{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:35:18Z","timestamp":1792895718036,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST\/INSPIRE Fellowship\/2013\/480"],"award-info":[{"award-number":["DST\/INSPIRE Fellowship\/2013\/480"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.cbi.2023.110379","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T02:14:24Z","timestamp":1675390464000},"page":"110379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Novel hybrids of quinoline with pyrazolylchalcones as potential antimalarial agents: Synthesis, biological evaluation, molecular docking and ADME prediction"],"prefix":"10.1016","volume":"373","author":[{"given":"Ajay","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-4390","authenticated-orcid":false,"given":"Shilpi","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpy","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8742-2411","authenticated-orcid":false,"given":"Deepika","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2023.110379_bib1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.bmc.2005.11.015","article-title":"Antimalarial activity: a QSAR modeling using CODESSA PRO software","volume":"14","author":"Katritzky","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib2","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1016\/j.bmc.2013.06.067","article-title":"Tetrazole-based deoxyamodiaquines: synthesis, ADME\/PK profiling and pharmacological evaluation as potential antimalarial agents","volume":"21","author":"Tukulula","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib3","first-page":"490","article-title":"4-Aminoquinoline-Pyrimidine hybrids: synthesis, antimalarial activity, heme binding and docking studies","volume":"89","author":"Kumar","year":"2015","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.cbi.2023.110379_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bmc.2019.115158","article-title":"6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum","volume":"27","author":"Saepua","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib5","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2147\/TCRM.S269336","article-title":"Safety and efficacy of tafenoquine for Plasmodium vivax malaria prophylaxis and radical cure: overview and perspectives","volume":"17","author":"Markus","year":"2021","journal-title":"Therapeut. Clin. Risk Manag."},{"issue":"2","key":"10.1016\/j.cbi.2023.110379_bib6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S2352-4642(21)00375-8","article-title":"Tafenoquine for children: a step towards implementation","volume":"6","author":"Commons","year":"2022","journal-title":"Lancet Child Adolesc. Health."},{"issue":"12","key":"10.1016\/j.cbi.2023.110379_bib7","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S1473-3099(22)00442-X","article-title":"Efficacy and immunogenicity of R21\/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1\/2b randomised controlled trial","volume":"22","author":"Datoo","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cbi.2023.110379_bib9","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.bmc.2017.02.025","article-title":"Synthesis of 1,3,5-trisubstituted pyrazolines as potential antimalarial and antimicrobial agents","volume":"25","author":"Mishra","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0968-0896(99)00004-8","article-title":"Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors","volume":"7","author":"Olson","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib11","first-page":"275","article-title":"Hemoglobin degradation","volume":"vol. 295","author":"Goldberg","year":"2005"},{"key":"10.1016\/j.cbi.2023.110379_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ejmech.2017.04.029","article-title":"Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide","volume":"135","author":"Ugwu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib13","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2174\/0929867003374615","article-title":"Target based drug discovery for malarial, leishmaniasis and trypanosomiasis","volume":"7","author":"Werbovertz","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib14","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.2174\/1381612023394197","article-title":"Cysteine proteases of malaria parasites, target for chemotherapy","volume":"8","author":"Rosenthal","year":"2002","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.cbi.2023.110379_bib15","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1128\/AAC.00882-09","article-title":"Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and anti-malarial mode of actions of cysteine and aspartic protease inhibitors","volume":"53","author":"Moura","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cbi.2023.110379_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejmech.2014.07.084","article-title":"A comprehensive review on synthetic approach for antimalarial agents","volume":"85","author":"Kumar","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib17","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.bmc.2013.12.032","article-title":"Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides","volume":"22","author":"Smit","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib18","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.ejmech.2017.10.046","article-title":"Quinoline derivatives bearing pyrazole moiety: synthesis and biological evaluation as possible antibacterial and antifungal agents","volume":"143","author":"Ei Shehry","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejmech.2013.06.049","article-title":"Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents","volume":"67","author":"Insuasty","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ejmech.2015.02.040","article-title":"An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents","volume":"93","author":"Insuasty","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.bioorg.2019.102933","article-title":"Synthesis