{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:10:22Z","timestamp":1793934622548,"version":"4.8.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016073","name":"Key Technologies Research and Development Program of Anhui Province","doi-asserted-by":"publisher","award":["2022e07020040"],"award-info":[{"award-number":["2022e07020040"]}],"id":[{"id":"10.13039\/100016073","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.cbi.2025.111480","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:43:38Z","timestamp":1742283818000},"page":"111480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Hypoxia-inducible factor-1 alpha (HIF-1\u03b1) inhibitor AMSP-30\u00a0m attenuates CCl4-induced liver fibrosis in mice by inhibiting the sonic hedgehog pathway"],"prefix":"10.1016","volume":"413","author":[{"given":"Lili","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111480_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hep.32285","article-title":"Hepatic fibrosis 2022: unmet needs and a blueprint for the future","volume":"75","author":"Friedman","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2025.111480_bib2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story","volume":"64","author":"Lee","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.cbi.2025.111480_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jconrel.2020.02.049","article-title":"Hyperbranched lipoid-based lipid nanoparticles for bidirectional regulation of collagen accumulation in liver fibrosis","volume":"321","author":"Qiao","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.cbi.2025.111480_bib4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","volume":"20","author":"Hammerich","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2025.111480_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110350","article-title":"\u03b2-catenin\/TCF4 inhibitors ICG-001 and LF3 alleviate BDL-induced liver fibrosis by suppressing LECT2 signaling","volume":"371","author":"Gao","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111480_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cbi.2014.10.005","article-title":"Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-\u03b2\/Smad signaling pathway","volume":"224","author":"Lee","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111480_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111572","article-title":"Hepatic stellate cell senescence in liver fibrosis: characteristics, mechanisms and perspectives","volume":"199","author":"Zhang","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cbi.2025.111480_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155465","article-title":"Esculin inhibits hepatic stellate cell activation and CCl(4)-induced liver fibrosis by activating the Nrf2\/GPX4 signaling pathway","volume":"128","author":"Xu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2025.111480_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cbi.2015.08.013","article-title":"Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-\u03b2\/Smad signaling pathway","volume":"240","author":"Balta","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111480_bib10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s40265-019-01126-9","article-title":"Fibrosis in chronic liver disease: an update on diagnostic and treatment modalities","volume":"79","author":"Manka","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.cbi.2025.111480_bib11","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.cbi.2025.111480_bib12","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jfma.2020.11.018","article-title":"Direct-acting antiviral therapy of chronic hepatitis C improves liver fibrosis, assessed by histological examination and laboratory markers","volume":"120","author":"Cheng","year":"2021","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.cbi.2025.111480_bib13","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.3390\/ijms23126689","article-title":"Galunisertib exerts antifibrotic effects on TGF-\u03b2-induced fibroproliferative dermal fibroblasts","volume":"23","author":"Peterson","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111480_bib14","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/ecco-jcc\/jjw101","article-title":"Genetic deletion of tissue inhibitor of metalloproteinase-1\/TIMP-1 alters inflammation and attenuates fibrosis in dextran sodium sulphate-induced murine models of colitis","volume":"10","author":"Breynaert","year":"2016","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.cbi.2025.111480_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-pharmtox-020524-012013","article-title":"Immunoregulation of liver fibrosis: new opportunities for antifibrotic therapy","volume":"65","author":"Gilgenkrantz","year":"2025","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2025.111480_bib16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12967-021-02854-x","article-title":"The roles and mechanisms of hypoxia in liver fibrosis","volume":"19","author":"Cai","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cbi.2025.111480_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-pathmechdis-051122-094743","article-title":"Hypoxia-induced signaling in gut and liver pathobiology","volume":"19","author":"Solanki","year":"2024","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cbi.2025.111480_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1\u03b1\/SLC7A11 pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.cbi.2025.111480_bib19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/HEP.0000000000000569","article-title":"Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A\/HIF-1\u03b1 transcriptional complex","volume":"79","author":"Wang","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2025.111480_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118819","article-title":"microRNA-322\/424 promotes liver fibrosis by regulating angiogenesis through targeting CUL2\/HIF-1\u03b1 pathway","volume":"266","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2025.111480_bib21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41392-020-00453-8","article-title":"HIF-1\u03b1-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.cbi.2025.111480_bib22","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.3390\/antiox11112152","article-title":"Effect of empagliflozin on thioacetamide-induced liver injury in rats: role of AMPK\/SIRT-1\/HIF-1\u03b1 pathway in halting liver fibrosis","volume":"11","author":"ElBaset","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbi.2025.111480_bib23","doi-asserted-by":"crossref","first-page":"14735","DOI":"10.1002\/jcb.28734","article-title":"Hypoxia inducible factor-1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN\/p65 signaling pathway","volume":"120","author":"Han","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cbi.2025.111480_bib24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jhep.2024.01.026","article-title":"HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1\u03b1- and