{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:41:02Z","timestamp":1793814062136,"version":"4.6.1"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1I1A2060024"],"award-info":[{"award-number":["NRF-2021R1I1A2060024"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019244","name":"Centro de Estudos de Sociologia e Est\u00e9tica Musical","doi-asserted-by":"publisher","award":["221610108292"],"award-info":[{"award-number":["221610108292"]}],"id":[{"id":"10.13039\/501100019244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019244","name":"Centro de Estudos de Sociologia e Est\u00e9tica Musical","doi-asserted-by":"publisher","award":["GRD.637"],"award-info":[{"award-number":["GRD.637"]}],"id":[{"id":"10.13039\/501100019244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014739","name":"University of Mysore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014738","name":"Vision Group on Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.cbi.2025.111528","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T19:03:37Z","timestamp":1745607817000},"page":"111528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Targeting breast cancer cells with 2-indolyl-1,3,4-oxadiazole compounds by inducing apoptosis, paraptosis and autophagy"],"prefix":"10.1016","volume":"415","author":[{"given":"Pradeep M.","family":"Uppar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-8085","authenticated-orcid":false,"given":"Na Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav Kumar","family":"Harish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narasimha M.","family":"Beeraka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh L.","family":"Gaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Madegowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchugarakoppal S.","family":"Rangappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir N.","family":"Nikolenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunachalam","family":"Chinnathambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman Ali","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-0612","authenticated-orcid":false,"given":"Kwang Seok","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basappa","family":"Basappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib1","first-page":"7","article-title":"Cancer statistics","volume":"69","author":"Siegel","year":"2019","journal-title":"Ca - Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib2","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.18632\/oncotarget.12284","article-title":"Triple-negative breast cancer: is there a treatment on the horizon?","volume":"8","author":"Yao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cbi.2025.111528_bib3","series-title":"Anti-tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule","author":"Basappa","year":"2012"},{"key":"10.1016\/j.cbi.2025.111528_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-020-01296-5","article-title":"Triple-negative breast cancer molecular subtyping and treatment progress","volume":"22","author":"Yin","year":"2020","journal-title":"Breast Cancer Res."},{"issue":"8","key":"10.1016\/j.cbi.2025.111528_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jscs.2021.101284","article-title":"1, 3, 4-Oxadiazole-containing hybrids as potential anticancer agents: recent developments, mechanism of action and structure-activity relationships","volume":"25","author":"Nayak","year":"2021","journal-title":"J. Saudi Chem. Soc."},{"issue":"22","key":"10.1016\/j.cbi.2025.111528_bib6","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1016\/j.bmc.2010.09.051","article-title":"Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1, 3, 4-oxadiazole moiety as potential antitumor agents","volume":"18","author":"Zheng","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"14","key":"10.1016\/j.cbi.2025.111528_bib7","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1021\/jm500303u","article-title":"1, 3, 4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells","volume":"57","author":"Valente","year":"2014","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.cbi.2025.111528_bib8","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/ph16020254","article-title":"An understanding of mechanism-based approaches for 1, 3, 4-oxadiazole scaffolds as cytotoxic agents and enzyme inhibitors","volume":"16","author":"Kumar","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.cbi.2025.111528_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejmech.2019.01.001","article-title":"Synthesis and anticancer evaluation of new lipophilic 1, 2, 4 and 1, 3, 4-oxadiazoles","volume":"165","author":"Caneschi","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/14756366.2021.2015342","article-title":"1, 3, 4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies","volume":"37","author":"Hagras","year":"2022","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3390\/chemistry3010027","article-title":"Discovery of novel 1, 2, 4-oxadiazole derivatives as potent caspase-3 activator for cancer treatment","volume":"3","author":"Vaidya","year":"2021","journal-title":"Chemistry"},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12929-024-01089-4","article-title":"Exploring