{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:09:19Z","timestamp":1778879359806,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["4.64\\u22C510\\u22123 M"],"award-info":[{"award-number":["4.64\\u22C510\\u22123 M"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["D2902"],"award-info":[{"award-number":["D2902"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["S33\\u2013S47"],"award-info":[{"award-number":["S33\\u2013S47"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cbi.2025.111561","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T04:54:46Z","timestamp":1747716886000},"page":"111561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Incorporating alkylthio groups provides potent in vitro anticancer activity to water-soluble and aqueous-stable diiron(I) bis-cyclopentadienyl complexes"],"prefix":"10.1016","volume":"418","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2538-3058","authenticated-orcid":false,"given":"Chiara","family":"Saviozzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-9880","authenticated-orcid":false,"given":"Marija","family":"Mojic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Biancalana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Funaioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarita","family":"Biver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-0518","authenticated-orcid":false,"given":"Stefano","family":"Zacchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-9098","authenticated-orcid":false,"given":"Sanja","family":"Mijatovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-5079","authenticated-orcid":false,"given":"Danijela","family":"Maksimovic-Ivanic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3683-8708","authenticated-orcid":false,"given":"Fabio","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111561_bib1","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: opportunities and challenges of discovery and development","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.cbi.2025.111561_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chempr.2019.10.013","article-title":"Classification of metal-based drugs according to their mechanisms of action","volume":"6","author":"Boros","year":"2020","journal-title":"Chem"},{"key":"10.1016\/j.cbi.2025.111561_bib3","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1021\/cr900134a","article-title":"Application of metal coordination chemistry to explore and manipulate cell biology","volume":"109","author":"Haas","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.cbi.2025.111561_bib4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ddtec.2019.06.001","article-title":"Organometallic compounds in drug discovery: past, present and future","volume":"37","author":"Ching Ong","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cbi.2025.111561_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202300645","article-title":"The therapeutic potential in cancer of terpyridine\u2010based metal complexes featuring group 11 elements","volume":"19","author":"Gil\u2010Moles","year":"2024","journal-title":"ChemMedChem"},{"key":"10.1016\/j.cbi.2025.111561_bib6","series-title":"Iron Metabolism: from Molecular Mechanisms to Clinical Consequences","first-page":"22","article-title":"The essential role of iron in biology","author":"Crichton","year":"2016"},{"key":"10.1016\/j.cbi.2025.111561_bib7","doi-asserted-by":"crossref","first-page":"20441","DOI":"10.1021\/acsomega.2c01833","article-title":"Iron absorption: factors, limitations, and improvement methods","volume":"7","author":"Piskin","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.cbi.2025.111561_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116603","article-title":"Anti-cancer property and DNA binding interaction of first row transition metal complexes: a decade update","volume":"275","author":"Dasmahapatra","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112109","article-title":"Ferrocene-containing hybrids as potential anticancer agents: current developments, mechanisms of action and structure-activity relationships","volume":"190","author":"Wang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib10","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1021\/om400446y","article-title":"A new age for iron: antitumoral ferrocenes","volume":"32","author":"Braga","year":"2013","journal-title":"Organometallics"},{"key":"10.1016\/j.cbi.2025.111561_bib11","first-page":"223","article-title":"Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents","volume":"vol. 6","author":"Valente","year":"2021"},{"key":"10.1016\/j.cbi.2025.111561_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41570-017-0066","article-title":"The medicinal chemistry of ferrocene and its derivatives","volume":"1","author":"Patra","year":"2017","journal-title":"Nat. Chem. Rev"},{"key":"10.1016\/j.cbi.2025.111561_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jorganchem.2019.121017","article-title":"Ferrocenes in medicinal chemistry; a personal perspective","volume":"905","author":"Sansook","year":"2020","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/BF00390468","article-title":"Ferricenium complexes: a new type of water-soluble antitumor agent","volume":"108","author":"Kopf-Maier","year":"1984","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.cbi.2025.111561_bib15","volume":"510","author":"Ben Yosef","year":"2020","journal-title":"Inorg. Chim. Acta."