{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:21:58Z","timestamp":1794241318866,"version":"4.9.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.cbi.2022.109850","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T20:21:41Z","timestamp":1644351701000},"page":"109850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury"],"prefix":"10.1016","volume":"355","author":[{"given":"Yujie","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3676-892X","authenticated-orcid":false,"given":"Xiaoli","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cbi.2022.109850_bib1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00204-011-0657-6","article-title":"Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells","volume":"85","author":"Buhrke","year":"2011","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.cbi.2022.109850_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/02652030701385241","article-title":"Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD","volume":"25","author":"Seefelder","year":"2008","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"issue":"1","key":"10.1016\/j.cbi.2022.109850_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fct.2006.07.014","article-title":"Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and beta-chlorolactic acid, using the single cell gel\/comet assay","volume":"45","author":"El Ramy","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2022.109850_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2903\/sp.efsa.2011.EN-187","article-title":"Comparison between 3\u2010MCPD and its palmitic esters in a 90\u2010day toxicological study","volume":"8","author":"Barocelli","year":"2011","journal-title":"EFSA Supporting Publications"},{"issue":"1","key":"10.1016\/j.cbi.2022.109850_bib5","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1021\/tx900400p","article-title":"Novel biomarkers of 3-Chloro-1,2-propanediol exposure by ultra-performance liquid chromatography\/Mass spectrometry based metabonomic analysis of rat urine","volume":"23","author":"Li","year":"2010","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.cbi.2022.109850_bib6","article-title":"Update of the risk assessment on 3\u2010monochloropropane diol and its fatty acid esters","volume":"16","author":"Knutsen","year":"2018","journal-title":"EFSA J."},{"issue":"5","key":"10.1016\/j.cbi.2022.109850_bib7","first-page":"1","article-title":"Pharmacokinetic profile of diosgenin and trigonelline following intravenous and oral administration of fenugreek seed extract and pure compound in rabbit","volume":"23","author":"Mohamadi","year":"2020","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.cbi.2022.109850_bib8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cbi.2010.02.005","article-title":"Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis","volume":"184","author":"Gong","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.cbi.2022.109850_bib9","first-page":"105575","article-title":"The role of diosgenin in diabetes and diabetic complications","volume":"198","author":"Gan","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.cbi.2022.109850_bib10","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.pharep.2015.10.011","article-title":"Renoprotective effect of diosgenin in streptozotocin induced diabetic rats","volume":"68","author":"Kanchan","year":"2016","journal-title":"Pharmacol. Rep."},{"issue":"4","key":"10.1016\/j.cbi.2022.109850_bib11","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"47","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.cbi.2022.109850_bib12","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.15252\/embj.201796697","article-title":"Molecular definitions of autophagy and related processes","volume":"36","author":"Galluzzi","year":"2017","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.cbi.2022.109850_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41419-020-2594-x","article-title":"Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy","volume":"11","author":"Jiang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.cbi.2022.109850_bib14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.cbi.2022.109850_bib15","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41419-018-0324-4","article-title":"Cinacalcet-mediated activation of the CaMKK\u03b2-LKB1-AMPK pathway attenuates diabetic nephropathy in db\/db mice by modulation of apoptosis and autophagy","volume":"9","author":"Lim","year":"2018","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.cbi.2022.109850_bib16","first-page":"895","article-title":"Advances on cell autophagy and its potential regulatory factors in renal ischemia-reperfusion injury","volume":"38","author":"Hou","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.cbi.2022.109850_bib17","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41556-018-0201-5","article-title":"Life, death and autophagy","volume":"20","author":"Doherty","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"4\u20135","key":"10.1016\/j.cbi.2022.109850_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/7158975","article-title":"Adaptive autophagy offers cardiorenal protection in rats with acute myocardial infarction","volume":"2020","author":"Feng","year":"2020","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.cbi.2022.109850_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbi.2022.109850_bib20","doi-asserted-by":"crossref","first-page":"111774","DOI":"10.1016\/j.fct.2020.111774","article-title":"Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin","volume":"145","author":"Avila-Rojas","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.cbi.2022.109850_bib21","doi-asserted-by":"crossref","first-page":"244","DOI":"10.23876\/j.krcp.20.082","article-title":"Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches","volume":"39","author":"Bhatia","year":"2020","journal-title":"Kidney Res Clin