{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:06:34Z","timestamp":1778853994976,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.cbi.2021.109430","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T15:21:26Z","timestamp":1614871286000},"page":"109430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria"],"prefix":"10.1016","volume":"339","author":[{"given":"Xiang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-lin","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu-ri","family":"Piao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-gao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2021.109430_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.yjmcc.2014.08.021","article-title":"Connexin40 abnormalities and atrial fibrillation in the human heart","volume":"76","author":"Gemel","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cbi.2021.109430_bib2","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1161\/01.RES.0000250607.34498.b4","article-title":"Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes","volume":"99","author":"Beauchamp","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbi.2021.109430_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1476-5381.2011.01460.x","article-title":"Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation","volume":"164","author":"Dhein","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2021.109430_bib4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1124\/pr.115.012062","article-title":"Connexins in cardiovascular and neurovascular health and disease: pharmacological implications","volume":"69","author":"Leybaert","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cbi.2021.109430_bib5","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s00018-015-1959-2","article-title":"Role of connexins and pannexins in cardiovascular physiology","volume":"72","author":"Meens","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbi.2021.109430_bib6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.apjtm.2016.07.022","article-title":"Effect and mechanism of Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia through connexin43 (cx43)","volume":"9","author":"Wu","year":"2016","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.cbi.2021.109430_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00280-006-0300-z","article-title":"In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng","volume":"59","author":"Wang","year":"2007","journal-title":"Canc. Chemother. Pharmacol."},{"key":"10.1016\/j.cbi.2021.109430_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.canlet.2009.01.005","article-title":"Novel ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action","volume":"278","author":"Wang","year":"2009","journal-title":"Canc. Lett."},{"key":"10.1016\/j.cbi.2021.109430_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10529-015-1964-4","article-title":"Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells","volume":"38","author":"Zhao","year":"2016","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.cbi.2021.109430_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.etap.2016.04.013","article-title":"Inhibitory effects and mechanism of 25-OH-PPD on glomerular mesangial cell proliferation induced by high glucose","volume":"44","author":"Yu","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2021.109430_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1113\/jphysiol.1993.sp019790","article-title":"Extracellular fluid translocation in perfused rabbit atria: implication in control of atrial natriuretic peptide secretion","volume":"468","author":"Cho Kw","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbi.2021.109430_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.lfs.2017.09.027","article-title":"Ginsenoside Re prevents angiotensin II-induced gap-junction remodeling by activation of PPARgamma in isolated beating rat atria","volume":"190","author":"Zhang","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2021.109430_bib13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jgr.2014.12.001","article-title":"Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties","volume":"39","author":"Aravinthan","year":"2015","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.cbi.2021.109430_bib14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-\u03b21 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2021.109430_bib15","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/bjp.2008.21","article-title":"Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts","volume":"153","author":"Hao","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2021.109430_bib16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/cvr\/cvr034","article-title":"AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure","volume":"90","author":"Beauloye","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cbi.2021.109430_bib17","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/db12-0533","article-title":"Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes","volume":"62","author":"He","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2021.109430_bib18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2014.04.018","article-title":"Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKalpha1","volume":"74","author":"Noppe","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cbi.2021.109430_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/jcmm.12220","article-title":"Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria","volume":"18","author":"Hernandez","year":"2014","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.cbi.2021.109430_bib20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","article-title":"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1","volume":"23","author":"Lizcano","year":"2004","journal-title":"EMBO J."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721000661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721000661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:48:11Z","timestamp":1762112891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279721000661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":20,"alternative-id":["S0009279721000661"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109430","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109430"}}