{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:04:23Z","timestamp":1791234263121,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.cbi.2021.109444","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T03:24:34Z","timestamp":1619753074000},"page":"109444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways"],"prefix":"10.1016","volume":"343","author":[{"given":"Patricia D.O.","family":"de Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleyce","family":"dos Santos Barbosa Jobim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio C\u00e9sar","family":"dos Santos Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Rocha Bernardes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-334X","authenticated-orcid":false,"given":"Rosane B.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline B.","family":"Schlaepfer Sales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila de F.","family":"Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa A.G.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena B.P.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"de Carvalho da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Filomena do Carmo","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Francisco","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa F.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirl\u00e2ndia","family":"Pires de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marne C.","family":"de Vasconcellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-2812","authenticated-orcid":false,"given":"Emerson S.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2021.109444_bib1","first-page":"1","volume":"vol. 300","author":"Vendramini-costa","year":"2016"},{"key":"10.1016\/j.cbi.2021.109444_bib2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tiv.2008.12.004","article-title":"Cytotoxic, genotoxic and oxidative stress induced by 1,4-naphthoquinone in B16F1 melanoma tumor cells","volume":"23","author":"Kumar","year":"2009","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.cbi.2021.109444_bib3","first-page":"191","article-title":"Biological evaluation of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone as an anti-breast cancer agent","volume":"29","author":"Kanaan","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.cbi.2021.109444_bib4","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1073\/pnas.0510962103","article-title":"Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.cbi.2021.109444_bib5","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1039\/b718116g","article-title":"Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds","author":"Hillard","year":"2008","journal-title":"Chem. Commun."},{"key":"10.1016\/j.cbi.2021.109444_bib6","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1021\/es203032v","article-title":"Hydroxyl radical generation mechanism during the redox cycling process of 1,4-naphthoquinone","volume":"46","author":"Shang","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2021.109444_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jinorgbio.2012.10.007","article-title":"Exploring the DNA binding\/cleavage , cellular accumulation and topoisomerase inhibition of 2-hydroxy-3- ( aminomethyl ) -1 , 4-naphthoquinone Mannich bases and their platinum ( II ) complexes","volume":"119","author":"Neves","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.cbi.2021.109444_bib8","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2021.109444_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cbi.2009.11.030","article-title":"Oxidative stress induction by (+)-cordiaquinone J triggers both mitochondria-dependent apoptosis and necrosis in leukemia cells","volume":"183","author":"Marinho-Filho","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2021.109444_bib10","doi-asserted-by":"crossref","first-page":"792639","DOI":"10.1155\/2011\/792639","article-title":"Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways?","volume":"2011","author":"Son","year":"2011","journal-title":"J. Signal Transduct."},{"key":"10.1016\/j.cbi.2021.109444_bib11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2013.11.019","article-title":"P38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents","volume":"344","author":"Sui","year":"2014","journal-title":"Canc. Lett."},{"key":"10.1016\/j.cbi.2021.109444_bib12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2021.109444_bib13","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2694","article-title":"Signal integration by JNK and p38 MAPK pathways in cancer development","volume":"9","author":"Wagner","year":"2009","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.cbi.2021.109444_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.cbi.2021.109444_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","article-title":"ERK1\/2 MAP kinases\u00a0: structure , function , and regulation","volume":"66","author":"Jr","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2021.109444_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1039\/c0md00074d","article-title":"Synthesis and biological evaluation of substituted \u03b1- and \u03b2-2,3-dihydrofuran naphthoquinones as potent anticandidal agents","volume":"1","author":"Freire","year":"2010","journal-title":"Medchemcomm"},{"key":"10.1016\/j.cbi.2021.109444_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1476-0711-13-26","article-title":"Antifungal activity of synthetic naphthoquinones against dermatophytes and opportunistic fungi: preliminary mechanism-of-action tests","volume":"13","author":"Ferreira","year":"2014","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.cbi.2021.109444_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-1759(94)90396-4","article-title":"A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay","volume":"170","author":"a