{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:56:15Z","timestamp":1786985775342,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Malaysia Ministry of Higher Education","doi-asserted-by":"publisher","award":["FRGS\/1\/2019\/STG04\/UKM\/02\/6"],"award-info":[{"award-number":["FRGS\/1\/2019\/STG04\/UKM\/02\/6"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.cbi.2024.111264","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T05:44:55Z","timestamp":1728539095000},"page":"111264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Binding characteristics of the major kratom alkaloid, mitragynine, towards serum albumin: Spectroscopic, calorimetric, microscopic, and computational investigations"],"prefix":"10.1016","volume":"404","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8559-6251","authenticated-orcid":false,"given":"Khairul Azreena","family":"Bakar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Datt","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-2911","authenticated-orcid":false,"given":"Shevin Rizal","family":"Feroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2024.111264_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/medicines6010035","article-title":"Mitragyna speciosa: clinical, toxicological aspects and analysis in biological and non-biological samples","volume":"6","author":"Meireles","year":"2019","journal-title":"Medicines"},{"key":"10.1016\/j.cbi.2024.111264_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainresbull.2016.03.015","article-title":"Neurobiology of kratom and its main alkaloid mitragynine","volume":"126","author":"Suhaimi","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.cbi.2024.111264_bib3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00414-015-1279-y","article-title":"The pharmacology and toxicology of kratom: from traditional herb to drug of abuse","volume":"130","author":"Warner","year":"2016","journal-title":"Int. J. Legal Med."},{"key":"10.1016\/j.cbi.2024.111264_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neubiorev.2012.11.012","article-title":"From kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction","volume":"37","author":"Hassan","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cbi.2024.111264_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/adb.12185","article-title":"Abuse potential and adverse cognitive effects of mitragynine (kratom)","volume":"21","author":"Yusoff","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.cbi.2024.111264_bib6","doi-asserted-by":"crossref","first-page":"E195","DOI":"10.36076\/ppj.2017.1.E195","article-title":"Is kratom the new \u201clegal high\u201d on the block?: the case of an emerging opioid receptor agonist with substance abuse potential","volume":"20","author":"Chang-Chien","year":"2017","journal-title":"Pain Physician"},{"key":"10.1016\/j.cbi.2024.111264_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.amepre.2021.02.004","article-title":"Past-year kratom use in the U.S.: estimates from a nationally representative sample","volume":"61","author":"Palamar","year":"2021","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.cbi.2024.111264_bib8","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.1021\/jacs.6b00360","article-title":"Synthetic and receptor signaling explorations of the Mitragyna alkaloids: mitragynine as an atypical molecular framework for opioid receptor modulators","volume":"138","author":"Kruegel","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cbi.2024.111264_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpba.2017.05.020","article-title":"Evaluation of pharmacokinetics and blood-brain barrier permeability of mitragynine using in vivo microdialysis technique","volume":"143","author":"Kong","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.cbi.2024.111264_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2022.805986","article-title":"The chemical and pharmacological properties of mitragynine and its diastereomers: an insight review","volume":"13","author":"Karunakaran","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111264_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2020.107946","article-title":"Mitragynine, bioactive alkaloid of kratom, reduces chemotherapy-induced neuropathic pain in rats through \u03b1-adrenoceptor mechanism","volume":"209","author":"Foss","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.cbi.2024.111264_bib12","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nrd3287","article-title":"The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery","volume":"9","author":"Smith","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cbi.2024.111264_bib13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/jps.21916","article-title":"Significance of protein binding in pharmacokinetics and pharmacodynamics","volume":"99","author":"Schmidt","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.cbi.2024.111264_bib14","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1016\/j.bbagen.2013.05.005","article-title":"Albumin\u2013drug interaction and its clinical implication","volume":"1830","author":"Yamasaki","year":"2013","journal-title":"Biochim. Biophys. Acta - Gen. Subj."},{"key":"10.1016\/j.cbi.2024.111264_bib15","first-page":"193","article-title":"Serum albumin: clinical significance of drug binding and development as drug delivery vehicle","volume":"vol. 123","author":"Tayyab","year":"2021"},{"key":"10.1016\/j.cbi.2024.111264_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/anatox\/35.1.54","article-title":"A drug toxicity death involving propylhexedrine and mitragynine","volume":"35","author":"Holler","year":"2011","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.cbi.2024.111264_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/968786","article-title":"Following \u201cthe roots\u201d of kratom (Mitragyna speciosa): the evolution of an enhancer from a traditional use to increase work and productivity in Southeast Asia to a recreational psychoactive drug in Western countries","volume":"2015","author":"Cinosi","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.cbi.2024.111264_bib18","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3390\/ijms17040580","article-title":"Hepatotoxicity induced by \u201cthe 3Ks\u201d: kava, kratom and khat","volume":"17","author":"Pantano","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2024.111264_bib19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/ADM.0000000000000968","article-title":"A case of potential pharmacokinetic kratom-drug interactions resulting in toxicity and subsequent treatment of kratom use disorder with buprenorphine\/naloxone","volume":"16","author":"Brogdon","year":"2022","journal-title":"J. Addict. Med."