{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:21:46Z","timestamp":1791721306337,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.cbi.2023.110796","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T05:39:58Z","timestamp":1699594798000},"page":"110796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Evaluation of the antitumoral effects of the mesoionic compound MI-D: Implications for endothelial cells viability and angiogenesis inhibition"],"prefix":"10.1016","volume":"387","author":[{"given":"Ronaldo Figueira de","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-7942","authenticated-orcid":false,"given":"Ian Rodrigo","family":"Stoltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Gyuliane","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea","family":"Echevarria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-339X","authenticated-orcid":false,"given":"Leandro","family":"Taborda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzzo Henrique","family":"Lepinsk Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Fernando","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-134X","authenticated-orcid":false,"given":"Selene","family":"Elifio-Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2023.110796_bib1","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1007\/s00018-017-2577-y","article-title":"Endothelial cell apoptosis in angiogenesis and vessel regression","volume":"74","author":"Watson","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbi.2023.110796_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumour vasculature: insights from physiological angiogenesis","volume":"10","author":"Chung","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cbi.2023.110796_bib3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.5551\/jat.28902","article-title":"Novel link between inhibition of angiogenesis and tolerance to vascular stress","volume":"22","author":"Sato","year":"2015","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.cbi.2023.110796_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1538\/expanim.17-0054","article-title":"Use of animal models for the imaging and quantification of angiogenesis","volume":"67","author":"Liu","year":"2018","journal-title":"Exp. Anim."},{"key":"10.1016\/j.cbi.2023.110796_bib5","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbi.2023.110796_bib6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2023.110796_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100849","article-title":"New insights into antiangiogenic therapy resistance in cancer: mechanisms and therapeutic aspects","volume":"64","author":"Huang","year":"2022","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.cbi.2023.110796_bib8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.87.6.434","article-title":"Endothelial cell apoptosis in angiogenesis and vessel regression","volume":"87","author":"Dimmeler","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbi.2023.110796_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-24998-6","article-title":"A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis","volume":"12","author":"Pradella","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2023.110796_bib10","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1016\/0040-4020(82)80186-5","article-title":"Meso-ionic heterocycles (1976\u20131980)","volume":"38","author":"Newton","year":"1982","journal-title":"Tetrahedron"},{"key":"10.1016\/j.cbi.2023.110796_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00001813-199701000-00012","article-title":"Synthesis and in vivo antitumor activity of new heterocyclic derivatives of the 1,3,4-thiadiazolium-2-aminide class","volume":"8","author":"Grynberg","year":"1997","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.cbi.2023.110796_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cbf.932","article-title":"Interference of MI-D, a new mesoionic compound, on artificial and native membranes","volume":"20","author":"Cadena","year":"2002","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.cbi.2023.110796_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.bjc.6601946","article-title":"Cytotoxic effect of a new 1,3,4-thiadiazolium mesoionic compound (MI-D) on cell lines of human melanoma","volume":"91","author":"Senff-Ribeiro","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cbi.2023.110796_bib14","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s11010-022-04423-2","article-title":"The mesoionic compound MI-D changes energy metabolism and induces apoptosis in T98G glioma cells","volume":"477","author":"Correa-Ferreira","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbi.2023.110796_bib15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/jbt.20303","article-title":"Metabolism of the mesoionic compound (MI-D) by mouse liver microsome, detection of its metabolite in vivo, and acute toxicity in mice","volume":"23","author":"Rom\u00e3o","year":"2009","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.cbi.2023.110796_bib16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1590\/S0103-50532011000800014","article-title":"Improved Synthesis of 1,3,4-thiadiazolium-2-phenylamines using microwave and ultrasound irradiation and investigation of their cytotoxic activity","volume":"22","author":"Reis","year":"2011","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.cbi.2023.110796_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-1-61779-080-5_19","article-title":"Cellular chemosensitivity assays: an overview","volume":"731","author":"Sumantran","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cbi.2023.110796_bib18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.biopha.2018.11.107","article-title":"Antiproliferative and antiangiogenic effect of Amblyomma sculptum (Acari: Ixodidae) crude saliva in endothelial cells in vitro","volume":"110","author":"de S\u00e1 Junior","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2023.110796_bib19","series-title":"ImageJ","author":"Rasband","year":"2018"},{"key":"10.1016\/j.cbi.2023.110796_bib20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jss.2005.04.042","article-title":"Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation","volume":"128","author":"Yang","year":"2005","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.cbi.2023.110796_bib21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10456-018-9613-x","article-title":"Consensus guidelines for the use and interpretation of angiogenesis assays","volume":"21","author":"Nowak-Sliwinska","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.cbi.2023.110796_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109675","article-title":"The toxicity of 1,3,4-thiadiazolium mesoionic derivatives on hepatocarcinoma cells (HepG2) is associated with mitochondrial dysfunction","volume":"349","author":"Pereira","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2023.110796_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0014-5793(98)01427-6","article-title":"Effect of MI-D, a new mesoionic compound, on energy-linked functions of rat liver mitochondria","volume":"440","author":"Cadena","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbi.2023.110796_bib24","doi-asserted-by":"crossref","first-page":"C56","DOI":"10.1152\/ajpcell.00250.2016","article-title":"Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells","volume":"312","author":"Lapel","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cbi.2023.110796_bib25","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.ATV.0000017728.55907.A9","article-title":"Regulation of endothelial cell survival and apoptosis during angiogenesis","volume":"22","author":"Chavakis","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cbi.2023.110796_bib26","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.abb.2006.09.030","article-title":"Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD\/SCID mice","volume":"459","author":"Zeisig","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2023.110796_bib27","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.2147\/JIR.S355158","article-title":"Endothelial mechanosensors for atheroprone and atheroprotective shear stress signals","volume":"15","author":"Li","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.cbi.2023.110796_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1469-7580.2003.00220.x","article-title":"In vivo time-course of the angiogenic response induced by multiple myeloma plasma cells in the chick embryo chorioallantoic membrane","volume":"203","author":"Ribatti","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.cbi.2023.110796_bib29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1158\/0008-5472.CAN-05-1195","article-title":"Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells","volume":"66","author":"Roccaro","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2023.110796_bib30","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1182\/blood-2007-10-116590","article-title":"Validation of PDGFRbeta and c-Src tyrosine kinases as tumor\/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib","volume":"112","author":"Coluccia","year":"2008","journal-title":"Blood"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723004635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723004635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T18:45:09Z","timestamp":1736361909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279723004635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"alternative-id":["S0009279723004635"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110796","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the antitumoral effects of the mesoionic compound MI-D: Implications for endothelial cells viability and angiogenesis inhibition","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110796","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110796"}}