{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:58:16Z","timestamp":1789469896577,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.cbi.2023.110812","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T20:09:00Z","timestamp":1700510940000},"page":"110812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1\/ERK signaling pathway leading to fetal growth restriction"],"prefix":"10.1016","volume":"387","author":[{"given":"Shuping","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-6126","authenticated-orcid":false,"given":"Shuxian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2023.110812_bib1","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1097\/AOG.0000000000003070","article-title":"Fetal growth restriction","volume":"133","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.cbi.2023.110812_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction, Ultrasound in obstetrics & gynecology","volume":"56","author":"Lees","year":"2020","journal-title":"Offi. J. Int. Soc. Ultrasound Obstetrics Gynecol."},{"key":"10.1016\/j.cbi.2023.110812_bib3","doi-asserted-by":"crossref","first-page":"S855","DOI":"10.1016\/j.ajog.2017.12.004","article-title":"Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy","volume":"218","author":"McCowan","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cbi.2023.110812_bib4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s40572-022-00354-8","article-title":"The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis","volume":"9","author":"Lapehn","year":"2022","journal-title":"Current environmental health reports"},{"key":"10.1016\/j.cbi.2023.110812_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106319","article-title":"Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts","volume":"147","author":"Zhu","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2023.110812_bib6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12884-019-2401-9","article-title":"Association between ambient particulate matter concentration and fetal growth restriction stratified by maternal employment","volume":"19","author":"Choe","year":"2019","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.cbi.2023.110812_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131427","article-title":"Gestational 1-nitropyrene exposure causes anxiety-like behavior partially by altering hippocampal epigenetic reprogramming of synaptic plasticity in male adult offspring","volume":"453","author":"Wang","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2023.110812_bib8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.chemosphere.2018.09.059","article-title":"Gestational 1-nitropyrene exposure causes fetal growth restriction through disturbing placental vascularity and proliferation","volume":"213","author":"Li","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2023.110812_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113984","article-title":"Reactive oxygen species-mediated cellular genotoxic stress is involved in 1-nitropyrene-induced trophoblast cycle arrest and fetal growth restriction","volume":"260","author":"Wang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2023.110812_bib10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbi.2023.110812_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2023.110812_bib12","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2023.110812_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.cbi.2023.110812_bib14","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.cbi.2023.110812_bib15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fncel.2020.00218","article-title":"Ferroptosis in neurological diseases","volume":"14","author":"Ren","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.cbi.2023.110812_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.cbi.2023.110812_bib17","series-title":"Ferroptosis and its Emerging Role in Pre-eclampsia","first-page":"11","author":"Chen","year":"2022"},{"key":"10.1016\/j.cbi.2023.110812_bib18","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/joim.13349","article-title":"The roles of free iron, heme, haemoglobin, and the scavenger proteins haemopexin and alpha-1-microglobulin in preeclampsia and fetal growth restriction","volume":"290","author":"Erlandsson","year":"2021","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.cbi.2023.110812_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.07.105","article-title":"PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2023.110812_bib20","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/s41467-019-10991-7","article-title":"Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis","volume":"10","author":"Yoshida","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2023.110812_bib21","first-page":"322","article-title":"The MAPK signalling pathways and colorectal cancer, the Lancet","volume":"6","author":"Fang","year":"2005","journal-title":"Oncology"},{"key":"10.1016\/j.cbi.2023.110812_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-phyto-082712-102314","article-title":"MAPK cascades in plant disease resistance signaling","volume":"51","author":"Meng","year":"2013","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1016\/j.cbi.2023.110812_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/21655979.2021.2009970","article-title":"Lipocalin-2 silencing suppresses inflammation and oxidative stress of acute respiratory distress syndrome by ferroptosis via inhibition of MAPK\/ERK pathway in neonatal mice","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.cbi.2023.110812_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6986445","article-title":"Modulation of the p38 MAPK pathway by anisomycin promotes ferroptosis of hepatocellular carcinoma through phosphorylation of H3S10","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cbi.2023.110812_bib25","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2022.5200","article-title":"Role of GADD45A in myocardial ischemia\/reperfusion through mediation of the JNK\/p38 MAPK and STAT3\/VEGF pathways","volume":"50","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cbi.2023.110812_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109977","article-title":"Acute 1-NP exposure induces inflammatory responses through activating various inflammatory signaling pathways in mouse lungs and human A549 cells","volume":"189","author":"Hu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2023.110812_bib27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pharmthera.2017.03.007","article-title":"Potential role of CYP1B1 in the development