},{"key":"10.1016\/j.cbi.2025.111561_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112386","article-title":"Iron (II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: ethylenebis (diphenylphosphane) vs. triphenylphosphine","volume":"249","author":"Pilon","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.cbi.2025.111561_bib17","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.3390\/molecules26185535","article-title":"N-heterocyclic carbene iron complexes as anticancer agents: in vitro and in vivo biological studies","volume":"26","author":"Lenis-Rojas","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111561_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115466","article-title":"First iron(II) organometallic compound acting as ABCB1 inhibitor","volume":"256","author":"Pilon","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41570-020-00226-5","article-title":"Bimetallic cooperation across the periodic table","volume":"4","author":"Campos","year":"2020","journal-title":"Nat. Rev. Chem"},{"key":"10.1016\/j.cbi.2025.111561_bib20","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/cr940270y","article-title":"Hydrocarbyl ligand transformations on heterobimetallic complexes","volume":"107","author":"Ritleng","year":"2007","journal-title":"Chem. Rev."},{"key":"10.1016\/j.cbi.2025.111561_bib21","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.1039\/c3dt51260f","article-title":"Dinuclear gold(i) complexes with propylene bridged N-heterocyclic dicarbene ligands: synthesis, structures, and trends in reactivities and properties","volume":"42","author":"Tubaro","year":"2013","journal-title":"Dalton Trans."},{"key":"10.1016\/j.cbi.2025.111561_bib22","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1038\/s41467-024-52116-9","article-title":"Water-catalyzed iron-molybdenum carbyne formation in bimetallic acetylene transformation","volume":"15","author":"Zhai","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2025.111561_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0010-8545(02)00116-9","article-title":"Remarkable reactions of cationic carbyne complexes of manganese, rhenium, and diiron with carbonylmetal anions","volume":"231","author":"Chen","year":"2002","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.cbi.2025.111561_bib24","doi-asserted-by":"crossref","first-page":"10174","DOI":"10.1002\/chem.201201040","article-title":"C-C bond formation in diiron complexes","volume":"18","author":"Mazzoni","year":"2012","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.cbi.2025.111561_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214203","article-title":"Aminocarbyne ligands in organometallic chemistry","volume":"449","author":"Biancalana","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.cbi.2025.111561_bib26","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1039\/D1SC05473B","article-title":"Combining metal \u2013 metal cooperativity, metal\u2013ligand cooperativity and chemical non-innocence in diiron carbonyl complexes","volume":"13","author":"van Beek","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.cbi.2025.111561_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/acs.organomet.9b00681","article-title":"Exploring the anticancer potential of diiron bis-cyclopentadienyl complexes with bridging hydrocarbyl ligands: behavior in aqueous media and in vitro cytotoxicity","volume":"39","author":"Agonigi","year":"2020","journal-title":"Organometallics"},{"key":"10.1016\/j.cbi.2025.111561_bib28","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.drudis.2016.07.007","article-title":"Quality guidelines for oral drug candidates: dose, solubility and lipophilicity","volume":"21","author":"Bayliss","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cbi.2025.111561_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cmdc.201900677","article-title":"Note of caution for the aqueous behaviour of metal-based drug candidates","volume":"15","author":"Notaro","year":"2020","journal-title":"ChemMedChem"},{"key":"10.1016\/j.cbi.2025.111561_bib30","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1021\/acs.jmedchem.8b00077","article-title":"Lipophilic efficiency as an important metric in drug design","volume":"61","author":"Johnson","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib31","doi-asserted-by":"crossref","first-page":"10169","DOI":"10.1002\/chem.202101048","article-title":"Easily available, amphiphilic diiron cyclopentadienyl complexes exhibit in vitro anticancer activity in 2D and 3D human cancer cells through redox modulation triggered by CO release","volume":"27","author":"Biancalana","year":"2021","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.cbi.2025.111561_bib32","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1021\/acs.jmedchem.4c00377","volume":"67","author":"Mihajlovi\u0107","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib33","doi-asserted-by":"crossref","first-page":"11138","DOI":"10.1021\/acs.jmedchem.4c00641","volume":"67","author":"De Franco","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib34","doi-asserted-by":"crossref","first-page":"14801","DOI":"10.1002\/chem.201902885","article-title":"Anticancer potential of diiron vinyliminium complexes","volume":"25","author":"Rocco","year":"2019","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.cbi.2025.111561_bib35","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3390\/pharmaceutics13081158","article-title":"Anticancer diiron vinyliminium complexes: a structure\u2013activity relationship study","volume":"13","author":"Braccini","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2025.111561_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110742","article-title":"N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity","volume":"385","author":"Bresciani","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111561_bib37","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1039\/D3DT00186E","article-title":"The beneficial effect of cyclohexyl substituent on the in vitro anticancer activity of diiron vinyliminium complexes","volume":"52","author":"Benetti","year":"2023","journal-title":"Dalton Trans."