{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:12:55Z","timestamp":1788459175412,"version":"build-2803163510"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31-AA024024"],"award-info":[{"award-number":["F31-AA024024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AA018332"],"award-info":[{"award-number":["R01-AA018332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21-AA021484"],"award-info":[{"award-number":["R21-AA021484"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.cbi.2019.108919","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T20:32:47Z","timestamp":1576355567000},"page":"108919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Modification of stem cell states by alcohol and acetaldehyde"],"prefix":"10.1016","volume":"316","author":[{"given":"Ryan N.","family":"Serio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine J.","family":"Gudas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2019.108919_bib1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature15515","article-title":"Hallmarks of pluripotency","volume":"525","author":"De Los Angeles","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.cell.2011.01.032","article-title":"Control of the embryonic stem cell state","volume":"144","author":"Young","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncb0511-490","article-title":"The transcriptional and signalling networks of pluripotency","volume":"13","author":"Ng","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2019.108919_bib4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1634\/stemcells.19-3-193","article-title":"Multilineage differentiation from human embryonic stem cell lines","volume":"19","author":"Odorico","year":"2001","journal-title":"Stem Cells"},{"key":"10.1016\/j.cbi.2019.108919_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cell.2008.01.039","article-title":"Stem cells and early lineage development","volume":"132","author":"Rossant","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.cellbio.17.1.435","article-title":"Embryo-derived stem cells: of mice and men","volume":"17","author":"Smith","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cbi.2019.108919_bib7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.stem.2014.09.015","article-title":"Regulatory principles of pluripotency: from the ground state up","volume":"15","author":"Hackett","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1440-169X.2010.01171.x","article-title":"Epiblast stem cells contribute new insight into pluripotency and gastrulation","volume":"52","author":"Chenoweth","year":"2010","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.cbi.2019.108919_bib9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ydbio.2003.12.034","article-title":"Differences between human and mouse embryonic stem cells","volume":"269","author":"Ginis","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbi.2019.108919_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature05950","article-title":"Derivation of pluripotent epiblast stem cells from mammalian embryos","volume":"448","author":"Brons","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nature05972","article-title":"New cell lines from mouse epiblast share defining features with human embryonic stem cells","volume":"448","author":"Tesar","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140803","article-title":"Differences in the early development of human and mouse embryonic stem cells","volume":"10","author":"Gabdoulline","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2019.108919_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/1526-968X(200009)28:1<23::AID-GENE30>3.0.CO;2-G","article-title":"A flattened mouse embryo: leveling the playing field","volume":"28","author":"Behringer","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.cbi.2019.108919_bib14","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1101\/gad.4.12b.2308","article-title":"Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations","volume":"4","author":"Rathjen","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbi.2019.108919_bib15","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1242\/dev.038893","article-title":"Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo","volume":"136","author":"Nichols","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.cbi.2019.108919_bib16","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1042\/BST0381027","article-title":"The ground state of pluripotency","volume":"38","author":"Wray","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.cbi.2019.108919_bib17","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1101\/gad.12.13.2048","article-title":"Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3","volume":"12","author":"Niwa","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbi.2019.108919_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(03)00847-X","article-title":"BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3","volume":"115","author":"Ying","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2012.03.026","article-title":"The transcriptional and epigenomic foundations of ground state pluripotency","volume":"149","author":"Marks","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/7651_2015_207","article-title":"Acquiring ground state pluripotency: switching mouse embryonic stem cells from serum\/LIF medium to 2i\/LIF medium","volume":"1341","author":"Tosolini","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cbi.2019.108919_bib21","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature09229","article-title":"Nuclear reprogramming to a pluripotent state by three approaches","volume":"465","author":"Yamanaka","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nbt1374","article-title":"Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts","volume":"26","author":"Nakagawa","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cbi.2019.108919_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature13551","article-title":"Abnormalities in human pluripotent cells due to reprogramming mechanisms","volume":"511","author":"Ma","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(00)80893-4","article-title":"The enhanceosome and transcriptional synergy","volume":"92","author":"Carey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tibs.2005.03.011","article-title":"Mediator and the mechanism of transcriptional activation","volume":"30","author":"Kornberg","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cbi.2019.108919_bib28","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1182\/blood-2008-08-078220","article-title":"The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases","volume":"112","author":"Weissman","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2019.108919_bib29","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/wsbm.86","article-title":"Hematopoietic stem cell: self-renewal versus differentiation","volume":"2","author":"Seita","year":"2010","journal-title":"Wiley Interdiscipl. