{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:42:00Z","timestamp":1769827320920,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organisation","doi-asserted-by":"publisher","award":["DIP-269"],"award-info":[{"award-number":["DIP-269"]}],"id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006083","name":"Ministry of Defence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.cbi.2022.110284","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T04:06:31Z","timestamp":1669781191000},"page":"110284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The interplay of calponin, wnt signaling, and cytoskeleton protein governs transgenerational phenotypic abnormalities in drosophila exposed to zinc oxide nanoparticles"],"prefix":"10.1016","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-5083","authenticated-orcid":false,"given":"Avnika Singh","family":"Anand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyani","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Amitabh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti N.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekta","family":"Kohli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2022.110284_bib1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1021\/acs.bioconjchem.9b00348","article-title":"Understanding the chemical nature of nanoparticle\u2013protein interactions","volume":"30","author":"Baimanov","year":"2019","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.cbi.2022.110284_bib2","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1166\/jbn.2017.2458","article-title":"Titanium dioxide nanoparticles trigger non-canonical receptor endocytosis to inhibit wnt signaling","volume":"13","author":"Liu","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.cbi.2022.110284_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-23215-7","article-title":"TiO2 nanoparticles induce omphalocele in chicken embryo by disrupting Wnt signaling pathway","volume":"8","author":"Patel","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2022.110284_bib4","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.7150\/thno.16127","article-title":"Silica nanoparticles target a Wnt signal transducer for degradation and impair embryonic development in zebrafish","volume":"6","author":"Yi","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.cbi.2022.110284_bib5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/17435390903471463","article-title":"Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time","volume":"4","author":"Mironava","year":"2010","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.cbi.2022.110284_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1062562","article-title":"The advancing of zinc oxide nanoparticles for biomedical applications","author":"Jiang","year":"2018","journal-title":"Bioinorgan. Chem. Appl."},{"key":"10.1016\/j.cbi.2022.110284_bib7","first-page":"1","article-title":"Properties of zinc oxide nanoparticles and their activity against microbes","volume":"13.1","author":"Siddiqi","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.cbi.2022.110284_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/NSA.S23932","article-title":"A review of mammalian toxicity of ZnO nanoparticles","volume":"5","author":"Vandebriel","year":"2012","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.cbi.2022.110284_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2217\/nnm.12.23","article-title":"Dermal toxicity of ZnO nanoparticles: a worrying feature of sunscreen?","volume":"7","author":"Hackenberg","year":"2012","journal-title":"Nanomedicine"},{"key":"10.1016\/j.cbi.2022.110284_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1039\/c2tx20016c","article-title":"Toxicity of nano zinc oxide to mitochondria","volume":"1","author":"Li","year":"2012","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.cbi.2022.110284_bib11","doi-asserted-by":"crossref","first-page":"579 1504","DOI":"10.1016\/j.scitotenv.2016.11.154","article-title":"Effects of chronic dietary exposure of zinc oxide nanoparticles on the serum protein profile of juvenile common carp (Cyprinus carpio L.)","volume":"579","author":"Chupani","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2022.110284_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.scitotenv.2017.08.129","article-title":"Insight into the modulation of intestinal proteome of juvenile common carp (Cyprinus carpio L.) after dietary exposure to ZnO nanoparticles","volume":"613","author":"Chupani","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2022.110284_bib13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ecoenv.2017.08.024","article-title":"Chronic dietary toxicity of zinc oxide nanoparticles in common carp (Cyprinus carpio L.). Tissue accumulation and physiological responses","volume":"147","author":"Chupani","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2022.110284_bib14","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/bies.10145","article-title":"Canonical and non\u2010canonical Wnt signaling pathways in Caenorhabditis elegans: variations on a common signaling theme","volume":"24","author":"Korswagen","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.cbi.2022.110284_bib15","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.3390\/ijms20225525","article-title":"The regulation of bone metabolism and disorders by Wnt signalling","volume":"20","author":"Maeda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2022.110284_bib16","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1534\/genetics.117.300157","article-title":"Wingless signaling: a genetic journey from morphogenesis to metastasis","volume":"208","author":"Bejsovec","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.cbi.2022.110284_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0012-1606(02)00036-2","article-title":"Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wing","volume":"254","author":"Whitworth","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbi.2022.110284_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2004.08.019","article-title":"Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways","volume":"7","author":"Ryoo","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cbi.2022.110284_bib19","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1126\/science.287.5458.1606","article-title":"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus","volume":"287","author":"Peifer","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cbi.2022.110284_bib20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jhazmat.2015.04.053","article-title":"A comprehensive study of the harmful effects of ZnO nanoparticles using Drosophila melanogaster as an in vivo