{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:20:22Z","timestamp":1793413222585,"version":"4.5.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cbi.2021.109568","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T13:27:59Z","timestamp":1624627679000},"page":"109568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":258,"special_numbering":"C","title":["Nuclear factor-kappa B and its role in inflammatory lung disease"],"prefix":"10.1016","volume":"345","author":[{"given":"Khalid Saad","family":"Alharbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj Kumar","family":"Fuloria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivkanya","family":"Fuloria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sk Batin","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed Hassan","family":"Al-Malki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Arshad","family":"Javed Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Thangavelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3823-6572","authenticated-orcid":false,"given":"Sachin K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Sita","family":"Rama Raju Allam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-4069","authenticated-orcid":false,"given":"Niraj Kumar","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5567-6663","authenticated-orcid":false,"given":"Dinesh Kumar","family":"Chellappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2021.109568_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1465-9921-7-21","article-title":"Epigenetics and airways disease","volume":"7","author":"Adcock","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.cbi.2021.109568_bib2","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1042\/CS20190331","article-title":"Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo","volume":"133","author":"Sun","year":"2019","journal-title":"Clin. Sci."},{"key":"10.1016\/j.cbi.2021.109568_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00441-019-03054-2","article-title":"Experimental pulmonary fibrosis was suppressed by microRNA-506 through NF-kappa-mediated apoptosis and inflammation","volume":"378","author":"Zhu","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cbi.2021.109568_bib4","first-page":"80","article-title":"Expression and localization of nuclear factor-kappa B subunits in cultured human paranasal sinus mucosal cells","volume":"41","author":"Osada","year":"2003","journal-title":"Rhinology"},{"key":"10.1016\/j.cbi.2021.109568_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevImmunol.2020033210","article-title":"Inflammation, NF-\u03baB, and chronic diseases: how are they linked?","volume":"40","author":"Kunnumakkara","year":"2020","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.cbi.2021.109568_bib6","first-page":"756","article-title":"[Expression of protein kinase C and nuclear factor kappa B in lung tissue of patients with chronic obstructive pulmonary disease]","volume":"43","author":"Zhang","year":"2004","journal-title":"Zhonghua nei ke za zhi"},{"key":"10.1016\/j.cbi.2021.109568_bib7","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1164\/ajrccm.164.12.2104017","article-title":"Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide","volume":"164","author":"Kang","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2021.109568_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbrc.2011.04.008","article-title":"Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation","volume":"408","author":"Huang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2021.109568_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1515\/bmc-2012-0039","article-title":"Role of nuclear I\u03baBs in inflammation regulation","volume":"4","author":"Chiba","year":"2013","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.cbi.2021.109568_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2008.02.043","article-title":"Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury","volume":"133","author":"Imai","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2021.109568_bib11","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.4049\/jimmunol.157.4.1630","article-title":"In vivo antioxidant treatment suppresses nuclear factor-kappa b activation and neutrophilic lung inflammation","volume":"157","author":"Blackwell","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbi.2021.109568_bib12","doi-asserted-by":"crossref","first-page":"647","DOI":"10.5858\/2009-0660-OAR1.1","article-title":"Increased levels of nuclear factor \u03baB and Fos-related antigen 1 in lung tissues from patients with acute respiratory distress syndrome","volume":"135","author":"Fudala","year":"2011","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.cbi.2021.109568_bib13","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1128\/JVI.02576-13","article-title":"Inhibition of NF-\u03baB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival","volume":"88","author":"DeDiego","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.cbi.2021.109568_bib14","doi-asserted-by":"crossref","first-page":"R82","DOI":"10.1186\/cc12696","article-title":"Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia","volume":"17","author":"Devaney","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.cbi.2021.109568_bib15","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/cgt.2012.54","article-title":"Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines","volume":"19","author":"Cramer","year":"2012","journal-title":"Canc. Gene Ther."