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.cbi.2019.108919_bib30","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1182\/blood.V93.6.1916.406k15_1916_1921","article-title":"Hematopoietic stem cell tracking in vivo: a comparison of short-term and long-term repopulating cells","volume":"93","author":"Lanzkron","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2019.108919_bib31","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nm.3651","article-title":"Stem cell aging: mechanisms, regulators and therapeutic opportunities","volume":"20","author":"Oh","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbi.2019.108919_bib32","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature05875","article-title":"DNA repair is limiting for haematopoietic stem cells during ageing","volume":"447","author":"Nijnik","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib33","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.4161\/cc.6.19.4759","article-title":"Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging","volume":"6","author":"Rossi","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cbi.2019.108919_bib34","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jcp.22417","article-title":"Retinoids regulate stem cell differentiation","volume":"226","author":"Gudas","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cbi.2019.108919_bib35","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.cell.2007.02.050","article-title":"Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors","volume":"129","author":"Schug","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib36","doi-asserted-by":"crossref","DOI":"10.1621\/nrs.07002","article-title":"Function of retinoic acid receptors during embryonic development","volume":"7","author":"Mark","year":"2009","journal-title":"Nucl. Recept. Signal."},{"key":"10.1016\/j.cbi.2019.108919_bib37","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.semcdb.2013.08.002","article-title":"Retinoids induce stem cell differentiation via epigenetic changes","volume":"24","author":"Gudas","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cbi.2019.108919_bib38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1530-0277.1991.tb00562.x","article-title":"A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step","volume":"15","author":"Duester","year":"1991","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib39","first-page":"701","article-title":"Effects of ethanol on physiological retinoic acid levels","volume":"63","author":"Napoli","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.cbi.2019.108919_bib40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1470-2045(07)70099-2","article-title":"Carcinogenicity of alcoholic beverages","volume":"8","author":"Baan","year":"2007","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cbi.2019.108919_bib41","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/jamapediatrics.2018.0058","article-title":"Global prevalence of fetal alcohol spectrum disorder in Italy-reply","volume":"172","author":"Lange","year":"2018","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.cbi.2019.108919_bib42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neubiorev.2006.06.016","article-title":"Fetal alcohol spectrum disorders: a practical clinical approach to diagnosis","volume":"31","author":"Manning","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cbi.2019.108919_bib43","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/hipo.20665","article-title":"Alcohol inhibition of neurogenesis: a mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model","volume":"20","author":"Morris","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.cbi.2019.108919_bib44","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1530-0277.2012.01952.x","article-title":"CIFASD, Further development of a neurobehavioral profile of fetal alcohol spectrum disorders","volume":"37","author":"Mattson","year":"2013","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib45","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/acer.14040","article-title":"Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure","volume":"43","author":"Mattson","year":"2019","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib46","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(73)91291-9","article-title":"Pattern of malformation in offspring of chronic alcoholic mothers","volume":"1","author":"Jones","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2019.108919_bib47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0092-8674(89)90848-9","article-title":"Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice","volume":"58","author":"Balling","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib48","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1530-0277.2010.01391.x","article-title":"Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation","volume":"35","author":"Zhou","year":"2011","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib49","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/scd.2010.0037","article-title":"Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol","volume":"20","author":"Tal\u00e9ns-Visconti","year":"2011","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.cbi.2019.108919_bib50","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1089\/scd.2012.0513","article-title":"Ethanol alters the