{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:24:10Z","timestamp":1773260650364,"version":"3.50.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020417","name":"Consejo Mexiquense de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["268769"],"award-info":[{"award-number":["268769"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["A1\u2010S\u201028619"],"award-info":[{"award-number":["A1\u2010S\u201028619"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["CAT2021-0183"],"award-info":[{"award-number":["CAT2021-0183"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.cbi.2021.109596","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T04:42:13Z","timestamp":1627447333000},"page":"109596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Differential response of immobile (pneumocytes) and mobile (monocytes) barriers against 2 types of metal oxide nanoparticles"],"prefix":"10.1016","volume":"347","author":[{"given":"Octavio","family":"Ispanixtlahuatl-Mer\u00e1z","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma L.","family":"Delgado-Buenrostro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"D\u00e9ciga-Alcaraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Pilar","family":"Ramos-Godinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-3934","authenticated-orcid":false,"given":"Diego","family":"Oliva-Rico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar O.","family":"L\u00f3pez-Villegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo J.","family":"V\u00e1zquez-Zapi\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica M.","family":"Mata-Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damaris","family":"Ilhuicatzi-Alvarado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Moreno-Fierros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia M.","family":"Garc\u00eda Cuellar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesennia","family":"S\u00e1nchez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda I.","family":"Chirino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2021.109596_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-019-4651-x","article-title":"Inhalation exposure to various nanoparticles in work environment\u2014contextual information and results of measurements","author":"Oberbek","year":"2019","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.cbi.2021.109596_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/mutage\/gew065","article-title":"Genotoxicity and gene expression analyses of liver and lung tissues of mice treated with titanium dioxide nanoparticles","author":"Li","year":"2017","journal-title":"Mutagenesis"},{"key":"10.1016\/j.cbi.2021.109596_bib3","doi-asserted-by":"crossref","DOI":"10.1165\/ajrcmb.24.2.4081","article-title":"Endocytosis of ultrafine particles by A549 cells","author":"Stearns","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2021.109596_bib4","doi-asserted-by":"crossref","DOI":"10.3109\/17435390.2016.1141338","article-title":"Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents","author":"Armand","year":"2016","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.cbi.2021.109596_bib5","article-title":"Pulmonary toxicity induced by three forms of titanium dioxide nanoparticles via intra-tracheal instillation in rats","author":"Liu","year":"2009","journal-title":"Prog. Nat. Sci."},{"key":"10.1016\/j.cbi.2021.109596_bib6","doi-asserted-by":"crossref","DOI":"10.1080\/08958370701497903","article-title":"Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: recent evaluations by an IARC Monographs Working Group","author":"Baan","year":"2007","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib7","doi-asserted-by":"crossref","DOI":"10.1021\/es204168d","article-title":"Titanium dioxide nanoparticles in food and personal care products","author":"Weir","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2021.109596_bib8","article-title":"A citizen science approach estimating titanium dioxide released from personal care products","author":"Wu","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.cbi.2021.109596_bib9","article-title":"Safety assessment of Tin(IV) oxide as used in cosmetics","author":"Johnson","year":"2014","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib10","doi-asserted-by":"crossref","DOI":"10.2478\/s13536-013-0164-y","article-title":"Synthesis and characterization of tin oxide nanoparticles via the Co-precipitation method","author":"Tazikeh","year":"2014","journal-title":"Materials Science-Poland"},{"key":"10.1016\/j.cbi.2021.109596_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s11671-021-03555-6","article-title":"Green and cost-effective synthesis of tin oxide nanoparticles: a review on the synthesis methodologies, mechanism of formation, and their potential applications","author":"Gebreslassie","year":"2021","journal-title":"Nanoscale research letters"},{"key":"10.1016\/j.cbi.2021.109596_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2016.11.017","article-title":"Cytotoxicity study of Piper nigrum seed mediated synthesized SnO2 nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines","author":"Tammina","year":"2017","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.cbi.2021.109596_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/0960327112462725","article-title":"Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549","author":"Srivastava","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2013.03.006","article-title":"Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats","author":"Tang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2021.109596_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/mutage\/gew055","article-title":"Comparison of the DNA damage response in BEAS-2B and A549 cells exposed to titanium dioxide nanoparticles","author":"Biola-Clier","year":"2017","journal-title":"Mutagenesis"},{"key":"10.1016\/j.cbi.2021.109596_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/08958370903005769","article-title":"Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models","author":"Nassimi","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib17","author":"Davoren"},{"key":"10.1016\/j.cbi.2021.109596_bib18","doi-asserted-by":"crossref","DOI":"10.1039\/c3tx50099c","article-title":"The toxic effects of single-wall carbon nanotubes are linked to the phagocytic ability of cells","author":"Foldbjerg","year":"2014","journal-title":"Toxicological Research"},{"key":"10.1016\/j.cbi.2021.109596_bib19","article-title":"Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells","author":"Wang","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.cbi.2021.109596_bib20","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.1103750","article-title":"Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential","author":"Gangwal","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2021.109596_bib21","article-title":"Trypan blue exclusion test of cell viability","author":"Strober","year":"2001","journal-title":"Curr. Protoc. Im."},{"key":"10.1016\/j.cbi.2021.109596_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.infrared.2020.103279","article-title":"A study of Parkinson's disease patients' serum using FTIR spectroscopy","author":"Wang","year":"2020","journal-title":"Infrared Phys. Technol."},{"key":"10.1016\/j.cbi.2021.109596_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010385","article-title":"Safe nanoparticles: are we there yet?","author":"Najahi-Missaoui","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2021.109596_bib24","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.cbi.2021.109596_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/498420","article-title":"Physicochemical properties of nanomaterials: implication in associated toxic manifestations","author":"Gatoo","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.cbi.2021.109596_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151365","article-title":"Shape-related toxicity of titanium dioxide nanofibres","author":"Allegri","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.cbi.2021.109596_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2016.01.005","article-title":"Protein corona: opportunities and challenges","author":"Zanganeh","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cbi.2021.109596_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1467","article-title":"Protein corona and nanoparticles: how can we investigate on?","author":"Pederzoli","year":"2017","journal-title":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology"},{"key":"10.1016\/j.cbi.2021.109596_bib29","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-60327-198-1_6","article-title":"Zeta potential measurement","author":"Clogston","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cbi.2021.109596_bib30","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrestox.0c00106","article-title":"Impact of the physicochemical features of TiO2 nanoparticles on their in vitro toxicity","author":"Kose","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-020-00341-7","article-title":"Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo","author":"Murugadoss","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/S0368-2242(55)80032-2","article-title":"Radiological changes in pneumoconiosis due to tin oxide","author":"Robertson","year":"1955","journal-title":"J. Facul. Radiol."},{"key":"10.1016\/j.cbi.2021.109596_bib33","series-title":"Stannosis: benign pneumoconiosis due to tin dioxide","author":"Robertson","year":"1961"},{"key":"10.1016\/j.cbi.2021.109596_bib34","article-title":"Stannosis in hearth tinners","author":"Cole","year":"1964","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.cbi.2021.109596_bib35","article-title":"Stannosis. A report of 2 cases","author":"Sluis-Cremer","year":"1989","journal-title":"S. Afr. Med. J."},{"key":"10.1016\/j.cbi.2021.109596_bib36","doi-asserted-by":"crossref","DOI":"10.4081\/cdr.2012.e8","article-title":"Increased bronchoalveolar lavage fluid tin content in stannosis","author":"Altraja","year":"2012","journal-title":"Chest Disease Reports"},{"key":"10.1016\/j.cbi.2021.109596_bib37","article-title":"Neumoconiosis ocupacional por \u00f3xido de esta\u00f1o","author":"Giraldo","year":"2013","journal-title":"Acta M\u00e9dica colombiana."