paraptosis as a therapeutic approach in cancer treatment","volume":"31","author":"Chang","year":"2024","journal-title":"J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.cbi.2025.111528_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188338","article-title":"The emerging role of paraptosis in tumor cell biology: perspectives for cancer prevention and therapy with natural compounds","volume":"1873","author":"Fontana","year":"2020","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"issue":"2","key":"10.1016\/j.cbi.2025.111528_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41401-023-01159-7","article-title":"Paraptosis: a non-classical paradigm of cell death for cancer therapy","volume":"45","author":"Xu","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2025.111528_bib15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pharmthera.2016.01.003","article-title":"Paraptosis in the anti-cancer arsenal of natural products","volume":"162","author":"Lee","year":"2016","journal-title":"Pharmacol. Therapeut."},{"issue":"3","key":"10.1016\/j.cbi.2025.111528_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41417-023-00722-y","article-title":"Targeting paraptosis in cancer: opportunities and challenges","volume":"31","author":"Chen","year":"2024","journal-title":"Cancer Gene Ther."},{"issue":"5","key":"10.1016\/j.cbi.2025.111528_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrd1718","article-title":"Poly (ADP-ribose) polymerase and the therapeutic effects of its inhibitors","volume":"4","author":"Jagtap","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cbi.2025.111528_bib18","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1007\/s00018-010-0490-8","article-title":"Targeting poly (ADP-ribose) polymerase activity for cancer therapy","volume":"67","author":"M\u00e9gnin-Chanet","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbi.2025.111528_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102651","article-title":"PARP-1 and its associated nucleases in DNA damage response","volume":"81","author":"Wang","year":"2019","journal-title":"DNA Repair"},{"issue":"8","key":"10.1016\/j.cbi.2025.111528_bib20","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1093\/nar\/gkz120","article-title":"Poly (ADP-ribosyl) ation by PARP1: reaction mechanism and regulatory proteins","volume":"47","author":"Alemasova","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.cbi.2025.111528_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.32604\/or.2023.028310","article-title":"Targeting DNA repair for cancer treatment: lessons from PARP inhibitor trials","volume":"31","author":"Nambiar","year":"2023","journal-title":"Oncol. Res."},{"issue":"4","key":"10.1016\/j.cbi.2025.111528_bib22","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/biom2040524","article-title":"Functional aspects of PARP1 in DNA repair and transcription","volume":"2","author":"Ko","year":"2012","journal-title":"Biomolecules"},{"issue":"11","key":"10.1016\/j.cbi.2025.111528_bib23","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1158\/1541-7786.MCR-15-0191-T","article-title":"Mechanistic dissection of PARP1 trapping and the impact on in vivo tolerability and efficacy of PARP inhibitors","volume":"13","author":"Hopkins","year":"2015","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.cbi.2025.111528_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.769280","article-title":"Emerging role of PARP inhibitors in metastatic triple negative breast cancer. Current scenario and future perspectives","volume":"11","author":"Barchiesi","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.cbi.2025.111528_bib25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11523-021-00796-4","article-title":"An overview of PARP inhibitors for the treatment of breast cancer","volume":"16","author":"Cortesi","year":"2021","journal-title":"Targeted Oncol."},{"issue":"12","key":"10.1016\/j.cbi.2025.111528_bib26","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s40262-022-01167-6","article-title":"Pharmacokinetics and pharmacodynamics of PARP inhibitors in oncology","volume":"61","author":"Bruin","year":"2022","journal-title":"Clin. Pharmacokinet."},{"issue":"8","key":"10.1016\/j.cbi.2025.111528_bib27","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.3390\/ijms22083825","article-title":"Novel pyrimidine derivatives as potential anticancer agents: synthesis, biological evaluation and molecular docking study","volume":"22","author":"Tyli\u0144ska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cbi.2025.111528_bib28","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.3390\/molecules28083450","article-title":"Discovery of pyrimidine-and coumarin-linked hybrid molecules as inducers of JNK phosphorylation through ROS generation in breast cancer cells","volume":"28","author":"Kim","year":"2023","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.cbi.2025.111528_bib29","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.3390\/biomedicines11102716","article-title":"Development of piperazine-and oxazine-linked pyrimidines as p65 subunit binders of NF\u2013\u03baB in human breast cancer