.cbi.2018.06.014_bib18","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.talanta.2006.07.048","article-title":"Study on DNA damage induced by CdSe quantum dots using nucleic acid molecular \u201clight switches\u201d as probe","volume":"71","author":"Liang","year":"2007","journal-title":"Talanta"},{"issue":"15","key":"10.1016\/j.cbi.2018.06.014_bib19","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.addr.2008.08.004","article-title":"Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer","volume":"60","author":"Juzenas","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.cbi.2018.06.014_bib20","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1021\/la060093j","article-title":"Long-term exposure to CdTe quantum dots causes functional impairments in live cells","volume":"23","author":"Cho","year":"2007","journal-title":"Langmuir ACS J. Surf. Colloids"},{"issue":"39","key":"10.1016\/j.cbi.2018.06.014_bib21","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.3748\/wjg.v19.i39.6559","article-title":"Effects of integrin-targeted photodynamic therapy on pancreatic carcinoma cell","volume":"19","author":"Zhou","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"21","key":"10.1016\/j.cbi.2018.06.014_bib22","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.3748\/wjg.v22.i21.5012","article-title":"CdSe\/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells","volume":"22","author":"He","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.cbi.2018.06.014_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/nl052405t","article-title":"Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects","volume":"6","author":"Cai","year":"2006","journal-title":"Nano Lett."},{"issue":"3","key":"10.1016\/j.cbi.2018.06.014_bib24","first-page":"331","article-title":"Near-infrared-emitting semiconductor quantum dots for tumor imaging and targeting","volume":"12","author":"Rogach","year":"2010","journal-title":"Curr. Opin. Mol. Therapeut."},{"key":"10.1016\/j.cbi.2018.06.014_bib25","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.2147\/IJN.S108039","article-title":"Construction of magnetic-carbon-quantum-dots-probe-labeled apoferritin nanocages for bioimaging and targeted therapy","volume":"11","author":"Yao","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.cbi.2018.06.014_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10544-014-9844-6","article-title":"Miniaturized fiber-optic ultrasound probes for endoscopic tissue analysis by micro-opto-mechanical technology","volume":"16","author":"Vannacci","year":"2014","journal-title":"Biomed. Microdevices"},{"issue":"4","key":"10.1016\/j.cbi.2018.06.014_bib27","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.17.4.046006","article-title":"Application of optical coherence tomography and high-frequency ultrasound imaging during noninvasive laser vasectomy","volume":"17","author":"Cilip","year":"2012","journal-title":"J. Biomed. Optic."},{"issue":"1","key":"10.1016\/j.cbi.2018.06.014_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0016-5107(03)02361-7","article-title":"EUS-guided photodynamic therapy of the pancreas: a pilot study","volume":"59","author":"Chan","year":"2004","journal-title":"Gastrointest. Endosc."},{"issue":"2","key":"10.1016\/j.cbi.2018.06.014_bib29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.11152\/mu-987","article-title":"Diagnostic utility of endoscopic ultrasonography-elastography in the evaluation of solid pancreatic masses: a meta-analysis and systematic review","volume":"19","author":"Lu","year":"2017","journal-title":"Med. Ultrasonogr."},{"issue":"5","key":"10.1016\/j.cbi.2018.06.014_bib30","first-page":"807","article-title":"Complications of diagnostic and therapeutic Endoscopic Ultrasound. Best practice & research","volume":"30","author":"Lakhtakia","year":"2016","journal-title":"Clin. Gastroenterol."},{"issue":"39","key":"10.1016\/j.cbi.2018.06.014_bib31","doi-asserted-by":"crossref","first-page":"8658","DOI":"10.3748\/wjg.v22.i39.8658","article-title":"Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: can we do better?","volume":"22","author":"Storm","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2018.06.014_bib32","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.2147\/IJN.S70092","article-title":"Toxicity assessment of repeated intravenous injections of arginine\u2013glycine\u2013aspartic acid peptide conjugated CdSeTe\/ZnS quantum dots in mice","author":"Yang","year":"2014","journal-title":"Int. J. Nanomed."},{"issue":"9","key":"10.1016\/j.cbi.2018.06.014_bib33","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/jat.2775","article-title":"Acute toxicity and tissue distribution of CdSe\/CdS-MPA quantum dots after repeated intraperitoneal injection to mice","volume":"33","author":"Haque","year":"2013","journal-title":"J. Appl. Toxicol. JAT (J. Appl. Toxicol.)"