model","volume":"296","author":"Alaraby","year":"2015","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2022.110284_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jhazmat.2016.12.040","article-title":"Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster","volume":"327","author":"Anand","year":"2017","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2022.110284_bib22","doi-asserted-by":"crossref","first-page":"9819","DOI":"10.1021\/ac901335x","article-title":"Software tool for researching annotations of proteins: open-source protein annotation software with data visualization","volume":"81","author":"Bhatia","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cbi.2022.110284_bib23","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbi.2022.110284_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2022.110284_bib25","first-page":"21 R560","article-title":"Building distinct actin filament networks in a common cytoplasm","author":"Michelot","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cbi.2022.110284_bib26","first-page":"3112","article-title":"Tuning the affinity of tandem calponin homology domains","volume":"26","author":"Harris","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.cbi.2022.110284_bib27","doi-asserted-by":"crossref","first-page":"E9376","DOI":"10.1073\/pnas.1707108114","article-title":"\u03b2-III-spectrin spinocerebellar ataxia type 5 mutation reveals a dominant cytoskeletal mechanism that underlies dendritic arborisation","volume":"114","author":"Avery","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2022.110284_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12013-008-9031-6","article-title":"Calponin in nonmuscle cells","volume":"52","author":"Wu","year":"2008","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cbi.2022.110284_bib29","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1073\/pnas.1018593108","article-title":"An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins","volume":"108","author":"Paredez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2022.110284_bib30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.celrep.2013.02.015","article-title":"Calponin 2 acts as an effector of noncanonical Wnt-mediated cell polarization during neural crest cell migration","volume":"3","author":"Ulmer","year":"2013","journal-title":"Cell Rep."},{"issue":"2021","key":"10.1016\/j.cbi.2022.110284_bib31","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1021\/acs.jproteome.1c00387","article-title":"High-resolution proteomic profiling shows sexual dimorphism in zebrafish heart-associated proteins","volume":"20","author":"Niksirat","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbi.2022.110284_bib32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/HYPERTENSIONAHA.114.04467","article-title":"Calcium\/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy","volume":"65","author":"Zhang","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.cbi.2022.110284_bib33","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/abbs\/gmr079","article-title":"Wnt\/Ca2+ signaling pathway: a brief overview","volume":"43","author":"De","year":"2011","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.cbi.2022.110284_bib34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"key":"10.1016\/j.cbi.2022.110284_bib35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/\u03b2-catenin signaling in development and disease","volume":"127","author":"Clevers","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2022.110284_bib36","article-title":"A novel role for Wnt\/Ca2+ signaling in actin cytoskeleton remodelling and cell motility in prostate cancer","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2022.110284_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm7010001","article-title":"Epithelial mesenchymal transition in embryonic development, tissue repair and cancer: a comprehensive overview","volume":"7","author":"Kim","year":"2018","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cbi.2022.110284_bib38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3934\/genet.2015.1.25","article-title":"Drosophila models of metastasis","volume":"2","author":"Murray","year":"2015","journal-title":"AIMS Genet."},{"key":"10.1016\/j.cbi.2022.110284_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4578373","article-title":"The role of actin dynamics and actin-binding proteins expression in epithelial-to-mesenchymal transition and its association with cancer progression and evaluation of possible therapeutic targets","author":"Izdebska","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.cbi.2022.110284_bib40","doi-asserted-by":"crossref","first-page":"a007930","DOI":"10.1101\/cshperspect.a007930","article-title":"Wnt\/wingless signaling in Drosophila","volume":"4","author":"Swarup","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.cbi.2022.110284_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1101\/gad.8.1.118","article-title":"The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal","volume":"8","author":"Klingensmith","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbi.2022.110284_bib42","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1242\/dev.129.17.3995","article-title":"Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge","volume":"129","author":"Rodr\u00edguez","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.cbi.2022.110284_bib43","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1242\/dev.00728","article-title":"Cell boundaries: knowing who to mix with and what to shout or whisper","volume":"130","author":"Wolpert","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.cbi.2022.110284_bib44","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/mrd.22228","article-title":"Wingless\/Wnt signaling in Drosophila: the pattern and the pathway","volume":"80","author":"Bejsovec","year":"2013","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.cbi.2022.110284_bib45","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1098\/rstb.2007.2251","article-title":"From individual Wnt pathways towards a Wnt signaling network","volume":"363","author":"Kestler","year":"2008","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722004896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279722004896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:12:58Z","timestamp":1757859178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279722004896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":45,"alternative-id":["S0009279722004896"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2022.110284","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interplay of calponin, wnt signaling, and cytoskeleton protein governs transgenerational phenotypic abnormalities in drosophila exposed to zinc oxide nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2022.110284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110284"}}