{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:42:45Z","timestamp":1793083365001,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["533-03-23-0006"],"award-info":[{"award-number":["533-03-23-0006"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["643-02\/23-01\/00016"],"award-info":[{"award-number":["643-02\/23-01\/00016"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Croatian Science Foundation","doi-asserted-by":"publisher","award":["HrZZ-UIP-2017-05-7260"],"award-info":[{"award-number":["HrZZ-UIP-2017-05-7260"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cbi.2025.111567","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T07:37:09Z","timestamp":1747813029000},"page":"111567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Cholinesterase activity modulators: Evaluation of dodecylaminoquinuclidines as inhibitors of human AChE and BChE"],"prefix":"10.1016","volume":"417","author":[{"given":"Ana-Marija","family":"Luli\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucija","family":"Marceli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Rami\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja Radman","family":"Kastelic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Zandona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Marakovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Primo\u017ei\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-4291","authenticated-orcid":false,"given":"Maja","family":"Katalini\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111567_bib1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"V Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2025.111567_bib2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbi.2025.111567_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.pa.34.040194.001433","article-title":"The cholinesterases: from genes to proteins","volume":"34","author":"Taylor","year":"1994","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0301-0082(93)90040-Y","article-title":"Molecular and cellular biology of cholinesterases","volume":"41","author":"Massouli\u00e9","year":"1993","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cbi.2025.111567_bib5","doi-asserted-by":"crossref","first-page":"17213","DOI":"10.1073\/pnas.0508575102","article-title":"Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent","volume":"102","author":"Greig","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2025.111567_bib6","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","article-title":"Monoamine oxidase inactivation: from pathophysiology to therapeutics","volume":"60","author":"Bortolato","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.cbi.2025.111567_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1567205054367829","article-title":"An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimers disease","volume":"2","author":"Greig","year":"2005","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.cbi.2025.111567_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tips.2004.11.007","article-title":"Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders","volume":"26","author":"Youdim","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2025.111567_bib9","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00204-020-02797-0","article-title":"Organophosphorus compounds and oximes: a critical review","volume":"94","author":"Worek","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib10","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1021\/acs.jmedchem.8b01398","article-title":"Pyridinium oximes with ortho -positioned chlorine moiety exhibit improved physicochemical properties and efficient reactivation of human acetylcholinesterase inhibited by several nerve agents","volume":"61","author":"Zorbaz","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00953-9","article-title":"Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase","volume":"11","author":"\u010cade\u017e","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2025.111567_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104639","article-title":"Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry","volume":"109","author":"Yadav","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib13","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1007\/s00204-020-02811-5","article-title":"Targeting organophosphorus compounds poisoning by novel quinuclidine-3 oximes: development of butyrylcholinesterase-based bioscavengers","volume":"94","author":"Zandona","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/ijms25010155","article-title":"Profiling novel quinuclidine-based derivatives as potential anticholinesterase drugs: enzyme inhibition and effects on cell viability","volume":"25","author":"\u017dunec","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111567_bib15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.colsurfb.2015.11.023","article-title":"Structure\u2013property relationship of quinuclidinium surfactants\u2014towards multifunctional biologically active molecules","volume":"140","author":"Sko\u010dibu\u0161i\u0107","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.cbi.2025.111567_bib16","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1021\/acschemneuro.3c00225","article-title":"Side groups convert the \u03b17 nicotinic receptor agonist ether quinuclidine into a type I positive allosteric modulator","volume":"14","author":"Viscarra","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.cbi.2025.111567_bib17","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1021\/acs.jmedchem.0c00297","article-title":"Regiospecific introduction of halogens on the 2-aminobiphenyl subunit leading to highly potent and selective M3 muscarinic acetylcholine receptor antagonists and weak inverse