{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:32:20Z","timestamp":1790994740147,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ20093"],"award-info":[{"award-number":["2022JJ20093"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202391"],"award-info":[{"award-number":["82202391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["YX202201"],"award-info":[{"award-number":["YX202201"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cbi.2025.111550","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T19:07:11Z","timestamp":1746817631000},"page":"111550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["TET2 promotes UVB-induced cell death by activating RIPK3-MLKL-necroptosis signaling"],"prefix":"10.1016","volume":"416","author":[{"given":"Daijing","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziting","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiule","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111550_bib1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/phpp.12679","article-title":"Research progress of keratinocyte-programmed cell death in UV-induced Skin photodamage","volume":"37","author":"Tang","year":"2021","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.cbi.2025.111550_bib2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4103\/0366-6999.200539","article-title":"Increased 5-hydroxymethylcytosine and Ten-eleven translocation protein expression in ultraviolet B-irradiated HaCaT cells","volume":"130","author":"Wang","year":"2017","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.cbi.2025.111550_bib3","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1002\/ctm2.781","article-title":"The IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease,","volume":"12","author":"Wu","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cbi.2025.111550_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1158\/0008-5472.CAN-18-1214","article-title":"Tet2-dependent hydroxymethylome plasticity reduces melanoma initiation and progression","volume":"79","author":"Bonvin","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2025.111550_bib5","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.jid.2019.10.016","article-title":"Loss of the epigenetic mark 5-hmC in psoriasis: implications for epidermal stem cell dysregulation","volume":"140","author":"Li","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cbi.2025.111550_bib6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41420-024-01957-w","article-title":"RIPK3 signaling and its role in regulated cell death and diseases","volume":"10","author":"Zhou","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cbi.2025.111550_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.trecan.2021.09.003","article-title":"Necroptosis and tumor progression","volume":"8","author":"Yan","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.cbi.2025.111550_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2025.111550_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2025.111550_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cr.2013.171","article-title":"Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death","volume":"24","author":"Chen","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.cbi.2025.111550_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/bs.ircmb.2019.12.006","article-title":"Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases","volume":"353","author":"Dion\u00edsio","year":"2020","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.cbi.2025.111550_bib12","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1073\/pnas.1716578115","article-title":"TWEAK and RIPK1 mediate a second wave of cell death during AKI","volume":"115","author":"Martin-Sanchez","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2025.111550_bib13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.resinv.2016.03.008","article-title":"The role of necroptosis in pulmonary diseases,","volume":"54","author":"Mizumura","year":"2016","journal-title":"Respir Investig"},{"key":"10.1016\/j.cbi.2025.111550_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.365","article-title":"Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers","volume":"5","author":"Weisel","year":"2017","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.cbi.2025.111550_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ajpath.2019.10.012","article-title":"Necroptosis in the pathophysiology of disease","volume":"190","author":"Khoury","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cbi.2025.111550_bib16","doi-asserted-by":"crossref","first-page":"109615","DOI":"10.1016\/j.biopha.2019.109615","article-title":"Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models","volume":"121","author":"Jiang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2025.111550_bib17","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/med.21754","article-title":"Mechanisms of melanocyte death in vitiligo","volume":"41","author":"Chen","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cbi.2025.111550_bib18","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1038\/s41467-021-25945-1","article-title":"OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice","volume":"12","author":"Sch\u00fcnke","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2025.111550_bib19","doi-asserted-by":"crossref","first-page":"eaax2398","DOI":"10.1126\/scitranslmed.aax2398","article-title":"Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"13","author":"Kinoshita","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cbi.2025.111550_bib20","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/febs.14738","article-title":"Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model","volume":"286","author":"Shlomovitz","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.cbi.2025.111550_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrm3819","article-title":"Polo-like kinases: structural variations lead to multiple functions","volume":"15","author":"Zitouni","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbi.2025.111550_bib22","first-page":"6826","article-title":"Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3","volume":"60","author":"Conn","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2025.111550_bib23","doi-asserted-by":"crossref","first-page":"4201287","DOI":"10.1155\/2022\/4201287","article-title":"Inhibition of PLK3 attenuates tubular epithelial cell apoptosis after renal ischemia-reperfusion injury by blocking the ATM\/P53-mediated DNA damage response","volume":"2022","author":"Deng","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cbi.2025.111550_bib24","first-page":"616","article-title":"Cell carcinoma","volume":"116","author":"Gutzmer","year":"2019","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.cbi.2025.111550_bib25","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.1249361","article-title":"Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis","volume":"343","author":"Newton","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cbi.2025.111550_bib26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2014.10.021","article-title":"RIP3 induces apoptosis independent of pronecrotic kinase activity","volume":"56","author":"Mandal","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.cbi.2025.111550_bib27","doi-asserted-by":"crossref","first-page":"1157054","DOI":"10.3389\/fphar.2023.1157054","article-title":"The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia\/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111550_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s13238-020-00796-6","article-title":"The function and regulation of TET2 in innate immunity and inflammation","volume":"12","author":"Cong","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.cbi.2025.111550_bib29","article-title":"DNA dioxygenases Tet2\/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation","volume":"9","author":"Chen","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cbi.2025.111550_bib30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tcb.2022.05.008","article-title":"The web of death: the expanding complexity of necroptotic signaling","volume":"33","author":"Horne","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cbi.2025.111550_bib31","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/1346-8138.15929","article-title":"Role of necroptosis in infection-related, immune-mediated, and autoimmune skin diseases","volume":"48","author":"Liu","year":"2021","journal-title":"J. Dermatol."},{"key":"10.1016\/j.cbi.2025.111550_bib32","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature20558","article-title":"RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation","volume":"540","author":"Lin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2025.111550_bib33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.3206","article-title":"The diverse role of RIP kinases in necroptosis and inflammation,","volume":"16","author":"Silke","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cbi.2025.111550_bib34","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1111\/febs.13034","article-title":"RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis","volume":"281","author":"Kearney","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.cbi.2025.111550_bib35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41420-021-00732-5","article-title":"Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice","volume":"7","author":"Li","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cbi.2025.111550_bib36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature15252","article-title":"Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2025.111550_bib37","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.celrep.2016.04.044","article-title":"TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities","volume":"15","author":"Montagner","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cbi.2025.111550_bib38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature11742","article-title":"TET2 promotes histone O-GlcNAcylation during gene transcription","volume":"493","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2025.111550_bib39","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1016\/j.celrep.2019.07.094","article-title":"Non-catalytic roles of Tet2 are essential to regulate hematopoietic stem and progenitor cell homeostasis","volume":"28","author":"Ito","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cbi.2025.111550_bib40","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1038\/sj.onc.1205850","article-title":"Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways","volume":"21","author":"Bahassi","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.cbi.2025.111550_bib41","doi-asserted-by":"crossref","first-page":"109225","DOI":"10.1016\/j.celrep.2021.109225","article-title":"miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3","volume":"35","author":"Liu","year":"2021","journal-title":"Cell Rep."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:52:14Z","timestamp":1762113134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725001802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":41,"alternative-id":["S0009279725001802"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111550","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TET2 promotes UVB-induced cell death by activating RIPK3-MLKL-necroptosis signaling","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111550"}}