},{"key":"10.1016\/j.cbi.2025.111561_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.213890","article-title":"Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents","volume":"439","author":"Steel","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.cbi.2025.111561_bib39","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.1039\/C4CC00419A","article-title":"The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells","volume":"50","author":"Cheng","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.cbi.2025.111561_bib40","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/chem.201504915","article-title":"Syntheses of platinum\u2013sulindac complexes and their nanoparticles as targeted anticancer drugs","volume":"22","author":"Ru Hwu","year":"2016","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.cbi.2025.111561_bib41","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1021\/acs.accounts.5b00127","article-title":"Metal complexes of curcumin for cellular imaging, targeting, and photoinduced anticancer activity","volume":"48","author":"Banerjee","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.cbi.2025.111561_bib42","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.3390\/app13095561","article-title":"Recent advances in bioconjugated transition metal complexes for cancer therapy","volume":"13","author":"Bortolamiol","year":"2023","journal-title":"Appl. Sci."},{"key":"10.1016\/j.cbi.2025.111561_bib43","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1399-3054.2008.01080.x","article-title":"The chemistry behind redox regulation with a focus on sulphur redox systems","volume":"133","author":"Jacob","year":"2008","journal-title":"Physiol. Plantarum"},{"key":"10.1016\/j.cbi.2025.111561_bib44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/187152011795347522","article-title":"Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds","volume":"11","author":"Cerella","year":"2011","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib45","first-page":"167","volume":"vol. 37","author":"De Gianni","year":"2015"},{"key":"10.1016\/j.cbi.2025.111561_bib46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/biof.5520260201","article-title":"Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review","volume":"26","author":"Ariga","year":"2006","journal-title":"Biofactors"},{"key":"10.1016\/j.cbi.2025.111561_bib47","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1039\/D1OB01992A","article-title":"Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffold","volume":"20","author":"Yoneda","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib48","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/carcin\/bgn165","article-title":"Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter","volume":"29","author":"Nian","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2025.111561_bib49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00726-010-0522-6","article-title":"Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy","volume":"41","author":"Melino","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbi.2025.111561_bib50","doi-asserted-by":"crossref","first-page":"15116","DOI":"10.1039\/C9RA09783J","article-title":"Synthesis of new N,N-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of their in vitro anticancer activity","volume":"10","author":"Akhmetova","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.cbi.2025.111561_bib51","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/molecules25071656","article-title":"Mono-, di- and tetra-iron complexes with selenium or sulphur functionalized vinyliminium ligands: synthesis, structural characterization and antiproliferative activity","volume":"25","author":"Agonigi","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111561_bib52","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1021\/om060550r","article-title":"Unprecedented zwitterionic Iminium\u2212Chalcogenide bridging ligands in diiron complexes","volume":"25","author":"Busetto","year":"2006","journal-title":"Organometallics"},{"key":"10.1016\/j.cbi.2025.111561_bib53","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0277-5387(00)84477-0","article-title":"Carbon-13 NMR shifts of bridging hydrocarbyls derived from the addition of nucleophiles to complexed organic ligands in di- and polynuclear complexes","volume":"11","author":"Cherkas","year":"1992","journal-title":"Polyhedron"},{"key":"10.1016\/j.cbi.2025.111561_bib54","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1021\/ja00122a010","article-title":"Alkyl, alkylidene, and alkylidyne complexes of osmium(VI)","volume":"117","author":"LaPointe","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cbi.2025.111561_bib55","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jorganchem.2008.04.010","article-title":"Zwitterionic diiron vinyliminium complexes: alkylation, metalation and oxidative coupling at the S and Se functionalities","volume":"693","author":"Busetto","year":"2008","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib56","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.1021\/ic049479c","article-title":"Tuning of redox potentials for the design of ruthenium anticancer drugs- an electrochemical study of [trans-RuCl4L(DMSO)]\u2212 and [trans-RuCl4L2]\u2212 complexes, where L = imidazole, 1,2,4-triazole, indazole","volume":"43","author":"Reisner","year":"2004","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib57","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S0891-5849(99)00145-8","article-title":"Glutathione redox potential in response to differentiation and enzyme inducers","volume":"27","author":"Kirlin","year":"1999","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.cbi.2025.111561_bib58","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111561_bib59","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1021\/jm2014937","article-title":"Aminoferrocene-based