{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:30:30Z","timestamp":1793809830523,"version":"4.6.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012253","name":"Guangxi University","doi-asserted-by":"publisher","award":["2019GXNSFDA245029"],"award-info":[{"award-number":["2019GXNSFDA245029"]}],"id":[{"id":"10.13039\/501100012253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012253","name":"Guangxi University","doi-asserted-by":"publisher","award":["2020GXNSFFA297008"],"award-info":[{"award-number":["2020GXNSFFA297008"]}],"id":[{"id":"10.13039\/501100012253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012253","name":"Guangxi University","doi-asserted-by":"publisher","award":["32272952"],"award-info":[{"award-number":["32272952"]}],"id":[{"id":"10.13039\/501100012253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019534","name":"Science Fund for Distinguished Young Scholars of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cbi.2023.110545","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T11:25:55Z","timestamp":1684927555000},"page":"110545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Tuberostemonine alleviates high-fat diet-induced obesity and hepatic steatosis by increasing energy consumption"],"prefix":"10.1016","volume":"381","author":[{"given":"Yu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingli","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cbi.2023.110545_bib1","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","article-title":"Obesity phenotypes, diabetes, and cardiovascular diseases","volume":"126","author":"Pich\u00e9","year":"2020","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.cbi.2023.110545_bib2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41574-021-00507-z","article-title":"Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus","volume":"17","author":"Ferguson","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"10","key":"10.1016\/j.cbi.2023.110545_bib3","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1172\/JCI129192","article-title":"Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis","volume":"129","author":"Marcelin","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"S1","key":"10.1016\/j.cbi.2023.110545_bib4","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/2327-6924.12510","article-title":"Obesity: risk factors, complications, and strategies for sustainable long-term weight management","volume":"29","author":"Fruh","year":"2017","journal-title":"j am assoc nurse pract."},{"key":"10.1016\/j.cbi.2023.110545_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2017.05.013","article-title":"Obesity and hypertension","volume":"122","author":"Seravalle","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2023.110545_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108645","article-title":"Calcium supplementation relieves high-fat diet-induced liver steatosis by reducing energy metabolism and promoting lipolysis","volume":"94","author":"Zhang","year":"2021","journal-title":"J. Nutr. Biochem."},{"issue":"4","key":"10.1016\/j.cbi.2023.110545_bib7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jhep.2017.06.003","article-title":"New trends on obesity and NAFLD in Asia","volume":"67","author":"Fan","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2023.110545_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155402","article-title":"The global syndemic of metabolic diseases in the young adult population: a consortium of trends and projections from the Global Burden of Disease 2000-2019","volume":"141","author":"Chong","year":"2023","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.cbi.2023.110545_bib9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jep.2010.02.018","article-title":"Antitussive and central respiratory depressant effects of Stemona tuberosa","volume":"128","author":"Xu","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2023.110545_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2016.02.006","article-title":"The therapeutic effects of tuberostemonine against cigarette smoke-induced acute lung inflammation in mice","volume":"774","author":"Jung","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.cbi.2023.110545_bib11","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.7150\/jca.17688","article-title":"Tuberostemonine reverses multidrug resistance in chronic myelogenous leukemia cells K562\/ADR","volume":"8","author":"Wang","year":"2017","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.cbi.2023.110545_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0006-8993(85)90564-5","article-title":"Inhibitory actions of tuberostemonine on the excitatory transmission at the crayfish neuromuscular junction","volume":"334","author":"Shinozaki","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.cbi.2023.110545_bib13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jpba.2017.04.018","article-title":"Metabolic profiles of neotuberostemonine and tuberostemonine in rats by high performance liquid chromatography\/quadrupole time-of-flight mass spectrometry","volume":"141","author":"Tong","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.cbi.2023.110545_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1021\/ja044280k","article-title":"Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13-epituberostemonine","volume":"127","author":"Wipf","year":"2005","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"10.1016\/j.cbi.2023.110545_bib15","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1080\/10408398.2020.1852171","article-title":"Plant extracts in prevention of obesity","volume":"62","author":"Wang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.cbi.2023.110545_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106002","article-title":"Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases","volume":"175","author":"Wan","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.cbi.2023.110545_bib17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/obr.12228","article-title":"Active ingredients from natural botanicals in the treatment of obesity","volume":"15","author":"Zhang","year":"2014","journal-title":"Obes. Rev."},{"key":"10.1016\/j.cbi.2023.110545_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biopha.2018.12.019","article-title":"Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation","volume":"111","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.cbi.2023.110545_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cbi.2006.11.004","article-title":"A human hepatocellular in vitro model to investigate steatosis","volume":"165","author":"G\u00f3mez-Lech\u00f3n","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2023.110545_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-023-01680-4","article-title":"Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis","author":"Hendriks","year":"2023","journal-title":"Nat. Biotechnol."