{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:08:35Z","timestamp":1790780915023,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2020B151520052"],"award-info":[{"award-number":["2020B151520052"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013093","name":"Science and Technology Planning Project of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20190806154207168"],"award-info":[{"award-number":["JCYJ20190806154207168"]}],"id":[{"id":"10.13039\/501100013093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","award":["2XK20041"],"award-info":[{"award-number":["2XK20041"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","award":["4SG21002G"],"award-info":[{"award-number":["4SG21002G"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","award":["4SG21004G"],"award-info":[{"award-number":["4SG21004G"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","award":["4SG21230G"],"award-info":[{"award-number":["4SG21230G"]}],"id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017127","name":"Shenzhen Municipal People's Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cbi.2022.110140","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T22:12:05Z","timestamp":1662588725000},"page":"110140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Quassinoids from Eurycoma longifolia and their bone formation evaluation in zebrafish, C3H10\u00a0cells and silico"],"prefix":"10.1016","volume":"367","author":[{"given":"Hongbo","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangmei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-8508","authenticated-orcid":false,"given":"Xin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2022.110140_bib1","first-page":"2020","article-title":"Vitamin D, calcium, parathyroid hormone, and sex steroids in bone health and effects of aging","author":"Bhattarai","year":"2020","journal-title":"J. Osteoporos."},{"key":"10.1016\/j.cbi.2022.110140_bib2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/ar125","article-title":"Bone loss-Epidemiology of bone loss","volume":"2","author":"Hunter","year":"2000","journal-title":"Arthritis Res."},{"key":"10.1016\/j.cbi.2022.110140_bib3","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.2174\/0929867327666200330142432","article-title":"Osteoporosis: mechanism, molecular target and current status on drug development","volume":"28","author":"Li","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.cbi.2022.110140_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031211","article-title":"Regulation of bone metabolism by sex steroids","volume":"8","author":"Khosla","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.cbi.2022.110140_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/19390211.2018.1472715","article-title":"The prevention and therapy of osteoporosis: a review on emerging trends from hormonal therapy to synthetic drugs to plant-based bioactives","volume":"16","author":"Gupta","year":"2019","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.cbi.2022.110140_bib6","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/1389450118666170321105425","article-title":"Therapeutic potential and outlook of alternative medicine for osteoporosis","volume":"18","author":"Wang","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.cbi.2022.110140_bib7","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2174\/1389450119666180219123815","article-title":"Recent advances in antibacterial, antiprotozoal and antifungal trends of Eurycoma longifolia: a review of therapeutic implications and future prospects","volume":"19","author":"Thu","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.cbi.2022.110140_bib8","first-page":"21","article-title":"Review on a traditional herbal medicine, Eurycoma longifolia jack (Tongkat Ali): its traditional uses, chemistry, evidence-based Pharmacology and toxicology","author":"Rehman","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2022.110140_bib9","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jep.2012.11.013","article-title":"Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic-pituitary-gonadal axis","volume":"145","author":"Low","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2022.110140_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/13685538.2010.511327","article-title":"The anti-osteoporotic effect of Eurycoma longifolia in aged orchidectomised rat model","volume":"14","author":"Shuid","year":"2011","journal-title":"Aging Male"},{"key":"10.1016\/j.cbi.2022.110140_bib11","article-title":"Effects of Eurycoma longifolia on testosterone level and bone structure in an aged orchidectomised rat model","volume":"2012","author":"Ariff","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.cbi.2022.110140_bib12","article-title":"Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen-deficient osteoporosis rat model","volume":"12","author":"Shuid","year":"2012","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.cbi.2022.110140_bib13","article-title":"Bone micro-CT assessments in an orchidectomised rat model supplemented with Eurycoma longifolia, evid. Based complement","volume":"2012","author":"Ramli","year":"2012","journal-title":"Alternat. Med."},{"key":"10.1016\/j.cbi.2022.110140_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/nu10070799","article-title":"The effects of quassinoid-rich Eurycoma longifolia extract on bone turnover and histomorphometry indices in the androgen-deficient osteoporosis rat model","volume":"10","author":"Jayusman","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.cbi.2022.110140_bib15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3233\/XST-17366","article-title":"Effects of standardized quassinoid-rich Eurycoma longifolia extract in a rat model of osteoporosis due to testosterone deficiency: a densitometric, morphometric and biomechanical study","volume":"26","author":"Jayusman","year":"2018","journal-title":"J. X Ray Sci. Technol."},{"key":"10.1016\/j.cbi.2022.110140_bib16","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jaim.2017.04.005","article-title":"Exploring molecular mechanism of bone-forming capacity of Eurycoma longifolia: evidence of enhanced expression of bone-related biomarkers","volume":"9","author":"Thu","year":"2018","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.cbi.2022.110140_bib17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jaim.2017.07.014","article-title":"Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: an in vitro mechanistic evaluation","volume":"10","author":"Thu","year":"2019","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.cbi.2022.110140_bib18","first-page":"35","article-title":"Tanshinol stimulates bone formation and attenuates dexamethasone-induced inhibition of osteogenesis in larval zebrafish","volume":"4","author":"Luo","year":"2016","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.cbi.2022.110140_bib19","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/acs.jcim.1c00135","article-title":"ePharmaLib: a versatile library of e-pharmacophores to address small-molecule (poly-) Pharmacology","volume":"61","author":"Moumbock","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.cbi.2022.110140_bib20","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"Software news and update AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2022.110140_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004586","article-title":"AutoDockFR: advances in protein-ligand docking with explicitly specified binding site flexibility","volume":"11","author":"Ravindranath","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cbi.2022.110140_bib22","series-title":"Plants as Sources of Antimalarial Drugs. Part 3","first-page":"105","author":"Chan","year":"1986"},{"key":"10.1016\/j.cbi.2022.110140_bib23","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0031-9422(01)00480-0","article-title":"Quassinoids from Eurycoma longifolia","volume":"59","author":"Ang","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cbi.2022.110140_bib24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bmc.2003.11.017","article-title":"Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia","volume":"12","author":"Kuo","year":"2004","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.cbi.2022.110140_bib25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1246\/cl.1990.749","article-title":"New quassinoids from the roots of Eurycoma longifolia","author":"Morita","year":"1990","journal-title":"Chem. Lett."