},{"key":"10.1016\/j.cbi.2018.06.014_bib34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chemosphere.2017.08.130","article-title":"Assessment of toxicity of selenium and cadmium selenium quantum dots: a review","volume":"188","author":"Sharma","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2018.06.014_bib35","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.2147\/IJN.S130799","article-title":"Effects of arginine-glycine-aspartic acid peptide-conjugated quantum dots-induced photodynamic therapy on pancreatic carcinoma in vivo","volume":"12","author":"Li","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.cbi.2018.06.014_bib36","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.taap.2015.09.019","article-title":"Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains","volume":"289","author":"Scoville","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"8","key":"10.1016\/j.cbi.2018.06.014_bib37","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2174\/138920021131400106","article-title":"Perspectives on the toxicology of cadmium-based quantum dots","volume":"14","author":"Wang","year":"2013","journal-title":"Curr. Drug Metabol."},{"issue":"1","key":"10.1016\/j.cbi.2018.06.014_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/tox.21890","article-title":"In vitro immunotoxicology of quantum dots and comparison with dissolved cadmium and tellurium","volume":"30","author":"Bruneau","year":"2015","journal-title":"Environ. Toxicol."},{"issue":"5","key":"10.1016\/j.cbi.2018.06.014_bib39","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.biomaterials.2011.10.070","article-title":"The cytotoxicity of cadmium-based quantum dots","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.cbi.2018.06.014_bib40","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1159\/000443062","article-title":"Peptide-conjugated quantum dots act as the target marker for human pancreatic carcinoma cells","volume":"38","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2018.06.014_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12951-016-0162-4","article-title":"Immunotoxicity assessment of CdSe\/ZnS quantum dots in macrophages, lymphocytes and BALB\/c mice","volume":"14","author":"Wang","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cbi.2018.06.014_bib42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.chemosphere.2015.12.077","article-title":"Bioconcentration of ionic cadmium and cadmium selenide quantum dots in zebrafish larvae","volume":"148","author":"Zarco-Fernandez","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2018.06.014_bib43","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.bios.2017.01.007","article-title":"Recent advances in nanomaterial-based biosensors for antibiotics detection","volume":"91","author":"Lan","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"9","key":"10.1016\/j.cbi.2018.06.014_bib44","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1080\/13543776.2017.1344216","article-title":"Targeted nanotechnologies for cancer intervention: a patent review (2010-2016)","volume":"27","author":"Pradeep","year":"2017","journal-title":"Expert Opin. Ther. Pat."},{"issue":"20","key":"10.1016\/j.cbi.2018.06.014_bib45","doi-asserted-by":"crossref","first-page":"10267","DOI":"10.1021\/acs.inorgchem.6b01522","article-title":"Near-Infrared light-mediated photodynamic therapy nanoplatform by the electrostatic assembly of upconversion nanoparticles with graphitic carbon nitride quantum dots","volume":"55","author":"Chan","year":"2016","journal-title":"Inorg. Chem."},{"issue":"5","key":"10.1016\/j.cbi.2018.06.014_bib46","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/26\/5\/055102","article-title":"Chlorin e6-ZnSe\/ZnS quantum dots based system as reagent for photodynamic therapy","volume":"26","author":"Martynenko","year":"2015","journal-title":"Nanotechnology"},{"issue":"8","key":"10.1016\/j.cbi.2018.06.014_bib47","first-page":"1278","article-title":"In vivo cancer dual-targeting and dual-modality imaging with functionalized quantum dots","volume":"56","author":"Hu","year":"2015","journal-title":"J. Nucl. Med. Official Publ. Soc. Nucl. Med."},{"issue":"10","key":"10.1016\/j.cbi.2018.06.014_bib48","doi-asserted-by":"crossref","first-page":"23279","DOI":"10.3390\/ijms161023279","article-title":"Liver toxicity of cadmium telluride quantum dots (CdTe QDs) due to oxidative stress in vitro and in vivo","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.cbi.2018.06.014_bib49","article-title":"Sulforaphane protects the liver against CdSe quantum dot-induced cytotoxicity","volume":"10","author":"Ulasov","year":"2015","journal-title":"PLoS One"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279718306173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279718306173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:49:26Z","timestamp":1757857766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279718306173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":49,"alternative-id":["S0009279718306173"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2018.06.014","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biodistribution and toxicity assessment of intratumorally injected arginine\u2013glycine\u2013aspartic acid peptide conjugated to CdSe\/ZnS quantum dots in mice bearing pancreatic neoplasm","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2018.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}