},{"key":"10.1016\/j.cbi.2021.109596_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2015.06.020","article-title":"Metal oxide nanoparticles with low toxicity","author":"Ng","year":"2015","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.cbi.2021.109596_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2016.09.003","article-title":"Size effect of SnO(2) nanoparticles on bacteria toxicity and their membrane damage","author":"Ch\u00e1vez-Calder\u00f3n","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2021.109596_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2013.07.019","article-title":"The modality of cell-particle interactions drives the toxicity of nanosized CuO and TiO\u2082 in human alveolar epithelial cells","author":"Moschini","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2021.109596_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/jat.3038","article-title":"Evaluation of cytotoxic, genotoxic and inflammatory response in human alveolar and bronchial epithelial cells exposed to titanium dioxide nanoparticles","author":"Ursini","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib42","doi-asserted-by":"crossref","DOI":"10.1080\/15287390801906675","article-title":"Comparison of the biological activity between ultrafine and fine titanium dioxide particles in RAW 264.7 cells associated with oxidative stress","author":"Kang","year":"2008","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.cbi.2021.109596_bib43","article-title":"Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicology","author":"Wilhelmi","year":"2011","journal-title":"In Vitro"},{"key":"10.1016\/j.cbi.2021.109596_bib44","article-title":"Titanium dioxide nanoparticles induce in vitro autophagy","author":"Dai","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib45","article-title":"Cartilage and ligament tissue engineering: biomaterials, cellular interactions, and regenerative strategies","author":"Kuo","year":"2013","journal-title":"Biomaterials Science"},{"key":"10.1016\/j.cbi.2021.109596_bib46","article-title":"Adhesion modulates cell morphology and migration within dense fibrous networks. Journal of Physics","author":"Moreira-Soares","year":"2019","journal-title":"Condensed Matter"},{"key":"10.1016\/j.cbi.2021.109596_bib47","doi-asserted-by":"crossref","DOI":"10.1089\/ten.tea.2010.0273","article-title":"Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices","author":"Hakkinen","year":"2011","journal-title":"Tissue Eng."},{"key":"10.1016\/j.cbi.2021.109596_bib48","article-title":"Zinc oxide nanoparticles cause morphological changes in human A549 cell line through alteration in the expression pattern of small GTPases at mRNA level","author":"Santimano","year":"2013","journal-title":"J. Bionanoscience"},{"key":"10.1016\/j.cbi.2021.109596_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.btre.2019.e00339","article-title":"Induction of intrinsic apoptotic signaling pathway in A549 lung cancer cells using silver nanoparticles from Gossypium hirsutum and evaluation of in vivo toxicity","author":"Kanipandian","year":"2019","journal-title":"Biotechnology Reports"},{"key":"10.1016\/j.cbi.2021.109596_bib50","article-title":"Epithelial to Mesenchymal transition, eIF2\u03b1 phosphorylation and Hsp70 expression enable greater tolerance in A549 cells to TiO2 over ZnO nanoparticles","author":"Martin","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2021.109596_bib51","doi-asserted-by":"crossref","DOI":"10.1166\/jnn.2018.14874","article-title":"Platinum nanoparticles induce apoptosis on RAW 264.7 macrophage cells","author":"Loan","year":"2018","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.cbi.2021.109596_bib52","doi-asserted-by":"crossref","DOI":"10.1039\/C9NR08261A","article-title":"The vacuolization of macrophages induced by large amounts of inorganic nanoparticle uptake to enhance the immune response","author":"Cheng","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.cbi.2021.109596_bib53","article-title":"Effect of luteolin on inflammatory responses in RAW 264.7 macrophages activated with LPS and IFN-\u03b3","author":"Wang","year":"2017","journal-title":"Journal of Functional Foods"},{"key":"10.1016\/j.cbi.2021.109596_bib54","doi-asserted-by":"crossref","DOI":"10.1080\/09540105.2018.1457628","article-title":"Effects of Lycium barbarum polysaccharides with different molecular weights on function of RAW264.7 macrophages","author":"Deng","year":"2018","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.cbi.2021.109596_bib55","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.08-1781","article-title":"Suppression of activation and induction of apoptosis in RAW 264.7 cells by amniotic membrane extract","author":"He","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cbi.2021.109596_bib56","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-014-2592-y","article-title":"Quantification of Al2O3 nanoparticles in human cell lines applying inductively coupled plasma mass spectrometry (neb-ICP-MS, LA-ICP-MS) and flow cytometry-based methods","author":"B\u00f6hme","year":"2014","journal-title":"J. Nanoparticle Res.: an interdisciplinary forum for nanoscale science and technology"},{"key":"10.1016\/j.cbi.2021.109596_bib57","doi-asserted-by":"crossref","DOI":"10.3791\/51345-v","article-title":"Detection of fluorescent nanoparticle interactions with primary immune cell subpopulations by flow cytometry. Journal of visualized experiments","author":"Gamucci","year":"2014","journal-title":"JoVE"},{"key":"10.1016\/j.cbi.2021.109596_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmmm.2018.10.062","article-title":"Physical characterization and uptake of iron oxide nanoparticles of different prostate cancer cells","author":"Youhannayee","year":"2019","journal-title":"J. Magn. Magn Mater."