{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:56:01Z","timestamp":1786985761416,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rajiv Gandhi National Fellowship for Students with Disabilities, New Delhi","award":["F.\/2013-14\/RGNF-2013-14D-OBC-TAM-56329"],"award-info":[{"award-number":["F.\/2013-14\/RGNF-2013-14D-OBC-TAM-56329"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.cbi.2019.01.008","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T12:10:21Z","timestamp":1547035821000},"page":"91-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"special_numbering":"C","title":["Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1\u202fcell line"],"prefix":"10.1016","volume":"300","author":[{"given":"Dhanaraj","family":"Teekaraman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugantha Priya","family":"Elayapillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangala Priya","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunakaran","family":"Jagadeesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cbi.2019.01.008_bib1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.cbi.2019.01.008_bib2","first-page":"28","article-title":"Study of'patterns of care'of ovarian cancer patients in a specialized cancer institute in Kolkata, eastern India","volume":"46","author":"Basu","year":"2009","journal-title":"Ind. J. Canc."},{"issue":"1","key":"10.1016\/j.cbi.2019.01.008_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00441-005-1100-1","article-title":"Loss of ovarian function and the risk of ovarian cancer","volume":"322","author":"Vanderhyden","year":"2005","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cbi.2019.01.008_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.pathol.4.110807.092246","article-title":"Ovarian cancer","volume":"4","author":"Cho","year":"2009","journal-title":"Annu. Rev. Pathol."},{"issue":"5","key":"10.1016\/j.cbi.2019.01.008_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrc1611","article-title":"Ovarian cancer metastasis: integrating insights from disparate model organisms","volume":"5","author":"Naora","year":"2005","journal-title":"Nat. Rev. Canc."},{"issue":"1","key":"10.1016\/j.cbi.2019.01.008_bib6","first-page":"304","article-title":"Capn4 overexpression indicates poor prognosis of ovarian cancer patients","volume":"9","author":"Yang","year":"2018","journal-title":"J. Canc."},{"issue":"1","key":"10.1016\/j.cbi.2019.01.008_bib7","first-page":"131","article-title":"The biology of cell death in tumours","volume":"5","author":"Wyllie","year":"1985","journal-title":"Anticancer Res."},{"key":"10.1016\/j.cbi.2019.01.008_bib8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1101\/gad.10.4.461","article-title":"The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein","volume":"10","author":"Han","year":"1996","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.cbi.2019.01.008_bib9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"34","key":"10.1016\/j.cbi.2019.01.008_bib10","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1038\/sj.onc.1209608","article-title":"Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy","volume":"25","author":"Fulda","year":"2006","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.cbi.2019.01.008_bib11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology","volume":"104","author":"Locksley","year":"2001","journal-title":"Cell"},{"issue":"5684","key":"10.1016\/j.cbi.2019.01.008_bib12","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.cbi.2019.01.008_bib13","first-page":"141","article-title":"Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review)","volume":"12","author":"Decaudin","year":"1998","journal-title":"Int. J. Oncol."},{"issue":"16","key":"10.1016\/j.cbi.2019.01.008_bib14","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1038\/sj.onc.1207523","article-title":"Toxic proteins released from mitochondria in cell death","volume":"23","author":"Saelens","year":"2004","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.cbi.2019.01.008_bib15","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1074\/jbc.275.9.6067","article-title":"Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes","volume":"275","author":"Cain","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cbi.2019.01.008_bib16","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.3892\/ol.2017.6750","article-title":"Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9","volume":"14","author":"Chen","year":"2017","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.cbi.2019.01.008_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.77","article-title":"Targeted apoptosis in ovarian cancer cells through mitochondrial dysfunction in response to Sambucus nigra agglutinin","volume":"8","author":"Chowdhury","year":"2017","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cbi.2019.01.008_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s13205-013-0117-5","article-title":"Anti-cancer potential of flavonoids: recent trends and future perspectives","volume":"3","author":"Batra","year":"2013","journal-title":"3 Biotech."