{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:48:56Z","timestamp":1793951336087,"version":"4.8.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872623"],"award-info":[{"award-number":["81872623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023-MS-269"],"award-info":[{"award-number":["2023-MS-269"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.cbi.2024.111310","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T20:59:35Z","timestamp":1731617975000},"page":"111310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Exploring the nephrotoxicity and molecular mechanisms of Di-2-ethylhexyl phthalate: A comprehensive review"],"prefix":"10.1016","volume":"405","author":[{"given":"Yun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1213-437X","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2024.111310_bib1","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1021\/es505233b","article-title":"Occurrence, fate, behavior and ecotoxicological state of phthalates in different environmental matrices","volume":"49","author":"Net","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2024.111310_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/ina.13026","article-title":"Dibutyl phthalate exposure alters T-cell subsets in blood from allergen-sensitized volunteers","volume":"32","author":"Maestre-Batlle","year":"2022","journal-title":"Indoor Air"},{"key":"10.1016\/j.cbi.2024.111310_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106987","article-title":"Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid","volume":"158","author":"Br\u00e4uner","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116394","article-title":"Plasticizer contamination in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hong Kong","volume":"271","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111310_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134573","article-title":"Diethylhexyl phthalate (DEHP) emission to indoor air and transfer to house dust from a PVC sheet","volume":"711","author":"Shinohara","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111310_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121957","article-title":"Phthalate exposure and the metabolic syndrome: a systematic review and meta-analysis","volume":"333","author":"M\u00e9rida","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111310_bib7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/10408444.2020.1816896","article-title":"An update on the hazard of and exposure to diethyl hexyl phthalate (DEHP) alternatives used in medical devices","volume":"50","author":"Den Braver-Sewradj","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/antiox12020477","article-title":"Di-(2-ethylhexyl) phthalate limits the lipid-lowering effects of simvastatin by promoting protein degradation of low-density lipoprotein receptor: role of ppar\u03b3-PCSK9 and lxr\u03b1-IDOL signaling pathways","volume":"12","author":"Guo","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbi.2024.111310_bib9","series-title":"Toxicological Profile for Di(2-Ethylhexyl)Phthalate (DEHP)","year":"2022"},{"key":"10.1016\/j.cbi.2024.111310_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1289\/ehp.5658","article-title":"Mechanisms of phthalate ester toxicity in the female reproductive system","volume":"111","author":"Lovekamp-Swan","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2024.111310_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cccn.2005.02.019","article-title":"Evaluation and analysis of exposure levels of di(2-ethylhexyl) phthalate from blood bags","volume":"358","author":"Inoue","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbi.2024.111310_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2011","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.cbi.2024.111310_bib13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.toxlet.2012.05.023","article-title":"Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin\u2013angiotensin system in offspring","volume":"212","author":"Wei","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2024.111310_bib14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/kfy094","article-title":"Plasticizer di-(2-Ethylhexyl)Phthalate induces epithelial-to-mesenchymal transition and renal fibrosis in vitro and in vivo","volume":"164","author":"Wu","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2024.111310_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112836","article-title":"The novel role of the aquaporin water channel in lycopene preventing DEHP-induced renal ionic homeostasis disturbance in mice","volume":"226","author":"Jiang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111310_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147371","article-title":"The effects of phthalate ester exposure on human health: a review","volume":"786","author":"Chang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111310_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13058-021-01419-6","article-title":"Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study","volume":"23","author":"Wu","year":"2021","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cbi.2024.111310_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113593","article-title":"Exposure to DEHP or its metabolite MEHP promotes progesterone secretion and inhibits proliferation in mouse placenta or JEG-3 cells","volume":"257","author":"Zhang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111310_bib19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/15376516.2020.1758980","article-title":"The implication of mitochondrial dysfunction and mitochondrial oxidative damage in Di (2 ethylhexyl) phthalate induced nephrotoxicity in both in vivo and in vitro models","volume":"30","author":"Ashari","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.cbi.2024.111310_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097607","article-title":"Mono-(2-Ethylhexyl) phthalate induces injury in human umbilical vein endothelial cells","volume":"9","author":"Ban","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2024.111310_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.129740","article-title":"Exposure to phthalates DEHP and DINP May lead to oxidative damage and lipidomic disruptions in mouse kidney","volume":"271","author":"Gu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2024.111310_bib22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.envint.2014.08.005","article-title":"Concentrations of phthalates and bisphenol A in Norwegian foods and beverages and estimated dietary exposure in adults","volume":"73","author":"Sakhi","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/00498258509045356","article-title":"Excretion and metabolism of di(2-ethylhexyl)-phthalate in man","volume":"15","author":"Schmid","year":"1985","journal-title":"Xenobiotica"},{"key":"10.1016\/j.cbi.2024.111310_bib24","unstructured":"P.W. Albro, Absorption, metabolism, and excretion of di(2-ethylhexyl) phthalate by rats and mice., (n.d.) 6."