prodrugs activated by reactive oxygen species","volume":"55","author":"Hagen","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib60","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfac096","article-title":"The choice of \u03bc-vinyliminium ligand substituents is key to optimize the antiproliferative activity of related diiron complexes","volume":"15","author":"Campanella","year":"2023","journal-title":"Metallomics"},{"key":"10.1016\/j.cbi.2025.111561_bib61","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1021\/acs.inorgchem.3c03408","article-title":"Triiron complex with N-ferrocenyl aminocarbyne ligand bridging a diiron core: DFT, electrochemical, and biological insights","volume":"63","author":"Saviozzi","year":"2024","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312827","article-title":"The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis","volume":"22","author":"Ghasemi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111561_bib63","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot087379","article-title":"Crystal violet assay for determining viability of cultured cells","author":"Feoktistova","year":"2016","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.cbi.2025.111561_bib64","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3892\/mmr.2014.2671","article-title":"Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells","volume":"11","author":"Bao","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cbi.2025.111561_bib65","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3390\/ijms19071985","article-title":"Detection of the mitochondrial membrane potential by the cationic dye JC-1 in L1210 cells with massive overexpression of the plasma membrane ABCB1 drug transporter","volume":"19","author":"Elefantova","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111561_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023211","article-title":"Mitochondrial network determines intracellular ROS dynamics and sensitivity to oxidative stress through switching inter-mitochondrial messengers","volume":"6","author":"Park","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2025.111561_bib67","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1021\/acs.jmedchem.6b01243","article-title":"Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria","volume":"60","author":"Dharmaraja","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/ar030113y","article-title":"A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity","volume":"37","author":"Tse","year":"2004","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.cbi.2025.111561_bib69","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1021\/acs.organomet.1c00270","article-title":"A strategy to conjugate bioactive fragments to cytotoxic diiron bis(cyclopentadienyl) complexes","volume":"40","author":"Schoch","year":"2021","journal-title":"Organometallics"},{"key":"10.1016\/j.cbi.2025.111561_bib70","series-title":"Spectragryph - Optical Spectroscopy Software","author":"Menges","year":"2016"},{"key":"10.1016\/j.cbi.2025.111561_bib71","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/om100106e","article-title":"NMR chemical shifts of trace impurities: common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist","volume":"29","author":"Fulmer","year":"2010","journal-title":"Organometallics"},{"key":"10.1016\/j.cbi.2025.111561_bib72","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/mrc.1260310315","article-title":"Gradient selection in inverse heteronuclear correlation spectroscopy","volume":"31","author":"Willker","year":"1993","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib73","series-title":"SADABS-2008\/1 - Bruker AXS Area Detector Scaling and Absorption Correction","author":"Sheldrick","year":"2008"},{"key":"10.1016\/j.cbi.2025.111561_bib74","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst. C"},{"key":"10.1016\/j.cbi.2025.111561_bib75","article-title":"OECD guidelines for testing of chemicals","volume":"107","year":"1995","journal-title":"OECD"},{"key":"10.1016\/j.cbi.2025.111561_bib76","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/qsar.19880070304","article-title":"The measurement of partition coefficients","volume":"7","author":"Dearden","year":"1988","journal-title":"Quant. Struct.-Act. Relat."},{"key":"10.1016\/j.cbi.2025.111561_bib77","first-page":"2014","article-title":"All about albumin: biochemistry, genetics, and medical applications","volume":"43","author":"Azzazy","year":"1997","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cbi.2025.111561_bib78","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0022-2836(65)80106-1","article-title":"A neighbor-interaction analysis of the hypochromism and spectra of DNA","volume":"13","author":"Felsenfeld","year":"1965","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cbi.2025.111561_bib79","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-2836(65)80096-1","article-title":"Complex formation between ethidium bromide and nucleic acids","volume":"13","author":"Waring","year":"1965","journal-title":"J. Mol. Biol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:17:31Z","timestamp":1778876251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725001917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":79,"alternative-id":["S0009279725001917"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111561","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incorporating alkylthio groups provides potent in vitro anticancer activity to water-soluble and aqueous-stable diiron(I) bis-cyclopentadienyl complexes","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111561"}}