{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:19:42Z","timestamp":1790198382170,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016399","name":"Reims Champagne-Ardenne University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.cbi.2024.110949","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T13:17:51Z","timestamp":1711631871000},"page":"110949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Methylglyoxal induces cardiac dysfunction through mechanisms involving altered intracellular calcium handling in the rat heart"],"prefix":"10.1016","volume":"394","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2397-1454","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Peyret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-1613","authenticated-orcid":false,"given":"C\u00e9line","family":"Konecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Terryn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-6368","authenticated-orcid":false,"given":"Florine","family":"Dubuisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Millart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Feliu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-7889","authenticated-orcid":false,"given":"Zoubir","family":"Djerada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2024.110949_bib1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/01.CIR.100.10.1134","article-title":"Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association","volume":"100","author":"Grundy","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cbi.2024.110949_bib2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s00125-003-1116-6","article-title":"Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes","volume":"46","author":"Laing","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.cbi.2024.110949_bib3","first-page":"853","article-title":"Endothelial dysfunction in diabetes mellitus, Vasc","volume":"3","author":"Hadi","year":"2007","journal-title":"Healthc. Risk Manag."},{"key":"10.1016\/j.cbi.2024.110949_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0002-9149(74)90089-7","article-title":"Role of diabetes in congestive heart failure: the Framingham study","volume":"34","author":"Kannel","year":"1974","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.cbi.2024.110949_bib5","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cbi.2024.110949_bib6","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.amjmed.2008.03.046","article-title":"Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options","volume":"121","author":"Aneja","year":"2008","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cbi.2024.110949_bib7","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1042\/CS20160491","article-title":"Are targeted therapies for diabetic cardiomyopathy on the horizon?","volume":"131","author":"Tate","year":"2017","journal-title":"Clin. Sci. Lond. Engl."},{"key":"10.1016\/j.cbi.2024.110949_bib8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/bst0210549","article-title":"Mechanism for the formation of methylglyoxal from triosephosphates","volume":"21","author":"Richard","year":"1993","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.cbi.2024.110949_bib9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0306-3623(95)02054-3","article-title":"Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy","volume":"27","author":"Thornalley","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.cbi.2024.110949_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/cs0870021","article-title":"Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications","volume":"87","author":"McLellan","year":"1994","journal-title":"Clin. Sci. Lond. Engl."},{"key":"10.1016\/j.cbi.2024.110949_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2337\/diabetes.48.1.198","article-title":"Metformin reduces systemic methylglyoxal levels in type 2 diabetes","volume":"48","author":"Beisswenger","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2024.110949_bib12","first-page":"1166","article-title":"Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC\/MS method","volume":"41","author":"Lapolla","year":"2003","journal-title":"Clin. Chem. Lab. Med. CCLM FESCC"},{"key":"10.1016\/j.cbi.2024.110949_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/abio.1993.1229","article-title":"The Assay of S-D-Lactoylglutathione in biological systems","volume":"211","author":"Mclellan","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2024.110949_bib14","doi-asserted-by":"crossref","first-page":"19891","DOI":"10.3390\/ijms141019891","article-title":"Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond","volume":"14","author":"Daffu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2024.110949_bib15","first-page":"809","article-title":"Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells, Hypertens","volume":"39","author":"Wu","year":"2002","journal-title":"Dallas Tex"},{"key":"10.1016\/j.cbi.2024.110949_bib16","doi-asserted-by":"crossref","first-page":"F420","DOI":"10.1152\/ajprenal.00415.2004","article-title":"Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation","volume":"289","author":"Rosca","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cbi.2024.110949_bib17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00125-010-1677-0","article-title":"Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress","volume":"53","author":"Brouwers","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.cbi.2024.110949_bib18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.33549\/physiolres.931585","article-title":"Glycotoxines, carbonyl stress and relevance to diabetes and its complications","volume":"59","author":"Turk","year":"2010","journal-title":"Physiol. Res."