},{"key":"10.1016\/j.cbi.2024.111264_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.molstruc.2013.09.053","article-title":"Clinical relevance of drug binding to plasma proteins","volume":"1077","author":"Ascenzi","year":"2014","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.cbi.2024.111264_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02879","article-title":"An overview of albumin and alpha-1-acid glycoprotein main characteristics: highlighting the roles of amino acids in binding kinetics and molecular interactions","volume":"5","author":"Bteich","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.cbi.2024.111264_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bpc.2013.06.004","article-title":"The location of the high- and low-affinity bilirubin-binding sites on serum albumin: ligand-competition analysis investigated by circular dichroism","volume":"180\u2013181","author":"Goncharova","year":"2013","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib23","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/pro.5560041120","article-title":"How to measure and predict the molar absorption coefficient of a protein","volume":"4","author":"Pace","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/j.cbi.2024.111264_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.112865","article-title":"Characterization of the interaction of diosgenin with human serum albumin and \u03b11-acid glycoprotein using biophysical and bioinformatic tools","volume":"306","author":"Bakar","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.cbi.2024.111264_bib25","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/es061491b","article-title":"UV degradation kinetics and modeling of pharmaceutical compounds in laboratory grade and surface water via direct and indirect photolysis at 254 nm","volume":"41","author":"Pereira","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2024.111264_bib26","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.bbapap.2017.07.017","article-title":"Hemin is able to disaggregate lysozyme amyloid fibrils into monomers","volume":"1865","author":"Sonavane","year":"2017","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.cbi.2024.111264_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117337","article-title":"A critical view on the analysis of fluorescence quenching data for determining ligand\u2013protein binding affinity","volume":"223","author":"Bakar","year":"2019","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.cbi.2024.111264_bib28","doi-asserted-by":"crossref","first-page":"W315","DOI":"10.1093\/nar\/gky497","article-title":"BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra","volume":"46","author":"Micsonai","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2024.111264_bib29","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/protein\/12.6.439","article-title":"Crystal structure of human serum albumin at 2.5 \u00c5 resolution","volume":"12","author":"Sugio","year":"1999","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.cbi.2024.111264_bib31","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera- A visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib32","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib33","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1107\/S0907444904011679","article-title":"Prodrg : a tool for high-throughput crystallography of protein\u2013ligand complexes","volume":"60","author":"Sch\u00fcttelkopf","year":"2004","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.cbi.2024.111264_bib34","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.carres.2008.12.025","article-title":"GROMOS96 43a1 performance on the characterization of glycoprotein conformational ensembles through molecular dynamics simulations","volume":"344","author":"Pol-Fachin","year":"2009","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.cbi.2024.111264_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139020","article-title":"New perspective into the interaction behavior explore of Nano-berberine with alpha-lactalbumin in the presence of beta-lactoglobulin: multi-spectroscopic and molecular dynamic investigations","volume":"1316","author":"Jouyaeian","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.cbi.2024.111264_bib36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/08927028808080941","article-title":"A leap-frog algorithm for stochastic dynamics","volume":"1","author":"Van Gunsteren","year":"1988","journal-title":"Mol. Simul."},{"key":"10.1016\/j.cbi.2024.111264_bib37","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: a linear constraint solver for molecular simulations","volume":"18","author":"Hess","year":"1997","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib38","first-page":"10089","volume":"98","author":"Darden","year":"1993","journal-title":"Particle mesh Ewald : An Nlog (N) method for Ewald sums in large systems"},{"key":"10.1016\/j.cbi.2024.111264_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.cbi.2024.111264_bib40","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: a new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.cbi.2024.111264_bib41","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/acsfoodscitech.3c00125","article-title":"Interaction of two commercial azobenzene food dyes, amaranth and new coccine, with human serum albumin: biophysical characterization","volume":"3","author":"Chaves","year":"2023","journal-title":"ACS Food Sci. Technol."