{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:32:55Z","timestamp":1780374775002,"version":"3.54.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M610576"],"award-info":[{"award-number":["2017M610576"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021A1515012474"],"award-info":[{"award-number":["2021A1515012474"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021A1515010978"],"award-info":[{"award-number":["2021A1515010978"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515013282"],"award-info":[{"award-number":["2024A1515013282"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572926"],"award-info":[{"award-number":["81572926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703349"],"award-info":[{"award-number":["81703349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.cbi.2025.111469","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T23:08:56Z","timestamp":1741302536000},"page":"111469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Small molecule as potent hepatocellular carcinoma progression inhibitor through stabilizing G-quadruplex DNA to activate replication stress responded DNA damage"],"prefix":"10.1016","volume":"412","author":[{"given":"Fei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbi.2025.111469_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd3428","article-title":"Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?","volume":"10","author":"Balasubramanian","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.cbi.2025.111469_bib2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ymeth.2012.01.008","article-title":"Experimental approaches to identify cellular G-quadruplex structures and functions","volume":"57","author":"Di Antonio","year":"2012","journal-title":"Methods"},{"issue":"10","key":"10.1016\/j.cbi.2025.111469_bib3","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nmeth.3965","article-title":"rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome","volume":"13","author":"Kwok","year":"2016","journal-title":"Nat. Methods"},{"issue":"20","key":"10.1016\/j.cbi.2025.111469_bib4","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1093\/nar\/gkt697","article-title":"G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold","volume":"41","author":"Marusic","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.cbi.2025.111469_bib5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1021\/acsmedchemlett.8b00275","article-title":"In silico Identification of piperidinyl-amine derivatives as novel dual binders of oncogene c-myc\/c-Kit G-quadruplexes","volume":"9","author":"Rocca","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.cbi.2025.111469_bib6","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1093\/nar\/gky187","article-title":"G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy","volume":"46","author":"Ruggiero","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"19","key":"10.1016\/j.cbi.2025.111469_bib7","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1093\/nar\/gky824","article-title":"Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells","volume":"46","author":"Sengupta","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2025.111469_bib8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ejmech.2018.01.091","article-title":"Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazolecarbazole ligands","volume":"148","author":"Kaulage","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.cbi.2025.111469_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nchem.1548","article-title":"Quantitative visualization of DNA G-quadruplex structures in human cells","volume":"5","author":"Biffi","year":"2013","journal-title":"Nat. Chem."},{"issue":"19","key":"10.1016\/j.cbi.2025.111469_bib10","doi-asserted-by":"crossref","first-page":"12675","DOI":"10.1021\/acs.jmedchem.2c00467","article-title":"Design, synthesis, and evaluation of new sugar-substituted imidazole derivatives as selective c-MYC transcription repressors targeting the promoter G-quadruplex","volume":"65","author":"Li","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111469_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116222","article-title":"Thiadiazole-, selenadiazole- and triazole-fused anthraquinones as G-quadruplex targeting anticancer compounds","volume":"268","author":"Andreeva","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.cbi.2025.111469_bib12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1039\/D1NJ05073G","article-title":"Synthesis of benzimidazole\/triphenylamine-based compounds, evaluation of their bioactivities and an in silico study with receptor tyrosine kinases","volume":"46","author":"Arulkumar","year":"2022","journal-title":"New J. Chem."},{"issue":"16","key":"10.1016\/j.cbi.2025.111469_bib13","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1039\/C8CC00328A","article-title":"Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation","volume":"54","author":"Shu","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.cbi.2025.111469_bib14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ejmech.2017.12.092","article-title":"5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions","volume":"145","author":"Wei","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"19","key":"10.1016\/j.cbi.2025.111469_bib15","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1158\/0008-5472.CAN-09-1304","article-title":"Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis","volume":"69","author":"Drygin","year":"2009","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.cbi.2025.111469_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-07215-2","article-title":"Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity","volume":"15","author":"Li","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2025.111469_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioorg.2018.12.020","article-title":"Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription","volume":"85","author":"Shu","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"13","key":"10.1016\/j.cbi.2025.111469_bib18","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1021\/acs.jmedchem.7b00016","article-title":"Discovery of novel 11-triazole substituted benzofuro[3,2-b]quinolone derivatives as c-myc G-quadruplex specific stabilizers via click chemistry","volume":"60","author":"Zeng","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111469_bib19","doi-asserted-by":"crossref","DOI":"10.1021\/acs.accounts.2c00337","article-title":"DNA G-quadruplex in human telomeres and oncogene promoters: structures, functions, and small molecule targeting","author":"Chen","year":"2022","journal-title":"Accounts of Chemical