TGF-\u03b21-dependent pathway","volume":"80","author":"Xu","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2025.111480_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12762","article-title":"Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1\u03b1 in liver fibrosis","volume":"53","author":"Yang","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.cbi.2025.111480_bib26","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1158\/1078-0432.CCR-07-4306","article-title":"Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitors","volume":"14","author":"Verheul","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cbi.2025.111480_bib27","doi-asserted-by":"crossref","first-page":"7659","DOI":"10.1021\/acs.jmedchem.5b01220","article-title":"Synthesis and biological evaluation of manassantin analogues for hypoxia-inducible factor 1\u03b1 inhibition","volume":"58","author":"Kwon","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111480_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12935-023-02924-8","article-title":"Hypoxia disrupt tight junctions and promote metastasis of oral squamous cell carcinoma via loss of par3","volume":"23","author":"Kim","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cbi.2025.111480_bib29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41467-022-28378-6","article-title":"In vivo CRISPR screens reveal a HIF-1\u03b1-mTOR-network regulates T follicular helper versus Th1 cells","volume":"13","author":"Huang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2025.111480_bib30","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1136\/ard-2023-224774","article-title":"Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis","volume":"83","author":"Kachler","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.cbi.2025.111480_bib31","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s12272-011-1021-3","article-title":"A novel approach to cancer therapy using PX-478 as a HIF-1\u03b1 inhibitor","volume":"34","author":"Lee","year":"2011","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.cbi.2025.111480_bib32","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.trsl.2014.12.001","article-title":"Therapeutic targeting of hypoxia and hypoxia-inducible factor 1 alpha in multiple myeloma","volume":"165","author":"Borsi","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.cbi.2025.111480_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104924","article-title":"Hypoxia-inducible factor-1\u03b1: a promising therapeutic target for vasculopathy in diabetic retinopathy","volume":"159","author":"Li","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2025.111480_bib34","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jconrel.2013.05.021","article-title":"Hypoxia as a target for tissue specific gene therapy","volume":"172","author":"Rhim","year":"2013","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.cbi.2025.111480_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106400","article-title":"Advances in antitumor research of HIF-1\u03b1 inhibitor YC-1 and its derivatives","volume":"133","author":"Ouyang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.cbi.2025.111480_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115171","article-title":"Design, synthesis and evaluation of the novel chalcone derivatives with 2,2-dimethylbenzopyran as HIF-1 inhibitors that possess anti-angiogenic potential","volume":"250","author":"Xu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111480_bib37","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1164\/rccm.201907-1285ED","article-title":"Hedgehog and WNT signaling hubs in tracheal morphogenesis","volume":"200","author":"Frank","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2025.111480_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109189","article-title":"In utero di-n-butyl phthalate exposure induced abnormal autophagy in renal tubular cells via hedgehog signaling in newborn rats","volume":"328","author":"Zhao","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111480_bib39","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.phrs.2019.01.014","article-title":"Targeting Hedgehog signaling pathway: paving the road for cancer therapy","volume":"141","author":"Salaritabar","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2025.111480_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12964-018-0220-7","article-title":"A highlight on Sonic hedgehog pathway","volume":"16","author":"Carballo","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.cbi.2025.111480_bib41","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2017.12.022","article-title":"Hedgehog-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells","volume":"154","author":"Du","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2025.111480_bib42","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.7150\/thno.91572","article-title":"Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling","volume":"14","author":"Hu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.cbi.2025.111480_bib43","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.7150\/ijbs.28089","article-title":"Role of canonical Hedgehog signaling pathway in liver","volume":"14","author":"Gao","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cbi.2025.111480_bib44","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1053\/j.gastro.2009.06.051","article-title":"Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease","volume":"137","author":"Syn","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2025.111480_bib45","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jhep.2015.10.007","article-title":"Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model","volume":"64","author":"Chung","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2025.111480_bib46","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.intimp.2019.04.016","article-title":"Geniposide, a sonic hedgehog signaling inhibitor, inhibits the activation of hepatic stellate cell","volume":"72","author":"Lin","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cbi.2025.111480_bib47","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1158\/0008-5472.CAN-11-1433","article-title":"Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer","volume":"73","author":"Spivak-Kroizman","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2025.111480_bib48","article-title":"HIF-1\u03b1 contributes to proliferation and invasiveness of neuroblastoma cells via SHH signaling","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2025.111480_bib49","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/hep4.1354","article-title":"Nocturnal hypoxia activation of the hedgehog signaling pathway affects pediatric nonalcoholic fatty liver disease