{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:38:20Z","timestamp":1789771100768,"version":"4.0.1"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005690","name":"Universit\u00e4t des Saarlandes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.cbi.2022.109982","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T22:17:27Z","timestamp":1652998647000},"page":"109982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["TRPC6 is altered in COVID-19 pneumonia"],"prefix":"10.1016","volume":"362","author":[{"given":"Gina","family":"Leidinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidelis","family":"Flockerzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Hohneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer M.","family":"Bohle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Fieguth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-1796","authenticated-orcid":false,"given":"Thomas","family":"Tschernig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2022.109982_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109567","article-title":"TRP channels in COVID-19 disease: potential targets for prevention and treatment","volume":"345","author":"Jaffal","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.cbi.2022.109982_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1165\/rcmb.2008-0373OC","article-title":"Expression of transient receptor potential C6 channels in human lung macrophages","volume":"43","author":"Finney-Hayward","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1\u20132","key":"10.1016\/j.cbi.2022.109982_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0169-328X(02)00527-2","article-title":"mRNA distribution analysis of human TRPC family in CNS and peripheral tissues","volume":"109","author":"Riccio","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.cbi.2022.109982_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/112_2012_10","article-title":"Chemosensory TRP channels in the respiratory tract: role in toxic lung injury and potential as \"sweet spots\" for targeted therapies","volume":"165","author":"B\u00fcch","year":"2013","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2022.109982_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ph12010023","article-title":"Modulators of transient receptor potential (TRP) channels as therapeutic options in lung disease","volume":"12","author":"Dietrich","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.cbi.2022.109982_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ceca.2017.04.005","article-title":"Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases","volume":"67","author":"Dietrich","year":"2017","journal-title":"Cell Calcium"},{"issue":"5","key":"10.1016\/j.cbi.2022.109982_bib7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3892\/br.2022.1525","article-title":"Evaluation of the presence of TRPC6 channels in human vessels: a pilot study using immunohistochemistry","volume":"16","author":"Abdinghoff","year":"2022","journal-title":"Biomed Rep"},{"key":"10.1016\/j.cbi.2022.109982_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3634974","article-title":"Protective role of tangshen formula on the progression of renal damage in db\/db mice by TRPC6\/talin1 pathway in podocytes","author":"Wang","year":"2020","journal-title":"J Diabetes Res 2020"},{"issue":"13","key":"10.1016\/j.cbi.2022.109982_bib9","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1021\/acsomega.1c00514","article-title":"Benzothiazole amides as TRPC3\/6 inhibitors for gastric cancer treatment","volume":"6","author":"Wei","year":"2021","journal-title":"ACS Omega"},{"issue":"10","key":"10.1016\/j.cbi.2022.109982_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9101360","article-title":"Reno-protective effect of GLP-1 receptor agonists in Type1 diabetes: dual action on TRPC6 and NADPH oxidases","volume":"9","author":"Youssef","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.cbi.2022.109982_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2147\/DDDT.S234262","article-title":"Tetrandrine suppresses transient receptor potential cation channel protein 6 overexpression- induced podocyte damage via blockage of RhoA\/ROCK1 signaling","volume":"14","author":"Yu","year":"2020","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722001879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722001879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:07:43Z","timestamp":1757858863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279722001879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":11,"alternative-id":["S0009279722001879"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2022.109982","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPC6 is altered in COVID-19 pneumonia","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2022.109982","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109982"}}