of thymol-based pyrazolines: an effort to perceive novel potent-antimalarials","volume":"88","author":"Raghuvanshi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib22","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1016\/j.bmcl.2016.05.074","article-title":"New indolizine\u2013chalcones as potent inhibitors of human farnesyltransferase: design, synthesis and biological evaluation","volume":"26","author":"Moise","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2023.110379_bib23","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ejmech.2016.08.039","article-title":"Hybrid molecules: the privileged scaffolds for various pharmaceuticals","volume":"124","author":"Shaveta","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.pharep.2019.04.006","article-title":"In silico ADMET study, docking, synthesis and antimalarial evaluation of thiazole-1,3,5-triazine derivatives as Pf-DHR inhibitor","volume":"71","author":"Sahu","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cbi.2023.110379_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.exppara.2015.06.016","article-title":"Synthesis, antimalarial activity and molecular docking of hybrid 4-aminoqionoline-1,3,5-triazine derivatives","volume":"157","author":"bhat","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.cbi.2023.110379_bib26","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1016\/j.bmc.2015.09.028","article-title":"Design, synthesis and antibacterial study of new potent and selective coumarin\u2013chalcone derivatives for the treatment of tenacibaculosis","volume":"23","author":"Vazquez-Rodriguez","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bioorg.2014.03.006","article-title":"Synthesis, characterization, theoretical, anti-bacterial and molecular docking studies of quinoline based chalcones as a DNA gyrase inhibitor","volume":"54","author":"Abdullah","year":"2014","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib28","doi-asserted-by":"crossref","first-page":"S2890","DOI":"10.1016\/j.arabjc.2013.11.018","article-title":"Green synthesis, characterization and biological evaluation of novel chalcones as antibacterial agents","volume":"10","author":"Khan","year":"2017","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib29","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/j.bmcl.2016.05.013","article-title":"The synthesis and synergistic antifungal effects of chalcones against drug resistant Candida albicans","volume":"26","author":"Wang","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2023.110379_bib30","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1016\/j.ejmech.2007.12.027","article-title":"Antifungal activity of chalcones: a mechanistic study using various yeast strains","volume":"43","author":"Lahtchev","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejmech.2014.11.016","article-title":"Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters","volume":"90","author":"Smit","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib32","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1016\/j.ejmech.2009.02.008","article-title":"Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro","volume":"44","author":"Bhattacharya","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.foodchem.2014.08.106","article-title":"Theoretical study on the structural and antioxidant properties of some recently synthesised 2,4,5-trimethoxy chalcones","volume":"171","author":"Wang","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.saa.2014.08.061","article-title":"Studies on chalcone derivatives: complex formation, thermal behavior, stability constant and antioxidant activity","volume":"137","author":"El-Sayed","year":"2015","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.cbi.2023.110379_bib35","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1016\/j.bmcl.2015.05.030","article-title":"Design, synthesis and biological evaluation of paralleled Aza resveratrol\u2013chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury","volume":"25","author":"Chen","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2023.110379_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejmech.2015.02.038","article-title":"New heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents","volume":"94","author":"Bekhit","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cbi.2007.11.001","article-title":"Influence of chalcone analogues on serum glucose levels in hyperglycemic rats","volume":"171","author":"Alberton","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2023.110379_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.taap.2015.07.009","article-title":"Attenuation of inflammatory response by a novel chalcone protects kidney and heart from hyperglycemia-induced injuries in type 1 diabetic mice","volume":"288","author":"Fang","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2023.110379_bib39","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.bmc.2016.04.045","article-title":"Synthesis and bioevaluation of substituted chalcones, coumaranones and other flavonoids as anti-HIV agents","volume":"24","author":"Cole","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejmech.2016.02.041","article-title":"Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities","volume":"113","author":"Kant","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib41","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/j.bmcl.2014.04.109","article-title":"Synthesis of novel \u03b2-carboline based chalcones with high cytotoxic activity against breast cancer cells","volume":"24","author":"Chauhan","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2023.110379_bib42","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.arabjc.2014.11.008","article-title":"Design, Synthesis and evaluation of 2-(4-(substituted benzoyl)-1,4-diazepan-1-yl)-N-phenylacetamide