{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:21:36Z","timestamp":1790749296268,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"am","delay-in-days":331,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006751","name":"U.S. Army","doi-asserted-by":"publisher","award":["N\\u00B0 W81XWH18-1-0666"],"award-info":[{"award-number":["N\\u00B0 W81XWH18-1-0666"]}],"id":[{"id":"10.13039\/100006751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.cbi.2019.108907","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T20:06:06Z","timestamp":1574712366000},"page":"108907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease"],"prefix":"10.1016","volume":"315","author":[{"given":"Charles C.","family":"Caldwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle M.","family":"Petzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Jakowec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Cadenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2019.108907_bib1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2019.108907_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington's disease: a clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.cbi.2019.108907_bib3","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/jgs.14059","article-title":"Effects of exercise on cognition: the Finnish Alzheimer disease exercise trial: a randomized, controlled trial","volume":"64","author":"Ohman","year":"2016","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.cbi.2019.108907_bib4","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1212\/01.WNL.0000151960.28687.93","article-title":"Physical activity and the risk of Parkinson disease","volume":"64","author":"Chen","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.cbi.2019.108907_bib5","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.2174\/0929867323666160627120408","article-title":"Nitric oxide: a universal modulator of brain function","volume":"23","author":"Philippu","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.cbi.2019.108907_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1440-1681.2000.03232.x","article-title":"Nitric oxide as a metabolic regulator during exercise: effects of training in health and disease","volume":"27","author":"Kingwell","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cbi.2019.108907_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2011.03.005","article-title":"Effects of moderate and chronic exercise on the nitrergic system and behavioral parameters in rats","volume":"1389","author":"Pietrelli","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2019.108907_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.brainresbull.2005.08.013","article-title":"Nitric oxide synthesis is required for exercise-induced increases in hippocampal BDNF and phosphatidylinositol 3' kinase expression","volume":"68","author":"Chen","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.cbi.2019.108907_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.niox.2018.12.002","article-title":"Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease","volume":"83","author":"Padovan-Neto","year":"2019","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.cbi.2019.108907_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0006-8993(02)03102-5","article-title":"Age-dependent changes in nitric oxide synthase activity and protein expression in striata of mice transgenic for the Huntington's disease mutation","volume":"951","author":"Perez-Severiano","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2019.108907_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jnr.1057","article-title":"Nitric oxide and nitric oxide synthase in Huntington's disease","volume":"64","author":"Deckel","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2019.108907_bib12","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cbi.2019.108907_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.410390317","article-title":"Mitochondrial defect in Huntington's disease caudate nucleus","volume":"39","author":"Gu","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cbi.2019.108907_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2013.04.016","article-title":"PGC-1alpha, mitochondrial dysfunction, and Huntington's disease","volume":"62","author":"Johri","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2019.108907_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.1999.tb07924.x","article-title":"Regulation of transglutaminases by nitric oxide","volume":"887","author":"Bernassola","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cbi.2019.108907_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.10776","article-title":"Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats","volume":"465","author":"Menalled","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cbi.2019.108907_bib17","doi-asserted-by":"crossref","first-page":"RRN1182","DOI":"10.1371\/currents.RRN1182","article-title":"Rescuing the corticostriatal synaptic disconnection in the R6\/2 mouse model of Huntington's disease: exercise, adenosine receptors and ampakines","volume":"2","author":"Cepeda","year":"2010","journal-title":"PLoS Curr."},{"key":"10.1016\/j.cbi.2019.108907_bib18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.neuroscience.2015.07.025","article-title":"Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6\/1 model of Huntington's disease","volume":"303","author":"Herbst","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbi.2019.108907_bib19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jnr.20162","article-title":"Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia","volume":"77","author":"Fisher","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2019.108907_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nbd.2017.05.004","article-title":"Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG140 knock-in mouse model of Huntington's disease","volume":"105","author":"Stefanko","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cbi.2019.108907_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbr.2010.05.009","article-title":"Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse","volume":"213","author":"Gorton","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbi.2019.108907_bib22","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1210\/en.2007-1227","article-title":"Progesterone and estrogen regulate oxidative metabolism in brain mitochondria","volume":"149","author":"Irwin","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbi.2019.108907_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00726-011-1090-0","article-title":"Nitric oxide regulates tissue transglutaminase localization and function in the vasculature","volume":"44","author":"Jandu","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbi.2019.108907_bib24","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s11064-005-8796-x","article-title":"Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain","volume":"30","author":"Kim","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbi.2019.108907_bib25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00441-014-1990-x","article-title":"Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological states","volume":"358","author":"Piacentini","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cbi.2019.108907_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/cns.12828","article-title":"Corticostriatal