{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:49:10Z","timestamp":1784810950657,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.cbi.2019.04.008","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T11:14:10Z","timestamp":1554722050000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis"],"prefix":"10.1016","volume":"306","author":[{"given":"Rania Nagi","family":"Abd-Ellatif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam Ibrahim","family":"Hegab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Mohamed","family":"Atef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Tayssir","family":"Sadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser Mostafa","family":"Hafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cbi.2019.04.008_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/labinvest.2017.120","article-title":"NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation","volume":"98","author":"Meng","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cbi.2019.04.008_bib2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/08860220802212965","article-title":"Experimental myoglobinuric acute renal failure: the effect of vitamin C","volume":"30","author":"Ustundag","year":"2008","journal-title":"Ren. Fail."},{"issue":"8","key":"10.1016\/j.cbi.2019.04.008_bib3","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/sj.ki.5000315","article-title":"Role of caspases on cell death, inflammation and cell cycle in glycerol-induced acute renal failure","volume":"69","author":"Homsiv","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbi.2019.04.008_bib4","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1681\/ASN.2014030262","article-title":"Regulated cell death in AKI","volume":"25","author":"Linkermann","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cbi.2019.04.008_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.cbi.2019.04.008_bib6","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1152\/ajprenal.00311.2014","article-title":"TNF-\u03b1-mediated cardiorenal injury after rhabdomyolysis in rats","volume":"308","author":"Homsi","year":"2015","journal-title":"Am. J. Physiol. Renal. Physiol."},{"issue":"5","key":"10.1016\/j.cbi.2019.04.008_bib7","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.freeradbiomed.2010.10.704","article-title":"Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure","volume":"51","author":"Boutaud","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2019.04.008_bib8","doi-asserted-by":"crossref","first-page":"9507563","DOI":"10.1155\/2016\/9507563","article-title":"Possible protective effect of diacerein on doxorubicin-induced nephrotoxicity in rats","volume":"2016","author":"Refaie","year":"2016","journal-title":"J. Toxicol."},{"issue":"04","key":"10.1016\/j.cbi.2019.04.008_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/s-0034-1396241","article-title":"Anti-hyperuricemic and nephroprotective effects of rhein in hyperuricemic mice","volume":"81","author":"Meng","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2019.04.008_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopha.2017.08.053","article-title":"Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats","volume":"95","author":"Refaiea","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cbi.2019.04.008_bib11","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1038\/s41598-017-10693-4","article-title":"Effect of curcumin on glycerol-induced acute kidney injury in rats","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.cbi.2019.04.008_bib12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.pbb.2012.06.018","article-title":"Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice","volume":"102","author":"Gadotti","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.cbi.2019.04.008_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2019.04.008_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal. Biochem."},{"issue":"1988","key":"10.1016\/j.cbi.2019.04.008_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cbi.2019.04.008_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1383-5718(97)00073-9","article-title":"Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow)","volume":"391","author":"Sasaki","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cbi.2019.04.008_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0076-6879(78)52008-9","article-title":"Preparation of microsomes with calcium","volume":"52","author":"JSchenkman","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbi.2019.04.008_bib18","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1016\/S0021-9258(18)63477-5","article-title":"Microsomal heme oxygenase. characterization of the enzyme","volume":"244","author":"Tenhunen","year":"1969","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cbi.2019.04.008_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.cbi.2019.04.008_bib20","first-page":"184","article-title":"The preventive role of pioglitazone in glycerol-induced acute kidney injury in rats during two different treatment periods","volume":"43","author":"Mousleh","year":"2018","journal-title":"Iran. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.cbi.2019.04.008_bib21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/0886022X.2012.760408","article-title":"L-Citrulline protects against glycerol- induced acute renal failure in rats","volume":"35","author":"Liu","year":"2013","journal-title":"Ren. Fail."},{"issue":"3","key":"10.1016\/j.cbi.2019.04.008_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/02640410903440892","article-title":"Relationship between serum creatine kinase activity following exercise-induced muscle damage and muscle fibre composition","volume":"28","author":"Magal","year":"2010","journal-title":"J. Sport. Sci."