{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:46:45Z","timestamp":1787964405406,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170645"],"award-info":[{"award-number":["82170645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0735"],"award-info":[{"award-number":["2024NSFSC0735"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017520","name":"Chengdu Medical College","doi-asserted-by":"publisher","award":["YCX2024-01-07"],"award-info":[{"award-number":["YCX2024-01-07"]}],"id":[{"id":"10.13039\/100017520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017520","name":"Chengdu Medical College","doi-asserted-by":"publisher","award":["23LHZY04"],"award-info":[{"award-number":["23LHZY04"]}],"id":[{"id":"10.13039\/100017520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cbi.2025.111614","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T02:29:31Z","timestamp":1750300171000},"page":"111614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma"],"prefix":"10.1016","volume":"418","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-0585","authenticated-orcid":false,"given":"Chun-fen","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-ruo","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-jing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-bai","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111614_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cbi.2025.111614_bib2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s13402-023-00807-8","article-title":"DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis","volume":"46","author":"Feng","year":"2023","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.cbi.2025.111614_bib3","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.cbi.2025.111614_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"Electronic address, L. European association for the study of the, EASL clinical practice guidelines: Management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2025.111614_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115801","article-title":"Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review","volume":"22","author":"Oura","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.cbi.2025.111614_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/myc.12054","article-title":"Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids","volume":"56","author":"Veraldi","year":"2013","journal-title":"Mycoses"},{"key":"10.1016\/j.cbi.2025.111614_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/00362178585380611","article-title":"Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents","volume":"23","author":"Odds","year":"1985","journal-title":"Sabouraudia"},{"key":"10.1016\/j.cbi.2025.111614_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jphs.2024.01.006","article-title":"Sulconazole induces pyroptosis promoted by interferon-gamma in monocyte\/macrophage lineage cells","volume":"154","author":"Miyawaki","year":"2024","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.cbi.2025.111614_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fmolb.2020.00044","article-title":"Identification of NUDT5 inhibitors from approved drugs","volume":"7","author":"Tong","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.cbi.2025.111614_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12040901","article-title":"Oxidative stress, inflammation and colorectal cancer: an overview","volume":"12","author":"Bardelcikova","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbi.2025.111614_bib11","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","article-title":"Oxidative stress and cancer: an overview","volume":"12","author":"Sosa","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cbi.2025.111614_bib12","article-title":"Oxidative stress and reprogramming of lipid metabolism in cancers","volume":"14","author":"Li","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbi.2025.111614_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202300768","article-title":"Piperlongumine and its derivatives against cancer: a recent update and future prospective","author":"Swain","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.cbi.2025.111614_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156604","article-title":"Alkannin triggered apoptosis and ferroptosis in gastric cancer by suppressing lipid metabolism mediated by the c-Fos\/SREBF1 axis","volume":"140","author":"Yu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2025.111614_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00280-011-1700-2","article-title":"Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin","volume":"69","author":"Afzal","year":"2012","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111614_bib16","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41416-020-0970-z","article-title":"IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src\/FAK signalling in hepatocellular carcinoma","volume":"123","author":"Mo","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cbi.2025.111614_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116251","article-title":"DDX39B protects against sorafenib-induced ferroptosis by facilitating the splicing and cytoplasmic export of GPX4 pre-mRNA in hepatocellular carcinoma","volume":"225","author":"Li","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111614_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-022-05508-y","article-title":"DDX17 induces epithelial-mesenchymal transition and metastasis through the miR-149-3p\/CYBRD1 pathway in colorectal cancer","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2025.111614_bib19","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300070RRR","article-title":"NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis","volume":"38","author":"He","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2025.111614_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41392-022-01096-7","article-title":"DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.cbi.2025.111614_bib21","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.1038\/s41388-022-02512-6","article-title":"Cystathionine gamma-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma","volume":"41","author":"Zhang","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.cbi.2025.111614_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.canlet.2018.09.033","article-title":"ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src\/FAK signaling in hepatocellular carcinoma","volume":"442","author":"Li","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cbi.2025.111614_bib23","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/hep.28574","article-title":"Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis","volume":"64","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2025.111614_bib24","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/ars.2012.5116","article-title":"The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice","volume":"20","author":"Mo","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.cbi.2025.111614_bib25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cbi.2025.111614_bib26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2017.05.023","article-title":"ROS