cells","volume":"11","author":"Ravish","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.cbi.2025.111528_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.136070","article-title":"Antimicrobial, antioxidant, and in silco studies of divalent metal complexes of novel aminopyrimidine Schiff base chelators","volume":"1291","author":"Chioma","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"9","key":"10.1016\/j.cbi.2025.111528_bib31","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.3390\/molecules28093913","article-title":"Novel pyrimidine derivatives as antioxidant and anticancer agents: design, synthesis and molecular modeling studies","volume":"28","author":"Myriagkou","year":"2023","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.cbi.2025.111528_bib32","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1021\/acs.orglett.5b01241","article-title":"Direct annulation of hydrazides to 1, 3, 4-oxadiazoles via oxidative C (CO)\u2013C (methyl) bond cleavage of methyl ketones","volume":"17","author":"Gao","year":"2015","journal-title":"Org. Lett."},{"issue":"20","key":"10.1016\/j.cbi.2025.111528_bib33","doi-asserted-by":"crossref","first-page":"10337","DOI":"10.1021\/jo401751h","article-title":"I2-mediated oxidative C\u2013O bond formation for the synthesis of 1, 3, 4-oxadiazoles from aldehydes and hydrazides","volume":"78","author":"Yu","year":"2013","journal-title":"J. Org. Chem."},{"issue":"5","key":"10.1016\/j.cbi.2025.111528_bib34","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1039\/C1OB06512B","article-title":"Synthesis of 1, 3, 4-oxadiazoles from 1, 2-diacylhydrazines using [Et 2 NSF 2] BF 4 as a practical cyclodehydration agent","volume":"10","author":"Pouliot","year":"2012","journal-title":"Org. Biomol. Chem."},{"issue":"14","key":"10.1016\/j.cbi.2025.111528_bib35","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1055\/s-0040-1719867","article-title":"Mechanochemical synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles mediated by PPh3-TCCA","volume":"33","author":"Yamano","year":"2022","journal-title":"Synlett"},{"issue":"3","key":"10.1016\/j.cbi.2025.111528_bib36","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/molecules27030703","article-title":"Design and activity of novel oxadiazole based compounds that target poly (ADP-ribose) polymerase","volume":"27","author":"Vishwanath","year":"2022","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.cbi.2025.111528_bib37","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1021\/jm301825t","article-title":"Design, synthesis, and biological evaluation of a series of benzo [de][1, 7] naphthyridin-7 (8 H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors","volume":"56","author":"Ye","year":"2013","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.cbi.2025.111528_bib38","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.saa.2011.02.018","article-title":"Density functional theory studies on vibrational and electronic spectra of 2-chloro-6-methoxypyridine","volume":"78","author":"Arjunan","year":"2011","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/ja00391a039","article-title":"Interaction frontier orbitals","volume":"103","author":"Fukui","year":"1981","journal-title":"J. Am. Chem. Soc."},{"issue":"26","key":"10.1016\/j.cbi.2025.111528_bib40","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1021\/ja00364a005","article-title":"Absolute hardness: companion parameter to absolute electronegativity","volume":"105","author":"Parr","year":"1983","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib41","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.saa.2010.09.016","article-title":"Spectroscopic investigations and quantum chemical computational study of (E)-4-methoxy-2-[(p-tolylimino) methyl] phenol","volume":"78","author":"Kosar","year":"2011","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"11","key":"10.1016\/j.cbi.2025.111528_bib42","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1063\/1.479749","article-title":"Topological analysis of the molecular electrostatic potential","volume":"111","author":"Leboeuf","year":"1999","journal-title":"J. Chem. Phys."},{"issue":"6","key":"10.1016\/j.cbi.2025.111528_bib43","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3390\/biomedicines11061662","article-title":"Methyl-thiol-bridged oxadiazole and triazole heterocycles as inhibitors of NF-\u03baB in chronic myelogenous leukemia cells","volume":"11","author":"Basappa","year":"2023","journal-title":"Biomedicines"},{"issue":"9","key":"10.1016\/j.cbi.2025.111528_bib44","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/biomedicines8090368","article-title":"Novel 1, 3, 4-oxadiazole targets STAT3 signaling to induce antitumor effect in lung cancer","volume":"8","author":"Malojirao","year":"2020","journal-title":"Biomedicines"},{"issue":"16","key":"10.1016\/j.cbi.2025.111528_bib45","article-title":"Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells","volume":"30","author":"Shanmugam","year":"2020","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.cbi.2025.111528_bib46","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fonc.2018.00042","article-title":"Novel 1, 3, 4-oxadiazole induces anticancer activity by targeting NF-\u03baB in hepatocellular carcinoma cells","volume":"8","author":"Mohan","year":"2018","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41698-023-00489-3","article-title":"Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer","volume":"8","author":"Tan","year":"2024","journal-title":"npj Precis. Oncol."