{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:40:56Z","timestamp":1793137256687,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005941","name":"Dietmar Hopp","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012042","name":"Manfred Lautenschl\u00e4ger Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.cbi.2019.108918","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T20:04:28Z","timestamp":1576008268000},"page":"108918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["The role of cytochrome P4502E1 in the pathogenesis of alcoholic liver disease and carcinogenesis"],"prefix":"10.1016","volume":"316","author":[{"given":"Helmut K.","family":"Seitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2019.108918_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.cbi.2019.108918_bib2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1470-2045(07)70099-2","article-title":"Carcinogenicity of alcoholic beverages","volume":"8","author":"Baan","year":"2007","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cbi.2019.108918_bib3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jhep.2012.12.005","article-title":"The burden of liver disease in Europe: a review of available epidemiological data","volume":"58","author":"Blachier","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.108918_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12263-009-0154-1","article-title":"Acetaldehyde, an underestimated risk factor in cancer development: role of genetics in ethanol metabolism","volume":"5","author":"Seitz","year":"2010","journal-title":"Gene. Nutr."},{"key":"10.1016\/j.cbi.2019.108918_bib5","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/S0021-9258(18)63099-6","article-title":"Hepatic microsomal ethanol oxidizing system: in vitro characteristics and adaptive properties in vivo","volume":"245","author":"Lieber","year":"1970","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108918_bib6","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1053\/jhep.2003.50228","article-title":"Proteasome inhibition potentiates CYP2E1 \u2013 mediated toxicity in HepG2 cells","volume":"37","author":"Perez","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib7","series-title":"Cytochrome P450 2E1: its Role in Disease and Drug Metabolism","first-page":"145","article-title":"The importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome","author":"French","year":"2013"},{"key":"10.1016\/j.cbi.2019.108918_bib8","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1079\/PNS2006496","article-title":"Alcohol, oxidative stress, and free radical damage","volume":"65","author":"Albano","year":"2006","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.cbi.2019.108918_bib9","series-title":"Cytochrome P4502E1: its Role in Disease and Drug Metabolism","first-page":"131","article-title":"The role of Cytochrome P4502E1 in ethanol mediated carcinogenesis","author":"Seitz","year":"2013"},{"issue":"10","key":"10.1016\/j.cbi.2019.108918_bib10","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/archinte.162.10.1193","article-title":"The effect of alcohol on acetaminophen hepatotoxicity","volume":"162","author":"Holtzman","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.cbi.2019.108918_bib11","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1053\/jhep.2003.50144","article-title":"Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis","volume":"37","author":"Huang","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib12","series-title":"Alcohol and Cancer","first-page":"55","article-title":"Effect of ethanol on procarcinogen activation","author":"Seitz","year":"1992"},{"key":"10.1016\/j.cbi.2019.108918_bib13","first-page":"120","article-title":"Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption","volume":"41","author":"Garro","year":"1981","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2019.108918_bib14","first-page":"239","article-title":"Intestinal and pulmonary microsomal Cytochrome P-450: effects of chronic ethanol ingestion","volume":"vol. 13","author":"Seitz","year":"1980"},{"key":"10.1016\/j.cbi.2019.108918_bib15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0090-9556(25)08147-4","article-title":"Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper alimentary tract, lung and hepatic tissues","volume":"132","author":"Farinati","year":"1985","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2019.108918_bib16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/ijc.25604","article-title":"Ethanol mediated carcinogenesis in the human esophagus implicates Cytochrome P-4502E1 induction and the generation of carcinogenic DNA-lesions","volume":"128","author":"Millonig","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.cbi.2019.108918_bib17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrm3932","article-title":"Mechanisms of retinoic acid signaling and its roles in organ and limb development","volume":"16","author":"Cunningham","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbi.2019.108918_bib18","series-title":"Molecular Aspects of Alcohol and Nutrition","first-page":"305","article-title":"Molecular mechanisms of alcohol-associated carcinogenesis","author":"Seitz","year":"2016"},{"key":"10.1016\/j.cbi.2019.108918_bib19","series-title":"Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake","first-page":"313","article-title":"Alcohol and retinoid interaction","author":"Wang","year":"2004"},{"key":"10.1016\/j.cbi.2019.108918_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1056\/NEJM198209023071006","article-title":"Hepatic vitamin A depletion in alcoholic liver injury","volume":"307","author":"Leo","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cbi.2019.108918_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/gast.2001.20877","article-title":"Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of Cytochrome P4502E1","volume":"120","author":"Liu","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2019.108918_bib22","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/j.1530-0277.2002.tb02474.x","article-title":"Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol fed rats","volume":"26","author":"Liu","year":"2002","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108918_bib23","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/carcin\/22.8.1213","article-title":"Restoration of retinoic acid concentration suppresses ethanol induced c-jun overexpression and hepatocyte hyperproliferation in rat liver","volume":"22","author":"Chung","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2019.108918_bib24","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.freeradbiomed.2013.09.009","article-title":"CYP2E1 