{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:33:30Z","timestamp":1794047610150,"version":"4.8.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011705"],"award-info":[{"award-number":["2024A1515011705"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110677"],"award-info":[{"award-number":["2023A1515110677"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cbi.2025.111709","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:26:32Z","timestamp":1755822392000},"page":"111709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The underexplored pulmonary toxicity of pyrrolizidine alkaloids: Emerging hazard from food contamination"],"prefix":"10.1016","volume":"420","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-8417","authenticated-orcid":false,"given":"Caibin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111709_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142822","article-title":"Occurrence of pyrrolizidine alkaloids in ragwort plants, soils and surface waters at the field scale in grassland","volume":"755","author":"Hama","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2025.111709_bib2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.envpol.2019.02.026","article-title":"Transfer of pyrrolizidine alkaloids between living plants: a disregarded source of contaminations","volume":"248","author":"Selmar","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111709_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.111107","article-title":"Pyrrolizidine alkaloids in food and phytomedicine: occurrence, exposure, toxicity, mechanisms, and risk assessment - a review","volume":"136","author":"Schrenk","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2025.111709_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144211","article-title":"Comprehensive review of pyrrolizidine alkaloids in bee products: occurrence, extraction, and analytical methods","volume":"483","author":"Brugnerotto","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.cbi.2025.111709_bib5","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.phymed.2015.03.020","article-title":"Detection of pyrrolizidine alkaloids in German licensed herbal medicinal teas","volume":"22","author":"Schulz","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2025.111709_bib6","article-title":"Dietary exposure assessment to pyrrolizidine alkaloids in the European population","volume":"14","author":"Authority","year":"2016","journal-title":"EFSA J."},{"key":"10.1016\/j.cbi.2025.111709_bib7","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41401-020-00553-9","article-title":"Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China","volume":"42","author":"Zhu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2025.111709_bib8","first-page":"124","article-title":"Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids","volume":"38","author":"Song","year":"2020","journal-title":"J. Environ. Sci. Health C., Toxicol Carcinog."},{"key":"10.1016\/j.cbi.2025.111709_bib9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/thx.22.2.176","article-title":"Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds","volume":"22","author":"Kay","year":"1967","journal-title":"Thorax"},{"key":"10.1016\/j.cbi.2025.111709_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/thx.30.4.399","article-title":"A pulmonary hypertension-producing plant from Tanzania","volume":"30","author":"Heath","year":"1975","journal-title":"Thorax"},{"key":"10.1016\/j.cbi.2025.111709_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4414\/smw.2009.12408","article-title":"Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy","volume":"139","author":"Gyorik","year":"2009","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.cbi.2025.111709_bib12","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1021\/acs.jafc.0c02582","article-title":"Linking dietary exposure to 1,2-dehydropyrrolizidine alkaloids with cancers and chemotherapy-induced pulmonary and hepatic veno-occlusive diseases","volume":"68","author":"Edgar","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2025.111709_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115542","article-title":"Comprehensive investigation and risk study on pyrrolizidine alkaloid contamination in Chinese retail honey","volume":"267","author":"He","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111709_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020977300","article-title":"Epidemiology of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: identification of the most accurate estimates from a systematic literature review","volume":"11","author":"Leber","year":"2021","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.cbi.2025.111709_bib15","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.029","article-title":"Updated clinical classification of pulmonary hypertension","volume":"62","author":"Simonneau","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cbi.2025.111709_bib16","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-2600(23)00264-3","article-title":"Treatment of pulmonary arterial hypertension: recent progress and a look to the future","volume":"11","author":"Humbert","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib17","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/jama.2022.4402","article-title":"Diagnosis and treatment of pulmonary arterial hypertension: a review","volume":"327","author":"Ruopp","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.cbi.2025.111709_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.14797\/OCDF4453","article-title":"Evaluation, diagnosis, and classification of pulmonary hypertension","volume":"17","author":"Sarah","year":"2021","journal-title":"Methodist. Debakey. Cardiovasc. J."