signalling in the biology of cancer","volume":"80","author":"Moloney","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cbi.2025.111614_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110661","article-title":"Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K\/AKT\/mTOR, and ROS pathways","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2025.111614_bib28","article-title":"Mitochondrial-targeted CS@KET\/P780 nanoplatform for site-specific delivery and high-efficiency cancer immunotherapy in hepatocellular carcinoma","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.cbi.2025.111614_bib29","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.2147\/DDDT.S227892","article-title":"Miconazole contributes to NRF2 activation by noncanonical P62-KEAP1 pathway in bladder cancer cells","volume":"14","author":"Tsai","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.cbi.2025.111614_bib30","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3892\/ijo.2012.1570","article-title":"Role of metallothionein 1E in the migration and invasion of human glioma cell lines","volume":"41","author":"Ryu","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cbi.2025.111614_bib31","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.febslet.2010.12.030","article-title":"Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells","volume":"585","author":"Kim","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbi.2025.111614_bib32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10456-015-9473-6","article-title":"Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression","volume":"18","author":"Schuermann","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1016\/j.cbi.2025.111614_bib33","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/labinvest.2008.17","article-title":"Metallothionein 1G acts as an oncosupressor in papillary thyroid carcinoma","volume":"88","author":"Ferrario","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cbi.2025.111614_bib34","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.3748\/wjg.v20.i16.4723","article-title":"MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma","volume":"20","author":"Ji","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2025.111614_bib35","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1158\/1055-9965.EPI-04-0659","article-title":"MT1G hypermethylation is associated with higher tumor stage in prostate cancer","volume":"14","author":"Henrique","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.cbi.2025.111614_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13045-018-0645-x","article-title":"The roles of metallothioneins in carcinogenesis","volume":"11","author":"Si","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cbi.2025.111614_bib37","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1158\/0008-5472.CAN-04-1063","article-title":"Increased expression of metallothionein is associated with irinotecan resistance in gastric cancer","volume":"64","author":"Chun","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2025.111614_bib38","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1126\/science.3175622","article-title":"Overexpression of metallothionein confers resistance to anticancer drugs","volume":"241","author":"Kelley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.cbi.2025.111614_bib39","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/elan.200704215","article-title":"Employment of electrochemical techniques for metallothionein determination in tumor cell lines and patients with a tumor disease","volume":"20","author":"Fabrik","year":"2008","journal-title":"Electroanalysis"},{"key":"10.1016\/j.cbi.2025.111614_bib40","doi-asserted-by":"crossref","first-page":"561","DOI":"10.18388\/abp.2010_2444","article-title":"Serum metallothionein in newly diagnosed patients with childhood solid tumours","volume":"57","author":"Krizkova","year":"2010","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.cbi.2025.111614_bib41","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00280-015-2702-2","article-title":"Serum metallothionein in patients with testicular cancer","volume":"75","author":"Tariba","year":"2015","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111614_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40164-021-00247-w","article-title":"CD44 promotes hepatocellular carcinoma progression via upregulation of YAP","volume":"10","author":"Zhang","year":"2021","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.cbi.2025.111614_bib43","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2014.08.039","article-title":"Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells","volume":"147","author":"Wan","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbi.2025.111614_bib44","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1084\/jem.20160935","article-title":"Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation","volume":"214","author":"Bakiri","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cbi.2025.111614_bib45","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.3892\/or.2016.5101","article-title":"RUNX2 promotes hepatocellular carcinoma cell migration and invasion by upregulating MMP9 expression","volume":"36","author":"Wang","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cbi.2025.111614_bib46","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.yexmp.2015.03.030","article-title":"ZEB2 promotes vasculogenic mimicry by TGF-beta1 induced epithelial-to-mesenchymal transition in hepatocellular carcinoma","volume":"98","author":"Yang","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.cbi.2025.111614_bib47","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbi.2025.111614_bib48","doi-asserted-by":"crossref","first-page":"14820","DOI":"10.1021\/acs.analchem.2c03515","article-title":"Living cell-target responsive accessibility profiling reveals silibinin targeting ACSL4 for combating ferroptosis","volume":"94","author":"Yan","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cbi.2025.111614_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115812","article-title":"The Hyaluronan\/CD44 axis: a double-edged sword in cancer","volume":"24","author":"Cirillo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111614_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116986","article-title":"The role of Nrf2 signaling in cancer stem cells: from stemness and self-renewal to tumorigenesis and chemoresistance","volume":"239","author":"Kahroba","year":"2019","journal-title":"Life Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725002443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725002443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:15:17Z","timestamp":1778876117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725002443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":50,"alternative-id":["S0009279725002443"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111614","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111614"}}