Ahmed","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cbi.2021.109444_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbi.2021.109444_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(91)90198-O","article-title":"A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow-cytometry","volume":"139","author":"Nicoletti","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cbi.2021.109444_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.cdd.4400959","article-title":"Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line","volume":"9","author":"Armstrong","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cbi.2021.109444_bib22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/ijerph2007040007","article-title":"N-acetyl-L-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells","volume":"4","author":"Yedjou","year":"2007","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.cbi.2021.109444_bib23","first-page":"6","article-title":"Antitumor properties of the leaf essential oil of zornia brasiliensis","author":"Costa","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2021.109444_bib24","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1242\/dev.091744","article-title":"Cdks, cyclins and CKIs: roles beyond cell cycle regulation","volume":"140","author":"Lim","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.cbi.2021.109444_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/cancers7010179","article-title":"Targeting cyclin-dependent kinases in human cancers: from small molecules to peptide inhibitors","volume":"7","author":"Peyressatre","year":"2015","journal-title":"Cancers"},{"key":"10.1016\/j.cbi.2021.109444_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res."},{"key":"10.1016\/j.cbi.2021.109444_bib27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1947601911408079","article-title":"RAS interaction with PI3K: more than just another effector pathway","volume":"2","author":"Castellano","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.cbi.2021.109444_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jbior.2016.05.001","article-title":"Gene regulation in the immediate-early response process","volume":"62","author":"Bahrami","year":"2016","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.cbi.2021.109444_bib29","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1021\/bi0522551","article-title":"Thermodynamics of protein-protein interactions of cMyc, Max, and Mad: effect of polyions on protein dimerization","volume":"45","author":"Banerjee","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2021.109444_bib30","first-page":"456","article-title":"Quinones derived from plant secondary metabolites as anti-cancer agents","volume":"13","author":"Lu","year":"2013","journal-title":"Anticancer. Agents Med. Chem."},{"key":"10.1016\/j.cbi.2021.109444_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/593195","article-title":"Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism","volume":"2012","author":"Korashy","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.cbi.2021.109444_bib32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2021.109444_bib33","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"11","author":"Tait","year":"2010","journal-title":"Nat. Rev. Cell Biol."},{"key":"10.1016\/j.cbi.2021.109444_bib34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bbabio.2011.03.010","article-title":"Recent advances in apoptosis, mitochondria and drug resistance in cancer cells","volume":"1807","author":"Indran","year":"2011","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.cbi.2021.109444_bib35","doi-asserted-by":"crossref","DOI":"10.1039\/C4RA13547D","article-title":"Understanding cancer and the anticancer activities of naphthoquinones \u2013 a review","volume":"5","author":"Wellington","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.cbi.2021.109444_bib36","first-page":"48","article-title":"The intracellular antioxidant balance of HL-60 cells and its implication in the apoptosis induced by quinoidal compounds","author":"Bironaite","year":"2004","journal-title":"Biologija"},{"key":"10.1016\/j.cbi.2021.109444_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0300-9084(02)01369-X","article-title":"Mitochondrial reactive oxygen species in cell death signaling","volume":"84","author":"Fleury","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.cbi.2021.109444_bib38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.abb.2010.02.002","article-title":"1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes","volume":"496","author":"Klaus","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2021.109444_bib39","first-page":"126","article-title":"Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells","volume":"5","author":"Tian","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cbi.2021.109444_bib40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cbi.2014.01.008","article-title":"Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species","volume":"211","author":"Lee","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2021.109444_bib41","doi-asserted-by":"crossref","first-page":"40485","DOI":"10.1074\/jbc.M607704200","article-title":"Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells","volume":"281","author":"Criddle","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2021.109444_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2012.10.033","article-title":"MAP kinase signalling cascades and transcriptional regulation","volume":"513","author":"Yang","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.cbi.2021.109444_bib43","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1158\/0008-5472.CAN-11-1982","article-title":"JNK-induced apoptosis, compensatory growth, and cancer stem cells","volume":"72","author":"Chen","year":"2012","journal-title":"Canc. Res."