},{"key":"10.1016\/j.cbi.2024.111310_bib25","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1021\/tx400170t","article-title":"Interaction of phthalates and phenoxy acid herbicide environmental pollutants with intestinal intracellular lipid binding proteins","volume":"26","author":"Carbone","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1289\/ehp.82453","article-title":"Overview of phthalate ester pharmacokinetics in mammalian species","volume":"45","author":"Kluwe","year":"1982","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2024.111310_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cccn.2005.05.003","article-title":"Monitoring phthalate exposure in humans","volume":"361","author":"Latini","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbi.2024.111310_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tox.2004.11.013","article-title":"Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate","volume":"208","author":"Stroheker","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2024.111310_bib29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2605.2005.00607.x","article-title":"Di(2\u2010ethylhexyl)phthalate (DEHP): human metabolism and internal exposure \u2013 an update and latest results","volume":"29","author":"Koch","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.cbi.2024.111310_bib30","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1021\/ac000422r","article-title":"Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS\/MS","volume":"72","author":"Blount","year":"2000","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cbi.2024.111310_bib31","first-page":"299","article-title":"Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP) in rats and marmosets: extrapolation of effects in rodents to man","volume":"65","author":"Rhodes","year":"1986","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2024.111310_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.chemosphere.2014.05.053","article-title":"Health hazard assessment of occupationally di-(2-ethylhexyl)-phthalate-exposed workers in China","volume":"120","author":"Wang","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2024.111310_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115881","article-title":"Association of phthalate exposure with all-cause mortality across renal function status: the U.S. National Health and Nutrition Examination Survey, 2005-2018","volume":"270","author":"Tao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111310_bib34","first-page":"4667","article-title":"Evaluation of renal function in children with congenital scoliosis and congenital anomalies of the kidney and urinary tract","volume":"24","author":"Gao","year":"2018","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.cbi.2024.111310_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113733","article-title":"The independent and interactive effects of phthalates exposure and hypertension on the indicators of early renal injury in US adults: evidence from NHANES 2001\u20132004","volume":"213","author":"Liu","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.cbi.2024.111310_bib36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.envpol.2018.10.044","article-title":"Association between urinary concentration of phthalate metabolites and impaired renal function in Shanghai adults","volume":"245","author":"Chen","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111310_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106585","article-title":"Xenoestrogen exposure and kidney function in the general population: results of a community-based study by laboratory tests and questionnaire-based interviewing","volume":"155","author":"Chen","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2024.104379","article-title":"Long-term impacts of endocrine-disrupting chemicals exposure on kidney function: a community-based cohort study","volume":"106","author":"Chen","year":"2024","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111310_bib39","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2215\/CJN.04570413","article-title":"Dietary phthalates and low-grade albuminuria in US children and adolescents","volume":"9","author":"Trasande","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cbi.2024.111310_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114453","article-title":"Phthalate metabolite concentrations and effects on albuminuria in the US population","volume":"249","author":"Zhao","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111310_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.envint.2016.01.015","article-title":"Intake of phthalate-tainted foods and microalbuminuria in children: the 2011 Taiwan food scandal","volume":"89\u201390","author":"Tsai","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.envpol.2017.12.107","article-title":"Interaction of melamine and di-(2-ethylhexyl) phthalate exposure on markers of early renal damage in children: the 2011 Taiwan food scandal","volume":"235","author":"Wu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111310_bib43","article-title":"Phthalate exposure increased the risk of early renal impairment in Taiwanese without type 2 diabetes