agonists","volume":"63","author":"Fischer","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/pharmaceutics13030420","article-title":"Quinuclidine-based carbamates as potential CNS active compounds","volume":"13","author":"Mato\u0161evi\u0107","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2025.111567_bib19","first-page":"13","article-title":"Comparison of protocols for measuring activities of human blood cholinesterases by the Ellman method","volume":"51","author":"Reiner","year":"2000","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.cbi.2025.111567_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-77647-5","article-title":"Naturally derived 3-aminoquinuclidine salts as new promising therapeutic agents","volume":"14","author":"Crn\u010devi\u0107","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2025.111567_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tox.2005.11.003","article-title":"In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity","volume":"219","author":"\u010cali\u0107","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2025.111567_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111567_bib23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0021-9258(18)51079-6","article-title":"The inhibition of arginase by amino acids","volume":"157","author":"Hunter","year":"1945","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cbi.2025.111567_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2025.111567_bib26","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1021\/ci800081s","article-title":"Fully automated molecular mechanics based induced fit protein\u2212ligand docking method","volume":"48","author":"Koska","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.cbi.2025.111567_bib27","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3390\/pharmaceutics14061305","article-title":"4-Aminoquinoline-based adamantanes as potential anticholinesterase agents in symptomatic treatment of Alzheimer's disease","volume":"14","author":"Komatovi\u0107","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2025.111567_bib28","doi-asserted-by":"crossref","first-page":"10282","DOI":"10.1021\/jm300871x","article-title":"Structures of human acetylcholinesterase in complex with pharmacologically important ligands","volume":"55","author":"Cheung","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib29","doi-asserted-by":"crossref","first-page":"41141","DOI":"10.1074\/jbc.M210241200","article-title":"Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products","volume":"278","author":"Nicolet","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib30","first-page":"173","article-title":"Inhibition of human blood acetylcholinesterase and butyrylcholinesterase by ethopropazine","volume":"74","author":"Simeon-Rudolf","year":"2001","journal-title":"Croat. Chem. Acta"},{"key":"10.1016\/j.cbi.2025.111567_bib31","series-title":"Mechanism of Action of Cholinesterase Inhibitors","first-page":"103","author":"Reiner","year":"2000"},{"key":"10.1016\/j.cbi.2025.111567_bib32","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1007\/s00204-021-03098-w","article-title":"Activation of (un)regulated cell death as a new perspective for bispyridinium and imidazolium oximes","volume":"95","author":"Zandona","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib33","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.3390\/molecules22122098","article-title":"Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: a crystallographic, kinetic and calorimetric study","volume":"22","author":"Rosenberry","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111567_bib34","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.tips.2022.04.008","article-title":"Countermeasures in organophosphorus intoxication: pitfalls and prospects","volume":"43","author":"Gorecki","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2025.111567_bib36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cbi.2016.04.032","article-title":"Oximes in organophosphate poisoning: 60 years of hope and despair","volume":"259","author":"Worek","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111567_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114377","article-title":"Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents","volume":"238","author":"Zorbaz","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib38","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.3390\/ijms23063121","article-title":"Structural modifications on chalcone framework for developing new class of cholinesterase inhibitors","volume":"23","author":"George","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111567_bib39","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/14756366.2019.1707197","article-title":"Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives","volume":"35","author":"\u0160agud","year":"2020","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib40","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn983","article-title":"Pathogenesis of Parkinson's disease: dopamine, vesicles and \u03b1-synuclein","volume":"3","author":"Lotharius","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cbi.2025.111567_bib41","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-025-03985-6","article-title":"Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging","author":"\u010cade\u017e","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib42","series-title":"Neuronal Cell Culture","year":"2013"},{"key":"10.1016\/j.cbi.2025.111567_bib43","first-page":"1086","article-title":"SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease","volume":"123","author":"Xie","year":"2010","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.cbi.2025.111567_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/ph16020187","article-title":"Synthesis and biological evaluation of 3-amidoquinuclidine quaternary ammonium