},{"issue":"2","key":"10.1016\/j.cbi.2019.04.008_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/08860220802599130","article-title":"L-Carnitine ameliorates glycerol-induced myoglobinuric acute renal failure in rats","volume":"31","author":"Ustundag","year":"2009","journal-title":"Ren. Fail."},{"issue":"7","key":"10.1016\/j.cbi.2019.04.008_bib24","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1681\/ASN.V1271391","article-title":"Glomerular injury and tubular loss in adriamycin nephrosis","volume":"12","author":"Javaid","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cbi.2019.04.008_bib25","series-title":"Rubin\u02bcs Pathology: Clinicopathologic Foundations of Medicine","first-page":"753","article-title":"The kidney","author":"Jennette","year":"2011"},{"issue":"1","key":"10.1016\/j.cbi.2019.04.008_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.15283\/ijsc.2013.6.1.55","article-title":"Histological study on effect of mesenchymal stem cell therapy on experimental renal injury induced by ischemia\/reperfusion in male albino rat","volume":"6","author":"Sadek","year":"2013","journal-title":"Int. J. Stem Cells"},{"issue":"1","key":"10.1016\/j.cbi.2019.04.008_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1248\/bpb.35.34","article-title":"Glycerol-induced renal damage improved by 7-O-galloyl-D-sedoheptulose treatment through attenuating oxidative stress","volume":"35","author":"Park","year":"2012","journal-title":"Biol. Pharm. Bull."},{"issue":"9","key":"10.1016\/j.cbi.2019.04.008_bib28","first-page":"430","article-title":"Mega doses of resveratrol enhance oxidative and nitrosative stress and accelerate inflammations in glycerol-rat model","volume":"7","author":"Mahmoud","year":"2011","journal-title":"J. Am. Sci."},{"key":"10.1016\/j.cbi.2019.04.008_bib29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000056138","article-title":"Effects of diacerein on indomethacin-induced gastric ulceration","volume":"63","author":"Tamura","year":"2001","journal-title":"Pharmacology"},{"issue":"12","key":"10.1016\/j.cbi.2019.04.008_bib30","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1590\/S0100-879X2006001200006","article-title":"DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay","volume":"39","author":"Zeljezi\u0107","year":"2006","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"4","key":"10.1016\/j.cbi.2019.04.008_bib31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/MPG.0b013e3182334fdf","article-title":"Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers","volume":"54","author":"Uc","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"30","key":"10.1016\/j.cbi.2019.04.008_bib32","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.2174\/1381612821666150803145508","article-title":"Role of the heme oxygenase-adiponectin-atrial natriuretic peptide axis in renal function","volume":"21","author":"Ndisang","year":"2015","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.cbi.2019.04.008_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/ajprenal.00438.2010","article-title":"Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury","volume":"301","author":"Wei","year":"2011","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.cbi.2019.04.008_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2017.11.021","article-title":"Diacerein alleviates kidney injury through attenuating inflammation and oxidative stress in obese insulin-resistant rats","volume":"115","author":"Chueakula","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.cbi.2019.04.008_bib35","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2337\/dc11-0357","article-title":"Effect of diacerein on insulin secretion and metabolic control in drug-Na\u00efve patients with type 2 diabetes a randomized clinical trial","volume":"34","author":"Ramos-Zavala","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cbi.2019.04.008_bib36","first-page":"23","article-title":"Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice","volume":"16","author":"Yu","year":"2018","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.cbi.2019.04.008_bib37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/ki.2013.68","article-title":"Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models","volume":"84","author":"Wei","year":"2013","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.cbi.2019.04.008_bib38","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.fct.2011.04.011","article-title":"Rhein protects against acetaminophen-induced hepatic and renal toxicity","volume":"49","author":"Zhao","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"48","key":"10.1016\/j.cbi.2019.04.008_bib39","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/onc.2008.301","article-title":"JNK signaling in apoptosis","volume":"27","author":"Dhanasekaran","year":"2008","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cbi.2019.04.008_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/labinvest.2017.115","article-title":"Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis","volume":"98","author":"Meng","year":"2018","journal-title":"Lab. Invest."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719301784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719301784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T13:53:22Z","timestamp":1757858002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279719301784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":40,"alternative-id":["S0009279719301784"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2019.04.008","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2019.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}