},{"key":"10.1016\/j.cbi.2024.110949_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/cvr\/24.5.381","article-title":"Chronic diabetes mellitus prolongs action potential duration of rat ventricular muscles: circumstantial evidence for impaired Ca2+ channel","volume":"24","author":"Nobe","year":"1990","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cbi.2024.110949_bib20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0022-2828(81)90318-7","article-title":"Depressed cardiac sarcoplasmic reticular function from diabetic rats","volume":"13","author":"Penpargkul","year":"1981","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cbi.2024.110949_bib21","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.yjmcc.2006.08.018","article-title":"Dyssynchronous (non-uniform) Ca2+ release in myocytes from streptozotocin-induced diabetic rats","volume":"42","author":"Shao","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cbi.2024.110949_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1124\/mol.112.078352","article-title":"Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus","volume":"82","author":"Shao","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cbi.2024.110949_bib23","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2337\/db10-1145","article-title":"Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes","volume":"60","author":"Shao","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2024.110949_bib24","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1073\/pnas.1001825107","article-title":"TRPC channels are necessary mediators of pathologic cardiac hypertrophy","volume":"107","author":"Wu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2024.110949_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/CIRCRESAHA.110.225888","article-title":"TRPC channels as effectors of cardiac hypertrophy","volume":"108","author":"Eder","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbi.2024.110949_bib26","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.devcel.2012.08.017","article-title":"A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo","volume":"23","author":"Davis","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cbi.2024.110949_bib27","doi-asserted-by":"crossref","first-page":"H1339","DOI":"10.1152\/ajpheart.01021.2013","article-title":"Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels","volume":"307","author":"Oguri","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cbi.2024.110949_bib28","doi-asserted-by":"crossref","first-page":"28291","DOI":"10.1074\/jbc.M111.328674","article-title":"Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies","volume":"287","author":"Eberhardt","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2024.110949_bib29","article-title":"Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells","volume":"7","author":"Cao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2024.110949_bib30","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bbrc.2013.03.089","article-title":"Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor","volume":"434","author":"Djerada","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2024.110949_bib31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.bbrc.2016.10.106","article-title":"Activated protein C prevents methylglyoxal-induced endoplasmic reticulum stress and cardiomyocyte apoptosis via regulation of the AMP-activated protein kinase signaling pathway","volume":"480","author":"Nam","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2024.110949_bib32","doi-asserted-by":"crossref","first-page":"E207","DOI":"10.1152\/ajpendo.00215.2010","article-title":"Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity","volume":"299","author":"Wang","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cbi.2024.110949_bib33","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/0006-2952(94)90584-3","article-title":"The reaction of methylglyoxal with aminoguanidine under physiological conditions and prevention of methylglyoxal binding to plasma proteins","volume":"48","author":"Lo","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2024.110949_bib34","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF01931488","article-title":"Effect of verapamil on contractile function of the isolated perfused rat heart during postnatal ontogeny","volume":"85","author":"Kol\u00e1r","year":"1990","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.cbi.2024.110949_bib35","doi-asserted-by":"crossref","first-page":"H812","DOI":"10.1152\/ajpheart.00335.2017","article-title":"Guidelines for experimental models of myocardial ischemia and infarction","volume":"314","author":"Lindsey","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cbi.2024.110949_bib36","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbrc.2018.10.171","article-title":"Enhanced calcium entry via activation of NOX\/PKC underlies increased vasoconstriction induced by methylglyoxal","volume":"506","author":"Eid","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2024.110949_bib37","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121264","article-title":"Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function","volume":"3","author":"Papadaki","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.cbi.2024.110949_bib38","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2337\/db15-0568","article-title":"Methylglyoxal-induced endothelial cell loss and inflammation contribute to the development of diabetic cardiomyopathy","volume":"65","author":"Vulesevic","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2024.110949_bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/1479164113518805","article-title":"Impaired left ventricular function and myocardial blood flow reserve in patients with long-term type 1 diabetes and no significant coronary artery disease: associations with protein glycation","volume":"11","author":"Sveen","year":"2014","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.cbi.2024.110949_bib40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jacc.2017.11.019","article-title":"Implications of underlying mechanisms for the recognition and management of diabetic cardiomyopathy","volume":"71","author":"Marwick","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cbi.2024.110949_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.201500552","article-title":"Reactivity, selectivity, and reaction mechanisms of aminoguanidine, hydralazine, pyridoxamine, and carnosine as sequestering agents of reactive carbonyl species: a comparative