},{"issue":"12","key":"10.1016\/j.cbi.2019.01.008_bib19","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1021\/jf00024a011","article-title":"Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands","volume":"40","author":"Hertog","year":"1992","journal-title":"J. Agric. Food Chem."},{"issue":"8S Suppl","key":"10.1016\/j.cbi.2019.01.008_bib20","doi-asserted-by":"crossref","first-page":"2073S","DOI":"10.1093\/jn\/130.8.2073S","article-title":"Dietary intake and bioavailability of polyphenols","volume":"130","author":"Scalbert","year":"2000","journal-title":"J. Nutr."},{"issue":"10","key":"10.1016\/j.cbi.2019.01.008_bib21","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1002\/ijc.22790","article-title":"A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer","volume":"121","author":"Gates","year":"2007","journal-title":"Int. J. Canc."},{"issue":"11","key":"10.1016\/j.cbi.2019.01.008_bib22","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/sj.bjc.6601872","article-title":"Fruit and vegetable consumption in relation to ovarian cancer incidence: the Swedish mammography cohort","volume":"90","author":"Larsson","year":"2004","journal-title":"Br. J. Canc."},{"issue":"11 Pt 1","key":"10.1016\/j.cbi.2019.01.008_bib23","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1158\/1055-9965.EPI-05-0159","article-title":"Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European prospective investigation into cancer and nutrition","volume":"14","author":"Schulz","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"5","key":"10.1016\/j.cbi.2019.01.008_bib24","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3945\/ajcn.114.088708","article-title":"Intake of dietary flavonoids and risk of epithelial ovarian cancer","volume":"100","author":"Cassidy","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbi.2019.01.008_bib25","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bionut.2014.07.003","article-title":"Epidermal growth factor-induced prostate cancer (PC3) cell survival and proliferation is inhibited by quercetin, a plant flavonoid through apoptotic machinery","volume":"4","author":"Bhat","year":"2014","journal-title":"Biomed. Prev. Nut."},{"issue":"4","key":"10.1016\/j.cbi.2019.01.008_bib26","first-page":"837","article-title":"Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin","volume":"19","author":"Choi","year":"2001","journal-title":"Int. J. Oncol."},{"issue":"53","key":"10.1016\/j.cbi.2019.01.008_bib27","doi-asserted-by":"crossref","first-page":"55875","DOI":"10.1074\/jbc.M407985200","article-title":"Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells","volume":"279","author":"Kuo","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cbi.2019.01.008_bib28","first-page":"727","article-title":"Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions","volume":"11","author":"Ong","year":"2004","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.cbi.2019.01.008_bib29","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.clnu.2013.08.011","article-title":"Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model","volume":"33","author":"Sharmila","year":"2014","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.cbi.2019.01.008_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3892\/or.2016.4786","article-title":"Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells","volume":"36","author":"Seo","year":"2016","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.cbi.2019.01.008_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/cbf.1725","article-title":"Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)","volume":"29","author":"Senthilkumar","year":"2011","journal-title":"Cell Biochem. Funct."},{"issue":"10","key":"10.1016\/j.cbi.2019.01.008_bib32","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1039\/C7FO00778G","article-title":"Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway","volume":"8","author":"Wu","year":"2017","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.cbi.2019.01.008_bib33","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1080\/01635580802100851","article-title":"Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids","volume":"60","author":"Luo","year":"2008","journal-title":"Nutr. Canc."},{"issue":"5","key":"10.1016\/j.cbi.2019.01.008_bib34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/cas.12395","article-title":"Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway","volume":"105","author":"Yi","year":"2014","journal-title":"Cancer Sci."},{"issue":"22","key":"10.1016\/j.cbi.2019.01.008_bib35","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1039\/c2nr32181e","article-title":"Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer","volume":"4","author":"Gao","year":"2012","journal-title":"Nanoscale"},{"issue":"1\u20132","key":"10.1016\/j.cbi.2019.01.008_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cbi.2019.01.008_bib37","article-title":"Acridine orange\/ethidium bromide (AO\/EB) staining to detect apoptosis","volume":"3","author":"Kasibhatla","year":"2006","journal-title":"CSH Protoc."