},{"key":"10.1016\/j.cbi.2024.111264_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jinorgbio.2015.03.001","article-title":"Properties of the indole ring in metal complexes. A comparison with the phenol ring","volume":"148","author":"Shimazaki","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.cbi.2024.111264_bib43","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"key":"10.1016\/j.cbi.2024.111264_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2023.107140","article-title":"Interaction mechanism of a cysteine protease inhibitor, odanacatib, with human serum albumin: in vitro and bioinformatics studies","volume":"305","author":"Asngari","year":"2024","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib45","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1055\/s-0034-1382760","article-title":"Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline","volume":"80","author":"Manda","year":"2014","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2024.111264_bib46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/acs.jmedchem.9b01465","article-title":"Investigation of the adrenergic and opioid binding affinities, metabolic stability, plasma protein binding properties, and functional effects of selected indole-based kratom alkaloids","volume":"63","author":"Obeng","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib47","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/adb.12661","article-title":"Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies","volume":"24","author":"Yusof","year":"2019","journal-title":"Addict. Biol."},{"key":"10.1016\/j.cbi.2024.111264_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.123472","article-title":"New perspective of the ternary complex of nano-curcumin with \u03b2-lactoglobulin in the presence of \u03b1-lactalbumin: spectroscopic and molecular dynamic investigations","volume":"392","author":"Tabasi","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.cbi.2024.111264_bib49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1590\/s1984-82502016000300010","article-title":"Characteristics and thermodynamics of the interaction of 6-shogaol with human serum albumin as studied by isothermal titration calorimetry","volume":"52","author":"Feroz","year":"2016","journal-title":"Brazilian J. Pharm. Sci."},{"key":"10.1016\/j.cbi.2024.111264_bib50","series-title":"Protein-Ligand Interactions: Methods and Applications, Methods in Molecular Biology","first-page":"211","article-title":"Circular and linear dichroism spectroscopy for the study of protein\u2013ligand interactions","author":"Daviter","year":"2013"},{"key":"10.1016\/j.cbi.2024.111264_bib51","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1021\/mp400027q","article-title":"Subdomain IB Is the third major drug binding region of human serum albumin: toward the three-sites model","volume":"10","author":"Zsila","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.cbi.2024.111264_bib52","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.2174\/0929867324666170202152134","article-title":"Displacement of drugs from human serum albumin: from molecular interactions to clinical significance","volume":"24","author":"Rimac","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.cbi.2024.111264_bib53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.5114\/bta.2020.94770","article-title":"Molecular docking and binding interaction between psychedelic drugs and human serum albumin","volume":"101","author":"Khastar","year":"2020","journal-title":"Biotechnologia"},{"key":"10.1016\/j.cbi.2024.111264_bib54","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3390\/molecules23081899","article-title":"Binding affinity via docking: fact or fiction","volume":"23","author":"Pantsar","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2024.111264_bib55","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.3390\/molecules28072979","article-title":"Detailed experimental and in silico investigation of indomethacin binding with human serum albumin considering primary and secondary binding sites","volume":"28","author":"Ali","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2024.111264_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules27030797","article-title":"Mechanistic insight into binding of huperzine a with human serum albumin: computational and spectroscopic approaches","volume":"27","author":"Shamsi","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2024.111264_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123815","article-title":"Spectroscopy and molecular simulation on the interaction of Nano-Kaempferol prepared by oil-in-water with two carrier proteins: an investigation of protein\u2013protein interaction","volume":"309","author":"Kaffash","year":"2024","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.cbi.2024.111264_bib58","first-page":"423","article-title":"Size of a human serum albumin molecule in solution","volume":"46","author":"Kiselev","year":"2001","journal-title":"Biofizika"},{"key":"10.1016\/j.cbi.2024.111264_bib59","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1080\/07391102.2018.1528181","article-title":"Exploration of binding studies of \u03b2-oxalyldiamino propionic acid (\u03b2-ODAP), a non-protein amino acid with human serum albumin-biophysical and computational approach","volume":"37","author":"Nagati","year":"2019","journal-title":"J. Biomol. Struct. Dyn."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724004101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724004101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:09:30Z","timestamp":1731499770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279724004101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":59,"alternative-id":["S0009279724004101"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111264","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Binding characteristics of the major kratom alkaloid, mitragynine, towards serum albumin: Spectroscopic, calorimetric, microscopic, and computational investigations","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111264"}}