network dysfunction in Huntington's disease: deficits in neural processing, glutamate transport, and ascorbate release","volume":"24","author":"Rebec","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.cbi.2019.108907_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ncb1080","article-title":"Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway","volume":"6","author":"Almeida","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2019.108907_bib28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cbi.2019.108907_bib29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1474-4422(04)00681-7","article-title":"Insulin and neurodegenerative disease: shared and specific mechanisms","volume":"3","author":"Craft","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cbi.2019.108907_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pneurobio.2006.06.003","article-title":"Insulin signaling in the central nervous system: learning to survive","volume":"79","author":"van der Heide","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cbi.2019.108907_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1515\/hukin-2015-0192","article-title":"Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality","volume":"52","author":"Jakowec","year":"2016","journal-title":"J. Hum. Kinet."},{"key":"10.1016\/j.cbi.2019.108907_bib32","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S1474-4422(13)70123-6","article-title":"Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease","volume":"12","author":"Petzinger","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cbi.2019.108907_bib33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.parkreldis.2016.06.023","article-title":"A randomized, controlled trial of a multi-modal exercise intervention in Huntington's disease","volume":"31","author":"Quinn","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.cbi.2019.108907_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JHD-170260","article-title":"Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review","volume":"6","author":"Fritz","year":"2017","journal-title":"J. Huntingt. Dis."},{"key":"10.1016\/j.cbi.2019.108907_bib35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2202-9-34","article-title":"Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease","volume":"9","author":"van Dellen","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.cbi.2019.108907_bib36","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1476-5381.2011.01567.x","article-title":"Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise","volume":"165","author":"Renoir","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2019.108907_bib37","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","article-title":"Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice","volume":"141","author":"Pang","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbi.2019.108907_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.312","article-title":"The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: an exploratory study","volume":"5","author":"Cruickshank","year":"2015","journal-title":"Brain Behav."},{"key":"10.1016\/j.cbi.2019.108907_bib39","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/1531-8257(199903)14:2<320::AID-MDS1018>3.0.CO;2-Z","article-title":"Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease","volume":"14","author":"Georgiou","year":"1999","journal-title":"Mov. Disord."},{"key":"10.1016\/j.cbi.2019.108907_bib40","series-title":"Exercise in Huntington's Disease: Current State and Clinical Significance. Tremor and Other Hyperkinetic Movements (New York, NY)","first-page":"601","volume":"vol. 9","author":"Mueller","year":"2019"},{"key":"10.1016\/j.cbi.2019.108907_bib41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1172\/JCI45691","article-title":"Energy deficit in Huntington disease: why it matters","volume":"121","author":"Mochel","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cbi.2019.108907_bib42","first-page":"1591","article-title":"Metabolic network abnormalities in early Huntington's disease: an [(18)F]FDG PET study","volume":"42","author":"Feigin","year":"2001","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.cbi.2019.108907_bib43","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cbi.2019.108907_bib44","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/mds.20373","article-title":"Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease","volume":"20","author":"Saft","year":"2005","journal-title":"Mov. Disord."},{"key":"10.1016\/j.cbi.2019.108907_bib45","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neulet.2005.09.076","article-title":"Evidence that brain nitric oxide inhibition increases metabolic cost of exercise, reducing running performance in rats","volume":"393","author":"Lacerda","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbi.2019.108907_bib46","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/CIRCRESAHA.111.241117","article-title":"Exercise protects against myocardial ischemia-reperfusion injury via stimulation of beta(3)-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols","volume":"108","author":"Calvert","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbi.2019.108907_bib47","doi-asserted-by":"crossref","first-page":"E179","DOI":"10.1161\/01.CIR.102.22.e179","article-title":"Exercise and endothelial function","volume":"102","author":"Kingwell","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cbi.2019.108907_bib48","first-page":"1","article-title":"Consequences on aging process and human wellness of generation of nitrogen and oxygen species during strenuous exercise","author":"Sessa","year":"2018","journal-title":"Aging Male"},{"key":"10.1016\/j.cbi.2019.108907_bib49","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0021-9258(19)86159-8","article-title":"Transglutaminase amine substrates for photochemical labeling and cleavable cross-linking of proteins","volume":"255","author":"Gorman","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108907_bib50","first-page":"1","article-title":"Cellular functions of tissue transglutaminase","volume":"294","author":"Nurminskaya","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2019.108907_bib51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mito.2014.09.008","article-title":"Transglutaminase type 2, mitochondria and Huntington's disease: menage a trois","volume":"19","author":"Altuntas","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.cbi.2019.108907_bib52","doi-asserted-by":"crossref","first-page":"7388","DOI":"10.1073\/pnas.96.13.7388","article-title":"Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei","volume":"96","author":"Karpuj","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2019.108907_bib53","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1046\/j.1471-4159.1999.02018.x","article-title":"Tissue transglutaminase is increased in Huntington's disease brain","volume":"73","author":"Lesort","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2019.108907_bib54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3233\/JHD-170264","article-title":"Towards an understanding of energy impairment in Huntington's disease brain","volume":"6","author":"Dubinsky","year":"2017","journal-title":"J. Huntingt. Dis."