},{"key":"10.1016\/j.cbi.2021.109568_bib16","first-page":"107","article-title":"The involvement of NF-?B Transcription factor in asthma","volume":"58","author":"Rico-Rosillo","year":"2011","journal-title":"Revista alergia Mexico"},{"key":"10.1016\/j.cbi.2021.109568_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2017.11.159","article-title":"Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses","volume":"496","author":"Chen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2021.109568_bib18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jaci.2011.03.045","article-title":"I\u03baB kinase-driven nuclear factor-\u03baB activation in patients with asthma and chronic obstructive pulmonary disease","volume":"128","author":"Gagliardo","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cbi.2021.109568_bib19","doi-asserted-by":"crossref","first-page":"104850","DOI":"10.1016\/j.phrs.2020.104850","article-title":"Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-\u03baB signaling pathway","volume":"158","author":"Ma","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2021.109568_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai9048","article-title":"Lung cancer-associated pulmonary hypertension: role of microenvironmental inflammation based on tumor cell-immune cell cross-talk","volume":"9","author":"Pullamsetti","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cbi.2021.109568_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/187152810792231904","article-title":"The role of nuclear factor-kappaB in inflammatory lung disease","volume":"9","author":"Imanifooladi","year":"2010","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.cbi.2021.109568_bib22","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3389\/fimmu.2020.01205","article-title":"Mechanisms of virus-induced airway immunity dysfunction in the pathogenesis of COPD disease, progression, and exacerbation","volume":"11","author":"Guo-Parke","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbi.2021.109568_bib23","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.biopha.2018.09.046","article-title":"miRNA-1246 suppresses acute lung injury-induced inflammation and apoptosis via the NF-\u03baB and Wnt\/\u03b2-catenin signal pathways","volume":"108","author":"Suo","year":"2018","journal-title":"Biomed. & Pharmacother. = Biomed. & Pharmacother."},{"key":"10.1016\/j.cbi.2021.109568_bib24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.arbres.2019.05.003","article-title":"Montelukast, leukotriene inhibitor, reduces LPS-induced acute lung inflammation and human neutrophil activation","volume":"55","author":"Davino-Chiovatto","year":"2019","journal-title":"Arch. Bronconeumol."},{"key":"10.1016\/j.cbi.2021.109568_bib25","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1097\/01.CCM.0000057843.47705.E8","article-title":"Neutrophils and acute lung injury","volume":"31","author":"Abraham","year":"2003","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.cbi.2021.109568_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-018-1247-9","article-title":"Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-\u03b1 mediated NF-\u03baB and HDAC-3 nuclear translocation","volume":"10","author":"Pooladanda","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2021.109568_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejmech.2013.12.052","article-title":"Novel lung adenocarcinoma and nuclear factor-kappa B (NF-\u03baB) inhibitors: synthesis and evaluation of lantadene congeners","volume":"74","author":"Suthar","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2021.109568_bib28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.tcb.2012.08.001","article-title":"The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation","volume":"22","author":"Tornatore","year":"2012","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cbi.2021.109568_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1615\/JEnvironPatholToxicolOncol.v31.i1.40","article-title":"Nuclear factor kappa B: a pro-inflammatory, transcription factor-mediated signalling pathway in lung carcinogenesis and its inhibition by nonsteroidal anti-inflammatory drugs","volume":"31","author":"Setia","year":"2012","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.cbi.2021.109568_bib30","doi-asserted-by":"crossref","first-page":"e75415","DOI":"10.1371\/journal.pone.0075415","article-title":"Nuclear factor \u03ba-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension","volume":"8","author":"Price","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.cbi.2021.109568_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00005537-200201000-00010","article-title":"Nuclear factor-kappa B activation in the nasal polyp epithelium: relationship to local cytokine gene expression","volume":"112","author":"Takeno","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cbi.2021.109568_bib32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000078940","article-title":"Nuclear factor-kappa B expression in alveolar macrophages of mechanically ventilated neonates with respiratory distress syndrome","volume":"86","author":"Cao","year":"2004","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.cbi.2021.109568_bib33","first-page":"685","article-title":"Nuclear factor-kappa B in signal conduction of protein kinase C in T lymphocytes from an asthmatic Guinea pig model","volume":"115","author":"Xiong","year":"2002","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.cbi.2021.109568_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3109\/08941939.2011.603817","article-title":"Nuclear factor-kappa B mediates one-lung ventilation-induced acute lung injury in rabbits","volume":"25","author":"You","year":"2012","journal-title":"J. Invest. Surg."},{"key":"10.1016\/j.cbi.2021.109568_bib35","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/bdra.23233","article-title":"Nuclear factor-kappa-B signaling in lung development and disease: one pathway, numerous functions, Birth defects research. Part A","volume":"100","author":"Alvira","year":"2014","journal-title":"Clin. Mol. Teratol."},{"key":"10.1016\/j.cbi.2021.109568_bib36","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jep.2012.03.013","article-title":"Sedative, antiepileptic and antipsychotic effects of Viscum album L.(Loranthaceae) in mice and rats","volume":"141","author":"Gupta","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2021.109568_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1067\/msy.2000.107419","article-title":"Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome","volume":"128","author":"Jaffray","year":"2000","journal-title":"Surgery"},{"key":"10.1016\/j.cbi.2021.109568_bib38","first-page":"232","article-title":"Activation of TWEAK\/Fn14 signaling suppresses TRAFs\/NF-\u03baB pathway in the pathogenesis of cancer","volume":"20","author":"Gupta","year":"2021","journal-title":"EXCLI J."