study","author":"Colzani","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.cbi.2024.110949_bib42","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.amjhyper.2006.12.003","article-title":"Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal","volume":"20","author":"Wang","year":"2007","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.cbi.2024.110949_bib43","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1111\/j.1476-5381.2010.01017.x","article-title":"Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose","volume":"161","author":"Dhar","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2024.110949_bib44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0197-0186(96)00056-3","article-title":"Ruthenium red as a tool to study calcium channels, neuronal death and the function of neural pathways","volume":"30","author":"Tapia","year":"1997","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbi.2024.110949_bib45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00944201","article-title":"Inhibition of the mitochondrial Ca2+ uniporter by pure and impure ruthenium red","volume":"139","author":"Broekemeier","year":"1994","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbi.2024.110949_bib46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0014-5793(00)02268-7","article-title":"Use of ruthenium red as an inhibitor of mitochondrial Ca2+ uptake in single rat cardiomyocytes","volume":"486","author":"Griffiths","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbi.2024.110949_bib47","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0006-291X(85)80019-X","article-title":"Ruthenium red and caffeine affect the Ca2+-ATPase of the sarcoplasmic reticulum","volume":"127","author":"M\u00e9sz\u00e1ros","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2024.110949_bib48","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0006-2952(97)00619-9","article-title":"Effects of methylglyoxal on rat pancreatic beta-cells","volume":"55","author":"Cook","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2024.110949_bib49","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cellsig.2004.11.007","article-title":"Effect of methylglyoxal on intracellular calcium levels and viability in renal tubular cells, Cell","volume":"17","author":"Jan","year":"2005","journal-title":"Signal."},{"key":"10.1016\/j.cbi.2024.110949_bib50","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.2337\/db14-1107","article-title":"Removal of abnormal myofilament O-GlcNAcylation restores Ca2+ sensitivity in diabetic cardiac muscle","volume":"64","author":"Ramirez-Correa","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2024.110949_bib51","doi-asserted-by":"crossref","first-page":"C1370","DOI":"10.1152\/ajpcell.00422.2006","article-title":"Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart","volume":"292","author":"F\u00fcl\u00f6p","year":"2007","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.cbi.2024.110949_bib52","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ijcard.2015.09.022","article-title":"Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: the arrhythmogenic substrate","volume":"202","author":"Sommese","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cbi.2024.110949_bib53","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2024.110949_bib54","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI200316326","article-title":"Linkage of \u03b21-adrenergic stimulation to apoptotic heart cell death through protein kinase A\u2013independent activation of Ca2+\/calmodulin kinase II","volume":"111","author":"Zhu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2024.110949_bib55","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1172\/JCI65268","article-title":"Diabetes increases mortality after myocardial infarction by oxidizing CaMKII","volume":"123","author":"Luo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbi.2024.110949_bib56","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/CIRCRESAHA.120.316947","article-title":"CaMKII\u03b4C drives early adaptive Ca2+ change and late eccentric cardiac hypertrophy","volume":"127","author":"Ljubojevic-Holzer","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbi.2024.110949_bib57","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/01.RES.84.6.713","article-title":"Identification and expression of delta-isoforms of the multifunctional Ca2+\/calmodulin-dependent protein kinase in failing and nonfailing human myocardium","volume":"84","author":"Hoch","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbi.2024.110949_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.695401","article-title":"CaMKII inhibition is a novel therapeutic strategy to prevent diabetic cardiomyopathy","volume":"12","author":"Veitch","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2024.110949_bib59","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1475-2840-10-97","article-title":"Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis","volume":"10","author":"Kain","year":"2011","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.cbi.2024.110949_bib60","doi-asserted-by":"crossref","first-page":"E1133","DOI":"10.1152\/ajpendo.90944.2008","article-title":"Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein","volume":"296","author":"Chen","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cbi.2024.110949_bib61","doi-asserted-by":"crossref","first-page":"936","DOI":"10.2337\/diab.37.7.936","article-title":"Beneficial effects of verapamil in diabetic cardiomyopathy","volume":"37","author":"Afzal","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.cbi.2024.110949_bib62","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ceca.2018.06.003","article-title":"Dysfunction of SERCA pumps as novel mechanism of methylglyoxal cytotoxicity","volume":"74","author":"Zizkova","year":"2018","journal-title":"Cell Calcium"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724000954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724000954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T04:06:40Z","timestamp":1714104400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279724000954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":62,"alternative-id":["S0009279724000954"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2024.110949","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylglyoxal induces cardiac dysfunction through mechanisms involving altered intracellular calcium handling in the rat heart","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2024.110949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110949"}}