{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:59:57Z","timestamp":1785473997583,"version":"3.56.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005319","name":"National Central University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.cbi.2024.111291","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T06:42:29Z","timestamp":1729838549000},"page":"111291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Enhancing cisplatin efficacy in hepatocellular carcinoma with selenocystine: The suppression of DNA repair and inhibition of proliferation in hepatoma cells"],"prefix":"10.1016","volume":"405","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-2939","authenticated-orcid":false,"given":"Pei-Yi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulfah","family":"Hasanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8240-7853","authenticated-orcid":false,"given":"Yueh-Hsia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-0884","authenticated-orcid":false,"given":"Chien-Chin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ssu-Ching","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cbi.2024.111291_bib1","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.3390\/cancers14112798","article-title":"Emerging therapies for hepatocellular carcinoma (HCC)","volume":"14","author":"Chakraborty","year":"2022","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.cbi.2024.111291_bib2","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.3390\/ijms22115801","article-title":"Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review","volume":"22","author":"Oura","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cbi.2024.111291_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40364-021-00350-4","article-title":"Recent advances in systemic therapy for hepatocellular carcinoma","volume":"10","author":"Zhang","year":"2022","journal-title":"Biomark. Res."},{"key":"10.1016\/j.cbi.2024.111291_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5391977","article-title":"miR-651-3p enhances the sensitivity of hepatocellular carcinoma to cisplatin via targeting ATG3-mediated cell autophagy","volume":"2021","author":"Zou","year":"2021","journal-title":"J Oncol"},{"issue":"1","key":"10.1016\/j.cbi.2024.111291_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1124\/mol.106.022244","article-title":"High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity","volume":"70","author":"Thomas","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"suppl 1","key":"10.1016\/j.cbi.2024.111291_bib6","article-title":"DNA repair pathways and cisplatin resistance: an intimate relationship","volume":"73","author":"Rocha","year":"2018","journal-title":"Clinics"},{"issue":"15","key":"10.1016\/j.cbi.2024.111291_bib7","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.3390\/ijms22158199","article-title":"Targeting DNA damage response and repair to enhance therapeutic index in cisplatin-based cancer treatment","volume":"22","author":"Kiss","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2024.111291_bib8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.freeradbiomed.2013.07.002","article-title":"Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway","volume":"65","author":"Fan","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.cbi.2024.111291_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.132","article-title":"Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo","volume":"5","author":"Fan","year":"2014","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cbi.2024.111291_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/md11010050","article-title":"Fucoxanthin enhances cisplatin-induced cytotoxicity via NF\u03baB-mediated pathway and downregulates DNA repair gene expression in human hepatoma HepG2 cells","volume":"11","author":"Liu","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.cbi.2024.111291_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110046","article-title":"Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells","volume":"365","author":"Wahyuni","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2024.111291_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152441","article-title":"4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: the role of miR-630 in downregulating RAD18 and MCM8","volume":"440","author":"Lin","year":"2020","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.cbi.2024.111291_bib36","first-page":"1642","article-title":"Selenium compounds as therapeutic agents in cancer","volume":"1850","author":"Fernandes","year":"2015","journal-title":"Acta"},{"key":"10.1016\/j.cbi.2024.111291_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107175","article-title":"Cisplatin-based combination therapies: their efficacy with a focus on ginsenosides co-administration","volume":"203","author":"Li","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.cbi.2024.111291_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171582","article-title":"Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay","volume":"12","author":"Ji","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.cbi.2024.111291_bib14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/10915818231182114","article-title":"Transcription factor E2F8 promotes cisplatin resistance in hepatocellular carcinoma by regulating DNA damage via NUSAP1","volume":"42","author":"Kong","year":"2023","journal-title":"Int. J. Toxicol."},{"issue":"13","key":"10.1016\/j.cbi.2024.111291_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310858","article-title":"Cisplatin in liver cancer therapy","volume":"24","author":"Hamaya","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.cbi.2024.111291_bib16","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1248\/bpb.b17-00457","article-title":"Caffeine has a synergistic anticancer effect with cisplatin via inhibiting Fanconi anemia group D2 protein monoubiquitination in hepatocellular carcinoma cells","volume":"40","author":"Oda","year":"2017","journal-title":"Biol. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.cbi.2024.111291_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1248\/bpb.35.400","article-title":"Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells","volume":"35","author":"Kawano","year":"2012","journal-title":"Biol. Pharm. Bull."},{"issue":"19","key":"10.1016\/j.cbi.2024.111291_bib18","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.3390\/cancers14194553","article-title":"Synergistic effects of sanglifehrin-based cyclophilin inhibitor NV651 with cisplatin in hepatocellular carcinoma","volume":"14","author":"Sim\u00f3n Serrano","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.cbi.2024.111291_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrgentox.2021.503352","article-title":"Differential effects of cisplatin combined with the flavonoid apigenin on HepG2, Hep3B, and Huh7 liver cancer cell lines","volume":"866","author":"Papachristou","year":"2021","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"issue":"6","key":"10.1016\/j.cbi.2024.111291_bib20","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.tiv.2006.01.004","article-title":"A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage","volume":"20","author":"Yu","year":"2006","journal-title":"Toxicol. Vitro"},{"issue":"3","key":"10.1016\/j.cbi.2024.111291_bib21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/jrr\/rrw001","article-title":"Differences in quantification of DNA double-strand breaks assessed by 53BP1\/\u03b3H2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine","volume":"57","author":"Kurashige","year":"2016","journal-title":"J. Radiat. Res."},{"issue":"1","key":"10.1016\/j.cbi.2024.111291_bib22","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1080\/21655979.2021.1938470","article-title":"Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma","volume":"12","author":"Xu","year":"2021","journal-title":"Bioengineered"},{"issue":"8","key":"10.1016\/j.cbi.2024.111291_bib23","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.3390\/ijms22084134","article-title":"The multifaceted roles of ku70\/80","volume":"22","author":"Zahid","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"27","key":"10.1016\/j.cbi.2024.111291_bib24","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1074\/jbc.TM117.000374","article-title":"Nonhomologous DNA end-joining for repair of DNA double-strand breaks","volume":"293","author":"Pannunzio","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cbi.2024.111291_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3727\/096504018X15179694020751","article-title":"Silencing Artemis enhances colorectal cancer cell sensitivity to DNA-damaging agents","volume":"27","author":"Liu","year":"2018","journal-title":"Oncol. Res."},{"issue":"6641","key":"10.1016\/j.cbi.2024.111291_bib26","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/41358","article-title":"Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells","volume":"388","author":"Grawunder","year":"1997","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.cbi.2024.111291_bib27","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1093\/nar\/gkn552","article-title":"Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF","volume":"36","author":"Jayaram","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"50","key":"10.1016\/j.cbi.2024.111291_bib28","doi-asserted-by":"crossref","first-page":"87955","DOI":"10.18632\/oncotarget.21360","article-title":"Prognostic significance of XRCC4 expression in hepatocellular carcinoma","volume":"8","author":"Lu","year":"2017","journal-title":"Oncotarget"},{"issue":"22","key":"10.1016\/j.cbi.2024.111291_bib29","doi-asserted-by":"crossref","first-page":"10574","DOI":"10.1021\/jf802125t","article-title":"Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation","volume":"56","author":"Chen","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.cbi.2024.111291_bib30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.biopha.2008.03.009","article-title":"Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells","volume":"63","author":"Chen","year":"2009","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.cbi.2024.111291_bib31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/bcpt.12207","article-title":"Selenium cytotoxicity in cancer","volume":"114","author":"Wallenberg","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.cbi.2024.111291_bib32","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1038\/s41598-017-06979-2","article-title":"Selenocysteine induces apoptosis in human glioma cells: evidence for TrxR1-targeted inhibition and signaling crosstalk","volume":"7","author":"Fan","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cbi.2024.111291_bib33","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41419-022-05512-2","article-title":"Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis","volume":"13","author":"Hsu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"20","key":"10.1016\/j.cbi.2024.111291_bib34","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1158\/0008-5472.CAN-13-1117","article-title":"Redox imbalance and biochemical changes in cancer","volume":"73","author":"Jorgenson","year":"2013","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.cbi.2024.111291_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26082382","article-title":"Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies","volume":"26","author":"Mirzaei","year":"2021","journal-title":"Molecules"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972400437X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972400437X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T17:11:21Z","timestamp":1733677881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927972400437X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":37,"alternative-id":["S000927972400437X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111291","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing cisplatin efficacy in hepatocellular carcinoma with selenocystine: The suppression of DNA repair and inhibition of proliferation in hepatoma cells","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111291"}}