potentiates binge ethanol-induced gut leakiness, steatohepatitis, and apoptosis","volume":"65","author":"Abdelmegeed","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2019.108918_bib25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/hep.510280321","article-title":"Chronic alcohol intake induces retinoic acid concentration and enhances AP-1 (c-jun and c-fos) expression in rat liver","volume":"28","author":"Wang","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib26","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1096\/fj.04-2809fje","article-title":"Hepatotoxicity of alcohol- induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential","volume":"19","author":"Dan","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2019.108918_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.1840030101","article-title":"Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat","volume":"3","author":"Leo","year":"1983","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib28","first-page":"1329","article-title":"High dose lycopene supplementation increases hepatic CYP2E1 protein and inflammation in alcohol fed rats","volume":"138","author":"Veeramachaneni","year":"2008","journal-title":"Hum. Nutr."},{"key":"10.1016\/j.cbi.2019.108918_bib29","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/gut.47.6.748","article-title":"Alcohol and retinoid metabolism (Editorial)","volume":"47","author":"Seitz","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.cbi.2019.108918_bib30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.redox.2014.08.009","article-title":"The role of reactive oxygen species (ROS) and Cytochrome P4502E1 in the generation of carcinogenic DNA adducts","volume":"3","author":"Linhart","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbi.2019.108918_bib31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-94-007-5881-0_2","article-title":"Nrfz and antioxidative defense against CAP2E1 toxicity","volume":"67","author":"Cederbaum","year":"2013","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.cbi.2019.108918_bib32","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/carcin\/bgh089","article-title":"Immunohistochemical detection of 1,-N6ethenodeoxyadenosine in nuclei of human livers effected by disease predisposing hepatocarcinogenesis","volume":"25","author":"Frank","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2019.108918_bib33","doi-asserted-by":"crossref","first-page":"11899","DOI":"10.1073\/pnas.91.25.11899","article-title":"Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells","volume":"91","author":"Moriya","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cbi.2019.108918_bib34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/hep.22978","article-title":"Ethanol \u2013 induced Cytochrome P-4502 E1 causes carcinogenic etheno DNA- lesions in alcoholic liver disease","volume":"50","author":"Wang","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib35","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.freeradbiomed.2010.07.026","article-title":"Chronic ethanol induced liver injury and oxidant stress in decreased in Cytochrome P4502E1 knockout mice and restored in humanized Cytochrome P4502E1 knocking mice","volume":"15","author":"Lu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2019.108918_bib36","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/hep.20532","article-title":"Cytochrome P4502E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver","volume":"41","author":"Bradford","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/jhep.2002.33720","article-title":"Production o a Cytochrome P4502E1 transgenic mouse and initial evaluation of alcoholic liver damage","volume":"36","author":"Morgan","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib38","first-page":"302","article-title":"Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by Chlormethiazole","volume":"224","author":"Gouillon","year":"2000","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.cbi.2019.108918_bib39","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3945\/jn.110.136531","article-title":"Long term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats","volume":"141","author":"Chavez","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.cbi.2019.108918_bib40","first-page":"5","article-title":"Cytochrome P4502E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats","volume":"1","author":"Ye","year":"2012","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.cbi.2019.108918_bib41","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1530-0277.2009.01122.x","article-title":"Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats","volume":"34","author":"Wang","year":"2010","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108918_bib42","series-title":"Alcohol and Cancer. Advances in Experimental Medicine and Biology 1032","first-page":"81","article-title":"Chronic ethanol consumption and generation of etheno-DNA adducts in cancer-prone tissues","author":"Peccerella","year":"2018"},{"key":"10.1016\/j.cbi.2019.108918_bib43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/hep.21241","article-title":"Enhancement of pyrazole of lipopolysaccharide induced liver injury in mice: role of Cytochrome P4502E1 and 2A5","volume":"44","author":"Lu","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib44","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/hep.22087","article-title":"Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha \u2013 induced liver injury through activation of mitogen-activated protein kinases in mice","volume":"47","author":"Wu","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib45","first-page":"147","article-title":"Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD)","volume":"4","author":"Seitz","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.cbi.2019.108918_bib46","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/ajg.2012.20","article-title":"What should we recommend to our patients with NAFLD regarding alcohol use","volume":"107","author":"Liangpunsakul","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.cbi.2019.108918_bib47","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jhep.2017.11.006","article-title":"The bidirectional impacts of alcohol consumption and the metabolic syndrome: cofactors for progressive fatty liver disease","volume":"68","author":"Boyle","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.108918_bib48","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hep.1840100407","article-title":"The