{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:22:56Z","timestamp":1770906176969,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.cbi.2024.111267","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T17:16:20Z","timestamp":1728666980000},"page":"111267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Isavuconazonium sulfate induces heart development defects in zebrafish larvae by upregulation of oxidative stress"],"prefix":"10.1016","volume":"404","author":[{"given":"Qiang","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiejun","family":"liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weitao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fasheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-4996","authenticated-orcid":false,"given":"Zigang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2024.111267_bib1","doi-asserted-by":"crossref","first-page":"23375","DOI":"10.1007\/s11356-020-08775-4","article-title":"Pollutant removal and the health effects of environmental pollution","volume":"27","author":"Kallel","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.cbi.2024.111267_bib2","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/wer.1404","article-title":"Fate of environmental pollutants: a review","volume":"92","author":"Aryal","year":"2020","journal-title":"Water Environ. Res."},{"key":"10.1016\/j.cbi.2024.111267_bib3","first-page":"928","article-title":"Ecological impact of pharmaceutical pollutants and options of river health improvements - a risk analysis-based approach","author":"Singh","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111267_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2022.135798","article-title":"Efficient detection and treatment of pharmaceutical contaminants to produce clean water for better health and environmental","volume":"387","author":"Letsoalo","year":"2023","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.cbi.2024.111267_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the world's rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2024.111267_bib6","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/jcph.2212","article-title":"Population pharmacokinetics, exposure\u2013safety, and probability of target attainment analyses for isavuconazole in Japanese patients with deep\u2010seated mycoses","volume":"63","author":"Shirae","year":"2023","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111267_bib7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/ijpp.12302","article-title":"Isavuconazonium sulfate: a triazole prodrug for invasive fungal infections","volume":"25","author":"Murrell","year":"2017","journal-title":"Int. J. Pharm. Pract."},{"key":"10.1016\/j.cbi.2024.111267_bib8","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/cid\/civ571","article-title":"Isavuconazole: a new broad-spectrum triazole antifungal agent","volume":"61","author":"Miceli","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cbi.2024.111267_bib9","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/jac\/dkae139","article-title":"Isavuconazole as prophylaxis and therapy for invasive fungal diseases: a real-life observational study","volume":"79","author":"Erg\u00fcn","year":"2024","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cbi.2024.111267_bib10","article-title":"Isavuconazole: mechanism of action, clinical efficacy, and resistance","volume":"6","author":"Ellsworth","year":"2020","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.cbi.2024.111267_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.106748","article-title":"Isavuconazole dosing in Asian patients with invasive mould infections: is there a role for therapeutic drug monitoring?","volume":"61","author":"Chan","year":"2023","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.cbi.2024.111267_bib12","first-page":"149","article-title":"Clinical hepatotoxicity associated with antifungal agents","volume":"16","author":"Kyriakidis","year":"2017","journal-title":"Expet Opin. Drug Saf."},{"key":"10.1016\/j.cbi.2024.111267_bib13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/bcp.12178","article-title":"Risk of oral antifungal agent-induced liver injury in Taiwanese","volume":"77","author":"Kao","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111267_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113926","article-title":"Exposure to diclofop-methyl induces cardiac developmental toxicity in zebrafish embryos","volume":"259","author":"Cao","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111267_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124753","article-title":"Characterization of boscalid-induced oxidative stress and neurodevelopmental toxicity in zebrafish embryos","volume":"238","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2024.111267_bib16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.envpol.2017.11.095","article-title":"Exposure to acrylamide induces cardiac developmental toxicity in zebrafish during cardiogenesis","volume":"234","author":"Huang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111267_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111339","article-title":"Famoxadone-cymoxanil induced cardiotoxicity in zebrafish embryos","volume":"205","author":"Huang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111267_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/35047564","article-title":"Zebrafish genetics and vertebrate heart formation","volume":"2","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cbi.2024.111267_bib19","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cbi.2024.111267_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbrc.2016.03.051","article-title":"Noncanonical function of threonyl-tRNA synthetase regulates vascular development in zebrafish","volume":"473","author":"Cao","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2024.111267_bib21","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.celrep.2019.01.061","article-title":"Germline stem cells drive ovary regeneration in zebrafish","volume":"26","author":"Cao","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cbi.2024.111267_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113752","article-title":"Low trifloxystrobin-tebuconazole concentrations induce cardiac and developmental toxicity in zebrafish by regulating notch mediated\u2010oxidative stress generation","volume":"241","author":"Jia","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111267_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152951","article-title":"Lenvatinib exposure induces hepatotoxicity in zebrafish via inhibiting Wnt signaling","volume":"462","author":"Huang","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2024.111267_bib24","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/tox.23485","article-title":"Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated-oxidative