},{"key":"10.1016\/j.cbi.2022.110140_bib26","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1248\/cpb.40.1053","article-title":"Cytotoxic quassinoids and tirucallane-type triterpenes from the woods of Eurycoma longifolia","volume":"40","author":"Itokawa","year":"1992","journal-title":"Chem. Pharm.l Bul."},{"key":"10.1016\/j.cbi.2022.110140_bib27","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0031-9422(93)85475-7","article-title":"Highly oxygenated quassinoids from Eurycoma longifolia","volume":"33","author":"Morita","year":"1993","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cbi.2022.110140_bib28","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1016\/S0040-4039(00)85785-8","article-title":"Structure of laurycolactone a and b, new c18-quassinoids from Eurycoma longifolia and revised structured of eurycomalactone (x-ray analysis)","volume":"23","author":"Nguyen-Ngoc-Suong","year":"1982","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.cbi.2022.110140_bib29","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1016\/S0031-9422(00)98272-4","article-title":"U. Sankawa, 13\u03b2,18-dihydroeurycomanol, a quassinoid from Eurycoma longifolia","volume":"30","author":"Chan","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cbi.2022.110140_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/1008-682X.122356","article-title":"Androgens and estrogens in skeletal sexual dimorphism","volume":"16","author":"Laurent","year":"2014","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.cbi.2022.110140_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jep.2013.06.023","article-title":"Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis","volume":"149","author":"Low","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2022.110140_bib32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF03343547","article-title":"Sex hormone-binding globulin: not only a transport protein. What news is around the corner?","volume":"22","author":"Fortunati","year":"1999","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.cbi.2022.110140_bib33","first-page":"8","article-title":"Androgens and androgen receptor actions on bone health and disease: from androgen deficiency to androgen therapy","author":"Chen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2022.110140_bib34","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1210\/en.2002-0032","article-title":"Human type 3 3 alpha-hydroxysteroid dehydrogenase (Aldo-Keto reductase 1C2) and androgen metabolism in prostate cells","volume":"144","author":"Rizner","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbi.2022.110140_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042105","article-title":"Osteoporosis in men: a review of an underestimated bone condition","volume":"22","author":"Rinonapoli","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2022.110140_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/beem.2000.0072","article-title":"Prevention of osteoporotic fractures in post-menopausal women","volume":"14","author":"Compston","year":"2000","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.cbi.2022.110140_bib37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/164_2019_329","article-title":"New targets and emergent therapies for osteoporosis","volume":"262","author":"Brommage","year":"2020","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.cbi.2022.110140_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40273-020-00965-9","article-title":"An updated systematic review of cost-effectiveness analyses of drugs for osteoporosis","volume":"39","author":"Li","year":"2021","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.cbi.2022.110140_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01344","article-title":"Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis","volume":"10","author":"He","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2022.110140_bib40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.fitote.2010.04.006","article-title":"Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance","volume":"81","author":"Bhat","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.cbi.2022.110140_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1439-0426.2010.01409.x","article-title":"Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging","volume":"26","author":"Spoorendonk","year":"2010","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.cbi.2022.110140_bib42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/dvdy.21838","article-title":"Tracking gene expression during zebrafish osteoblast differentiation","volume":"238","author":"Li","year":"2009","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.cbi.2022.110140_bib43","first-page":"6","article-title":"Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells","author":"Liu","year":"2018","journal-title":"Bone Res."},{"key":"10.1016\/j.cbi.2022.110140_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/03008207.2014.923872","article-title":"Sp7 and Runx2 molecular complex synergistically regulate expression of target genes","volume":"55","author":"Rashid","year":"2014","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.cbi.2022.110140_bib45","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijbiomac.2015.04.008","article-title":"Runx2: structure, function, and phosphorylation in osteoblast differentiation","volume":"78","author":"Vimalraj","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.cbi.2022.110140_bib46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.12659\/MSMBR.901142","article-title":"Osteoblast differentiation at a glance","volume":"22","author":"Rutkovskiy","year":"2016","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"10.1016\/j.cbi.2022.110140_bib47","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-020-2814-z","article-title":"Effect of herbal extract Eurycoma longifolia (Physta (R)) on female reproductive hormones and bone biochemical markers: an ovariectomised rat model study","volume":"20","author":"Chinnappan","year":"2020","journal-title":"BMC Complement. Med. Ther."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722003453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722003453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:49:33Z","timestamp":1762112973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279722003453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":47,"alternative-id":["S0009279722003453"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2022.110140","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quassinoids from Eurycoma longifolia and their bone formation evaluation in zebrafish, C3H10\u00a0cells and silico","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2022.110140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110140"}}