{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:26:37Z","timestamp":1790367997073,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.cbi.2019.01.019","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T17:21:26Z","timestamp":1548091286000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPAR\u03b1-autophagy pathway"],"prefix":"10.1016","volume":"300","author":[{"given":"Zhidong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiance","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2019.01.019_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0971-6580.84258","article-title":"Mechanisms pertaining to arsenic toxicity","volume":"18","author":"Singh","year":"2011","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.cbi.2019.01.019_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2559.2011.04145.x","article-title":"The epidemiology, pathogenesis and histopathology of fatty liver disease","volume":"61","author":"Levene","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.cbi.2019.01.019_bib3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2007.08.020","article-title":"Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice","volume":"226","author":"Arteel","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2019.01.019_bib4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1021\/pr400719u","article-title":"Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced Fatty liver disease","volume":"13","author":"Shi","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbi.2019.01.019_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/toxsci\/kfn120","article-title":"Liver is a target of arsenic carcinogenesis","volume":"105","author":"Jie","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2019.01.019_bib6","series-title":"Hepatic Stellate Cells and Liver Fibrosis","author":"Puche","year":"2007"},{"key":"10.1016\/j.cbi.2019.01.019_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cbi.2019.01.019_bib8","first-page":"49","article-title":"Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis","author":"Gressner","year":"1996","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.cbi.2019.01.019_bib9","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1080\/17474124.2016.1251309","article-title":"Epigenetic regulation of hepatic stellate cell activation and liver fibrosis","volume":"10","author":"El","year":"2016","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2019.01.019_bib10","first-page":"223","article-title":"[Hepatic stellate cells and oxidative stress]","volume":"99","author":"Urtasun","year":"2007","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"10.1016\/j.cbi.2019.01.019_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.cbi.2019.01.019_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.taap.2010.11.016","article-title":"Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice","volume":"251","author":"Ghatak","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2019.01.019_bib13","first-page":"938","article-title":"Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues","volume":"142","author":"Hern\u00e3","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.cbi.2019.01.019_bib14","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jhep.2011.07.010","article-title":"A role for autophagy during hepatic stellate cell activation","volume":"55","author":"Thoen","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.01.019_bib15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41419-018-1004-0","article-title":"Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway","volume":"9","author":"Qiu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2019.01.019_bib16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jhep.2014.04.013","article-title":"PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism","volume":"61","author":"van Diepen","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.01.019_bib17","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Original article: liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.cbi.2019.01.019_bib18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3945\/jn.110.135210","article-title":"PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver","volume":"141","author":"Abdelmegeed","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.cbi.2019.01.019_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/jhep.2003.50307","article-title":"Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice","volume":"38","author":"Ip","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.01.019_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature13961","article-title":"Nutrient-sensing nuclear receptors coordinate autophagy","volume":"516","author":"Lee","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.01.019_bib21","series-title":"Maternal Taurine Supplementation Prevents Misprogramming","author":"Arany","year":"2017"},{"key":"10.1016\/j.cbi.2019.01.019_bib22","first-page":"1","article-title":"Taurine attenuates the development of hepatic steatosis through the inhibition of oxidative stress in a model of nonalcoholic fatty liver disease in vivo and in vitro","author":"Murakami","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbi.2019.01.019_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01345280","article-title":"Taurine: protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats","volume":"15","author":"Kerai","year":"1998","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbi.2019.01.019_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0278-6915(97)00146-4","article-title":"Effect of taurine on toxicity of copper in rats","volume":"36","author":"Hwang","year":"1998","journal-title":"Food Chem. Toxicol. An Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.cbi.2019.01.019_bib25","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1742-7843.2008.00208.x","article-title":"Taurine prevents tamoxifen-induced mitochondrial oxidative damage in mice","volume":"102","author":"Parvez","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2019.01.019_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.taap.2004.08.010","article-title":"Implications of oxidative stress and hepatic cytokine (TNF-alpha and IL-6) response in the pathogenesis of hepatic collagenesis in chronic arsenic toxicity","volume":"204","author":"Das","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2019.01.019_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.taap.2011.04.022","article-title":"Inhibition of arsenic-induced rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-\u03b2\/Smad activation","volume":"254","author":"Pan","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2019.01.019_bib28","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.jhep.2004.12.008","article-title":"Fibrosis in chronic liver diseases: diagnosis and management","volume":"42","author":"Pinzani","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.01.019_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7243\/2056-3779-1-1","article-title":"Fetal exposure to arsenic results in hyperglycemia, hypercholesterolemia, and nonalcoholic fatty liver disease in adult mice","volume":"1","author":"Sanchez-Soria","year":"2014","journal-title":"J. Toxicol. Health"},{"key":"10.1016\/j.cbi.2019.01.019_bib30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3181\/0710-RM-269","article-title":"High dietary fat exacerbates arsenic-induced liver fibrosis in mice","volume":"233","author":"Wu","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.cbi.2019.01.019_bib31","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.01.019_bib32","doi-asserted-by":"crossref","first-page":"C1200","DOI":"10.1152\/ajpcell.1995.269.5.C1200","article-title":"Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation","volume":"269","author":"Cuervo","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cbi.2019.01.019_bib33","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00018-007-7278-5","article-title":"Peroxisome proliferator-activated receptors as sensors of fatty acids and derivatives","volume":"64","author":"Grimaldi","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbi.2019.01.019_bib34","first-page":"85","article-title":"An overview on biological mechanisms of PPARs","volume":"51","author":"Bhavani Prasad","year":"2005","journal-title":"Pharmacol. Res. Offic. J. Ital. Pharmacol. Soc."},{"key":"10.1016\/j.cbi.2019.01.019_bib35","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Michal","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.01.019_bib36","first-page":"1131","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.cbi.2019.01.019_bib37","first-page":"282041","article-title":"Lipophagy: connecting autophagy and lipid metabolism","author":"Singh","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.cbi.2019.01.019_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2012.63","article-title":"Regulation of lipid stores and metabolism by lipophagy","volume":"20","author":"Liu","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cbi.2019.01.019_bib39","series-title":"Taurine Protects Mouse Liver against Arsenic-Induced Apoptosis through JNK Pathway","author":"Li","year":"2017"},{"key":"10.1016\/j.cbi.2019.01.019_bib40","doi-asserted-by":"crossref","first-page":"27733","DOI":"10.1038\/srep27733","article-title":"Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPAR\u03b3 pathway","volume":"6","author":"Bai","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971831425X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927971831425X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:52:18Z","timestamp":1757857938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927971831425X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":40,"alternative-id":["S000927971831425X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2019.01.019","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPAR\u03b1-autophagy pathway","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2019.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}