{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:14:00Z","timestamp":1782872040689,"version":"3.54.5"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972686"],"award-info":[{"award-number":["81972686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972694"],"award-info":[{"award-number":["81972694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2300603"],"award-info":[{"award-number":["2021YFC2300603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.cbi.2022.110251","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T22:25:38Z","timestamp":1667600738000},"page":"110251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Edaravone protects against liver fibrosis progression via decreasing the IL-1\u03b2 secretion of macrophages"],"prefix":"10.1016","volume":"368","author":[{"given":"Rongrong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanjuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-2308","authenticated-orcid":false,"given":"Qiuju","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2022.110251_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.cbi.2022.110251_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.matbio.2018.04.006","article-title":"Liver fibrosis: direct antifibrotic agents and targeted therapies","volume":"68\u201369","author":"Schuppan","year":"2018","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.cbi.2022.110251_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hep.32285","article-title":"Hepatic fibrosis 2022: unmet needs and a blueprint for the future","volume":"75","author":"Friedman","year":"2022","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.cbi.2022.110251_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2022.110251_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspect. Med."},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.cbi.2022.110251_bib7","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.cbi.2022.110251_bib8","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/gutjnl-2018-317593","article-title":"Advances in non-invasive assessment of hepatic fibrosis","volume":"69","author":"Loomba","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.cbi.2022.110251_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.redox.2018.09.007","article-title":"Curcumol induces RIPK1\/RIPK3 complex-dependent necroptosis via JNK1\/2-ROS signaling in hepatic stellate cells","volume":"19","author":"Jia","year":"2018","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.cbi.2022.110251_bib10","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1080\/15548627.2018.1503146","article-title":"Activation of ferritinophagy is required for the RNA-binding protein ELAVL1\/HuR to regulate ferroptosis in hepatic stellate cells","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.cbi.2022.110251_bib11","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.cbi.2022.110251_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000069318","article-title":"Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters","volume":"15","author":"Group","year":"2003","journal-title":"Cerebrovasc. Dis."},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuroscience.2011.11.005","article-title":"Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury","volume":"201","author":"Zhang","year":"2012","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1527-3458.2006.00009.x","article-title":"Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury","volume":"12","author":"Yoshida","year":"2006","journal-title":"CNS Drug Rev."},{"issue":"7","key":"10.1016\/j.cbi.2022.110251_bib15","doi-asserted-by":"crossref","first-page":"13909","DOI":"10.3390\/ijms140713909","article-title":"The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease","volume":"14","author":"Kiyoshi","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/01.HYP.0000163461.71943.e9","article-title":"The antioxidant edaravone attenuates pressure overload\u2013induced left ventricular hypertrophy","volume":"45","author":"Tsujimoto","year":"2005","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.intimp.2010.10.012","article-title":"Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?","volume":"11","author":"Zhi","year":"2011","journal-title":"Int. Immunopharm."},{"issue":"10","key":"10.1016\/j.cbi.2022.110251_bib18","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1002\/art.30470","article-title":"The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis","volume":"63","author":"Yoshizaki","year":"2011","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cbi.2022.110251_bib19","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.2147\/DDDT.S144807","article-title":"Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor","volume":"11","author":"Zhang","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib20","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3892\/etm.2013.1308","article-title":"Inhibition of fibrosis and inflammation by triple therapy with pirfenidone, edaravone and erythropoietin in rabbits with drug-induced lung injury: comparison of CT imaging and pathological findings","volume":"6","author":"Shobu","year":"2013","journal-title":"Exp. Ther. Med."},{"issue":"8","key":"10.1016\/j.cbi.2022.110251_bib21","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/15548627.2015.1058473","article-title":"Macrophage autophagy protects against liver fibrosis in mice","volume":"11","author":"Lodder","year":"2015","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.cbi.2022.110251_bib22","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jhep.2015.07.033","article-title":"Activation of Slit2-Robo1 signaling promotes liver fibrosis","volume":"63","author":"Chang","year":"2015","journal-title":"J. Hepatol."},{"issue":"51","key":"10.1016\/j.cbi.2022.110251_bib23","article-title":"Seven steps to stellate cells","volume":"51","author":"Maschmeyer","year":"2011","journal-title":"Journal of Visualized Experiments Jove"},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"L","year":"2005","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.cbi.2022.110251_bib25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2022.110251_bib26","article-title":"Nonalcoholic fatty liver disease","volume":"1","author":"Brunt","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"2","key":"10.1016\/j.cbi.2022.110251_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver--from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2022.110251_bib28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fimmu.2017.00301","article-title":"Immunoregulatory role of NK cells in tissue inflammation and regeneration","volume":"8","author":"Tosello-Trampont","year":"2017","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.cbi.2022.110251_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12040926","article-title":"Natural killer cell responses in hepatocellular carcinoma: implications for novel immunotherapeutic approaches","volume":"12","author":"Mantovani","year":"2020","journal-title":"Cancers"},{"issue":"539","key":"10.1016\/j.cbi.2022.110251_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw8523","article-title":"LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling","volume":"12","author":"Wan","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.cbi.2022.110251_bib31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jhep.2014.03.031","article-title":"Modulation