compounds as new soft antibacterial agents","volume":"16","author":"Od\u017eak","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.cbi.2025.111567_bib45","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/antibiotics12081231","article-title":"Further study of the polar group's influence on the antibacterial activity of the 3-substituted quinuclidine salts with long alkyl chains","volume":"12","author":"Od\u017eak","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.cbi.2025.111567_bib46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3390\/pathogens9060459","article-title":"Biological activity of quaternary ammonium salts and their derivatives","volume":"9","author":"Kwa\u015bniewska","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.cbi.2025.111567_bib47","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00204-020-02733-2","article-title":"Mode of action-based risk assessment of genotoxic carcinogens","volume":"94","author":"Hartwig","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib48","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.3390\/ijms23095072","article-title":"Kinetic modeling of time-dependent enzyme inhibition by pre-steady-state analysis of progress curves: the case study of the anti-Alzheimer\u2019s drug galantamine","volume":"23","author":"Lamba","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111567_bib49","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1007\/s00204-021-03155-4","article-title":"Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety","volume":"95","author":"Borgert","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib50","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1021\/acs.chemrestox.3c00352","article-title":"Advancing drug safety in drug development: bridging computational predictions for enhanced toxicity prediction","volume":"37","author":"Amorim","year":"2024","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2025.111567_bib51","doi-asserted-by":"crossref","first-page":"G58","DOI":"10.1152\/ajpgi.1983.244.1.G58","article-title":"Development of neurotransmitter enzyme activity in the rat gastrointestinal tract","volume":"244","author":"Heitkemper","year":"1983","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cbi.2025.111567_bib52","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.3390\/nu15102366","article-title":"Effect of inhibiting butyrylcholinesterase activity using fractionated coffee extracts digested in vitro in gastrointestinal tract: docking simulation and calorimetric and studies","volume":"15","author":"Grzelczyk","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.cbi.2025.111567_bib53","doi-asserted-by":"crossref","DOI":"10.2174\/1570163814666170404160911","article-title":"Prediction of human intestinal absorption of compounds using artificial intelligence techniques","volume":"14","author":"Kumar","year":"2017","journal-title":"Curr. Drug Discov. Technol."},{"key":"10.1016\/j.cbi.2025.111567_bib54","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mi.3.2.90","article-title":"Blood-brain barrier drug targeting: the future of brain drug development","volume":"3","author":"Pardridge","year":"2003","journal-title":"Mol. Interv."},{"key":"10.1016\/j.cbi.2025.111567_bib55","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3390\/ph15080975","article-title":"Intestinal absorption study: challenges and absorption enhancement strategies in improving oral drug delivery","volume":"15","author":"Azman","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.cbi.2025.111567_bib56","doi-asserted-by":"crossref","first-page":"217","DOI":"10.9734\/BJPR\/2015\/18013","article-title":"In silico identification of novel potential BACE-1 inhibitors for Alzheimer's disease treatment: molecular docking, pharmacophore modeling and activity and synthetic accessibility predictions","volume":"7","author":"Pinhiero","year":"2015","journal-title":"Br. J. Pharmaceut. Res."},{"key":"10.1016\/j.cbi.2025.111567_bib57","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3390\/molecules23040911","article-title":"Evaluating molecular properties involved in transport of small molecules in stratum corneum: a quantitative structure-activity relationship for skin permeability","volume":"23","author":"Chen","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111567_bib58","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/pharmaceutics7040438","article-title":"Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum","volume":"7","author":"Alkilani","year":"2015","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2025.111567_bib59","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111567_bib60","author":"Held"},{"key":"10.1016\/j.cbi.2025.111567_bib61","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/jps.2600640540","article-title":"Synthesis and CMC determination of a series of aliphatic diamines","volume":"64","author":"Powers","year":"1975","journal-title":"J. Pharmaceut. Sci."},{"key":"10.1016\/j.cbi.2025.111567_bib62","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/ijms17020223","article-title":"Micellization behavior of long-chain substituted Alkylguanidinium surfactants","volume":"17","author":"Bouchal","year":"2016","journal-title":"Int. J. Mol. Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725001978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T20:44:51Z","timestamp":1749069891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725001978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":62,"alternative-id":["S0009279725001978"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111567","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholinesterase activity modulators: Evaluation of dodecylaminoquinuclidines as inhibitors of human AChE and BChE","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111567"}}