Research"},{"key":"10.1016\/j.cbi.2025.111469_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejmech.2018.02.052","article-title":"Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors","volume":"149","author":"Binder","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111469_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.eng.2024.03.015","article-title":"DNA G-quadruplexes as targets for natural product drug discovery","volume":"38","author":"Wang","year":"2024","journal-title":"Engineering"},{"issue":"23","key":"10.1016\/j.cbi.2025.111469_bib22","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1021\/acs.jmedchem.8b01018","article-title":"Tanshinone-IIA-based analogues of imidazole alkaloid act as potent inhibitors to block breast cancer invasion and metastasis in vivo","volume":"61","author":"Wu","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111469_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104433","article-title":"Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer","volume":"106","author":"Zeng","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.cbi.2025.111469_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111627","article-title":"Targeting multiple G-quadruplex-forming DNA sequences: design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives","volume":"182","author":"Catalano","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.cbi.2025.111469_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1039\/a705982e","article-title":"DNA minor-groove recognition by small molecules","volume":"18","author":"Neidle","year":"2001","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.cbi.2025.111469_bib26","first-page":"439","article-title":"Complicated behavior of G-quadruplexes and evaluating G-quadruplexes' ligands in various systems mimicking cellular circumstance","volume":"5","author":"Wang","year":"2016","journal-title":"Biochem Biophys Rep"},{"issue":"3","key":"10.1016\/j.cbi.2025.111469_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nchembio.780","article-title":"Small-molecule-induced DNA damage identifies alternative DNA structures in human genes","volume":"8","author":"Rodriguez","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbi.2025.111469_bib28","article-title":"CK-3, A novel methsulfonyl pyridine derivative, suppresses hepatocellular carcinoma proliferation and invasion by blocking the PI3K\/AKT\/mTOR and MAPK\/ERK pathways","volume":"11","author":"Wu","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.cbi.2025.111469_bib29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s41065-020-00145-x","article-title":"Identification of MMP1 as a potential gene conferring erlotinib resistance in non-small cell lung cancer based on bioinformatics analyses","volume":"157","author":"Zhou","year":"2020","journal-title":"Hereditas"},{"key":"10.1016\/j.cbi.2025.111469_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3422393","article-title":"VEGF family gene expression as prognostic biomarkers for alzheimer's disease and primary liver cancer","volume":"2021","author":"Xu","year":"2021","journal-title":"Comput. Math. Methods Med."},{"issue":"8","key":"10.1016\/j.cbi.2025.111469_bib31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nbt.3295","article-title":"High-throughput sequencing of DNA G-quadruplex structures in the human genome","volume":"33","author":"Chambers","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.cbi.2025.111469_bib32","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1111\/febs.15900","article-title":"G-quadruplex regulation of neural gene expression","volume":"289","author":"Cave","year":"2022","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.cbi.2025.111469_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12943-021-01328-4","article-title":"G-quadruplexes: a promising target for cancer therapy","volume":"20","author":"Kosiol","year":"2021","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.cbi.2025.111469_bib34","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1021\/acs.jmedchem.7b01176","article-title":"Interfering with HuR-RNA interaction: design, synthesis and biological characterization of tanshinone mimics as novel, effective HuR inhibitors","volume":"61","author":"Manzoni","year":"2018","journal-title":"J. Med. Chem."},{"issue":"46","key":"10.1016\/j.cbi.2025.111469_bib35","doi-asserted-by":"crossref","first-page":"9499","DOI":"10.1039\/C5CC02756J","article-title":"Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition","volume":"51","author":"Edwards","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.cbi.2025.111469_bib36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.saa.2017.10.012","article-title":"A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO","volume":"191","author":"Gu","year":"2018","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.cbi.2025.111469_bib37","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ejmech.2017.02.051","article-title":"Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[c]acridine derivatives as new c-KIT promoter G-quadruplex binding ligands","volume":"130","author":"Guo","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111469_bib38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijbiomac.2016.04.074","article-title":"Interaction of KRAS G-quadruplex with natural polyphenols: a spectroscopic analysis with molecular modeling","volume":"89","author":"Pattanayak","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.cbi.2025.111469_bib39","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.ijbiomac.2019.08.109","article-title":"Molecular recognition of 3+1 hybrid human telomeric G-quadruplex DNA d-[AGGG(TTAGGG)3] by anticancer drugs epirubicin and adriamycin leads to thermal stabilization","volume":"139","author":"Raje","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"17","key":"10.1016\/j.cbi.2025.111469_bib40","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1002\/chem.201705945","article-title":"Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex","volume":"24","author":"Asamitsu","year":"2018","journal-title":"Chemistry"},{"issue":"7","key":"10.1016\/j.cbi.2025.111469_bib41","article-title":"In vivo angiogenesis screening and mechanism of action of novel tanshinone derivatives produced by one-pot combinatorial modification of natural tanshinone mixture from Salvia miltiorrhiza","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.cbi.2025.111469_bib42","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/s41416-018-0051-8","article-title":"A multicentre, open-label, phase-I\/randomised phase-II study to evaluate safety, pharmacokinetics, and efficacy of nintedanib vs. sorafenib in European patients with advanced hepatocellular carcinoma","volume":"118","author":"Palmer","year":"2018","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.cbi.2025.111469_bib43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/j.seminoncol.2014.02.007","article-title":"Angiogenesis and the tumor microenvironment: vascular endothelial growth factor and beyond","volume":"41","author":"Mittal","year":"2014","journal-title":"Semin. Oncol."