of monocyte\/macrophage function: a therapeutic strategy in the treatment of acute liver failure","volume":"61","author":"Possamai","year":"2014","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"46","key":"10.1016\/j.cbi.2022.110251_bib33","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"4","key":"10.1016\/j.cbi.2022.110251_bib34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jhep.2016.12.018","article-title":"HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1\u03b2 production via suppressing the NF-\u03baB pathway and ROS production","volume":"66","author":"Yu","year":"2017","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.cbi.2022.110251_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"10308","key":"10.1016\/j.cbi.2022.110251_bib36","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gines","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib38","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1183\/09031936.00164407","article-title":"Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice","volume":"32","author":"Tajima","year":"2008","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib39","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.bbrc.2017.10.165","article-title":"Edaravone attenuates lipopolysaccharide-induced acute respiratory distress syndrome associated early pulmonary fibrosis via amelioration of oxidative stress and transforming growth factor-\u03b21\/Smad3 signaling","volume":"495","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.cbi.2022.110251_bib40","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1002\/art.30470","article-title":"The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis","volume":"63","author":"Yoshizaki","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cbi.2022.110251_bib41","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.2147\/DDDT.S144807","article-title":"Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor","volume":"11","author":"Zhang","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"issue":"3","key":"10.1016\/j.cbi.2022.110251_bib42","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.cbi.2022.110251_bib43","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jhep.2016.04.018","article-title":"Sinusoidal communication in liver fibrosis and regeneration","volume":"65","author":"Marrone","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2022.110251_bib44","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3389\/fimmu.2020.01142","article-title":"T cells in fibrosis and fibrotic diseases","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.cbi.2022.110251_bib45","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1053\/j.gastro.2018.09.010","article-title":"Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice","volume":"155","author":"Luo","year":"2018","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib46","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/ncb3340","article-title":"Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis","volume":"18","author":"Nielsen","year":"2016","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.cbi.2022.110251_bib47","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1002\/hep.31875","article-title":"Metabotropic glutamate receptor 5 in natural killer cells attenuates liver fibrosis by exerting cytotoxicity to activated stellate cells","volume":"74","author":"Choi","year":"2021","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.cbi.2022.110251_bib48","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"Calvente","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.cbi.2022.110251_bib49","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib50","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.cbi.2022.110251_bib51","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/hep.28456","article-title":"Interleukin-1 and inflammasomes in alcoholic liver disease\/acute alcoholic hepatitis and nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"64","author":"Tilg","year":"2016","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.cbi.2022.110251_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2019.01.014","article-title":"Serine metabolism supports macrophage IL-1\u03b2 production","volume":"29","author":"Rodriguez","year":"2019","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib53","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/imr.12608","article-title":"Metabolic regulation of NLRP3","volume":"281","author":"Hughes","year":"2018","journal-title":"Immunol. Rev."},{"issue":"6","key":"10.1016\/j.cbi.2022.110251_bib54","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/j.cbi.2022.110251_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111419","article-title":"Nadja: TGF-\u03b2 in hepatic stellate cell activation and liver fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib56","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.jhep.2017.06.001","article-title":"Hepatic stellate cell activation and pro-fibrogenic signals","volume":"67","author":"Gandhi","year":"2017","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"5","key":"10.1016\/j.cbi.2022.110251_bib58","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib59","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/hep.27793","article-title":"Liver inflammation abrogates immunological tolerance induced by Kupffer cells","volume":"62","author":"Heymann","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.cbi.2022.110251_bib60","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.cbi.2022.110251_bib61","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41575-020-0304-x","article-title":"Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis","volume":"17","author":"Ramachandran","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2022.110251_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119377","article-title":"Selenium-containing ruthenium complex synergizes with natural killer cells to enhance immunotherapy against prostate cancer via activating TRAIL\/FasL signaling","volume":"219","author":"Lai","year":"2019","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.cbi.2022.110251_bib63","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/cmi.2016.17","article-title":"IL-1\u03b2 limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis","volume":"14","author":"Tufa","year":"2017","journal-title":"Cell. Mol. Immunol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722004562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722004562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:17:50Z","timestamp":1757859470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279722004562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":63,"alternative-id":["S0009279722004562"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2022.110251","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Edaravone protects against liver fibrosis progression via decreasing the IL-1\u03b2 secretion of macrophages","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2022.110251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110251"}}