mellitus","volume":"224","author":"Liao","year":"2020","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.cbi.2024.111310_bib44","doi-asserted-by":"crossref","first-page":"13754","DOI":"10.1021\/es403141u","article-title":"Temporal changes of urinary oxidative metabolites of di(2-ethylhexyl)phthalate after the 2011 phthalate incident in Taiwanese children: findings of a six month follow-up","volume":"47","author":"Wu","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2024.111310_bib45","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2019.01.028","article-title":"Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women","volume":"124","author":"Kang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib46","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1210\/jc.2018-01797","article-title":"Phthalates exposure as determinant of albuminuria in subjects with type 2 diabetes: a cross-sectional study","volume":"104","author":"Mengozzi","year":"2019","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.cbi.2024.111310_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105877","article-title":"Association of exposure to phthalates and environmental phenolics with markers of kidney function: Korean National Environmental Health Survey (KoNEHS) 2015\u20132017","volume":"143","author":"Lee","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160208","article-title":"Relationship between phthalates exposures and hyperuricemia in U.S. general population, a multi-cycle study of NHANES 2007\u20132016","volume":"859","author":"Tan","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111310_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167039","article-title":"C\/EBP\u03b1 aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells","volume":"1870","author":"Xia","year":"2024","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.cbi.2024.111310_bib50","doi-asserted-by":"crossref","first-page":"F827","DOI":"10.1152\/ajprenal.00262.2023","article-title":"TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells","volume":"326","author":"Bradford","year":"2024","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.cbi.2024.111310_bib51","doi-asserted-by":"crossref","first-page":"324","DOI":"10.7150\/thno.63735","article-title":"Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy","volume":"12","author":"Jiang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.cbi.2024.111310_bib52","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1681\/ASN.2021101293","article-title":"Mechanisms and models of kidney tubular necrosis and nephron loss","volume":"33","author":"Maremonti","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cbi.2024.111310_bib53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2016.08.035","article-title":"Intracellular regulation of TNF activity in health and disease","volume":"101","author":"Varfolomeev","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.cbi.2024.111310_bib54","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/toxics11090742","article-title":"Lutein modulates oxidative stress, inflammatory and apoptotic biomarkers related to di-(2-ethylhexyl) phthalate (DEHP) hepato-nephrotoxicity in male rats: role of nuclear factor kappa B","volume":"11","author":"Gad El-Karim","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.cbi.2024.111310_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104857","article-title":"PINK1\/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling","volume":"66","author":"Duan","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.cbi.2024.111310_bib56","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1021\/acs.jafc.2c08351","article-title":"Lycopene attenuates di(2-ethylhexyl) phthalate-induced mitochondrial damage and inflammation in kidney via cGAS\u2013STING signaling","volume":"71","author":"Li","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2024.111310_bib57","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/tox.22774","article-title":"Di (2\u2010ethylhexyl) phthalate induces cytotoxicity in HEK\u2010293 cell line, implication of the Nrf\u20102\/HO\u20101 antioxidant pathway","volume":"34","author":"Amara","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib58","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/sj.cdd.4401975","article-title":"Proapoptotic multidomain Bcl-2\/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities","volume":"13","author":"Reed","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cbi.2024.111310_bib59","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s12192-020-01127-8","article-title":"Effect of di(2-ethylhexyl) phthalate on Nrf2-regulated glutathione homeostasis in mouse kidney","volume":"25","author":"Amara","year":"2020","journal-title":"Cell Stress & Chaperones"},{"key":"10.1016\/j.cbi.2024.111310_bib60","article-title":"Molecular mechanisms and physiological functions of autophagy in kidney diseases","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111310_bib61","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/15548627.2022.2072054","article-title":"Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis","volume":"19","author":"Livingston","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.cbi.2024.111310_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176715","article-title":"Acteoside delays the fibrosis process of diabetic nephropathy by anti-oxidation and regulating the autophagy-lysosome pathway","author":"Zhou","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111310_bib63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41419-020-03362-4","article-title":"Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI","volume":"12","author":"Chen","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2024.111310_bib64","first-page":"198","article-title":"The metabolic modulator PGC-1\u03b1 in cancer","volume":"9","author":"Bost","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cbi.2024.111310_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113521","article-title":"Combined exposure to di(2-ethylhexyl) phthalate and polystyrene microplastics induced renal autophagy through