},{"issue":"11","key":"10.1016\/j.cbi.2025.111469_bib44","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets","volume":"17","author":"Weis","year":"2011","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.cbi.2025.111469_bib45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41420-021-00478-0","article-title":"Fibroblast CEBPD\/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4","volume":"7","author":"Chi","year":"2021","journal-title":"Cell Death Discov"},{"issue":"12","key":"10.1016\/j.cbi.2025.111469_bib46","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jnutbio.2010.09.012","article-title":"gamma-Tocotrienol inhibits angiogenesis of human umbilical vein endothelial cell induced by cancer cell","volume":"22","author":"Li","year":"2011","journal-title":"J. Nutr. Biochem."},{"issue":"22","key":"10.1016\/j.cbi.2025.111469_bib47","doi-asserted-by":"crossref","first-page":"9785","DOI":"10.1021\/jm301019w","article-title":"Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death","volume":"55","author":"Cosconati","year":"2012","journal-title":"J. Med. Chem."},{"issue":"13","key":"10.1016\/j.cbi.2025.111469_bib48","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1158\/1078-0432.CCR-16-0083","article-title":"Achieving precision death with cell-cycle inhibitors that target DNA replication and repair","volume":"23","author":"Lin","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.cbi.2025.111469_bib49","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1007\/s00204-021-03164-3","article-title":"Cell survival after DNA damage in the comet assay","volume":"95","author":"Bankoglu","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111469_bib50","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/B978-0-12-380888-2.00003-0","article-title":"The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer","volume":"108","author":"Smith","year":"2010","journal-title":"Adv. Cancer Res."},{"issue":"2","key":"10.1016\/j.cbi.2025.111469_bib51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41571-018-0114-z","article-title":"State-of-the-art strategies for targeting the DNA damage response in cancer","volume":"16","author":"Pilie","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.cbi.2025.111469_bib52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.trecan.2017.02.001","article-title":"Mitotic DNA damage response: at the crossroads of structural and numerical cancer chromosome instabilities","volume":"3","author":"Bakhoum","year":"2017","journal-title":"Trends Cancer"},{"issue":"5","key":"10.1016\/j.cbi.2025.111469_bib53","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nrm.2016.177","article-title":"Control of structure-specific endonucleases to maintain genome stability","volume":"18","author":"Dehe","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.cbi.2025.111469_bib54","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrg.2017.46","article-title":"The impact of replication stress on replication dynamics and DNA damage in vertebrate cells","volume":"18","author":"Techer","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cbi.2025.111469_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105748","article-title":"Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4\/NLRP3\/GSDMD-dependent pyroptosis","volume":"170","author":"Yuan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2025.111469_bib56","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1756-9966-28-31","article-title":"Suppression of lung cancer in murine model: treated by combination of recombinant human endostsatin adenovirus with low-dose cisplatin","volume":"28","author":"Bai","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.cbi.2025.111469_bib57","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.yexcr.2012.11.013","article-title":"The role of BRCA1 in DNA double-strand repair: past and present","volume":"319","author":"Caestecker","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.cbi.2025.111469_bib58","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.1021\/acs.nanolett.6b02786","article-title":"Preferential cancer cell self-recognition and tumor self-targeting by coating nanoparticles with homotypic cancer cell membranes","volume":"16","author":"Zhu","year":"2016","journal-title":"Nano Lett."},{"issue":"8","key":"10.1016\/j.cbi.2025.111469_bib59","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.cellsig.2011.04.005","article-title":"Emerging roles of DNA-PK besides DNA repair","volume":"23","author":"Kong","year":"2011","journal-title":"Cell. Signal."},{"issue":"13","key":"10.1016\/j.cbi.2025.111469_bib60","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41388-022-02197-x","article-title":"PBLD inhibits angiogenesis via impeding VEGF\/VEGFR2-mediated microenvironmental cross-talk between HCC cells and endothelial cells","volume":"41","author":"Han","year":"2022","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.cbi.2025.111469_bib61","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/ijc.28319","article-title":"Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel","volume":"134","author":"Zhang","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cbi.2025.111469_bib62","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3389\/fonc.2019.01189","article-title":"MUS81 participates in the progression of serous ovarian cancer associated with dysfunctional DNA repair system","volume":"9","author":"Lu","year":"2019","journal-title":"Front. Oncol."},{"issue":"7581","key":"10.1016\/j.cbi.2025.111469_bib63","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nature16139","article-title":"Replication stress activates DNA repair synthesis in mitosis","volume":"528","author":"Minocherhomji","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cbi.2025.111469_bib64","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.canlet.2009.12.001","article-title":"ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968","volume":"292","author":"Zuco","year":"2010","journal-title":"Cancer Lett."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725000997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725000997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:51:36Z","timestamp":1762113096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725000997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":64,"alternative-id":["S0009279725000997"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111469","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small molecule as potent hepatocellular carcinoma progression inhibitor through stabilizing G-quadruplex DNA to activate replication stress responded DNA damage","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111469"}}