balance of Sox2, Oct4, and Nanog expression in distinct subpopulations during differentiation of embryonic stem cells","volume":"22","author":"Ogony","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.cbi.2019.108919_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063794","article-title":"Ethanol diverts early neuronal differentiation trajectory of embryonic stem cells by disrupting the balance of lineage specifiers","volume":"8","author":"S\u00e1nchez-Alvarez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2019.108919_bib52","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1530-0277.2011.01682.x","article-title":"Ethanol affects differentiation-related pathways and suppresses Wnt signaling protein expression in human neural stem cells","volume":"36","author":"Vangipuram","year":"2012","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.alcohol.2016.11.006","article-title":"Involvement of Wnt pathway in ethanol-induced inhibition of mouse embryonic stem cell differentiation","volume":"58","author":"Wang","year":"2017","journal-title":"Alcohol"},{"key":"10.1016\/j.cbi.2019.108919_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112698","article-title":"Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK\/ERK signaling pathway in vitro","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2019.108919_bib55","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1073\/pnas.72.4.1441","article-title":"Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro","volume":"72","author":"Martin","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2019.108919_bib56","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/74199","article-title":"Quantitative expression of Oct-3\/4 defines differentiation, dedifferentiation or self-renewal of ES cells","volume":"24","author":"Niwa","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cbi.2019.108919_bib57","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2011.05.017","article-title":"Pluripotency factors in embryonic stem cells regulate differentiation into germ layers","volume":"145","author":"Thomson","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib58","doi-asserted-by":"crossref","first-page":"13524","DOI":"10.1073\/pnas.96.23.13524","article-title":"Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells","volume":"96","author":"Lane","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2019.108919_bib59","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1002\/jnr.21729","article-title":"Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons","volume":"86","author":"Martinez-Ceballos","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib60","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1111\/j.1530-0277.2009.01057.x","article-title":"Effects of ethanol on mouse embryonic stem cells","volume":"33","author":"Arzumnayan","year":"2009","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib61","first-page":"1534","article-title":"Ethanol, acetaldehyde, and estradiol affect growth and differentiation of rhesus monkey embryonic stem cells","volume":"35","author":"VandeVoort","year":"2011","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib62","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1074\/jbc.RA118.007153","article-title":"Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-\u03b3","volume":"294","author":"Serio","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108919_bib63","first-page":"916","article-title":"Formation of spherical colonies as a property of stem cells","volume":"49","author":"Sukach","year":"2007","journal-title":"Tsitologiia"},{"key":"10.1016\/j.cbi.2019.108919_bib64","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0012-1606(90)90211-Z","article-title":"Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis","volume":"138","author":"H\u00e9bert","year":"1990","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbi.2019.108919_bib65","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1582-4934.2010.01105.x","article-title":"Teratogen screening using transcriptome profiling of differentiating human embryonic stem cells","volume":"15","author":"Mayshar","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cbi.2019.108919_bib66","doi-asserted-by":"crossref","first-page":"14971","DOI":"10.1074\/jbc.271.25.14971","article-title":"An analysis of retinoic acid-induced gene expression and metabolism in AB1 embryonic stem cells","volume":"271","author":"Chen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108919_bib67","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1242\/dev.00476","article-title":"Involvement of Oct3\/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures","volume":"130","author":"Shimozaki","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.cbi.2019.108919_bib68","doi-asserted-by":"crossref","first-page":"20193","DOI":"10.1074\/jbc.C114.561860","article-title":"A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation","volume":"289","author":"Wu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108919_bib69","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/acer.14146","article-title":"Different effects of knockouts in ALDH2 and ACSS2 on embryonic stem cell differentiation","volume":"43","author":"Serio","year":"2019","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib70","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ntt.2004.06.012","article-title":"Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish","volume":"26","author":"Reimers","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.cbi.2019.108919_bib71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bcp.2004.09.001","article-title":"4-Hydroxynonenal inhibits cell proliferation and alters differentiation pathways in human fetal liver hematopoietic stem cells","volume":"69","author":"Moneypenny","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2019.108919_bib72","first-page":"219","article-title":"Isozymes of human liver alcohol dehydrogenase","volume":"8","author":"Vallee","year":"1983","journal-title":"Isozymes Curr. Top. Biol. Med. