{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:41:23Z","timestamp":1792035683519,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760669"],"award-info":[{"award-number":["81760669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Innovation Project of Guangxi Graduate Education","award":["YCSW2018211"],"award-info":[{"award-number":["YCSW2018211"]}]},{"name":"Guangxi Natural Science Foundation Project of Guangxi Province, China","award":["2017GXNSFAA198259"],"award-info":[{"award-number":["2017GXNSFAA198259"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.cbi.2018.12.006","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T21:37:16Z","timestamp":1544477836000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"special_numbering":"C","title":["Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-\u03b21\/Smad and NOX4\/ROS pathways"],"prefix":"10.1016","volume":"299","author":[{"given":"Qi","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-juan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"48","key":"10.1016\/j.cbi.2018.12.006_bib1","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2018.12.006_bib2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cbi.2018.12.006_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2018.12.006_bib4","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.cbi.2018.12.006_bib5","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.ajpath.2017.01.021","article-title":"Toll-like receptor 4-independent carbon tetrachloride-induced fibrosis and Lipopolysa- ccharide-induced acute liver injury in mice: role of hepatic stellate cells","volume":"187","author":"Kumar","year":"2017","journal-title":"Am. J. Pathol."},{"issue":"23","key":"10.1016\/j.cbi.2018.12.006_bib6","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.3748\/wjg.v20.i23.7260","article-title":"Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: an update","volume":"20","author":"Elpek","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2018.12.006_bib7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jep.2017.08.029","article-title":"Liuweiwuling tablets attenuate BDL- induced hepatic fibrosis via modulation of TGF-\u03b2\/Smad and NF-\u03baB signalling pathways","volume":"210","author":"Liu","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"48","key":"10.1016\/j.cbi.2018.12.006_bib8","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.cbi.2018.12.006_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.cbi.2018.12.006_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/jhep.2002.30362","article-title":"Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P4502E1-derived reactive oxygen species","volume":"35","author":"Nieto","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2018.12.006_bib11","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"Sanchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"10.1016\/j.cbi.2018.12.006_bib12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrc3339","article-title":"Aiding and abetting roles of NOX oxidases in cellular transformation","volume":"12","author":"Block","year":"2012","journal-title":"Nat. Rev. Canc."},{"issue":"2","key":"10.1016\/j.cbi.2018.12.006_bib13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.abb.2007.04.016","article-title":"NOX in liver fibrosis","volume":"462","author":"De Minicis","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.cbi.2018.12.006_bib14","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.23804","article-title":"Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis","volume":"52","author":"De Minicis","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2018.12.006_bib15","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.23804","article-title":"Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis","volume":"52","author":"De Minicis","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2018.12.006_bib16","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1016\/j.bbagen.2016.09.009","article-title":"Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function","volume":"1861","author":"Sun","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbi.2018.12.006_bib17","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1053\/j.gastro.2010.05.074","article-title":"Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo","volume":"139","author":"Jiang","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2018.12.006_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fphys.2016.00017","article-title":"The role of NADPH oxidases (NOXs) in liver fibrosis and the activation of myofibroblasts","volume":"7","author":"Liang","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbi.2018.12.006_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fphar.2014.00167","article-title":"The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies","volume":"5","author":"Xu","year":"2014","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.cbi.2018.12.006_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.cbi.2018.12.006_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2005-858989","article-title":"TGF-\u03b2\/Smad signaling in the injured liver","volume":"44","author":"Breitkopf","year":"2006","journal-title":"Z. Gastroenterol."},{"key":"10.1016\/j.cbi.2018.12.006_bib22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2018.12.006_bib23","doi-asserted-by":"crossref","first-page":"d793","DOI":"10.2741\/gressner","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Front. Biosci."},{"issue":"Suppl 1","key":"10.1016\/j.cbi.2018.12.006_bib24","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.clinre.2015.06.015","article-title":"Reversibility of liver fibrosis","volume":"39","author":"Sun","year":"2015","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"issue":"4","key":"10.1016\/j.cbi.2018.12.006_bib25","first-page":"2306","article-title":"NOX4\/ROS mediate ethanol-induced apoptosis via MAPK signal pathway in L-02 cells","volume":"41","author":"Yang","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.cbi.2018.12.006_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbrc.2017.09.030","article-title":"Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4\/ROS-MAPK pathway","volume":"493","author":"Li","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2018.12.006_bib27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.cbi.2018.06.028","article-title":"Methyl ferulic acid attenuates ethanol-induced hepatic steatosis by regulating AMPK and FoxO1 Pathways in Rats and L-02 cells","volume":"291","author":"Cheng","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2018.12.006_bib28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cbi.2014.10.005","article-title":"Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-\u03b2\/Smad signalling pathway","volume":"224","author":"Lee","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.cbi.2018.12.006_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jphs.2015.12.002","article-title":"Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro","volume":"130","author":"Chu","year":"2016","journal-title":"J. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.cbi.2018.12.006_bib30","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3109\/13880209.2015.1035795","article-title":"Protective effect of Lepidium sativum seed extract against hydrogen peroxide-induced cytotoxicity and oxidative stress in human liver cells (HepG2)","volume":"54","author":"Al-Sheddi","year":"2016","journal-title":"Pharm. Biol."