{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:13:44Z","timestamp":1781349224445,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cbi.2023.110555","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T02:08:04Z","timestamp":1685066884000},"page":"110555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Fluoride resistance capacity in mammalian cells involves global gene expression changes associate with ferroptosis"],"prefix":"10.1016","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-8068","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4413-2377","authenticated-orcid":false,"given":"Jialong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenkang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2023.110555_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116227","article-title":"Effects of water improvement and defluoridation on fluorosis-endemic areas in China: a meta-analysis","volume":"270","author":"Wang","year":"2021","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.cbi.2023.110555_bib2","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1007\/s12011-020-02435-x","article-title":"Calcium and vitamin D supplementation effectively alleviates dental and skeletal fluorosis and retain elemental homeostasis in mice","volume":"199","author":"Dey Bhowmik","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"issue":"8","key":"10.1016\/j.cbi.2023.110555_bib3","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1021\/acs.jcim.2c01228","article-title":"Uncovering the mechanism of the proton-coupled fluoride transport in the CLCF antiporter","volume":"63","author":"Mills","year":"2023","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.cbi.2023.110555_bib4","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2017.1344509","article-title":"Fluoride resistance in Streptococcus mutans: a mini review","volume":"9","author":"Liao","year":"2017","journal-title":"J. Oral Microbiol."},{"issue":"4","key":"10.1016\/j.cbi.2023.110555_bib5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12223-021-00867-z","article-title":"High fluoride resistance and virulence profile of environmental Pseudomonas isolated from water sources","volume":"66","author":"Chellaiah","year":"2021","journal-title":"Folia Microbiol (Praha)"},{"issue":"6065","key":"10.1016\/j.cbi.2023.110555_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1215063","article-title":"Widespread genetic switches and toxicity resistance proteins for fluoride","volume":"335","author":"Baker","year":"2012","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.cbi.2023.110555_bib7","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1007\/s11356-014-3957-6","article-title":"Changes in mesophyll element distribution and phytometabolite contents involved in fluoride tolerance of the arid gypsum-tolerant plant species Atractylis serratuloides Sieber ex Cass. (Asteraceae)","volume":"22","author":"Boukhris","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"7","key":"10.1016\/j.cbi.2023.110555_bib8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/2211-5463.12236","article-title":"Fluoride resistance capacity in mammalian cells involves complex global gene expression changes","volume":"7","author":"Ran","year":"2017","journal-title":"FEBS Open Bio"},{"issue":"6","key":"10.1016\/j.cbi.2023.110555_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"issue":"1","key":"10.1016\/j.cbi.2023.110555_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"3","key":"10.1016\/j.cbi.2023.110555_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cbi.2023.110555_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pneurobio.2015.09.012","article-title":"Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease","volume":"155","author":"Zucca","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.cbi.2023.110555_bib13","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/cells9061505","article-title":"Ferroptosis and cancer: mitochondria meet the \"iron maiden\" cell death","volume":"9","author":"Battaglia","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2023.110555_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.773055","article-title":"Prospects for the role of ferroptosis in fluorosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.cbi.2023.110555_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.cbi.2023.110555_bib16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0891-5849(02)00848-1","article-title":"C11-BODIPY(581\/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology","volume":"33","author":"Drummen","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.cbi.2023.110555_bib17","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/php.13020","article-title":"A silica-based nanostructured fluorogenic probe for the detection of reactive oxygen species","volume":"94","author":"Bresol\u00ed-Obach","year":"2018","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.cbi.2023.110555_bib18","first-page":"646","article-title":"International journal of environmental research and public health editorial office. Retraction","volume":"vol. 13","year":"2016"},{"key":"10.1016\/j.cbi.2023.110555_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.lfs.2018.02.001","article-title":"Toxic effects of fluoride on organisms","volume":"198","author":"Zuo","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2023.110555_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114021","article-title":"Effects of chronic fluorosis on the brain","volume":"244","author":"Ren","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2023.110555_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/102954","article-title":"A role of fluoride on free radical generation and oxidative stress in BV-2 microglia cells","author":"Shuhua","year":"2012","journal-title":"Mediat. Inflamm."},{"issue":"8","key":"10.1016\/j.cbi.2023.110555_bib22","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.tiv.2013.09.005","article-title":"Cytotoxicity of ammonium hexafluorosilicate on human gingival fibroblasts","volume":"27","author":"Song","year":"2013","journal-title":"Toxicol. Vitro"},{"issue":"2","key":"10.1016\/j.cbi.2023.110555_bib23","first-page":"217","article-title":"Effects of fluoride on lipid peroxidation, DNA damage and apoptosis in human embryo hepatocytes","volume":"17","author":"Wang","year":"2004","journal-title":"Biomed. Environ. Sci."},{"issue":"1","key":"10.1016\/j.cbi.2023.110555_bib24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/nchembio.2261","article-title":"Ferroptosis: oxidized PEs trigger death","volume":"13","author":"D'Herde","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"3","key":"10.1016\/j.cbi.2023.110555_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"issue":"3","key":"10.1016\/j.cbi.2023.110555_bib26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"issue":"16","key":"10.1016\/j.cbi.2023.110555_bib27","doi-asserted-by":"crossref","first-page":"9014","DOI":"10.3390\/ijms23169014","article-title":"Combination RSL3 treatment sensitizes ferroptosis- and EGFR-inhibition-resistant HNSCCs to cetuximab","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.cbi.2023.110555_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/00220345000790040301","article-title":"International collaborative research on fluoride","volume":"79","year":"2000","journal-title":"J. Dent. Res."},{"issue":"3","key":"10.1016\/j.cbi.2023.110555_bib29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/2211-5463.12786","article-title":"Fluoride resistance in fibroblasts is conferred via reduced susceptibility to oxidative stress and apoptosis","volume":"10","author":"Ni","year":"2020","journal-title":"FEBS Open Bio"},{"issue":"12","key":"10.1016\/j.cbi.2023.110555_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118535","article-title":"Iron homeostasis and oxidative stress: an intimate relationship","volume":"1866","author":"Galaris","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.cbi.2023.110555_bib31","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.redox.2017.03.007","article-title":"BID links ferroptosis to mitochondrial cell death pathways","volume":"12","author":"Neitemeier","year":"2017","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.cbi.2023.110555_bib32","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.kint.2022.07.034","article-title":"Repression of the antiporter SLC7A11\/glutathione\/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification","volume":"102","author":"Ye","year":"2022","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.cbi.2023.110555_bib33","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1158\/0008-5472.CAN-18-3037","article-title":"The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11","volume":"79","author":"Liu","year":"2019","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cbi.2023.110555_bib34","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2018.03.113","article-title":"ENPP2 protects cardiomyocytes from erastin-induced ferroptosis","volume":"499","author":"Bai","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723002223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723002223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:16:18Z","timestamp":1757859378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279723002223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":34,"alternative-id":["S0009279723002223"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110555","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluoride resistance capacity in mammalian cells involves global gene expression changes associate with ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110555","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110555"}}