the ROS\/AMPK\/ULK1 pathway","volume":"171","author":"Sun","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170724","article-title":"Di (2-ethylhexyl) phthalate induced lipophagy-related renal ferroptosis in quail (Coturnix japonica)","volume":"919","author":"Zhu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111310_bib67","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cbi.2024.111310_bib68","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"IJMS"},{"key":"10.1016\/j.cbi.2024.111310_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112818","article-title":"DEHP-induced mitophagy and mitochondrial damage in the heart are associated with dysregulated mitochondrial biogenesis","volume":"161","author":"Zhang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116103","article-title":"Mitochondrial dysfunction mediated by thioredoxin-interacting protein: A crucial determinant in di(2-ethylhexyl) phthalate-induced liver failure","volume":"272","author":"Xu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111310_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105751","article-title":"Mediating role of oxidative\/nitrosative stress biomarkers in the associations between phthalate exposure and thyroid function in Taiwanese adults","volume":"140","author":"Huang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib72","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/tox.24029","article-title":"Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K\/AKT pathway","volume":"39","author":"Chen","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib73","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2016.6665","article-title":"Oxidant mechanisms in renal injury and disease","volume":"25","author":"Ratliff","year":"2016","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.cbi.2024.111310_bib74","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1476-069X-13-43","article-title":"Phthalates and diet: a review of the food monitoring and epidemiology data","volume":"13","author":"Serrano","year":"2014","journal-title":"Environ. Health"},{"key":"10.1016\/j.cbi.2024.111310_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107018","article-title":"Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal","volume":"158","author":"Tsai","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2024.111310_bib76","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3109\/15376516.2012.666652","article-title":"Di(2-ethylhexyl)phthalate-induced renal oxidative stress in rats and protective effect of selenium","volume":"22","author":"Erkekoglu","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.cbi.2024.111310_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102389","article-title":"Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway","volume":"54","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbi.2024.111310_bib78","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","article-title":"The Nrf2 antioxidant defense system in intervertebral disc degeneration: molecular insights","volume":"54","author":"Xiang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cbi.2024.111310_bib79","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10753-022-01746-6","article-title":"Dimethyl fumarate attenuates di-(2-ethylhexyl) phthalate-induced nephrotoxicity through the Nrf2\/HO-1 and NF-\u03baB signaling pathways","volume":"46","author":"Ashari","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.cbi.2024.111310_bib80","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.envpol.2018.07.080","article-title":"Crosstalk between unfolded protein response and Nrf2-mediated antioxidant defense in Di-(2-ethylhexyl) phthalate-induced renal injury in quail (Coturnix japonica)","volume":"242","author":"Zhao","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111310_bib81","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3389\/fphar.2019.01192","article-title":"Inflammation in renal diseases: new and old players","volume":"10","author":"Andrade-Oliveira","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111310_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2017.04.004","article-title":"Promotion of Wilms' tumor cells migration and invasion by mono-2-ethyhexyl phthalate (MEHP) via activation of NF-\u03baB signals","volume":"270","author":"Wang","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2024.111310_bib83","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1517\/13543780903321490","article-title":"The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer","volume":"18","author":"Yong","year":"2009","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.cbi.2024.111310_bib84","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxres\/tfad022","article-title":"Di(2-ethylhexyl) phthalate mediates oxidative stress and activates p38MAPK\/NF-kB to exacerbate diabetes-induced kidney injury in vitro and in vivo models","volume":"12","author":"Ding","year":"2023","journal-title":"Toxicology Research"},{"key":"10.1016\/j.cbi.2024.111310_bib85","article-title":"Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-\u03baB\/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney","volume":"926","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111310_bib86","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1681\/ASN.2006060597","article-title":"Peroxisome proliferator\u2013activated receptor \u03b1 protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-Ethylhexyl)Phthalate","volume":"18","author":"Kamijo","year":"2007","journal-title":"JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.cbi.2024.111310_bib87","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41581-022-00671-z","article-title":"Pathological consequences of DNA damage in the kidney","volume":"19","author":"Garaycoechea","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cbi.2024.111310_bib88","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.fct.2018.12.010","article-title":"Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo","volume":"124","author":"Kim","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160432","article-title":"m6A