{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:56:43Z","timestamp":1768478203767,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.cbi.2020.109219","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T17:44:24Z","timestamp":1598204664000},"page":"109219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Retinol palmitate against toxicogenic damages of antineoplastic drugs on normal and tumor cells"],"prefix":"10.1016","volume":"330","author":[{"given":"Ricardo Melo","family":"de Carvalho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Vinicius Oliveira Barros","family":"de Alencar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Oliveira Ferreira","family":"da Mata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e1lia Maria T\u00f4rres","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rai Pablo","family":"Sousa de Aguiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadson","family":"Silva Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Fernanda","family":"Correia Jardim Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soane Kaline","family":"Morais Chaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Marcelo de Castro e","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Michel","family":"Pinheiro Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Am\u00e9lia de Carvalho","family":"Melo Cavalcante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahare","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2020.109219_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2014.00309","article-title":"The social brain meets the reactive genome: neuroscience, epigenetics and the new social biology","volume":"8","author":"Meloni","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.cbi.2020.109219_bib2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1126\/science.1260638","article-title":"Restricted epigenetic inheritance of H3K9 methylation","volume":"3","author":"Audergon","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cbi.2020.109219_bib3","first-page":"195","article-title":"Colorectal cancer: epidemiology, disease mechanisms and interventions to reduce onset and mortality","volume":"15","author":"Aran","year":"2016","journal-title":"Clin. Colorectal Canc."},{"key":"10.1016\/j.cbi.2020.109219_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016. CA","volume":"66","author":"Siegel","year":"2016","journal-title":"A Canc. J. Clin."},{"key":"10.1016\/j.cbi.2020.109219_bib5","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.etap.2015.08.035","article-title":"Prevention of cyclophosphamide-induced hepatotoxicity and genotoxicity: effect of an l-cysteine based oxovanadium (IV) complex on oxidative stress and DNA damage","volume":"40","author":"Basu","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2020.109219_bib6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1631\/jzus.B1500015","article-title":"Protective effect of L-carnitine in cyclophosphamide-induced germ cell apoptosis","volume":"16","author":"Zhu","year":"2015","journal-title":"J. Zhejiang Univ. - Sci. B."},{"key":"10.1016\/j.cbi.2020.109219_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","article-title":"Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems","volume":"65","author":"Tacar","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2020.109219_bib8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2015.05.006","article-title":"Ovatodiolide sensitizes aggressive breast cancer cells to doxorubicin, eliminates their cancer stem cell-like phenotype, and reduces doxorubicin-associated toxicity","volume":"364","author":"Bamodu","year":"2015","journal-title":"Canc. Lett."},{"key":"10.1016\/j.cbi.2020.109219_bib9","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.ejca.2013.06.012","article-title":"Doxorubicin\/cyclophosphamide with concurrent versus sequential docetaxel as neoadjuvant treatment in patients with breast c\u00e2ncer","volume":"49","author":"Riens","year":"2013","journal-title":"Eur. J. Canc."},{"key":"10.1016\/j.cbi.2020.109219_bib10","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.2459\/JCM.0000000000000376","article-title":"Pathophysiology of cardiotoxicity induced by nonanthracycline chemotherapy","volume":"17","author":"Madeddu","year":"2016","journal-title":"J. Cardiovasc. Med."},{"key":"10.1016\/j.cbi.2020.109219_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399404008488","article-title":"Retinoids: potential in cancer prevention and therapy","volume":"6","author":"Clarke","year":"2004","journal-title":"Expet Rev. Mol. Med."},{"key":"10.1016\/j.cbi.2020.109219_bib12","first-page":"1","article-title":"Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis","volume":"6","author":"Fritz","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.cbi.2020.109219_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejmech.2015.04.040","article-title":"The role of antioxidants in the chemistry of oxidative stress: a review","volume":"97","author":"Pisoschi","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2020.109219_bib14","first-page":"3257","article-title":"Comparison of retinyl palmitate and red palm oil \u03b2-carotene as strategies to address vitamin A deficiency","volume":"5","author":"Souganidis","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.cbi.2020.109219_bib15","first-page":"140267","article-title":"Vitamin A and retinoids as mitochondrial toxicants","author":"Oliveira","year":"2015","journal-title":"Oxidat. Med. Cellul. Longev."