derivatives as a new class of falcipain-2 inhibitors","volume":"12","author":"Mahesh","year":"2019","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib43","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.compbiolchem.2018.08.003","article-title":"Quinoline containing chalcone derivatives as cholinesterase inhibitors and their in-silico modelling studies","volume":"76","author":"Shah","year":"2018","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib44","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.apjtb.2017.07.004","article-title":"Chalcone analogue as potent anti-malarial compounds against Plasmodium falciparum: synthesis, biological evaluation and docking simulation study","volume":"7","author":"Syahri","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.cbi.2023.110379_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109576","article-title":"Identification of a new class of potent aldose reductase inhibitors: design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines","volume":"345","author":"Sever","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2023.110379_bib46","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1139\/v06-015","article-title":"Synthesis of some new 1-aryl-4-formyl-3-(4- hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)pyrazoles using the Vilsmeier\u2013Haack reaction \u2014 isolation of the key intermediate 1-aryl-3-(4-hydroxy-6-methyl- 2-oxo-2H-pyran-3-yl)pyrazoles","volume":"84","author":"Kumar","year":"2006","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib47","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/j.bmc.2012.12.053","article-title":"Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffold as potent inhibitors of tyrosinase","volume":"21","author":"Gawande","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0140-6736(78)90365-3","article-title":"Drug sensitivity of Plasmodium falciparum: an in-vitro microtechnique","volume":"1","author":"Rieckmann","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2023.110379_bib49","first-page":"730","article-title":"Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives","volume":"15","author":"Saini","year":"2016","journal-title":"EXCLI. J."},{"key":"10.1016\/j.cbi.2023.110379_bib50","series-title":"The Basis of Toxicology Testing","author":"Ecobichon","year":"1977"},{"key":"10.1016\/j.cbi.2023.110379_bib51","article-title":"1,2,3-Triazole derivatives: synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity","volume":"350","author":"Lopes","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.cbi.2023.110379_bib52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.9734\/BJAST\/2011\/273","article-title":"Suppressive, curative and prophylactic potentials of Morinda lucida (benth) against erythrocytic stage of mice infective chloroquine sensitive Plasmodium berghei NK-65","volume":"1","author":"Unekwuojo","year":"2011","journal-title":"Br. j. appl. sci."},{"key":"10.1016\/j.cbi.2023.110379_bib53","first-page":"917","article-title":"Antiplasmodial effect of three medicinal plants: a preliminary study","volume":"80","author":"Devi","year":"2001","journal-title":"Curr. Sci."},{"key":"10.1016\/j.cbi.2023.110379_bib54","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/ml3000808","article-title":"Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity","volume":"3","author":"Manohar","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.cbi.2023.110379_bib55","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.exppara.2018.01.015","article-title":"Novel arylidene derivatives of quinoline based thiazolidinones: synthesis, in vitro, in vivo and in silico study as antimalarials","volume":"185","author":"Jain","year":"2018","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.cbi.2023.110379_bib56","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejps.2013.11.001","article-title":"In vitro and in silico antimalarial activity of 2-(2-hydrazinyl)thiazole derivatives","volume":"52","author":"Makam","year":"2014","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.cbi.2023.110379_bib57","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDockVina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2023.110379_bib58","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jtbi.2016.05.019","article-title":"Comparative molecular field analysis and molecular docking studies on novel aryl chalcone derivatives against an important drug target cysteine protease in Plasmodium falciparum","volume":"403","author":"Thillainayagam","year":"2016","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.cbi.2023.110379_bib59","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2165\/00002018-199512060-00003","article-title":"CNS adverse events associated with antimalarial agents","volume":"12","author":"Phillips-Howard","year":"1995","journal-title":"Drug Saf."},{"key":"10.1016\/j.cbi.2023.110379_bib60","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bbrc.2005.08.213","article-title":"A role of falcipain-2, principal cysteine proteases of Plasmodium falciparum in merozoite egression","volume":"336","author":"Dasaradhi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723000467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723000467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:51:23Z","timestamp":1736383883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279723000467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":59,"alternative-id":["S0009279723000467"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110379","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel hybrids of quinoline with pyrazolylchalcones as potential antimalarial agents: Synthesis, biological evaluation, molecular docking and ADME prediction","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110379","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110379"}}