},{"key":"10.1016\/j.cbi.2025.111709_bib19","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03957-2020","article-title":"Endothelial cells in the pathogenesis of pulmonary arterial hypertension","volume":"58","author":"Evans","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cbi.2025.111709_bib20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1378\/chest.14-0862","article-title":"New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication","volume":"147","author":"Guignabert","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.cbi.2025.111709_bib21","first-page":"4058","article-title":"COX2 expression is downregulated in a shear stress magnitude-dependent manner in BMPR2-silenced HPAECs: implications for prostacyclin deficiency in PAH","volume":"60","author":"Mahomed","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cbi.2025.111709_bib22","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1089\/ars.2018.7673","article-title":"Focus on early events: pathogenesis of pulmonary arterial hypertension development","volume":"31","author":"Rafikova","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.cbi.2025.111709_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031989","article-title":"Bone morphogenetic proteins in vascular homeostasis and disease","volume":"10","author":"Goumans","year":"2018","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.cbi.2025.111709_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41569-019-0242-x","article-title":"Molecular genetic framework underlying pulmonary arterial hypertension","volume":"17","author":"Southgate","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cbi.2025.111709_bib25","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3390\/ijms19092499","article-title":"Consequences of BMPR2 deficiency in the pulmonary vasculature and beyond: contributions to pulmonary arterial hypertension","volume":"19","author":"Andruska","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111709_bib26","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/CIRCULATIONAHA.107.736801","article-title":"Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension","volume":"118","author":"Hong","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cbi.2025.111709_bib27","doi-asserted-by":"crossref","first-page":"H677","DOI":"10.1152\/ajpheart.91519.2007","article-title":"Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice","volume":"295","author":"Song","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cbi.2025.111709_bib28","doi-asserted-by":"crossref","first-page":"33134","DOI":"10.1074\/jbc.M111.274100","article-title":"Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation","volume":"286","author":"Gangopahyay","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2025.111709_bib29","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1164\/rccm.200712-1807OC","article-title":"Clinical outcomes of pulmonary arterial hypertension in carriers of BMPR2 mutation","volume":"177","author":"Sztrymf","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2025.111709_bib30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S2213-2600(15)00544-5","article-title":"BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis","volume":"4","author":"Evans","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.21037\/sci.2017.05.11","article-title":"Rescuing BMPR2-driven endothelial dysfunction in PAH: a novel treatment strategy for the future?","volume":"4","author":"Quarck","year":"2017","journal-title":"Stem Cell Invest."},{"key":"10.1016\/j.cbi.2025.111709_bib32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/path.4833","article-title":"The role of genetics in pulmonary arterial hypertension","volume":"241","author":"Ma","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.cbi.2025.111709_bib33","doi-asserted-by":"crossref","first-page":"15652","DOI":"10.1074\/jbc.M608318200","article-title":"Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase","volume":"282","author":"Fish","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2025.111709_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s11658-022-00408-7","article-title":"The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability","volume":"27","author":"Jaskiewicz","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.cbi.2025.111709_bib35","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.1073\/pnas.1602978113","article-title":"HIF2\u03b1-arginase axis is essential for the development of pulmonary hypertension","volume":"113","author":"Cowburn","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2025.111709_bib36","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3390\/biom11070982","article-title":"Endothelial dysfunction driven by hypoxia-the influence of oxygen deficiency on NO bioavailability","volume":"11","author":"Janaszak-Jasiecka","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.cbi.2025.111709_bib37","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3389\/fphys.2017.01110","article-title":"Effects of hypoxia on erythrocyte membrane properties-implications for intravascular hemolysis and purinergic control of blood flow","volume":"8","author":"Grygorczyk","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbi.2025.111709_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191869","article-title":"Hypoxemia in patients with idiopathic or heritable pulmonary arterial hypertension","volume":"13","author":"Khirfan","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2025.111709_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117487","article-title":"ICAM-1 and VCAM-1: gatekeepers in various inflammatory and cardiovascular disorders","volume":"548","author":"Singh","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbi.2025.111709_bib40","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1164\/rccm.201402-0322OC","article-title":"Proinflammatory signature of the dysfunctional endothelium in pulmonary hypertension. Role of the macrophage migration inhibitory factor\/CD74 complex","volume":"192","author":"Le Hiress","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2025.111709_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006674","article-title":"Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension","volume":"5","author":"Tian","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111709_bib43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.rmed.2018.02.020","article-title":"Pulmonary hypertension in chronic hemolytic anemias: pathophysiology and treatment","volume":"137","author":"Haw","year":"2018","journal-title":"Respir. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11110660","article-title":"Hemolysis derived products toxicity and endothelium: model of the second hit","volume":"11","author":"Frimat","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.cbi.2025.111709_bib45","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm1202-799","article-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","volume":"8","author":"Reiter","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2013-04-495887","article-title":"Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease","volume":"123","author":"Belcher","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2025.111709_bib47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.molmed.2020.02.004","article-title":"Haptoglobin therapeutics and compartmentalization of cell-free hemoglobin toxicity","volume":"26","author":"Buehler","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/ars.2009.2787","article-title":"Heme scavenging and the other facets of hemopexin","volume":"12","author":"Tolosano","year":"2010","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.cbi.2025.111709_bib49","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1182\/blood-2015-08-618561","article-title":"Pathophysiology and treatment of pulmonary hypertension in sickle cell disease","volume":"127","author":"Gordeuk","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2025.111709_bib50","doi-asserted-by":"crossref","first-page":"L312","DOI":"10.1152\/ajplung.00074.2012","article-title":"Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism","volume":"303","author":"Buehler","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cbi.2025.111709_bib51","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.freeradbiomed.2015.01.012","article-title":"Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration","volume":"82","author":"Irwin","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib52","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1378\/chest.14-0809","article-title":"Elevation of plasma cell-free hemoglobin in pulmonary arterial hypertension","volume":"146","author":"Brittain","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.cbi.2025.111709_bib53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tcm.2020.02.002","article-title":"Cardiovascular complications of sickle cell disease","volume":"31","author":"Sachdev","year":"2021","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib54","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","article-title":"Inflammation, growth factors, and pulmonary vascular remodeling","volume":"54","author":"Hassoun","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cbi.2025.111709_bib55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1164\/rccm.201606-1226PP","article-title":"Translational advances in the field of pulmonary hypertension. from cancer biology to new pulmonary arterial hypertension therapeutics. targeting cell growth and proliferation signaling hubs","volume":"195","author":"Pullamsetti","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2025.111709_bib56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/cells10010084","article-title":"Altered TGFbeta\/SMAD signaling in human and rat models of pulmonary hypertension: an old target needs attention","volume":"10","author":"Sanada","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2025.111709_bib57","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02341-2020","article-title":"Targeting transforming growth factor-\u03b2 receptors in pulmonary hypertension","volume":"57","author":"Guignabert","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cbi.2025.111709_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030458","article-title":"Endothelial cells tissue-specific origins affects their responsiveness to TGF-\u03b22 during endothelial-to-mesenchymal transition","volume":"20","author":"Ursoli Ferreira","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111709_bib59","article-title":"Therapeutic approaches for treating pulmonary arterial hypertension by correcting imbalanced TGF-beta superfamily signaling","volume":"8","author":"Andre","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113894","article-title":"Vitex negundo Linn. extract alleviates inflammatory aggravation and lung injury by modulating AMPK\/PI3K\/Akt\/p38-NF-\u03baB and TGF-\u03b2\/Smad\/Bcl2\/caspase\/LC3 cascade and macrophages activation in murine model of OVA-LPS induced allergic asthma","volume":"271","author":"Tirpude","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2025.111709_bib61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.biocel.2016.06.006","article-title":"Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN\/AKT pathways","volume":"77","author":"Liu","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cbi.2025.111709_bib62","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1165\/rcmb.2018-0275LE","article-title":"Chronic TGF-\u03b21 signaling in pulmonary arterial hypertension induces sustained canonical Smad3 pathways in vascular smooth muscle cells","volume":"61","author":"Calvier","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2025.111709_bib63","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1172\/JCI65592","article-title":"FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension","volume":"123","author":"Spiekerkoetter","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cbi.2025.111709_bib64","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02449-2016","article-title":"Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension","volume":"50","author":"Spiekerkoetter","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cbi.2025.111709_bib65","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1056\/NEJMoa2024277","article-title":"Sotatercept