},{"issue":"9","key":"10.1016\/j.cbi.2025.111528_bib48","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.3390\/molecules27092848","article-title":"Development of 1-(4-(substituted) piperazin-1-yl)-2-((2-((4-methoxybenzyl) thio) pyrimidin-4-yl) oxy) ethanones that target poly (ADP-Ribose) polymerase in human breast cancer cells","volume":"27","author":"Deveshegowda","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111528_bib49","article-title":"A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to \u03b2-catenin and suppressing the Wnt signaling pathway","author":"Yang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"8","key":"10.1016\/j.cbi.2025.111528_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.387","article-title":"Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1","volume":"8","author":"Yan","year":"2017","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.cbi.2025.111528_bib51","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/sj.cdd.4400456","article-title":"Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein","volume":"6","author":"Missotten","year":"1999","journal-title":"Cell Death Differ."},{"issue":"32","key":"10.1016\/j.cbi.2025.111528_bib52","doi-asserted-by":"crossref","first-page":"29108","DOI":"10.1074\/jbc.M204019200","article-title":"Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization","volume":"277","author":"Chatellard-Causse","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.cbi.2025.111528_bib53","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.cdd.4401465","article-title":"Paraptosis: mediation by MAP kinases and inhibition by AIP-1\/Alix","volume":"11","author":"Sperandio","year":"2004","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.cbi.2025.111528_bib54","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/jcb.22870","article-title":"Identification of new modulators and protein alterations in non\u2010apoptotic programmed cell death","volume":"111","author":"Sperandio","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib55","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41392-022-01131-7","article-title":"Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.cbi.2025.111528_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.7202","article-title":"\u03b1\u2010Hederin induces paraptosis by targeting GPCRs to activate Ca2+\/MAPK signaling pathway in colorectal cancer","volume":"13","author":"Rao","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.cbi.2025.111528_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115487","article-title":"Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1)","volume":"210","author":"Zhao","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111528_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122164","article-title":"Rifampicin-induced ER stress and excessive cytoplasmic vacuolization instigate hepatotoxicity via alternate programmed cell death paraptosis in vitro and in vivo","volume":"333","author":"Kainat","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2025.111528_bib59","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cbi.2018.02.003","article-title":"Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer","volume":"283","author":"Xue","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111528_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.019","article-title":"Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells","volume":"21","author":"Chen","year":"2019","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.cbi.2025.111528_bib61","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.yexcr.2018.02.018","article-title":"6-Shogaol induces caspase-independent paraptosis in cancer cells via proteasomal inhibition","volume":"364","author":"Nedungadi","year":"2018","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib62","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/antiox11010117","article-title":"Induction of paraptotic cell death in breast cancer cells by a novel pyrazolo [3, 4-h] quinoline derivative through ROS production and endoplasmic reticulum stress","volume":"11","author":"Nguyen","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbi.2025.111528_bib63","article-title":"DHW-221, a dual PI3K\/mTOR inhibitor, overcomes multidrug resistance by targeting P-glycoprotein (P-gp\/ABCB1) and akt-mediated FOXO3a nuclear translocation in non-small cell lung cancer","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.cbi.2025.111528_bib64","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/iub.2827","article-title":"Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP\u20101 expression, and the STAT3 pathway","volume":"76","author":"Jung","year":"2024","journal-title":"IUBMB Life"},{"key":"10.1016\/j.cbi.2025.111528_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110125","article-title":"Inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation","volume":"366","author":"Zheng","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"7576","key":"10.1016\/j.cbi.2025.111528_bib66","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature15548","article-title":"Autophagy