},{"key":"10.1016\/j.cbi.2021.109568_bib39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1164\/rccm.2109077","article-title":"Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation","volume":"165","author":"Haeberle","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2021.109568_bib40","doi-asserted-by":"crossref","first-page":"153296","DOI":"10.1016\/j.phymed.2020.153296","article-title":"Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-\u03baB) signaling pathway","volume":"78","author":"Ma","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2021.109568_bib41","doi-asserted-by":"crossref","first-page":"26357","DOI":"10.1038\/srep26357","article-title":"Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway","volume":"6","author":"Zheng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2021.109568_bib42","doi-asserted-by":"crossref","first-page":"e14209","DOI":"10.1111\/dth.14209","article-title":"Beta\u2010catenin non\u2010canonical pathway: a potential target for inflammatory and hyperproliferative state via expression of transglutaminase 2 in psoriatic skin keratinocyte","volume":"33","author":"Gupta","year":"2020","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.cbi.2021.109568_bib43","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.5665\/sleep.3236","article-title":"A pro-inflammatory role for nuclear factor kappa B in childhood obstructive sleep apnea syndrome","volume":"36","author":"Israel","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.cbi.2021.109568_bib44","first-page":"435","article-title":"[Regulatory function of nuclear factor kappa B on lymphocyte proliferation and apoptosis in bronchial asthmatic rats and effect of triptolide on the regulation]","volume":"24","author":"Zhang","year":"2004","journal-title":"Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi"},{"key":"10.1016\/j.cbi.2021.109568_bib45","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1038\/s41467-020-17314-1","article-title":"Rieske iron-sulfur protein induces FKBP12.6\/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-\u03baB\/cyclin D1 pathway","volume":"11","author":"Mei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2021.109568_bib46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF03256650","article-title":"The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy","volume":"2","author":"Wright","year":"2003","journal-title":"Am. J. Respir. Med."},{"key":"10.1016\/j.cbi.2021.109568_bib47","first-page":"29","article-title":"Current update on preclinical and clinical studies of resveratrol, a naturally occurring phenolic compound","author":"Samuel","year":"2019","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.cbi.2021.109568_bib48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","article-title":"The role of nuclear factor-kappa B in cytokine gene regulation","volume":"17","author":"Blackwell","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2021.109568_bib49","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1378\/chest.117.5.1482","article-title":"The role of nuclear factor-kappa B in pulmonary diseases","volume":"117","author":"Christman","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.cbi.2021.109568_bib50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00005-011-0136-z","article-title":"Nuclear factor-\u03baB: a key regulator in health and disease of lungs","volume":"59","author":"Batra","year":"2011","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.cbi.2021.109568_bib51","first-page":"7414","article-title":"The roles of NF-kB in the development of lung injury after one-lung ventilation","volume":"22","author":"Pan","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2021.109568_bib52","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/cns.12696","article-title":"Calcitonin gene\u2010related peptide (CGRP): a novel target for Alzheimer's disease","volume":"23","author":"Singh","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.cbi.2021.109568_bib53","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1254\/jphs.14037FP","article-title":"Salidroside attenuates allergic airway inflammation through negative regulation of nuclear factor-kappa B and p38 mitogen-activated protein kinase","volume":"126","author":"Yan","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2021.109568_bib54","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41419-020-03178-2","article-title":"Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-\u03baB\/NLRP3-mediated epithelial-mesenchymal transition and inflammation","volume":"11","author":"Peng","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2021.109568_bib55","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1164\/rccm.200409-1257OC","article-title":"Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation","volume":"172","author":"Birrell","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2021.109568_bib56","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12931-020-01391-3","article-title":"Suppressed nuclear factor-kappa B alleviates lipopolysaccharide-induced acute lung injury through downregulation of CXCR4 mediated by microRNA-194","volume":"21","author":"Chen","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.cbi.2021.109568_bib57","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.drudis.2020.09.013","article-title":"Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms","volume":"25","author":"Sanghai","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cbi.2021.109568_bib58","article-title":"Recent update on biological activities and pharmacological actions of liraglutide","author":"Tiwari","year":"2017","journal-title":"EXCLI J."