for the treatment of pulmonary arterial hypertension","volume":"384","author":"Humbert","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib66","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1056\/NEJMoa2213558","article-title":"Phase 3 trial of Sotatercept for treatment of pulmonary arterial hypertension","volume":"388","author":"Hoeper","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1164\/rccm.200707-1037OC","article-title":"Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension","volume":"178","author":"Perros","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2025.111709_bib68","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1159\/000479401","article-title":"PDGF promotes the warburg effect in pulmonary arterial smooth muscle cells via activation of the PI3K\/AKT\/mTOR\/HIF-1alpha signaling pathway","volume":"42","author":"Xiao","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cbi.2025.111709_bib69","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1172\/JCI24838","article-title":"Reversal of experimental pulmonary hypertension by PDGF inhibition","volume":"115","author":"Schermuly","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cbi.2025.111709_bib70","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMc051946","article-title":"Imatinib for the treatment of pulmonary arterial hypertension","volume":"353","author":"Ghofrani","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib71","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02356-2021","article-title":"Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension","volume":"60","author":"Galkin","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cbi.2025.111709_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612653","article-title":"Pharmacology and rationale for seralutinib in the treatment of pulmonary arterial hypertension","volume":"24","author":"Pullamsetti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111709_bib73","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1164\/rccm.200608-1189OC","article-title":"Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling","volume":"175","author":"Taraseviciene-Stewart","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cbi.2025.111709_bib74","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1165\/rcmb.2014-0488OC","article-title":"Marked strain-specific differences in the SU5416 rat model of severe pulmonary arterial hypertension","volume":"54","author":"Jiang","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2025.111709_bib75","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1165\/rcmb.2014-0045TR","article-title":"The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox","volume":"51","author":"Voelkel","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2025.111709_bib76","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1038\/s41598-025-89130-w","article-title":"Elevated serum levels of HIF-1\u03b1 and VEGF as potential biomarkers in connective tissue disease-associated pulmonary arterial hypertension","volume":"15","author":"Shi","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2025.111709_bib77","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2466-9-18","article-title":"Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis","volume":"9","author":"Papaioannou","year":"2009","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.cbi.2025.111709_bib78","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1172\/JCI35070","article-title":"Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents","volume":"119","author":"Izikki","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cbi.2025.111709_bib79","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1165\/rcmb.2010-0317OC","article-title":"Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension","volume":"45","author":"Tu","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cbi.2025.111709_bib80","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cytogfr.2021.09.002","article-title":"FGF\/FGFR signaling: from lung development to respiratory diseases","volume":"62","author":"Yang","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.cbi.2025.111709_bib81","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1111\/bph.14807","article-title":"Effects of the FGF receptor-1 inhibitor, infigratinib, with or without sildenafil, in experimental pulmonary arterial hypertension","volume":"176","author":"Felix","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111709_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/diseases6020038","article-title":"Pulmonary arterial hypertension: pathophysiology and treatment","volume":"6","author":"Lan","year":"2018","journal-title":"Diseases"},{"key":"10.1016\/j.cbi.2025.111709_bib83","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.drudis.2018.12.001","article-title":"TGF\u03b2 and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension","volume":"24","author":"Tielemans","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cbi.2025.111709_bib84","article-title":"Pulmonary arterial hypertension: pathogenesis and clinical management","volume":"360","author":"Thenappan","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.cbi.2025.111709_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117390","article-title":"The toxicokinetic and metabolism of structurally diverse pyrrolizidine alkaloids in rats","volume":"321","author":"To","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2025.111709_bib86","first-page":"130","article-title":"The role of kinetics as key determinant in toxicity of pyrrolizidine alkaloids and their