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib73","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/alcalc\/agm059","article-title":"Ethanol oxidation in the living brain","volume":"42","author":"Zimatkin","year":"2007","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.cbi.2019.108919_bib74","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","article-title":"Alcohol metabolism","volume":"16","author":"Cederbaum","year":"2012","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.cbi.2019.108919_bib75","doi-asserted-by":"crossref","first-page":"21931","DOI":"10.1073\/pnas.1016071107","article-title":"Histone H3K27ac separates active from poised enhancers and predicts developmental state","volume":"107","author":"Creyghton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2019.108919_bib76","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-94-017-9050-5_7","article-title":"The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes","volume":"70","author":"Urvalek","year":"2014","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.cbi.2019.108919_bib77","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cbi.2019.108919_bib78","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(06)70598-1","article-title":"Vitamin B12, folic acid, and the nervous system","volume":"5","author":"Reynolds","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cbi.2019.108919_bib79","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3945\/an.111.000661","article-title":"Vitamin-dependent methionine metabolism and alcoholic liver disease","volume":"2","author":"Halsted","year":"2011","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.cbi.2019.108919_bib80","doi-asserted-by":"crossref","first-page":"10072","DOI":"10.1073\/pnas.112336399","article-title":"Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig","volume":"99","author":"Halsted","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2019.108919_bib81","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1096\/fasebj.14.1.95","article-title":"Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation","volume":"14","author":"Torres","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2019.108919_bib82","doi-asserted-by":"crossref","first-page":"1177S","DOI":"10.1093\/ajcn\/76.5.1177S","article-title":"Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury","volume":"76","author":"Mart\u00ednez-Chantar","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbi.2019.108919_bib83","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.scr.2014.03.009","article-title":"Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells","volume":"12","author":"Khalid","year":"2014","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.cbi.2019.108919_bib84","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrc2191","article-title":"Molecular mechanisms of alcohol-mediated carcinogenesis","volume":"7","author":"Seitz","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cbi.2019.108919_bib85","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12263-009-0159-9","article-title":"Ethanol-induced oxidative stress: basic knowledge","volume":"5","author":"Comporti","year":"2010","journal-title":"Genes Nutr."},{"key":"10.1016\/j.cbi.2019.108919_bib86","doi-asserted-by":"crossref","first-page":"26458","DOI":"10.1074\/jbc.M004160200","article-title":"Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins","volume":"275","author":"Luong","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108919_bib87","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0098-2997(03)00011-6","article-title":"Intracellular metabolism of 4-hydroxynonenal","volume":"24","author":"Siems","year":"2003","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.cbi.2019.108919_bib88","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/abbi.1995.1028","article-title":"The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase","volume":"316","author":"Hartley","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2019.108919_bib89","first-page":"353","article-title":"Structure of the STRA6 receptor for retinol uptake","author":"Chen","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cbi.2019.108919_bib90","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1111\/febs.12296","article-title":"Structural diversity of calmodulin binding to its target sites","volume":"280","author":"Tidow","year":"2013","journal-title":"FEBS J."},{"issue":"Suppl 3","key":"10.1016\/j.cbi.2019.108919_bib91","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1289\/ehp.96104s3563","article-title":"Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes","volume":"104","author":"Morimoto","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2019.108919_bib92","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/tx900147g","article-title":"Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation","volume":"22","author":"LoPachin","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2019.108919_bib93","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0969-2126(97)00224-4","article-title":"Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion","volume":"5","author":"Steinmetz","year":"1997","journal-title":"Structure"},{"key":"10.1016\/j.cbi.2019.108919_bib94","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.81.1.258","article-title":"Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in orientals","volume":"81","author":"Yoshida","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2019.108919_bib95","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/carcin\/23.10.1759","article-title":"Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer","volume":"23","author":"Muto","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2019.108919_bib96","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/carcin\/22.3.433","article-title":"Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics","volume":"22","author":"Yokoyama","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2019.108919_bib97","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.molcel.2014.07.010","article-title":"Maternal aldehyde elimination during pregnancy preserves the fetal