contributes to a pro-survival state in GC-2 cells by facilitating DNA damage repair: novel perspectives on the mechanism underlying DEHP genotoxicity in male germ cells","volume":"859","author":"Fu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2024.111310_bib90","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ecoenv.2018.07.066","article-title":"Di (2-ethylhexyl) phthalate-induced reproductive toxicity involved in dna damage-dependent oocyte apoptosis and oxidative stress in Caenorhabditis elegans","volume":"163","author":"Yin","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2024.111310_bib91","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.etap.2015.03.016","article-title":"Oxidative DNA damage induced by di-(2-ethylhexyl) phthalate in HEK-293 cell line","volume":"39","author":"Wang","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2024.111310_bib92","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.kint.2024.02.025","article-title":"The key role of altered tubule cell lipid metabolism in kidney disease development","volume":"106","author":"Lee","year":"2024","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbi.2024.111310_bib93","doi-asserted-by":"crossref","first-page":"15210","DOI":"10.1074\/jbc.REV120.007933","article-title":"Nuclear receptor phosphorylation in xenobiotic signal transduction","volume":"295","author":"Negishi","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2024.111310_bib94","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-physiol-012110-142200","article-title":"Endocrine disruptors: from endocrine to metabolic disruption","volume":"73","author":"Casals-Casas","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cbi.2024.111310_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114162","article-title":"Di-(2-ethylhexyl) phthalate induced nephrotoxicity in quail (Coturnix japonica) by triggering nuclear xenobiotic receptors and modulating the cytochrome P450 system","volume":"261","author":"Wang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2024.111310_bib96","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1177\/0192623318796784","article-title":"Cross talk from tubules to glomeruli","volume":"46","author":"Wang","year":"2018","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2024.111310_bib97","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s10787-022-01061-4","article-title":"Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)","volume":"30","author":"Khongthaw","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.cbi.2024.111310_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109266","article-title":"Lycopene ameliorates DEHP exposure-induced renal pyroptosis through the Nrf2\/Keap-1\/NLRP3\/Caspase-1 axis","volume":"113","author":"Li","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.cbi.2024.111310_bib99","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.3390\/cells11233856","article-title":"Identification and functional characterization of the transcription factors AhR\/ARNT in dendroctonus armandi","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2024.111310_bib100","doi-asserted-by":"crossref","first-page":"12853","DOI":"10.1021\/acs.jafc.1c05250","article-title":"Lycopene preventing DEHP-induced renal cell damage is targeted by aryl hydrocarbon receptor","volume":"69","author":"Li","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2024.111310_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117463","article-title":"A review on anti-cancer properties of Quercetin in breast cancer","volume":"248","author":"Ezzati","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2024.111310_bib102","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/toxres\/tfac006","article-title":"Quercetin ameliorates Di (2-ethylhexyl) phthalate-induced nephrotoxicity by inhibiting NF-\u03baB signaling pathway","volume":"11","author":"Ashari","year":"2022","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.cbi.2024.111310_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23092","article-title":"The protective effects of thymol and carvacrol against di (2-ethylhexyl) phthalate-induced cytotoxicity in HEK-293 cells","volume":"36","author":"Amara","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.cbi.2024.111310_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110465","article-title":"Green tea actions on miRNAs expression - an update","volume":"378","author":"Sousa-Filho","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2024.111310_bib105","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000534106","article-title":"Green tea polyphenols alleviate kidney injury induced by di(2-ethylhexyl) phthalate in mice","volume":"55","author":"Shi","year":"2024","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.cbi.2024.111310_bib106","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/life14030420","article-title":"Antitumor mechanisms of lycium barbarum fruit: an overview of in vitro and in vivo potential","volume":"14","author":"Miranda","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.cbi.2024.111310_bib107","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12192-022-01266-0","article-title":"Effects of Lycium barbarum glycopeptide on renal and testicular injury induced by di(2-ethylhexyl) phthalate","volume":"27","author":"Zhou","year":"2022","journal-title":"Cell Stress & Chaperones"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724004563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279724004563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T12:12:07Z","timestamp":1733659927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279724004563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":107,"alternative-id":["S0009279724004563"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111310","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the nephrotoxicity and molecular mechanisms of Di-2-ethylhexyl phthalate: A comprehensive review","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2024.111310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111310"}}