N-oxides","volume":"88","author":"Widjaja","year":"2021","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2025.111709_bib87","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00204-021-03060-w","article-title":"Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids","volume":"95","author":"He","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111709_bib88","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jhep.2010.07.031","article-title":"Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum","volume":"54","author":"Lin","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2025.111709_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154162","article-title":"Nrf2-mediated liver protection by 18beta-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K\/Akt\/GSK3beta pathway","volume":"102","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2025.111709_bib90","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/acs.chemrestox.8b00369","article-title":"Pyrrole-hemoglobin adducts, a more feasible potential biomarker of pyrrolizidine alkaloid exposure","volume":"32","author":"Ma","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2025.111709_bib91","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00204-020-02947-4","article-title":"Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans","volume":"95","author":"Ma","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111709_bib92","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00204-020-02921-0","article-title":"Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites","volume":"95","author":"He","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111709_bib93","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/0006-2952(84)90721-4","article-title":"Hepatic metabolism and pulmonary toxicity of monocrotaline using isolated perfused liver and lung","volume":"33","author":"Lafranconi","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111709_bib94","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.reprotox.2019.02.006","article-title":"Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats","volume":"85","author":"Guo","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbi.2025.111709_bib95","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/HYPERTENSIONAHA.122.18261","article-title":"Evolving concepts in endothelial pathobiology of pulmonary arterial hypertension","volume":"79","author":"Cober","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.cbi.2025.111709_bib96","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/10937409809524557","article-title":"Chronic pulmonary hypertension--the monocrotaline model and involvement of the hemostatic system","volume":"1","author":"Schultze","year":"1998","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.cbi.2025.111709_bib97","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00204-023-03443-1","article-title":"Targeting erythrocyte-mediated hypoxia to alleviate lung injury induced by pyrrolizidine alkaloids","volume":"97","author":"Song","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2025.111709_bib98","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41569-021-00536-1","article-title":"Ceramides and other sphingolipids as drivers of cardiovascular disease","volume":"18","author":"Choi","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cbi.2025.111709_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010307","article-title":"Iron and sphingolipids as common players of (mal)adaptation to hypoxia in pulmonary diseases","volume":"21","author":"Ottolenghi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111709_bib100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cmet.2012.06.004","article-title":"Sphingolipid signaling mediates iron toxicity","volume":"16","author":"Lee","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cbi.2025.111709_bib101","article-title":"Sphingosine kinase 1 deficiency in smooth muscle cells protects against hypoxia-mediated pulmonary hypertension via YAP1 signaling","volume":"23","author":"Chen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111709_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127472","article-title":"Rapid identification and determination of pyrrolizidine alkaloids in herbal and food samples via direct analysis in real-time mass spectrometry","volume":"334","author":"Chen","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.cbi.2025.111709_bib103","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/pca.1183","article-title":"The analysis of pyrrolizidine alkaloids in Jacobaea vulgaris; a comparison of extraction and detection methods","volume":"21","author":"Joosten","year":"2010","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.cbi.2025.111709_bib104","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1079\/PHN2004624","article-title":"Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids","volume":"7","author":"Oberlies","year":"2004","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.cbi.2025.111709_bib105","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1021\/np2009412","article-title":"Profiling of alkaloids and eremophilanes in miracle tea (Packera candidissima and P. bellidifolia) products","volume":"75","author":"Fragoso-Serrano","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.cbi.2025.111709_bib106","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jpba.2012.05.021","article-title":"Simultaneous determination of sesquiterpenes and pyrrolizidine alkaloids from the rhizomes of Petasites hybridus (L.) G.M. et Sch. and dietary supplements using UPLC-UV and HPLC-TOF-MS methods","volume":"70","author":"Avula","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.cbi.2025.111709_bib107","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1039\/c2ay25300c","article-title":"Pyrrolizidine alkaloid profile in a traditional Chinese herbal medicine Chuan Zi Wan (Ligulariae Radix et Rhizoma) by liquid chromatography\/electrospray ionization ion trap mass