},{"key":"10.1016\/j.cbi.2019.108907_bib55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1471-4159.2008.05350.x","article-title":"Increased levels of gamma-glutamylamines in Huntington disease CSF","volume":"106","author":"Jeitner","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2019.108907_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-319-71779-1_3","article-title":"Mitochondrial dysfunction in Huntington's disease","volume":"1049","author":"Carmo","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cbi.2019.108907_bib57","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0197-0186(01)00062-6","article-title":"Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration","volume":"40","author":"Citron","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbi.2019.108907_bib58","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/jnen\/64.1.58","article-title":"Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3","volume":"64","author":"Zainelli","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cbi.2019.108907_bib59","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nbd.2017.01.007","article-title":"Identification of brain substrates of transglutaminase by functional proteomics supports its role in neurodegenerative diseases","volume":"101","author":"Andre","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cbi.2019.108907_bib60","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1096\/fj.14-251413","article-title":"Transglutaminase 2 exacerbates alpha-synuclein toxicity in mice and yeast","volume":"28","author":"Grosso","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2019.108907_bib61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1471-4159.2007.04491.x","article-title":"Type 2 transglutaminase differentially modulates striatal cell death in the presence of wild type or mutant huntingtin","volume":"102","author":"Ruan","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbi.2019.108907_bib62","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/sj.cdd.4401093","article-title":"'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease","volume":"9","author":"Mastroberardino","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cbi.2019.108907_bib63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/bj3490035","article-title":"Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage","volume":"349","author":"Schopfer","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2019.108907_bib64","doi-asserted-by":"crossref","first-page":"29405","DOI":"10.1016\/S0021-9258(18)43893-8","article-title":"Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not","volume":"269","author":"Hausladen","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108907_bib65","doi-asserted-by":"crossref","first-page":"11986","DOI":"10.1021\/bi0509393","article-title":"Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione","volume":"44","author":"Han","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2019.108907_bib66","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1089\/ars.2013.5387","article-title":"Dysregulation of corticostriatal ascorbate release and glutamate uptake in transgenic models of Huntington's disease","volume":"19","author":"Rebec","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.cbi.2019.108907_bib67","doi-asserted-by":"crossref","first-page":"E1191","DOI":"10.1152\/ajpendo.00602.2006","article-title":"Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle","volume":"292","author":"Arias","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cbi.2019.108907_bib68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2337\/diabetes.54.1.41","article-title":"Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity","volume":"54","author":"Bruss","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2019.108907_bib69","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/hmg\/ddw045","article-title":"Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease","volume":"25","author":"Yin","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cbi.2019.108907_bib70","doi-asserted-by":"crossref","first-page":"14382","DOI":"10.1073\/pnas.97.26.14382","article-title":"Nitric oxide negatively regulates c-Jun N-terminal kinase\/stress-activated protein kinase by means of S-nitrosylation","volume":"97","author":"Park","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2019.108907_bib71","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/acel.12127","article-title":"Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt\/JNK signaling and PGC1alpha transcriptional pathway","volume":"12","author":"Jiang","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.cbi.2019.108907_bib72","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1111\/j.1460-9568.2005.03985.x","article-title":"Akt is altered in an animal model of Huntington's disease and in patients","volume":"21","author":"Colin","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.cbi.2019.108907_bib73","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/ars.2012.4774","article-title":"Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration","volume":"20","author":"Yin","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.cbi.2019.108907_bib74","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/jnr.24430","article-title":"Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice","volume":"97","author":"Lundquist","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2019.108907_bib75","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1089\/ars.2011.4498","article-title":"Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling","volume":"18","author":"Radak","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.cbi.2019.108907_bib76","doi-asserted-by":"crossref","first-page":"E2717","DOI":"10.3390\/ijms20112717","article-title":"Exercise and sirtuins: a way to mitochondrial health in skeletal muscle","volume":"20","author":"Vargas-Ortiz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2019.108907_bib77","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.arr.2011.05.002","article-title":"Neurophysiological and epigenetic effects of physical exercise on the aging process","volume":"10","author":"Kaliman","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cbi.2019.108907_bib78","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.exger.2012.08.004","article-title":"Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissue","volume":"47","author":"Bayod","year":"2012","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cbi.2019.108907_bib79","doi-asserted-by":"crossref","first-page":"a013102","DOI":"10.1101\/cshperspect.a013102","article-title":"Mitochondrial metabolism, sirtuins, and aging","volume":"4","author":"Sack","year":"2012","journal-title":"Cold Spring Harb Perspect. Biol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719318228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719318228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:56:35Z","timestamp":1778626595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279719318228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":79,"alternative-id":["S0009279719318228"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2019.108907","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2019.108907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108907"}}