stress generation","volume":"37","author":"Liu","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbi.2024.111267_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127860","article-title":"Development toxicity and cardiotoxicity in zebrafish from exposure to iprodione","volume":"263","author":"Wei","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2024.111267_bib26","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.1226850","article-title":"Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations","volume":"339","author":"Brodin","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cbi.2024.111267_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2019.105253","article-title":"Exposure to diclofop-methyl induces immunotoxicity and behavioral abnormalities in zebrafish embryos","volume":"214","author":"Cao","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbi.2024.111267_bib28","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.chemosphere.2018.12.199","article-title":"Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages","volume":"220","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2024.111267_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114865","article-title":"Resveratrol ameliorates penconazole-induced cardiotoxicity by inhibition of oxidative stress and apoptosis in zebrafish larvae","volume":"256","author":"Jiang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111267_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098077","article-title":"A descriptive whole-genome transcriptomics study in a stem cell-based tool predicts multiple tissue-specific beneficial potential and molecular targets of carnosic acid","volume":"24","author":"Ferdousi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2024.111267_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.849603","article-title":"Blood flow disturbance and morphological alterations following the right atrial ligation in the chick embryo","volume":"13","author":"Alser","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbi.2024.111267_bib32","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1161\/ATVBAHA.115.307087","article-title":"Aminoacyl-transfer RNA synthetase deficiency promotes angiogenesis via the unfolded protein response pathway","volume":"36","author":"Castranova","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cbi.2024.111267_bib33","article-title":"Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish","volume":"vol. 43","author":"Lv","year":"2020"},{"key":"10.1016\/j.cbi.2024.111267_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38889","article-title":"The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling","volume":"7","author":"Rasouli","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.cbi.2024.111267_bib35","article-title":"Associations of GATA4 genetic mutations with the risk of congenital heart disease","volume":"96","author":"Zhang","year":"2017","journal-title":"A meta-analysis, Medicine (Baltimore)"},{"key":"10.1016\/j.cbi.2024.111267_bib36","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1073\/pnas.0401833101","article-title":"Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity","volume":"101","author":"Aries","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2024.111267_bib37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","article-title":"Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway","volume":"19","author":"Holze","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cbi.2024.111267_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225342","article-title":"Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: recent advances and future directions","volume":"25","author":"Chang","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2024.111267_bib39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cbi.2017.11.012","article-title":"Astaxanthin-antioxidant impact on excessive Reactive Oxygen Species generation induced by ischemia and reperfusion injury","volume":"279","author":"Zuluaga","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2024.111267_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116539","article-title":"Bifenazate exposure induces cardiotoxicity in zebrafish embryos","volume":"274","author":"Ma","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111267_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.phrs.2016.04.010","article-title":"Notch in fibrosis and as a target of anti-fibrotic therapy","volume":"108","author":"Hu","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2024.111267_bib42","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-018-0100-2","article-title":"Notch and interacting signalling pathways in cardiac development, disease, and regeneration","volume":"15","author":"MacGrogan","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cbi.2024.111267_bib43","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.cbi.2024.111267_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.656364","article-title":"Aspects of the tumor microenvironment involved in immune resistance and drug resistance","volume":"12","author":"Khalaf","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbi.2024.111267_bib45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00246-008-9368-z","article-title":"Notch signaling in cardiac development and disease","volume":"30","author":"de la Pompa","year":"2009","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.cbi.2024.111267_bib46","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3389\/fphys.2020.00669","article-title":"Notch3 modulates cardiac fibroblast proliferation, apoptosis, and fibroblast to myofibroblast transition via negative regulation of the RhoA\/ROCK\/Hif1alpha Axis","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbi.2024.111267_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102388","article-title":"Multiple pathways coordinating reprogramming of endothelial cells into osteoblasts by BMP4","volume":"24","author":"Yu","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.cbi.2024.111267_bib48","volume":"vol. 9","author":"Ben Ayed","year":"2021"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724004137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724004137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:57:06Z","timestamp":1730825826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279724004137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":48,"alternative-id":["S0009279724004137"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111267","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isavuconazonium sulfate induces heart development defects in zebrafish larvae by upregulation of oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111267"}}