},{"key":"10.1016\/j.cbi.2021.109568_bib59","doi-asserted-by":"crossref","first-page":"L1037","DOI":"10.1152\/ajplung.2001.281.5.L1037","article-title":"Transcriptional mechanisms of acute lung injury","volume":"281","author":"Fan","year":"2001","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.cbi.2021.109568_bib60","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/mi.2013.65","article-title":"Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease","volume":"7","author":"Starkey","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.cbi.2021.109568_bib61","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00134-014-3613-0","article-title":"Understanding ARDS-associated fibroproliferation","volume":"41","author":"Meduri","year":"2015","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.cbi.2021.109568_bib62","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.toxlet.2019.10.019","article-title":"Vaporized perfluorocarbon inhalation attenuates primary blast lung injury in canines by inhibiting mitogen-activated protein kinase\/nuclear factor-\u03baB activation and inducing nuclear factor, erythroid 2 like 2 pathway","volume":"319","author":"Zhang","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2021.109568_bib63","doi-asserted-by":"crossref","first-page":"224","DOI":"10.23736\/S0031-0808.18.03479-1","article-title":"Current updates on pharmacological roles of glucagon-like peptide 1 in obesity","volume":"60","author":"Verma","year":"2018","journal-title":"Panminerva Med."},{"key":"10.1016\/j.cbi.2021.109568_bib64","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2180-4-28","article-title":"Activation of cytokines and NF-kappa B in corneal epithelial cells infected by respiratory syncytial virus: potential relevance in ocular inflammation and respiratory infection","volume":"4","author":"Bitko","year":"2004","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.cbi.2021.109568_bib65","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-\u03baB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cbi.2021.109568_bib66","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.7150\/ijbs.30193","article-title":"The antioxidant MitoQ protects against CSE-induced endothelial barrier injury and inflammation by inhibiting ROS and autophagy in human umbilical vein endothelial cells","volume":"15","author":"Chen","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"Suppl 3","key":"10.1016\/j.cbi.2021.109568_bib67","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1017\/S0022215115001322","article-title":"Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta","volume":"129","author":"Phan","year":"2015","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.cbi.2021.109568_bib68","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.stem.2019.08.011","article-title":"Chronic inflammation directs an olfactory stem cell functional switch from neuroregeneration to immune defense","volume":"25","author":"Chen","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cbi.2021.109568_bib69","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbrc.2017.06.047","article-title":"Chronic intermittent hypoxia induces liver fibrosis in mice with diet-induced obesity via TLR4\/MyD88\/MAPK\/NF-kB signaling pathways","volume":"490","author":"Kang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2021.109568_bib70","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1002\/ptr.6444","article-title":"Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma","volume":"33","author":"Song","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.cbi.2021.109568_bib71","doi-asserted-by":"crossref","DOI":"10.1615\/JEnvironPatholToxicolOncol.2019029388","article-title":"Metformin: a salutary candidate for colorectal cancer treatment in patients with diabetes","volume":"38","author":"Samuel","year":"2019","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.cbi.2021.109568_bib72","first-page":"2213","article-title":"Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-\u03baB signaling in an Nrf2-dependent manner","volume":"44","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cbi.2021.109568_bib73","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.intimp.2016.02.014","article-title":"Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPAR\u03b3-dependent pathway","volume":"34","author":"Zhu","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.cbi.2021.109568_bib74","series-title":"Role of Oxidative Stress in Pathophysiology of Diseases","first-page":"49","article-title":"Oxidative stress in neurology and in neurodegenerative processes","author":"Gupta","year":"2020"},{"key":"10.1016\/j.cbi.2021.109568_bib75","first-page":"25","article-title":"The role of diazepam in epigenetics: from the molecular level to clinical implications","volume":"35","author":"Sachchidanand Pathak","year":"2021","journal-title":"Adv. Mind Body Med."},{"key":"10.1016\/j.cbi.2021.109568_bib76","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ajpath.2018.10.002","article-title":"Key functions and therapeutic prospects of Nur77 in inflammation related lung diseases","volume":"189","author":"Banno","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cbi.2021.109568_bib77","first-page":"31","article-title":"Wound healing effect of ethanolic extract from Morning Glory (Ipomoea carnea Jacq.) leaves by using different models in rats","author":"Shukla","year":"2018","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.cbi.2021.109568_bib78","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1080\/15384101.2018.1509635","article-title":"MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting in\ufb02ammation and apoptosis through modulating TLR4\/MyD88\/NF-\u03baB pathway","volume":"17","author":"Ju","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cbi.2021.109568_bib79","doi-asserted-by":"crossref","first-page":"109761","DOI":"10.1016\/j.cellsig.2020.109761","article-title":"The multifaceted role of plasminogen in inflammation","volume":"75","author":"Heissig","year":"2020","journal-title":"Cell. Signal."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721002064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721002064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:07:21Z","timestamp":1757858841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279721002064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":79,"alternative-id":["S0009279721002064"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109568","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear factor-kappa B and its role in inflammatory lung disease","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109568"}}