spectrometry","volume":"4","author":"Tang","year":"2012","journal-title":"Anal. Methods-Uk"},{"key":"10.1016\/j.cbi.2025.111709_bib108","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1751-2980.2011.00552.x","article-title":"Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids","volume":"13","author":"Gao","year":"2012","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.cbi.2025.111709_bib109","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1080\/19440049.2013.817686","article-title":"Pyrrolizidine alkaloids: their occurrence in Spanish honey collected from purple viper's bugloss (Echium spp.)","volume":"30","author":"Orantes-Bermejo","year":"2013","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.cbi.2025.111709_bib110","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1080\/19440049.2014.900193","article-title":"Investigation of targeted pyrrolizidine alkaloids in traditional Chinese medicines and selected herbal teas sourced in Ireland using LC-ESI-MS\/MS","volume":"31","author":"Griffin","year":"2014","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.cbi.2025.111709_bib111","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1080\/19440049.2014.964337","article-title":"Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey","volume":"31","author":"Bodi","year":"2014","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.cbi.2025.111709_bib112","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.foodcont.2013.09.037","article-title":"Easy and rapid method for the quantitative determination of pyrrolizidine alkaloids in honey by ultra performance liquid chromatography-mass spectrometry: an evaluation in commercial honey","volume":"37","author":"Martinello","year":"2014","journal-title":"Food Control"},{"key":"10.1016\/j.cbi.2025.111709_bib113","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jep.2015.06.012","article-title":"Pro-toxic dehydropyrrolizidine alkaloids in the traditional Andean herbal medicine \"asmachilca\"","volume":"172","author":"Colegate","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2025.111709_bib114","first-page":"2058","article-title":"Pyrrolizidine and tropane alkaloids in teas and the herbal teas peppermint, rooibos and chamomile in the Israeli market","volume":"32","author":"Shimshoni","year":"2015","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.cbi.2025.111709_bib115","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1080\/19440049.2015.1086821","article-title":"Pyrrolizidine alkaloids in food and feed on the Belgian market","volume":"32","author":"Huybrechts","year":"2015","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.cbi.2025.111709_bib116","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.foodchem.2017.04.186","article-title":"Development and validation of a QuEChERS method coupled to liquid chromatography and high resolution mass spectrometry to determine pyrrolizidine and tropane alkaloids in honey","volume":"234","author":"Martinello","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.cbi.2025.111709_bib117","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/19440049.2017.1382726","article-title":"Occurrence of pyrrolizidine alkaloids in animal- and plant-derived food: results of a survey across Europe","volume":"35","author":"Mulder","year":"2018","journal-title":"Food Addit. Contam. Part A Chem Anal Control Expo Risk Assess"},{"key":"10.1016\/j.cbi.2025.111709_bib118","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/pca.2775","article-title":"Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset","volume":"29","author":"Colegate","year":"2018","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.cbi.2025.111709_bib119","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24122214","article-title":"Pyrrolizidine Alkaloids: the botanical origin of pollen collected during the flowering period of Echium vulgare and the stability of pyrrolizidine alkaloids in bee bread","volume":"24","author":"Kast","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111709_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03593","article-title":"Pyrrolizidine alkaloids in bee pollen identified by LC-MS\/MS analysis and colour parameters using multivariate class modeling","volume":"6","author":"De Jesus Inacio","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.cbi.2025.111709_bib121","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2478\/jvetres-2022-0032","article-title":"Simultaneous determination of pyrrolizidine and tropane alkaloids in honey by liquid chromatography-mass spectrometry","volume":"66","author":"Kowalczyk","year":"2022","journal-title":"J. Vet. Res."},{"key":"10.1016\/j.cbi.2025.111709_bib122","article-title":"Sorting out the plants responsible for a contamination with pyrrolizidine alkaloids in spice seeds by means of LC-MS\/MS and DNA barcoding: proof of principle with cumin and anise spice seeds","volume":"4","author":"Willocx","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.cbi.2025.111709_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28145346","article-title":"Pyrrolizidine alkaloids in food on the Italian market","volume":"28","author":"Peloso","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111709_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20075410","article-title":"Pyrrolizidine alkaloids from monofloral and multifloral Italian honey","volume":"20","author":"Roncada","year":"2023","journal-title":"Int. J. Environ. Res. Publ. Health"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725003394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725003394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:12:29Z","timestamp":1772813549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725003394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":124,"alternative-id":["S0009279725003394"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111709","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The underexplored pulmonary toxicity of pyrrolizidine alkaloids: Emerging hazard from food contamination","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111709"}}