{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:48:29Z","timestamp":1788320909475,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["427078\/2016-4"],"award-info":[{"award-number":["427078\/2016-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["APQ-0350-4.03\/18"],"award-info":[{"award-number":["APQ-0350-4.03\/18"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["427078\/2016-4"],"award-info":[{"award-number":["427078\/2016-4"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0350-4.03\/18"],"award-info":[{"award-number":["APQ-0350-4.03\/18"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cbi.2021.109514","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T23:52:09Z","timestamp":1621554729000},"page":"109514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Structural design, synthesis and anti-Trypanosoma cruzi profile of the second generation of 4-thiazolidinones chlorine derivatives"],"prefix":"10.1016","volume":"345","author":[{"given":"Gevanio","family":"Bezerra de Oliveira Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Ver\u00edssimo de Oliveira Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Caroline da Silva Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Andr\u00e9","family":"Ramos dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catarina","family":"Cristov\u00e3o-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Gonz\u00e1lez","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9119-6947","authenticated-orcid":false,"given":"Luiz","family":"da Silva Maia Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Gaio","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Sim\u00e3o","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Andr\u00e9","family":"Brayner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria R\u00eago","family":"Alves Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Lima Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2021.109514_bib1","series-title":"WHO | what Is Chagas Disease","year":"2016"},{"key":"10.1016\/j.cbi.2021.109514_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1590\/0037-8682-0248-2013","article-title":"Yasuda the present situation, challenges, and perspectives regarding the production and utilization of effective drugs against human Chagas disease","volume":"47","author":"Dias","year":"2014","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.cbi.2021.109514_bib3","series-title":"WHO | Transmission of Chagas Disease","year":"2016"},{"key":"10.1016\/j.cbi.2021.109514_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/136793","article-title":"A growing concern in non-endemic countries","volume":"2012","author":"Klein","year":"2012","journal-title":"Epidemiol. Res. Int."},{"key":"10.1016\/j.cbi.2021.109514_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/789758","article-title":"Human Chagas disease and migration in the context of globalization: some particular aspects","volume":"2013","author":"Dias","year":"2013","journal-title":"J. Trop. Med."},{"issue":"6","key":"10.1016\/j.cbi.2021.109514_bib6","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1021\/jm801313t","article-title":"Rational modification of a candidate cancer drug for use against Chagas disease","volume":"52","author":"Kraus","year":"2009","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cbi.2021.109514_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1087057114550585","article-title":"Chagas disease drug discovery: toward a new era","volume":"20","author":"Chatelain","year":"2015","journal-title":"J. Biomol. Screen. [Internet]"},{"issue":"10","key":"10.1016\/j.cbi.2021.109514_bib8","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1021\/jm9013136","article-title":"Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-chagas disease drug discovery","volume":"53","author":"Kraus","year":"2010","journal-title":"J. Med. Chem."},{"issue":"14","key":"10.1016\/j.cbi.2021.109514_bib9","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1017\/S0031182017001469","article-title":"Biological factors that impinge on Chagas disease drug development","volume":"144","author":"Francisco","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/j.cbi.2021.109514_bib10","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ejmech.2018.06.040","article-title":"Current advances in drug discovery for Chagas disease","volume":"155","author":"Scarim","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2021.109514_bib11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ejmech.2017.09.047","article-title":"Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi","volume":"141","author":"Oliveira Filho","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2021.109514_bib12","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ejmech.2015.06.048","article-title":"Synthesis and structure\u2013activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain","volume":"101","author":"Esp\u00edndola","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2021.109514_bib13","doi-asserted-by":"crossref","first-page":"7478","DOI":"10.1016\/j.bmc.2015.10.048","article-title":"Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi","volume":"23","author":"Oliveira Filho","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"10.1016\/j.cbi.2021.109514_bib14","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.bmc.2016.02.027","article-title":"Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi","volume":"24","author":"Costa","year":"2016","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"10.1016\/j.cbi.2021.109514_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejmech.2014.08.012","article-title":"2-Pyridyl thiazoles as novel anti- Trypanosoma cruzi agents\u00a0: structural design , synthesis and pharmacological evaluation","volume":"86","author":"Cardoso","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2021.109514_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ejmech.2016.05.050","article-title":"New 1,3-thiazole derivatives and their biological and ultrastructural effects on Trypanosoma cruzi","volume":"121","author":"Moraes","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2021.109514_bib17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ejmech.2014.02.001","article-title":"Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death","volume":"75","author":"Moreira","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cbi.2021.109514_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cmdc.201300354","article-title":"Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-trypanosoma cruzi activity","volume":"9","author":"Moreira","year":"2014","journal-title":"ChemMedChem"},{"issue":"24","key":"10.1016\/j.cbi.2021.109514_bib19","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1021\/jm301518v","article-title":"Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice","volume":"55","author":"Moreira","year":"2012","journal-title":"J. Med. Chem."},{"issue":"13","key":"10.1016\/j.cbi.2021.109514_bib20","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1021\/jm010459j","article-title":"Synthesis and Structure\u2212Activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain","volume":"45","author":"Du","year":"2002","journal-title":"J. Med. Chem."},{"issue":"22","key":"10.1016\/j.cbi.2021.109514_bib21","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1016\/j.bmc.2010.09.056","article-title":"Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents","volume":"18","author":"Hernandes","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2021.109514_bib22","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00044-017-2072-x","article-title":"Ashima Pahwa. Convenient synthesis, antimalarial and antimicrobial potential of thioethereal 1,4-disubstituted 1,2,3-triazoles with ester functionality","volume":"27","author":"Kaushik","year":"2018","journal-title":"Med. Chem. Res."},{"issue":"24","key":"10.1016\/j.cbi.2021.109514_bib23","doi-asserted-by":"crossref","DOI":"10.1021\/jm301518v","article-title":"Structural investigation of anti-trypanosoma cruzi 2-iminothiazolidin-4- ones allows the identification of agents with efficacy in infected mice","volume":"55","author":"Moreira","year":"2012","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.cbi.2021.109514_bib24","first-page":"1","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, druglikeness and medicinal chemistry. friendliness of small molecules","volume":"7","author":"Antoine","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2021.109514_bib25","series-title":"Lead Profiling Lead- and Drug-like Compounds\u00a0: the Rule-Of-Five Revolution","first-page":"337","author":"\u00c3","year":"2004"},{"issue":"1\u20133","key":"10.1016\/j.cbi.2021.109514_bib26","first-page":"3","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"23","author":"Franc","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"12","key":"10.1016\/j.cbi.2021.109514_bib27","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.cbi.2021.109514_bib28","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/tx200211v","article-title":"Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety","volume":"24","author":"Meanwell","year":"2011","journal-title":"Chem. Res. Toxicol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721001502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721001502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:04:35Z","timestamp":1757858675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279721001502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":28,"alternative-id":["S0009279721001502"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109514","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural design, synthesis and anti-Trypanosoma cruzi profile of the second generation of 4-thiazolidinones chlorine derivatives","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109514"}}