genome","volume":"55","author":"Oberbeck","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib98","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/nar\/26.7.1769","article-title":"Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases","volume":"26","author":"Matsuda","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2019.108919_bib99","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41598-018-37239-6","article-title":"Acetaldehyde forms covalent GG intrastrand crosslinks in DNA","volume":"9","author":"Sonohara","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2019.108919_bib100","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/carcin\/bgm057","article-title":"Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol","volume":"28","author":"Matsuda","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2019.108919_bib101","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-7992(86)90075-8","article-title":"Metabolism of ethanol in vitro produces a compound which induces sister-chromatid exchanges in human peripheral lymphocytes in vitro: acetaldehyde not ethanol is mutagenic","volume":"174","author":"Obe","year":"1986","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cbi.2019.108919_bib102","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature25154","article-title":"Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells","volume":"553","author":"Garaycoechea","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.stem.2018.01.011","article-title":"Clonal hematopoiesis and evolution to hematopoietic malignancies","volume":"22","author":"Bowman","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cbi.2019.108919_bib104","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature10192","article-title":"Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice","volume":"475","author":"Langevin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib105","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nature11368","article-title":"Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function","volume":"489","author":"Garaycoechea","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2019.108919_bib106","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1182\/blood-2013-06-507962","article-title":"Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients","volume":"122","author":"Hira","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2019.108919_bib107","doi-asserted-by":"crossref","first-page":"16796","DOI":"10.1074\/jbc.274.24.16796","article-title":"Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid","volume":"274","author":"Deltour","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2019.108919_bib108","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1432-0436.2006.00147.x","article-title":"Early molecular effects of ethanol during vertebrate embryogenesis","volume":"75","author":"Yelin","year":"2007","journal-title":"Differentiation"},{"key":"10.1016\/j.cbi.2019.108919_bib109","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41598-017-18719-7","article-title":"Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity","volume":"8","author":"Shabtai","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2019.108919_bib110","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/dmm.001420","article-title":"Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation","volume":"2","author":"Kot-Leibovich","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.cbi.2019.108919_bib111","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0736-5748(92)90016-S","article-title":"Patterns of ethanol-induced cell death in the developing nervous system of mice; neural fold states through the time of anterior neural tube closure","volume":"10","author":"Kotch","year":"1992","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.cbi.2019.108919_bib112","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0741-8329(02)00279-3","article-title":"Morphologic and neurotoxic effects of ethanol vary with timing of exposure in vitro","volume":"28","author":"Lindsley","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.cbi.2019.108919_bib113","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043067","article-title":"Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent","volume":"7","author":"Lipinski","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2019.108919_bib114","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1021\/ac702030f","article-title":"Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry","volume":"80","author":"Kane","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cbi.2019.108919_bib115","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1096\/fj.09-141572","article-title":"Ethanol elevates physiological all-trans-retinoic acid levels in select loci through altering retinoid metabolism in multiple loci: a potential mechanism of ethanol toxicity","volume":"24","author":"Kane","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2019.108919_bib116","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41556-018-0147-7","article-title":"Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures","volume":"20","author":"Sozen","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2019.108919_bib117","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41467-019-08378-9","article-title":"J. Han, Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2019.108919_bib118","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1126\/science.aax0164","article-title":"Self-organization of stem cells into embryos: a window on early mammalian development","volume":"364","author":"Shahbazi","year":"2019","journal-title":"Science"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719312955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279719312955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:18:20Z","timestamp":1788455900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279719312955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":118,"alternative-id":["S0009279719312955"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2019.108919","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modification of stem cell states by alcohol and acetaldehyde","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2019.108919","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108919"}}