},{"key":"10.1016\/j.cbi.2021.109444_bib44","first-page":"11","volume":"vol. 15","author":"Zarubin","year":"2005"},{"key":"10.1016\/j.cbi.2021.109444_bib45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1478-811X-8-23","article-title":"Rac and Rho GTPases in cancer cell motility control","volume":"8","author":"Parri","year":"2010","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.cbi.2021.109444_bib46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/sj.cdd.4401349","article-title":"Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells","volume":"11","author":"Appierto","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cbi.2021.109444_bib47","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1038\/sj.onc.1208905","article-title":"cFos is critical for MCF-7 breast cancer cell growth","volume":"24","author":"Lu","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.cbi.2021.109444_bib48","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1111\/j.1742-4658.2009.07093.x","article-title":"Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin","volume":"276","author":"Markopoulou","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.cbi.2021.109444_bib49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.6061\/clinics\/2015(05)12","article-title":"Immediate expression of c-fos and c-jun mRNA in a model of intestinal autotransplantation and ischemia-reperfusion in situ","volume":"70","author":"Santos","year":"2015","journal-title":"Clinics"},{"key":"10.1016\/j.cbi.2021.109444_bib50","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1038\/onc.2008.312","article-title":"Apoptotic signaling by c-MYC","volume":"27","author":"Hoffman","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.cbi.2021.109444_bib51","doi-asserted-by":"crossref","first-page":"25313","DOI":"10.1074\/jbc.M400932200","article-title":"c-Fos is a mediator of the c-Myc-induced apoptotic signaling in serum-deprived hepatoma cells via the p38 mitogen-activated protein kinase pathway","volume":"279","author":"Kalra","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2021.109444_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11245","article-title":"RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression","volume":"7","author":"Castellano","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2021.109444_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ydbio.2003.06.003","article-title":"Cell migration: rho GTPases lead the way","volume":"265","author":"Raftopoulou","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbi.2021.109444_bib54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jep.2012.09.017","article-title":"In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma","volume":"144","author":"Rajasekar","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2021.109444_bib55","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jep.2016.04.011","article-title":"Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and its component Casearin X: in vivo and ex vivo methods and microscopy examinations","volume":"186","author":"Ferreira","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2021.109444_bib56","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1158\/0008-5472.CAN-08-2494","article-title":"Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer","volume":"68","author":"Aziz","year":"2008","journal-title":"Canc. Res."},{"key":"10.1016\/j.cbi.2021.109444_bib57","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.taap.2007.05.018","article-title":"Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II","volume":"223","author":"Kawiak","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2021.109444_bib58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jphs.2015.06.005","article-title":"Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression","volume":"128","author":"Niu","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2021.109444_bib59","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/np4010085","article-title":"Plumbagin downregulates wnt signaling independent of p53 in human colorectal cancer cells","volume":"77","author":"Raghu","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.cbi.2021.109444_bib60","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1476-4598-10-107","article-title":"Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4","volume":"10","author":"Manu","year":"2011","journal-title":"Mol. Canc."},{"key":"10.1016\/j.cbi.2021.109444_bib61","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1158\/1535-7163.MCT-11-0731","article-title":"Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling","volume":"11","author":"Sung","year":"2012","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.cbi.2021.109444_bib62","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/jcb.21966","article-title":"Plumbagin-induced apoptosis of human breast cancer cells is mediated by inactivation of NF-\u03baB and Bcl-2","volume":"105","author":"Ahmad","year":"2008","journal-title":"J. Cell. Biochem."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721000806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721000806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:48:40Z","timestamp":1762112920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279721000806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":62,"alternative-id":["S0009279721000806"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109444","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109444"}}