{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:50:30Z","timestamp":1762113030393,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 di Catania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-19-1-0413"],"award-info":[{"award-number":["FA9550-19-1-0413"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012640","name":"ExxonMobil Foundation","doi-asserted-by":"publisher","award":["S18200000000256"],"award-info":[{"award-number":["S18200000000256"]}],"id":[{"id":"10.13039\/501100012640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007254","name":"Creighton University","doi-asserted-by":"publisher","award":["2UL1TR001409-06-10086545"],"award-info":[{"award-number":["2UL1TR001409-06-10086545"]}],"id":[{"id":"10.13039\/100007254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006831","name":"U.S. Air Force","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.cbi.2020.109327","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T11:11:25Z","timestamp":1606129885000},"page":"109327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Putative hormetic mechanisms and effects of atypical antipsychotic agents: Implications for study design and clinical psychopharmacotherapeutics"],"prefix":"10.1016","volume":"333","author":[{"given":"Edward J.","family":"Calabrese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2020.109327_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41514-017-0013-z","article-title":"How does hormesis impact biology, toxicology and medicine","author":"Calabrese","year":"2017","journal-title":"NPJ Aging Mech. Dis. UNSP"},{"key":"10.1016\/j.cbi.2020.109327_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/bs.irn.2020.03.024","article-title":"Hormesis: a potential strategic approach to the treatment of neurodegenerative disease","volume":"155","author":"Calabrese","year":"2020","journal-title":"Int. Rev. Neurobiol."},{"issue":"4","key":"10.1016\/j.cbi.2020.109327_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/10408440801981957","article-title":"Neuroscience and hormesis: overview and general finding","volume":"38","author":"Calabrese","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.cbi.2020.109327_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10408440801981965","article-title":"Dose-response features of neuroprotective agents: an integrative summary","volume":"38","author":"Calabrese","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.cbi.2020.109327_bib5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jnr.10290","article-title":"Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal","volume":"69","author":"Bai","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2020.109327_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2394-8108.203257","article-title":"The role of hormesis in the function performance of neural systems","volume":"3","author":"Calabrese","year":"2017","journal-title":"Brain Circ"},{"key":"10.1016\/j.cbi.2020.109327_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0022-3956(97)00014-9","article-title":"The effects of early and sustained intervention of the long-term morbidity of schizophrenia","volume":"32","author":"Wyatt","year":"1998","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.cbi.2020.109327_bib8","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1007\/s12035-016-9904-4","article-title":"The atypical atypical antipsychotic agent, clozapine, protects against corticosterone-induced death of PC12 cells by regulating the Akt\/Fox03a signalizing pathway","volume":"54","author":"Zeng","year":"2017","journal-title":"Mol. Neurobiol."},{"year":"2001","series-title":"Neuroprotective effects of some atypical anti-psychotics","author":"Wei","key":"10.1016\/j.cbi.2020.109327_bib9"},{"key":"10.1016\/j.cbi.2020.109327_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1523\/JNEUROSCI.16-01-00253.1996","article-title":"Downregulation of Cu\/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway","volume":"16","author":"Troy","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbi.2020.109327_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/383166a0","article-title":"Induction of cell death by endogenous nerve growth factor through to p75 receptor","volume":"383","author":"Frade","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2020.109327_bib12","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/383716a0","article-title":"Death of oligodendryocytes mediated by the interaction of nerve growth factor with its receptor p75","volume":"383","author":"Casaccia-Bonnefil","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2020.109327_bib13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/jnr.10796","article-title":"Opposing effects of low and high-dose clozapine on survival of transgenic amyotropiihc lateral sclerosis mice","volume":"74","author":"Turner","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbi.2020.109327_bib14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.euroneuro.2007.03.003","article-title":"Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells","volume":"17","author":"Tan","year":"2007","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.cbi.2020.109327_bib15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/0269881108096506","article-title":"Effects of quetiapine, risperidone, 9-hydroxyrisperidone and ziprasidone on the survival of human neuronal and immune cells in vitro","volume":"24","author":"Schmidt","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.cbi.2020.109327_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2019.04.009","article-title":"Neuroprotective effects of the second generation antipyschotics","volume":"208","author":"Chen","year":"2019","journal-title":"Schizophrenia"},{"issue":"4","key":"10.1016\/j.cbi.2020.109327_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4306\/pi.2017.14.4.383","article-title":"Neuroprotection in schizophrenia and its therapeutic implications","volume":"14","author":"Kim","year":"2017","journal-title":"Psychiatr. Invest."},{"key":"10.1016\/j.cbi.2020.109327_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2009.05.063","article-title":"Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation","volume":"1283","author":"Magliaro","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2020.109327_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20193156","article-title":"Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy","volume":"40","author":"Lundberg","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.cbi.2020.109327_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainres.2017.09.006","article-title":"Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse","volume":"1676","author":"Chikama","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2020.109327_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-5793(04)00082-1","article-title":"The effects of clozapine on the GSK-3-mediated signaling pathway","volume":"560","author":"Kang","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbi.2020.109327_bib22","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3109\/10408444.2013.808172","article-title":"Hormetic mechanisms","volume":"43","author":"Calabrese","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.cbi.2020.109327_bib23","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.3390\/molecules25184206","article-title":"Ayptical antipsychotic drug ziprasidone protects against rotenone-induced neurotoxicity: an in vitro study","volume":"25","author":"Terada","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2020.109327_bib24","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s13311-016-0438-2","article-title":"The atypical antipsychotic paliperidone regulates endogenous antioxidant\/anti-inflammatory pathways in rat models of acute and chronic restraint stress","volume":"13","author":"MacDowell","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.cbi.2020.109327_bib25","article-title":"The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf-2-mediated hormesis","author":"Calabrese","year":"2020","journal-title":"Pharm. Res."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279720317488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279720317488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:48:43Z","timestamp":1762112923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279720317488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":25,"alternative-id":["S0009279720317488"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2020.109327","relation":{},"ISSN":["0009-2797"],"issn-type":[{"type":"print","value":"0009-2797"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putative hormetic mechanisms and effects of atypical antipsychotic agents: Implications for study design and clinical psychopharmacotherapeutics","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2020.109327","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109327"}}