and treatment of metabolic diseases","volume":"178","author":"Li","year":"2017","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.cbi.2023.110812_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/HYPERTENSIONAHA.114.03275","article-title":"Estrogen metabolism by cytochrome P450 1B1 modulates the hypertensive effect of angiotensin II in female mice","volume":"64","author":"Jennings","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.cbi.2023.110812_bib29","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s00109-015-1300-4","article-title":"Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1","volume":"93","author":"Li","year":"2015","journal-title":"Journal of molecular medicine (Berlin, Germany)"},{"key":"10.1016\/j.cbi.2023.110812_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10815-022-02395-2","article-title":"Suppression of FPR2 expression inhibits inflammation in preeclampsia by improving the biological functions of trophoblast via NF-\u03baB pathway","volume":"39","author":"Li","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.cbi.2023.110812_bib31","first-page":"24","article-title":"FPR2 serves a role in recurrent spontaneous abortion by regulating trophoblast function via the PI3K\/AKT signaling pathway","author":"Li","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cbi.2023.110812_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110097","article-title":"RNA-DNA hybrids regulate meiotic recombination","volume":"37","author":"Yang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cbi.2023.110812_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11658-020-00205-0","article-title":"Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis","volume":"25","author":"Liu","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.cbi.2023.110812_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127268","article-title":"Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation","volume":"424","author":"Zhu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2023.110812_bib35","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1038\/s41596-020-0381-x","article-title":"Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta","volume":"15","author":"Sheridan","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbi.2023.110812_bib36","doi-asserted-by":"crossref","first-page":"60805","DOI":"10.1007\/s11356-023-26850-4","article-title":"BPA induces placental trophoblast proliferation inhibition and fetal growth restriction by inhibiting the expression of SRB1","volume":"30","author":"Cao","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.cbi.2023.110812_bib37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-981-33-4187-6_7","article-title":"Toxicological effects of BPDE on dysfunctions of female trophoblast cells","volume":"1300","author":"Wang","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cbi.2023.110812_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131543","article-title":"BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14\/ZBP1\/NLRP3 axis","volume":"455","author":"Wang","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2023.110812_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9314342","article-title":"1-Nitropyrene induced reactive oxygen species-mediated apoptosis in macrophages through AIF nuclear translocation and AMPK\/Nrf-2\/HO-1 pathway activation","volume":"2021","author":"Su","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cbi.2023.110812_bib40","doi-asserted-by":"crossref","first-page":"869","DOI":"10.4014\/jmb.2206.06004","article-title":"Effect of methyl gallate on 1-nitropyrene-induced keratinocyte toxicity in a human and canine skin model","volume":"32","author":"Lee","year":"2022","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.cbi.2023.110812_bib41","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/mutage\/ger035","article-title":"DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis","volume":"26","author":"Oya","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.cbi.2023.110812_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.taap.2008.02.015","article-title":"1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells","volume":"230","author":"Asare","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2023.110812_bib43","article-title":"Dapagliflozin alleviates myocardial ischemia\/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2023.110812_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106670","article-title":"Ferrostatin-1 mitigates cognitive impairment of epileptic rats by inhibiting P38 MAPK activation","volume":"103","author":"Ye","year":"2020","journal-title":"Epilepsy Behav. : E&B"},{"key":"10.1016\/j.cbi.2023.110812_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091393","article-title":"Toxic effects of the major components of diesel exhaust in human alveolar basal epithelial cells (A549)","volume":"17","author":"Rossner","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2023.110812_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107393","article-title":"Mitochondrial ROS-mediated ribosome stalling and GCN2 activation are partially involved in 1-nitropyrene-induced steroidogenic inhibition in testes","volume":"167","author":"Li","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2023.110812_bib47","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1383-5718(01)00254-6","article-title":"Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS\/umu assay","volume":"497","author":"Hatanaka","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cbi.2023.110812_bib48","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/14767058.2019.1610379","article-title":"Knockdown of CYP1B1 suppresses the behavior of the extravillous trophoblast cell line HTR-8\/SVneo under hyperglycemic condition","volume":"34","author":"Wu","year":"2021","journal-title":"J. Matern. Fetal Neonatal Med."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723004799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279723004799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T18:45:36Z","timestamp":1736361936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279723004799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":48,"alternative-id":["S0009279723004799"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110812","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1\/ERK signaling pathway leading to fetal growth restriction","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2023.110812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110812"}}