},{"key":"10.1016\/j.cbi.2020.109219_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/mutage\/geq075","article-title":"Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies","volume":"26","author":"Bonassi","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.cbi.2020.109219_bib17","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1158\/1055-9965.EPI-14-0462","article-title":"The cytokinesis blocked micronucleus assay as a strong predictor of lung cancer: extension of a lung cancer risk prediction model","volume":"23","author":"El-Zein","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.cbi.2020.109219_bib18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejphar.2015.07.011","article-title":"Antitumor effect investigation of obtustatin and crude Macrovipera lebetina obtusa venom in S-180sarcoma bearing mice","volume":"764","author":"Ghazaryan","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2020.109219_bib19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/01635581.2016.1158298","article-title":"Parkia javanica extract induces apoptosis in S-180 cells via the intrinsic pathway of apoptosis","volume":"68","author":"Patra","year":"2016","journal-title":"Nutr. Canc."},{"key":"10.1016\/j.cbi.2020.109219_bib20","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.4161\/cbt.215","article-title":"Retinoid targets in cancer therapy and chemoprevention","volume":"2","author":"Dragnev","year":"2003","journal-title":"Canc. Biol. Ther."},{"key":"10.1016\/j.cbi.2020.109219_bib21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1534735404270335","article-title":"Chemotheraphy-associated oxidative stress: impact on chemotherapeutic effectiveness","volume":"3","author":"Conklin","year":"2004","journal-title":"Integr. Canc. Ther."},{"key":"10.1016\/j.cbi.2020.109219_bib22","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12291-013-0375-3","article-title":"Vitamin C in disease prevention and cure: an overview","volume":"28","author":"Chambial","year":"2013","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.cbi.2020.109219_bib23","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/nprot.2007.77","article-title":"Cytokinesis-block micronucleus cytome assay","volume":"2","author":"Fenech","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbi.2020.109219_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cbi.2020.109219_bib25","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single cell gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.cbi.2020.109219_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/mutage\/18.1.45","article-title":"Recommendations for conducting the in vivo alkaline Comet assay","volume":"18","author":"Hartmann","year":"2003","journal-title":"Mutagenesis"},{"key":"10.1016\/j.cbi.2020.109219_bib27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bcp.2015.05.005","article-title":"Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases","volume":"96","author":"Hofman","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2020.109219_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2015.06.009","article-title":"High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1\/CD107a-expressing CD4-positive T cells into tumor sites","volume":"366","author":"Naito","year":"2015","journal-title":"Canc. Lett."},{"key":"10.1016\/j.cbi.2020.109219_bib29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3325\/cmj.2014.55.206","article-title":"Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study","volume":"55","author":"Panchuk","year":"2014","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.cbi.2020.109219_bib30","first-page":"828","article-title":"Potential applications of antioxidants - a review","volume":"7","author":"Sindhi","year":"2013","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.cbi.2020.109219_bib31","doi-asserted-by":"crossref","first-page":"956835","DOI":"10.1155\/2014\/956835","article-title":"Potential uses, limitations, and basic procedures of micronuclei and nuclear abnormalities in buccal cells","volume":"2014","author":"Torres-Bugar\u00edn","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cbi.2020.109219_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mrrev.2015.07.002","article-title":"Clinical application of micronucleus test in exfoliated buccal cells: a systematic review and metanalysis","volume":"766","author":"Bolognesi","year":"2015","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.cbi.2020.109219_bib33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nprot.2012.043","article-title":"Mussel micronucleus cytome assay","volume":"7","author":"Bolognesi","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbi.2020.109219_bib34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/mutage\/geq052","article-title":"Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells","volume":"26","author":"Fenech","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.cbi.2020.109219_bib35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3109\/10520295.2015.1101163","article-title":"Increased micronucleus, nucleoplasmic bridge, nuclear bud frequency and oxidative DNA damage associated with prolactin levels and pituitary adenoma diameters in patients with prolactinoma","volume":"91","author":"Bitgen","year":"2016","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.cbi.2020.109219_bib36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/10934520903388863","article-title":"Induction