Pract"},{"issue":"6098","key":"10.1016\/j.cbi.2022.109850_bib22","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"issue":"14","key":"10.1016\/j.cbi.2022.109850_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cub.2006.06.054","article-title":"Mitochondria: more than just a powerhouse","volume":"16","author":"McBride","year":"2006","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.cbi.2022.109850_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.devcel.2008.08.011","article-title":"Mitochondrial dynamics and apoptosis: a painful separation","volume":"15","author":"James","year":"2008","journal-title":"Dev. Cell"},{"issue":"12","key":"10.1016\/j.cbi.2022.109850_bib25","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1101\/gad.1658508","article-title":"Mitochondrial dynamics and apoptosis","volume":"22","author":"Suen","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbi.2022.109850_bib26","doi-asserted-by":"crossref","first-page":"111740","DOI":"10.1016\/j.fct.2020.111740","article-title":"Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells","volume":"145","author":"Jin","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2022.109850_bib27","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1124\/mol.105.018408","article-title":"Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons","volume":"69","author":"Shacka","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.cbi.2022.109850_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.yexcr.2014.01.028","article-title":"The effects of diosgenin in the regulation of renal proximal tubular fibrosis","volume":"323","author":"Wang","year":"2014","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.cbi.2022.109850_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.pharep.2015.10.011","article-title":"Renoprotective effect of diosgenin in streptozotocin induced diabetic rats","volume":"68","author":"Kanchan","year":"2016","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.cbi.2022.109850_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.yexcr.2014.01.028","article-title":"The effects of diosgenin in the regulation of renal proximal tubular fibrosis","volume":"323","author":"Wang","year":"2014","journal-title":"Exp. Cell Res."},{"issue":"5497","key":"10.1016\/j.cbi.2022.109850_bib31","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.cbi.2022.109850_bib32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.cbi.2022.109850_bib33","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"mTOR regulation of autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.cbi.2022.109850_bib34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2022.109850_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ceb.2016.02.010","article-title":"Structure and function of the ULK1 complex in autophagy","volume":"39","author":"Lin","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"issue":"4","key":"10.1016\/j.cbi.2022.109850_bib36","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.molcel.2016.05.005","article-title":"The incredible ULKs: autophagy and beyond","volume":"62","author":"Zhao","year":"2016","journal-title":"Mol. Cell."},{"issue":"9","key":"10.1016\/j.cbi.2022.109850_bib37","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.cbi.2022.109850_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.cbi.2022.109850_bib39","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/bph.14079","article-title":"Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21","volume":"175","author":"Sun","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"40","key":"10.1016\/j.cbi.2022.109850_bib40","doi-asserted-by":"crossref","first-page":"29776","DOI":"10.1074\/jbc.M603783200","article-title":"Enhancing macroautophagy protects against ischemia\/reperfusion injury in cardiac myocytes","volume":"281","author":"Hamacher-Brady","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2022.109850_bib41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"issue":"1999","key":"10.1016\/j.cbi.2022.109850_bib42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0005-2728(98)00160-1","article-title":"Mitochondrial disorders","volume":"1410","author":"Schapira","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.cbi.2022.109850_bib43","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1242\/jcs.00423","article-title":"Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p","volume":"116","author":"Jakobs","year":"2003","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.cbi.2022.109850_bib44","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1242\/jcs.01058","article-title":"Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology","volume":"117","author":"Stojanovski","year":"2004","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.cbi.2022.109850_bib45","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1534-5807(01)00055-7","article-title":"The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis","volume":"1","author":"Frank","year":"2001","journal-title":"Del Cell"},{"issue":"2","key":"10.1016\/j.cbi.2022.109850_bib46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.cbi.2022.109850_bib47","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.cbi.2022.109850_bib48","first-page":"7797","article-title":"Zearalenone regulates endometrial stromal cell apoptosis and migration via the promotion of mitochondrial fission by activation of the JNK\/Drp1 pathway","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722000552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722000552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:07:17Z","timestamp":1757858837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279722000552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":48,"alternative-id":["S0009279722000552"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2022.109850","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2022.109850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109850"}}