mediates degradation of nuclear lamina","volume":"527","author":"Dou","year":"2015","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.cbi.2025.111528_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137675","article-title":"Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines","volume":"10","author":"Koukourakis","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib68","doi-asserted-by":"crossref","first-page":"7620","DOI":"10.1038\/ncomms8620","article-title":"PTEN regulates DNA replication progression and stalled fork recovery","volume":"6","author":"He","year":"2015","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.cbi.2025.111528_bib69","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/ncb2363","article-title":"Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes","volume":"13","author":"Florey","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.cbi.2025.111528_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd 871 edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.cbi.2025.111528_bib71","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.3390\/molecules27123824","article-title":"Euphorbiasteroid abrogates EGFR and Wnt\/\u03b2-catenin signaling in non-small-cell lung cancer cells to impart anticancer activity","volume":"27","author":"Kim","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111528_bib72","article-title":"Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species\/JNK pathway in human breast cancer cells","volume":"49","author":"Kim","year":"2024","journal-title":"Translation. Oncol."},{"key":"10.1016\/j.cbi.2025.111528_bib73","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.biochi.2022.05.018","article-title":"Tanshinone IIA exerts autophagic cell death through down-regulation of \u03b2-catenin in renal cell carcinoma cells","volume":"200","author":"Kim","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.cbi.2025.111528_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/bcr1370","article-title":"Comprehensive copy number profiles of breast cancer cell model genomes","volume":"8","author":"Shadeo","year":"2006","journal-title":"Breast Cancer Res."},{"issue":"3","key":"10.1016\/j.cbi.2025.111528_bib75","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.3390\/cimb46030171","article-title":"Unveiling the molecular mechanism of trastuzumab resistance in SKBR3 and BT474 cell lines for HER2 positive breast cancer","volume":"46","author":"Kokot","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"issue":"4","key":"10.1016\/j.cbi.2025.111528_bib76","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.arabjc.2013.02.001","article-title":"Synthesis, characterization and anticancer evaluation of 2-(naphthalen-1-ylmethyl\/naphthalen-2-yloxymethyl)-1-[5-(substituted phenyl)-[1, 3, 4] oxadiazol-2-ylmethyl]-1H-benzimidazole","volume":"7","author":"Shaharyar","year":"2014","journal-title":"Arab. J. Chem."},{"issue":"3","key":"10.1016\/j.cbi.2025.111528_bib77","first-page":"294","article-title":"Synthesis, anticancer and molecular docking studies of 2-(4-chlorophenyl)-5-aryl-1, 3, 4-oxadiazole analogues","volume":"33","author":"Ahsan","year":"2013","journal-title":"Med. Chem."},{"issue":"6","key":"10.1016\/j.cbi.2025.111528_bib78","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jcc.20634","article-title":"A semiempirical free energy force field with charge\u2010based desolvation","volume":"28","author":"Huey","year":"2007","journal-title":"J. Comput. Chem."},{"issue":"13","key":"10.1016\/j.cbi.2025.111528_bib79","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2025.111528_bib80","series-title":"Discovery Studio Visualizer 4.5","author":"Biovia","year":"2021"},{"key":"10.1016\/j.cbi.2025.111528_bib81","series-title":"Gaussian 09, Revision D. 01\/Gaussian","author":"Frisch","year":"2009"},{"key":"10.1016\/j.cbi.2025.111528_bib82","series-title":"GaussView","author":"Dennington","year":"2009"},{"key":"10.1016\/j.cbi.2025.111528_bib83","article-title":"A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF\/c-MET axis in hepatocellular carcinoma","author":"Gowda","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.cbi.2025.111528_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111285","article-title":"Isoxazole based nucleosides induce autophagy through the production of ROS and the suppression of the beta-catenin pathway in human colorectal carcinoma cells","volume":"404","author":"Kim","year":"2024","journal-title":"Chem. Biol. Interact."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:51:17Z","timestamp":1762113077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725001589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":84,"alternative-id":["S0009279725001589"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111528","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting breast cancer cells with 2-indolyl-1,3,4-oxadiazole compounds by inducing apoptosis, paraptosis and autophagy","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111528"}}