of micronuclei and nuclear abnormalities by cyclophosphamide and colchicine in Xenotoca melanosoma (Pisces, Goodeidae) from Lake la Alberca in Michoacan, Mexico","volume":"45","author":"Zavala-Aguirre","year":"2010","journal-title":"J. Environ. Sci. Health"},{"key":"10.1016\/j.cbi.2020.109219_bib37","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3945\/ajcn.115.114306","article-title":"Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies","volume":"102","author":"Key","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbi.2020.109219_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2014.01.065","article-title":"Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis","volume":"5","author":"Mantawy","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2020.109219_bib39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1667\/RR13991.1","article-title":"Development of a high-throughput and miniaturized cytokinesis-block micronucleus assay for use as a biological dosimetry population triage tool","volume":"184","author":"Lue","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.cbi.2020.109219_bib40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5045\/kjh.2011.46.1.24","article-title":"Treatment outcome of all-trans retinoic acid\/anthracycline combination chemotherapy and the prognostic impact of FLT3\/ITD mutation in acute promyelocytic leukemia patients","volume":"46","author":"Hong","year":"2011","journal-title":"Korean J. Hematol."},{"key":"10.1016\/j.cbi.2020.109219_bib41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jcma.2014.08.010","article-title":"The protective role of carotenoids and polyphenols in patients with head and neck cancer","volume":"78","author":"Chang","year":"2015","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.cbi.2020.109219_bib42","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.3390\/ijms15023145","article-title":"Autophagic cell death and cancer","volume":"15","author":"Shimizu","year":"2014","journal-title":"Int. J. Molecul. Sci."},{"key":"10.1016\/j.cbi.2020.109219_bib43","article-title":"Autophagy, cell death, and cancer","volume":"2","author":"Lin","year":"2015","journal-title":"Molecul. Cellul. Oncol."},{"key":"10.1016\/j.cbi.2020.109219_bib44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/aje\/kwf210","article-title":"Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer","volume":"157","author":"Huang","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.cbi.2020.109219_bib45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2241-5793-21-14","article-title":"Use of the comet assay technique for quick and reliable prediction of in vitro response to chemotherapeutics in breast and colon cancer","volume":"21","author":"Apostolou","year":"2014","journal-title":"J. Biol. Res.-Thessaloniki"},{"key":"10.1016\/j.cbi.2020.109219_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/em.21822","article-title":"Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow-cytometric peripheral blood micronucleus test, and pathway-focused gene expression profiling","volume":"55","author":"Manjanatha","year":"2013","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.cbi.2020.109219_bib47","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.envpol.2015.12.017","article-title":"Ecotoxicity and genotoxicity of cyclophosphamide, ifosfamide, their metabolites\/transformation products and their mixtures","volume":"210","author":"\u010cesen","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2020.109219_bib48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4161\/oxim.3.4.12858","article-title":"Exogenous antioxidants\u2014double-edged swords in cellular redoc state: health beneficial effects at physiologic doses versus deleterious effects at high doses","volume":"3","author":"Bouayed","year":"2010","journal-title":"Oxidat. Med. Cellul. Longev."},{"key":"10.1016\/j.cbi.2020.109219_bib49","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/2251-6581-12-60","article-title":"Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans","volume":"12","author":"Eleazu","year":"2013","journal-title":"J. Diabetes Metab. Disord."},{"key":"10.1016\/j.cbi.2020.109219_bib50","first-page":"294303","article-title":"Increased oxidative stress as a selective anticancer therapy","author":"Liu","year":"2015","journal-title":"Oxidative Med. Cellul. Longev"},{"key":"10.1016\/j.cbi.2020.109219_bib51","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2020.109219_bib52","first-page":"1","article-title":"Ascorbic acid modulates doxorubicin and cyclophosphamide-induced cytogenetic damages in sarcoma 180 cells","volume":"9","author":"Alencar","year":"2016","journal-title":"Int. Arch. Med."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972030884X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972030884X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:00:52Z","timestamp":1757858452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927972030884X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":52,"alternative-id":["S000927972030884X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2020.109219","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinol palmitate against toxicogenic damages of antineoplastic drugs on normal and tumor cells","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2020.109219","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109219"}}