},{"issue":"7","key":"10.1016\/j.cbi.2018.12.006_bib31","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1530-0277.2011.01720.x","article-title":"Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation","volume":"36","author":"Roychowdhury","year":"2012","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.cbi.2018.12.006_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s13167-017-0115-5","article-title":"High regenerative capacity of the liver and irreversible injury of male reproductive system in carbon tetrachloride-induced liver fibrosis rat model","volume":"9","author":"Bubnov","year":"2017","journal-title":"EPMA J."},{"issue":"4","key":"10.1016\/j.cbi.2018.12.006_bib33","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/hep.22758","article-title":"Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats","volume":"49","author":"Mejias","year":"2009","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.cbi.2018.12.006_bib34","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.cbi.2018.12.006_bib35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.5603\/EP.2013.0022","article-title":"Transforming growth factor beta1 (TGF beta1) in physiology and pathology","volume":"64","author":"Kajdaniuk","year":"2013","journal-title":"Endokrynol. Pol."},{"issue":"6","key":"10.1016\/j.cbi.2018.12.006_bib36","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/liv.12465","article-title":"Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever","volume":"34","author":"Carloni","year":"2014","journal-title":"B Liver Int."},{"issue":"2","key":"10.1016\/j.cbi.2018.12.006_bib37","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/hep.25670","article-title":"Fibrosis-dependent mechanisms of hepatocarcinogenesis","volume":"56","author":"Zhang","year":"2012","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.cbi.2018.12.006_bib38","first-page":"2228","article-title":"Hepatoprotective effect of methyl ferulic acid against carbon tetrachloride-induced acute liver injury in rats","volume":"15","author":"Yang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cbi.2018.12.006_bib39","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0399-8320(07)73970-2","article-title":"Liver fibrosis: from mechanisms to treatment","volume":"31","author":"Friedman","year":"2007","journal-title":"Gastroenterol. Clin. Et. Biol."},{"key":"10.1016\/j.cbi.2018.12.006_bib40","first-page":"30382","article-title":"Effects of NLRP6 on the proliferation and activation of human hepatic stellate cells","author":"Zhu","year":"2018","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.cbi.2018.12.006_bib41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jep.2013.03.067","article-title":"Effect of bioactive peptide of Carapax Trionycis on TGF-\u03b21-induced intracellular events in hepatic stellate cells","volume":"148","author":"Tang","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.cbi.2018.12.006_bib42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.pharep.2017.11.017","article-title":"Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: oxidative stress\/TGF-\u03b21-induced HSCs activation pathway","volume":"70","author":"Atallah","year":"2018","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.cbi.2018.12.006_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/1440-1681.12182","article-title":"Probucol attenuates ethanol-induced liver fibrosis in rats by inhibiting oxidative stress, extracellular matrix protein accumulation and cytokine production","volume":"41","author":"Su","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cbi.2018.12.006_bib44","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.biopha.2018.06.118","article-title":"Flavonoid-rich Scabiosa comosa inflorescence extract attenuates CCl4-induced hepatic fibrosis by modulating TGF-\u03b2-induced Smad3 phosphorylation","volume":"106","author":"Ma","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2018.12.006_bib45","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.biopha.2017.11.117","article-title":"Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs\/TIMPs system in rats","volume":"97","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"Suppl 1","key":"10.1016\/j.cbi.2018.12.006_bib46","first-page":"S84","article-title":"Astaxanthin ameliorates hepatic damage and oxidative stress in carbon tetrachloride- administered rats","volume":"9","author":"Islam","year":"2017","journal-title":"Pharmacogn. Res."},{"key":"10.1016\/j.cbi.2018.12.006_bib47","first-page":"1","article-title":"Oxidative stress and hepatic stellate cells: a paradoxical relationship","volume":"7","author":"Gandhi","year":"2012","journal-title":"Trends Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2018.12.006_bib48","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.fct.2018.07.048","article-title":"Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice","volume":"120","author":"Sun","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.cbi.2018.12.006_bib49","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1002\/hep.25938","article-title":"Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent","volume":"56","author":"Aoyama","year":"2012","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.cbi.2018.12.006_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129743","article-title":"Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation","volume":"10","author":"Lan","year":"2015","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.cbi.2018.12.006_bib51","doi-asserted-by":"crossref","first-page":"8750","DOI":"10.1074\/jbc.RA117.001045","article-title":"Quantitative interaction analysis permits molecular insights into functional NOX4 NADPH oxidase heterodimer assembly","volume":"293","author":"O'Neill","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2018.12.006_bib52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopha.2017.06.006","article-title":"Scoparone attenuates hepatic stellate cell activation through inhibiting TGF-\u03b2\/Smad signalling pathway","volume":"93","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cbi.2018.12.006_bib53","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12906-016-1507-0","article-title":"Effect of ginseng extract on the TGF-\u03b21 signalling pathway in CCl4-induced liver fibrosis in rats","volume":"17","author":"Hafez","year":"2017","journal-title":"BMC Complement Altern. Med."},{"issue":"3","key":"10.1016\/j.cbi.2018.12.006_bib54","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbrc.2011.05.023","article-title":"The antifibrotic effects of TGF-\u03b21 siRNA on hepatic fibrosis in rats","volume":"409","author":"Lang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.cbi.2018.12.006_bib55","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.cbi.2018.12.006_bib56","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.ajpath.2014.04.014","article-title":"Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro","volume":"184","author":"Duan","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"34","key":"10.1016\/j.cbi.2018.12.006_bib57","doi-asserted-by":"crossref","first-page":"56267","DOI":"10.18632\/oncotarget.17453","article-title":"Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-\u03b2\/Smad signalling pathway","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279718310706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279718310706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:52:48Z","timestamp":1757857968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279718310706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":57,"alternative-id":["S0009279718310706"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2018.12.006","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-\u03b21\/Smad and NOX4\/ROS pathways","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2018.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}