{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:25:17Z","timestamp":1793993117747,"version":"4.8.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.cbi.2024.111157","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T08:02:39Z","timestamp":1721808159000},"page":"111157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Jujuboside A through YY1\/CYP2E1 signaling alleviated type 2 diabetes-associated fatty liver disease by ameliorating hepatic lipid accumulation, inflammation, and oxidative stress"],"prefix":"10.1016","volume":"400","author":[{"given":"Wenjing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2024.111157_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113888","article-title":"Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.cbi.2024.111157_bib2","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1002\/ptr.6486","article-title":"Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db\/db mice","volume":"33","author":"Yang","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.cbi.2024.111157_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22157772","article-title":"Diabetes mellitus and cardiovascular diseases: nutraceutical interventions related to caloric restriction","volume":"22","author":"Senesi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2024.111157_bib4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nrendo.2011.72","article-title":"Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment","volume":"7","author":"Smith","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cbi.2024.111157_bib5","first-page":"494","article-title":"Jujuboside A inhibits oxidative stress damage and enhances immunomodulatory capacity of human umbilical cord mesenchymal stem cells through up-regulating Ido expression","volume":"20","author":"Chen","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.cbi.2024.111157_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jep.2018.04.045","article-title":"Therapeutic potential of root and stem bark of wild medicinal plant Ziziphus mauritiana (Lamk.) against silica induced toxicity in Wistar albino rats","volume":"224","author":"Dutta","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2024.111157_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clnesp.2022.03.043","article-title":"Effect of Ziziphus jujube on cardiometabolic factors and systemic inflammation in type 2 diabetic patients: a randomized controlled trial","volume":"49","author":"Farhadnejad","year":"2022","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.cbi.2024.111157_bib8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/ptr.5796","article-title":"Effect of Ziziphus jujube fruit infusion on lipid profiles, glycaemic index and antioxidant status in type 2 diabetic patients: a randomized controlled clinical trial","volume":"31","author":"Yazdanpanah","year":"2017","journal-title":"Phytother Res."},{"key":"10.1016\/j.cbi.2024.111157_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105723","article-title":"The novel FAT4 activator jujuboside A suppresses NSCLC tumorigenesis by activating HIPPO signaling and inhibiting YAP nuclear translocation","volume":"170","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2024.111157_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112697","article-title":"Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy","volume":"159","author":"Zhong","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2024.111157_bib11","first-page":"656","article-title":"Jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice through down-regulating the YY1\/TGF-\u03b21 signaling pathway","volume":"20","author":"Liu","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.cbi.2024.111157_bib12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1055\/s-0037-1607451","article-title":"Multifunctional YY1 in liver diseases","volume":"37","author":"Zhang","year":"2017","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.cbi.2024.111157_bib13","article-title":"YY1 lactylation aggravates autoimmune uveitis by enhancing microglial functions via inflammatory genes","author":"Huang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.cbi.2024.111157_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149985","article-title":"YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis","volume":"6","author":"Lin","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.cbi.2024.111157_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010034","article-title":"MiR-192-5p ameliorates hepatic lipid metabolism in non-alcoholic fatty liver disease by targeting Yy1","volume":"14","author":"Ma","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.cbi.2024.111157_bib16","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000928","article-title":"Multifaceted regulation of hepatic lipid metabolism by YY1","volume":"4","author":"Pan","year":"2021","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.cbi.2024.111157_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161962","article-title":"Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production","volume":"871","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111157_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12638","article-title":"Induction of SIRT1 by melatonin improves alcohol-mediated oxidative liver injury by disrupting the CRBN-YY1-CYP2E1 signaling pathway","volume":"68","author":"Lee","year":"2020","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.cbi.2024.111157_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154703","article-title":"Targeting mTOR\/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation","volume":"113","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2024.111157_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.freeradbiomed.2013.06.034","article-title":"A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3\u03b2 aggravates acetaminophen-induced hepatic protein nitration","volume":"65","author":"Yun","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2024.111157_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2023.07.011","article-title":"Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis","volume":"35","author":"Kuang","year":"2023","journal-title":"Cell Metabol."},{"key":"10.1016\/j.cbi.2024.111157_bib23","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.apsb.2022.02.004","article-title":"Crosstalk between CYP2E1 and PPAR\u03b1 substrates and agonists modulate adipose browning and obesity","volume":"12","author":"Zhang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cbi.2024.111157_bib24","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2024.111157_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2024.111157_bib26","first-page":"4295","article-title":"[Advances in pharmacological effects of jujuboside B]","volume":"48","author":"Dong","year":"2023","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.cbi.2024.111157_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5796","article-title":"An integrated liver, hippocampus and serum metabolomics based on UPLC-Q-TOF-MS revealed the therapeutical mechanism of Ziziphi Spinosae Semen in p-chlorophenylalanine-induced insomnia rats","volume":"38","author":"Chu","year":"2024","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.cbi.2024.111157_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11418-022-01648-9","article-title":"Hepatoprotective functions of jujuboside B","volume":"77","author":"Kim","year":"2023","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.cbi.2024.111157_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00204-021-03211-z","article-title":"Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose","volume":"96","author":"Akakpo","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2024.111157_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115810","article-title":"Jujuboside B alleviates acetaminophen-induced hepatotoxicity in mice by regulating Nrf2-STING signaling pathway","volume":"269","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111157_bib31","article-title":"Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study","volume":"384","author":"Kim","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.cbi.2024.111157_bib32","article-title":"The hypoglycemic activities and underlying mechanisms of two saponins-rich components from fried Ziziphus jujuba mill","volume":"67","author":"Li","year":"2023","journal-title":"Kernel, Mol Nutr Food Res"},{"key":"10.1016\/j.cbi.2024.111157_bib33","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/jpp\/rgad057","article-title":"Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice","volume":"75","author":"Du","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111157_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175451","article-title":"Jujuboside A attenuates sepsis-induced cardiomyopathy by inhibiting inflammation and regulating autophagy","volume":"947","author":"Wang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111157_bib35","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejphar.2014.05.041","article-title":"Jujuboside A, a neuroprotective agent from semen Ziziphi Spinosae ameliorates behavioral disorders of the dementia mouse model induced by A\u03b2 1-42","volume":"738","author":"Liu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111157_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136473","article-title":"Jujuboside a promotes proliferation and neuronal differentiation of APPswe-overexpressing neural stem cells by activating Wnt\/\u03b2-catenin signaling pathway","volume":"772","author":"Wang","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbi.2024.111157_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154659","article-title":"YY1 was indispensable for the alleviation of quercetin on diabetic nephropathy-associated tubulointerstitial inflammation","volume":"111","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2024.111157_bib38","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.freeradbiomed.2013.09.009","article-title":"CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis","volume":"65","author":"Abdelmegeed","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2024.111157_bib39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/hep.32538","article-title":"Intestinal peroxisome proliferator-activated receptor \u03b1-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis","volume":"77","author":"Yan","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2024.111157_bib40","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/er.2018-00064","article-title":"Molecular actions of PPAR\u03b1 in lipid metabolism and inflammation","volume":"39","author":"Bougarne","year":"2018","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cbi.2024.111157_bib41","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972400303X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972400303X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T05:37:28Z","timestamp":1723527448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927972400303X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":40,"alternative-id":["S000927972400303X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111157","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jujuboside A through YY1\/CYP2E1 signaling alleviated type 2 diabetes-associated fatty liver disease by ameliorating hepatic lipid accumulation, inflammation, and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111157"}}