intralobular distribution of ethanol-inducible P4502E1 in rat and human liver","volume":"10","author":"Tstutsumi","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib49","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/hep.510260423","article-title":"Chlormethiazole inhibition of Cytochrome P4502E1 as assessed by chlorzoxazone hydroxylation in humans","volume":"26","author":"Gebhart","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0168-8278(01)00223-9","article-title":"Dynamics of Cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase","volume":"36","author":"Oneta","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.108918_bib51","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cbi.2019.108918_bib52","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/acer.13180","article-title":"Possible mechanisms of ethanol-mediated colorectal carcinogenesis: the role of Cytochrome P-4502E1, etheno DNA adducts, and the anti-apoptotic protein Mcl-1","volume":"40","author":"K\u00f6hler","year":"2016","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108918_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hepres.2003.08.001","article-title":"CYP2E1: from ASH to NASH","volume":"28","author":"Lieber","year":"2004","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.cbi.2019.108918_bib54","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.510270121","article-title":"Hepatic Cytochrome P4502E1 is increased in patients with nonalcoholic steatohepatitis","volume":"27","author":"Weltman","year":"1998","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.cbi.2019.108918_bib55","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2003.50095","article-title":"Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis","volume":"37","author":"Chalasani","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib56","series-title":"Cytochrome P4502E1 \u2013 Expression und histologische Ver\u00e4nderungen bei alkoholischer und nichtalkoholischer Steatohepatitis","author":"Glassen","year":"2017"},{"key":"10.1016\/j.cbi.2019.108918_bib57","first-page":"117","article-title":"Generation of carcinogenic etheno DNA adducts in the liver of patients with NAFLD","volume":"4","author":"Linhart","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.cbi.2019.108918_bib58","first-page":"426","article-title":"Detection of highly carcinogenic exocyclic etheno DNA adducts in the liver of children and adolescents with non-alcoholic steatohepatitis","volume":"4","author":"Teufel","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.cbi.2019.108918_bib59","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/hep.23527","article-title":"The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis","volume":"51","author":"Ascha","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib60","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cgh.2015.11.019","article-title":"Effects of alcohol consumption on hepatocarcinogenesis in Japanese patients with fatty liver disease","volume":"14","author":"Kawamura","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2019.108918_bib61","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jhep.2012.03.024","article-title":"Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"57","author":"Dunn","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2019.108918_bib62","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/gutjnl-2013-305718","article-title":"Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43.175 individuals","volume":"63","author":"Sookoian","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.cbi.2019.108918_bib63","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/00365520802555991","article-title":"Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease","volume":"44","author":"Ekstedt","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.cbi.2019.108918_bib64","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S1542-3565(05)00743-3","article-title":"Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population","volume":"3","author":"Ruhl","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.cbi.2019.108918_bib65","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.cgh.2018.11.033","article-title":"Effects of alcohol consumption and metabolic syndrome on mortality in patients with nonalcoholic and alcohol-related fatty liver disease","volume":"17","author":"Younossi","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2019.108918_bib66","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/S0022-3565(25)38876-2","article-title":"Chlormethiazole as an efficient inhibitor of Cytochrome P4502E1 expression in rat liver","volume":"26","author":"Hu","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbi.2019.108918_bib67","first-page":"1464","article-title":"Identification of Cytochrome P4502E1 as a critical mediator of alcohol effects on steatotic hepatocytes","volume":"8","author":"Mahli","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.cbi.2019.108918_bib68","doi-asserted-by":"crossref","first-page":"9853","DOI":"10.1074\/jbc.M110506200","article-title":"Cytochrome P 4502E1 derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells","volume":"277","author":"Nieto","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108918_bib69","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/jhep.2002.30362","article-title":"Stimulation and proliferation of primary rat hepatic stellate cells by Cytochrome P4502E1 derived reactive oxygen species","volume":"35","author":"Nieto","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2019.108918_bib70","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/acer.13546","article-title":"Carcinogenic etheno-DNA adducts in alcoholic liver disease: correlation with Cytochrome P4502E1 and fibrosis","volume":"42","author":"Mueller","year":"2018","journal-title":"Alcohol Clin. Exp. Res."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719312244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719312244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:19:31Z","timestamp":1788455971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279719312244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":70,"alternative-id":["S0009279719312244"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2019.108918","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of cytochrome P4502E1 in the pathogenesis of alcoholic liver disease and carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2019.108918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108918"}}