},{"issue":"2","key":"10.1016\/j.cbi.2019.01.008_bib38","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nprot.2006.83","article-title":"The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on","volume":"1","author":"Chomczynski","year":"2006","journal-title":"Nat. Protoc."},{"issue":"4","key":"10.1016\/j.cbi.2019.01.008_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.cbi.2019.01.008_bib40","first-page":"659","article-title":"Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition","volume":"2","author":"Ferry","year":"1996","journal-title":"Clin. Canc. Res."},{"issue":"9","key":"10.1016\/j.cbi.2019.01.008_bib41","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/jn\/138.9.1615","article-title":"Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans","volume":"138","author":"Egert","year":"2008","journal-title":"J. Nutr."},{"issue":"11","key":"10.1016\/j.cbi.2019.01.008_bib42","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.jnutbio.2014.06.008","article-title":"Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR\/PI3K\/Akt pathway","volume":"25","author":"Bhat","year":"2014","journal-title":"J. Nutr. Biochem."},{"issue":"1\u20132","key":"10.1016\/j.cbi.2019.01.008_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11010-005-9085-3","article-title":"Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3)","volume":"287","author":"Vijayababu","year":"2006","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.cbi.2019.01.008_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3727\/000000006783981224","article-title":"Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3","volume":"16","author":"Vijayababu","year":"2006","journal-title":"Oncol. Res."},{"issue":"5","key":"10.1016\/j.cbi.2019.01.008_bib45","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.3892\/ijo.2015.2931","article-title":"The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells","volume":"46","author":"Wang","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.cbi.2019.01.008_bib46","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jmst.2017.01.004","article-title":"Synergistic anticancer effect of green synthesized nickel nanoparticles and quercetin extracted from Ocimum sanctum leaf extract","volume":"34","author":"Rameshthangam","year":"2017","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.cbi.2019.01.008_bib47","doi-asserted-by":"crossref","first-page":"24049","DOI":"10.1038\/srep24049","article-title":"Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis","volume":"6","author":"Srivastava","year":"2016","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.cbi.2019.01.008_bib48","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00432-005-0005-4","article-title":"Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression","volume":"131","author":"Vijayababu","year":"2005","journal-title":"J. Canc. Res. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.cbi.2019.01.008_bib49","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.fct.2012.01.025","article-title":"Antitumor activities of quercetin and quercetin-5\u2032, 8-disulfonate in human colon and breast cancer cell lines","volume":"50","author":"Zhang","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.cbi.2019.01.008_bib50","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s12272-001-2107-0","article-title":"Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells","volume":"31","author":"Choi","year":"2008","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"12","key":"10.1016\/j.cbi.2019.01.008_bib51","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1021\/cb500259e","article-title":"Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity","volume":"9","author":"Primikyri","year":"2014","journal-title":"ACS Chem. Biol."},{"issue":"1","key":"10.1016\/j.cbi.2019.01.008_bib52","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s12906-017-2023-6","article-title":"Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways","volume":"17","author":"Liu","year":"2017","journal-title":"BMC Complement Altern. Med."},{"issue":"9","key":"10.1016\/j.cbi.2019.01.008_bib53","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1021\/jf305263r","article-title":"Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells","volume":"61","author":"Zhang","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.cbi.2019.01.008_bib54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/cpr.12017","article-title":"Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2\/M, in cervical carcinoma: signal cascade and drug-DNA interaction","volume":"46","author":"Bishayee","year":"2013","journal-title":"Cell Prolif"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279718310652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279718310652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:51:57Z","timestamp":1757857917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279718310652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":54,"alternative-id":["S0009279718310652"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2019.01.008","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1\u202fcell line","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2019.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}