},{"key":"10.1016\/j.cbi.2021.109596_bib59","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/454072","article-title":"Evaluation of viability and proliferation profiles on macrophages treated with silica nanoparticles in vitro via plate-based, flow cytometry, and coulter counter assays","author":"Bancos","year":"2012","journal-title":"ISRN Nanotechnology"},{"key":"10.1016\/j.cbi.2021.109596_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2017.04.005","article-title":"Impact of anatase titanium dioxide nanoparticles on mutagenic and genotoxic response in Chinese hamster lung fibroblast cells (V-79): the role of cellular uptake","author":"Jain","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib61","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-016-0174-0","article-title":"Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels","author":"Lopes","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cbi.2021.109596_bib62","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrestox.8b00284","article-title":"Internalization of titanium dioxide nanoparticles is mediated by actin-dependent reorganization and clathrin-and dynamin-mediated endocytosis in H9c2 rat cardiomyoblasts","author":"Huerta-Garc\u00eda","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109063","article-title":"Irreversible disruption of the cytoskeleton as induced by non-cytotoxic exposure to titanium dioxide nanoparticles in lung epithelial cells","author":"D\u00e9ciga-Alcaraz","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2021.109596_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.infrared.2018.08.017","article-title":"FTIR spectroscopic study on apoptosis of lung cancer cell line A549 induced by arsenic trioxide","author":"Liu","year":"2018","journal-title":"Infrared Phys. Technol."},{"key":"10.1016\/j.cbi.2021.109596_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.201960012","article-title":"FTIR spectra signatures reveal different cellular effects of EGFR inhibitors on non-small cell lung cancer cells","author":"Tabtimmai","year":"2020","journal-title":"J. Biophot."},{"key":"10.1016\/j.cbi.2021.109596_bib66","doi-asserted-by":"crossref","DOI":"10.1504\/IJNBM.2009.027736","article-title":"FT-IR spectroscopy as a tool for identification of apoptosis-induced structural changes in A549 cells treated with PM 701","author":"Ahmed","year":"2009","journal-title":"Int. J. Nano Biomaterials (IJNBM)"},{"key":"10.1016\/j.cbi.2021.109596_bib67","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-011-0722-1","article-title":"Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles","author":"Heng","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2021.109596_bib68","doi-asserted-by":"crossref","DOI":"10.1021\/nn800511k","article-title":"Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties","author":"Xia","year":"2008","journal-title":"ACS Nano"},{"key":"10.1016\/j.cbi.2021.109596_bib69","article-title":"In vitro evaluation of cytotoxicity and oxidative stress induced by multiwalled carbon nanotubes in murine RAW 264.7 macrophages and human A549 lung cells","author":"Chen","year":"2011","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.cbi.2021.109596_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2018.08.040","article-title":"Oxidative stress mediated cytotoxicity of tin (IV) oxide (SnO2) nanoparticles in human breast cancer (MCF-7) cells. Colloids and surfaces. B","author":"Ahamed","year":"2018","journal-title":"Biointerfaces"},{"key":"10.1016\/j.cbi.2021.109596_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2013.03.006","article-title":"Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats","author":"Tang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721002349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279721002349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:03:31Z","timestamp":1757858611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279721002349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":71,"alternative-id":["S0009279721002349"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109596","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential response of immobile (pneumocytes) and mobile (monocytes) barriers against 2 types of metal oxide nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2021.109596","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109596"}}