},{"issue":"15","key":"10.1016\/j.cbi.2023.110545_bib21","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.7150\/ijbs.74348","article-title":"Small intestine-specific knockout of CIDEC improves obesity and hepatic steatosis by inhibiting synthesis of phosphatidic acid","volume":"18","author":"Huang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cbi.2023.110545_bib22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.freeradbiomed.2022.12.093","article-title":"5-Methoxyflavone ameliorates non-alcoholic fatty liver disease through targeting the cytochrome P450 1A1","volume":"195","author":"Zhang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.cbi.2023.110545_bib23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial dysfunction and signaling in chronic liver diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"issue":"15\u201316","key":"10.1016\/j.cbi.2023.110545_bib24","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cca.2011.04.013","article-title":"The role of oxidative stress in non-alcoholic steatohepatitis","volume":"412","author":"Koek","year":"2011","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.cbi.2023.110545_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11020310","article-title":"Anti-obesity effects of ecklonia cava extract in high-fat diet-induced obese rats","volume":"11","author":"Abbas","year":"2022","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.cbi.2023.110545_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051305","article-title":"Obesity, bioactive lipids, and adipose tissue inflammation in insulin resistance","volume":"12","author":"Kojta","year":"2020","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.cbi.2023.110545_bib27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1053\/j.gastro.2018.04.017","article-title":"Disruption of epithelial HDAC3 in intestine prevents diet-induced obesity in mice","volume":"155","author":"Whitt","year":"2018","journal-title":"Gastroenterology"},{"issue":"18","key":"10.1016\/j.cbi.2023.110545_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184556","article-title":"Plant extracts and reactive oxygen species as two counteracting agents with anti- and pro-obesity properties","volume":"20","author":"Zielinska-Blizniewska","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cbi.2023.110545_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bcp.2014.07.018","article-title":"Natural product agonists of peroxisome proliferator-activated receptor gamma (PPAR\u03b3): a review","volume":"92","author":"Wang","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.cbi.2023.110545_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13039","article-title":"Oral intake of Lactobacillus plantarum L-14 extract alleviates TLR2- and AMPK-mediated obesity-associated disorders in high-fat-diet-induced obese C57BL\/6J mice","volume":"54","author":"Lee","year":"2021","journal-title":"Cell Prolif."},{"issue":"9","key":"10.1016\/j.cbi.2023.110545_bib31","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1096\/fj.05-5678fje","article-title":"Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression","volume":"20","author":"Jern\u00e5s","year":"2006","journal-title":"Faseb. J."},{"issue":"8","key":"10.1016\/j.cbi.2023.110545_bib32","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.metabol.2016.05.003","article-title":"Non-alcoholic fatty liver disease and dyslipidemia: an update","volume":"65","author":"Katsiki","year":"2016","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.cbi.2023.110545_bib33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ-linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr. Rev."},{"issue":"11","key":"10.1016\/j.cbi.2023.110545_bib34","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2337\/db10-1032","article-title":"Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy","volume":"59","author":"Rizza","year":"2010","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.cbi.2023.110545_bib35","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1053\/j.gastro.2020.01.051","article-title":"Therapeutic landscape for NAFLD in 2020","volume":"158","author":"Neuschwander-Tetri","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.cbi.2023.110545_bib36","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action","volume":"5","author":"Alam","year":"2014","journal-title":"Adv. Nutr."},{"issue":"3","key":"10.1016\/j.cbi.2023.110545_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/biom11030412","article-title":"Natural extracts to augment energy expenditure as a complementary approach to tackle obesity and associated metabolic alterations","volume":"11","author":"Reguero","year":"2021","journal-title":"Biomolecules"},{"issue":"44","key":"10.1016\/j.cbi.2023.110545_bib38","doi-asserted-by":"crossref","first-page":"13080","DOI":"10.1021\/acs.jafc.1c05213","article-title":"Erythritol improves nonalcoholic fatty liver disease by activating Nrf2 antioxidant capacity","volume":"69","author":"Jin","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2023.110545_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153140","article-title":"Protective effect of Hedansanqi Tiaozhi Tang against non-alcoholic fatty liver disease in vitro and in vivo through activating Nrf2\/HO-1 antioxidant signaling pathway","volume":"67","author":"Qiu","year":"2020","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.cbi.2023.110545_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20010026","article-title":"Oxyresveratrol increases energy expenditure through foxo3a-mediated Ucp1 induction in high-fat-diet-induced obese mice","volume":"20","author":"Choi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.cbi.2023.110545_bib41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jsfa.10675","article-title":"Chlorogenic acid ameliorates obesity by preventing energy balance shift in high-fat diet induced obese mice","volume":"101","author":"He","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.cbi.2023.110545_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2021.111263","article-title":"Curcumin improves insulin sensitivity and increases energy expenditure in high-fat-diet-induced obese mice associated with activation of FNDC5\/irisin","volume":"90","author":"Zou","year":"2021","journal-title":"Nutrition"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723002120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723002120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:15:55Z","timestamp":1757859355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279723002120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":42,"alternative-id":["S0009279723002120"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110545","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tuberostemonine alleviates high-fat diet-induced obesity and hepatic steatosis by increasing energy consumption","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110545"}}