severity","volume":"3","author":"Sundaram","year":"2019","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.cbi.2025.111480_bib50","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.1021\/acs.jmedchem.9b01313","article-title":"Discovery of novel aryl carboxamide derivatives as hypoxia-inducible factor 1\u03b1 signaling inhibitors with potent activities of anticancer metastasis","volume":"62","author":"Liu","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111480_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108467","article-title":"AMSP-30 m as a novel HIF-1\u03b1 inhibitor attenuates the development and severity of adjuvant-induced arthritis in rats: impacts on synovial apoptosis, synovial angiogenesis and sonic hedgehog signaling pathway","volume":"103","author":"Meng","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cbi.2025.111480_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2022.11.001","article-title":"20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-\u03b21\/Smad3 signaling pathway","volume":"373","author":"Li","year":"2023","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2025.111480_bib53","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1038\/s41467-021-25221-2","article-title":"Deep learning-based transformation of H&E stained tissues into special stains","volume":"12","author":"de Haan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2025.111480_bib54","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1080\/07853890.2022.2069854","article-title":"Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review","volume":"54","author":"Aghemo","year":"2022","journal-title":"Ann. Med."},{"key":"10.1016\/j.cbi.2025.111480_bib55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s40265-024-02015-6","article-title":"Comparative efficacy of drug interventions on NAFLD over 24 Weeks: a traditional and network meta-analysis of randomized controlled trials","volume":"84","author":"Wang","year":"2024","journal-title":"Drugs"},{"key":"10.1016\/j.cbi.2025.111480_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105926","article-title":"Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl(4)-induced liver fibrosis","volume":"174","author":"Zhu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2025.111480_bib57","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1002\/ptr.7558","article-title":"Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1\/P53\/SLC7A11 pathway","volume":"36","author":"Liu","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.cbi.2025.111480_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154585","article-title":"Hastatoside attenuatescarbon tetrachloride-induced liver fibrosis by targeting glycogen synthase kinase-3\u03b2","volume":"109","author":"Du","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2025.111480_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2024.102467","article-title":"Pharmacological regulation of HIF-1\u03b1, RGC death, and glaucoma","volume":"77","author":"Husain","year":"2024","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111480_bib60","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.3350\/cmh.2024.0351","article-title":"Prevalence of clinically significant liver fibrosis in the general population: a systematic review and meta-analysis","volume":"30","author":"Kim","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.cbi.2025.111480_bib61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.cbi.2025.111480_bib62","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41423-023-00983-5","article-title":"Mesenchymal stromal cells in hepatic fibrosis\/cirrhosis: from pathogenesis to treatment","volume":"20","author":"Yang","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.cbi.2025.111480_bib63","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jcmgh.2015.09.005","article-title":"Role of hypoxia-inducible factors in the development of liver fibrosis","volume":"1","author":"Roth","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2025.111480_bib64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2025.111480_bib65","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.4049\/jimmunol.1303195","article-title":"Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1\u03b1-dependent manner by modulating macrophage phenotype in mice","volume":"192","author":"Mochizuki","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbi.2025.111480_bib66","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jhep.2014.08.025","article-title":"Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions","volume":"61","author":"Wilson","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2025.111480_bib67","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1007\/s10753-023-01878-3","article-title":"Novel HIF-1\u03b1 inhibitor AMSP-30m mitigates the pathogenic cellular behaviors of hypoxia-stimulated fibroblast-like synoviocytes and alleviates collagen-induced arthritis in rats via inhibiting sonic hedgehog pathway","volume":"46","author":"Cai","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.cbi.2025.111480_bib68","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jcb.30296","article-title":"Quercetin ameliorates thioacetamide-induced hepatic fibrosis and oxidative stress by antagonizing the Hedgehog signaling pathway","volume":"123","author":"Aslam","year":"2022","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cbi.2025.111480_bib69","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1080\/15384101.2017.1325976","article-title":"Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signaling pathway","volume":"16","author":"Pan","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cbi.2025.111480_bib70","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.apsb.2023.10.023","article-title":"Epigenetic modification in liver fibrosis: promising therapeutic direction with significant challenges ahead","volume":"14","author":"Liu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cbi.2025.111480_bib71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12951-023-01788-4","article-title":"Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K\/Akt\/mTOR pathway and remodeling choline metabolism","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cbi.2025.111480_bib72","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41392-022-01071-2","article-title":"A dual-specific CRISPR-Cas nanosystem for precision therapeutic editing of liver disorders","volume":"7","author":"Xu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T19:53:16Z","timestamp":1744401196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725001103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":72,"alternative-id":["S0009279725001103"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111480","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia-inducible factor-1 alpha (HIF-1\u03b1) inhibitor AMSP-30\u00a0m attenuates CCl4-induced liver fibrosis in mice by inhibiting the sonic hedgehog pathway","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111480"}}