{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:14:13Z","timestamp":1783210453841,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303950\/2022\\u20136"],"award-info":[{"award-number":["303950\/2022\\u20136"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.cbi.2025.111715","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T06:28:17Z","timestamp":1755930497000},"page":"111715","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Novel aryloxy-hydrazone-thiazoles: Design, synthesis, ADMET prediction and antifungal activity against Sporothrix spp."],"prefix":"10.1016","volume":"421","author":[{"given":"Vanessa Gouveia","family":"de Melo Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Rodrigues","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Lopes","family":"de Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"da Silva Tib\u00farcio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Manoel da Silva","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella Leite","family":"Brondani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Soares","family":"Sales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Policarpo Ademar","family":"Sales Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria R\u00eago Alves","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Patr\u00edcia Cerqueira","family":"Mac\u00eado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginaldo Gon\u00e7alves","family":"de Lima-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-2292","authenticated-orcid":false,"given":"Ana Cristina Lima","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111715_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s12982-025-00598-3","article-title":"Reemergence of zoonotic sporotrichosis in Brazil as a public health threat","volume":"22","author":"de Aguiar Freire","year":"2025","journal-title":"Discover Public Health"},{"key":"10.1016\/j.cbi.2025.111715_bib2","first-page":"354","article-title":"Sporothrix schenckii and sporotrichosis","volume":"24","author":"de Lima Barros","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.cbi.2025.111715_bib3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1590\/abd1806-4841.2017279","article-title":"Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics","volume":"92","author":"Orofino-Costa","year":"2017","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.cbi.2025.111715_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.simyco.2016.07.001","article-title":"The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship","volume":"83","author":"de Beer","year":"2016","journal-title":"Stud. Mycol."},{"key":"10.1016\/j.cbi.2025.111715_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/jof4030095","article-title":"Ecological determinants of sporotrichosis etiological agents","volume":"4","author":"Ram\u00edrez-Soto","year":"2018","journal-title":"J. Fungi"},{"key":"10.1016\/j.cbi.2025.111715_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/jof9050533","article-title":"Current progress in Sporothrix brasiliensis basic aspects","volume":"9","author":"G\u00f3mez-Gaviria","year":"2023","journal-title":"J. Fungi"},{"key":"10.1016\/j.cbi.2025.111715_bib7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/zph.12504","article-title":"Sporotrichosis in Southern Brazil, towards an epidemic?","volume":"65","author":"Poester","year":"2018","journal-title":"Zoonoses Public Health"},{"key":"10.1016\/j.cbi.2025.111715_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/jof5030067","article-title":"Emerging fungal infections: new patients, new patterns, and new pathogens","volume":"5","author":"Friedman","year":"2019","journal-title":"J. Fungi"},{"key":"10.1016\/j.cbi.2025.111715_bib9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s11046-020-00425-0","article-title":"The threat of emerging and re-emerging pathogenic sporothrix species","volume":"185","author":"Rodrigues","year":"2020","journal-title":"Mycopathologia"},{"key":"10.1016\/j.cbi.2025.111715_bib10","article-title":"Emerging sporotrichosis is driven by clonal and recombinant sporothrix species","volume":"3","author":"Rodrigues","year":"2014","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.cbi.2025.111715_bib11","article-title":"Trends in the molecular epidemiology and population genetics of emerging Sporothrix species","volume":"100","author":"de Carvalho","year":"2021","journal-title":"Stud. Mycol."},{"key":"10.1016\/j.cbi.2025.111715_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005903","article-title":"Exploring virulence and immunogenicity in the emerging pathogen Sporothrix brasiliensis","volume":"11","author":"Della Terra","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.cbi.2025.111715_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01057-17","article-title":"Multicenter, international study of MIC\/MEC distributions for definition of epidemiological cutoff values for Sporothrix species identified by molecular methods","volume":"61","author":"Espinel-Ingroff","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cbi.2025.111715_bib14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12281-013-0140-3","article-title":"Diagnosis and treatment of lymphocutaneous sporotrichosis: what are the options?","volume":"7","author":"Bonifaz","year":"2013","journal-title":"Curr. Fungal Infect. Rep."},{"key":"10.1016\/j.cbi.2025.111715_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/mmy\/myu061","article-title":"Feline sporotrichosis: epidemiological and clinical aspects","volume":"53","author":"Gremi\u00e3o","year":"2014","journal-title":"Med. Mycol."},{"key":"10.1016\/j.cbi.2025.111715_bib16","author":"Lazzarini"},{"key":"10.1016\/j.cbi.2025.111715_bib17","doi-asserted-by":"crossref","first-page":"8249","DOI":"10.1021\/acs.jmedchem.9b01004","article-title":"SAR studies on aromatic acylhydrazone-based inhibitors of fungal sphingolipid synthesis as next-generation antifungal agents","volume":"62","author":"Haranahalli","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111715_bib18","author":"Lazzarini"},{"key":"10.1016\/j.cbi.2025.111715_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00647-15","article-title":"Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids","volume":"6","author":"Mor","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.cbi.2025.111715_bib20","author":"Jhamilton Artunduaga Bonilla"},{"key":"10.1016\/j.cbi.2025.111715_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03967-23","article-title":"Combination therapy of itraconazole and an acylhydrazone derivative (D13) for the treatment of sporotrichosis in cats","volume":"12","author":"Dib Ferreira Gremi\u00e3o","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.cbi.2025.111715_bib22","article-title":"Synthesis of novel thiazole derivatives bearing \u03b2-amino acid and aromatic moieties as promising scaffolds for the development of new antibacterial and antifungal candidates targeting multidrug-resistant pathogens","volume":"27","author":"Mal\u016bkait\u0117","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2025.111715_bib23","doi-asserted-by":"crossref","first-page":"21213","DOI":"10.1039\/D4RA03290J","article-title":"Enhancing C-S and C-N bond formation with ultrasound assistance: lipase-catalyzed synthesis of 2,4-disubstituted thiazole derivatives from arylethanones and thioamides","volume":"14","author":"Mahaur","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.cbi.2025.111715_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ejmech.2014.02.001","article-title":"Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death","volume":"75","author":"Magalhaes Moreira","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111715_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/fcp.12230","article-title":"Targeting CYP51 for drug design by the contributions of molecular modeling","volume":"31","author":"Rabelo","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111715_bib26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2025.111715_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52764-8","article-title":"Potential inhibitors of galactofuranosyltransferase 2 (GlfT2): molecular docking, 3D-QSAR, and in silico ADMETox studies","volume":"9","author":"Ortiz","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2025.111715_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"64","author":"Lipinski","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.cbi.2025.111715_bib29","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/tx200211v","article-title":"Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety","volume":"24","author":"Meanwell","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2025.111715_bib30","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111715_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13030364","article-title":"Assessment of finite and infinite dose in vitro experiments in transdermal drug delivery","volume":"13","author":"Coderch","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2025.111715_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123488","article-title":"Strat-M\u00ae positioning for skin permeation studies: a comparative study including EpiSkin\u00ae RHE, and human skin","volume":"647","author":"Kichou","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.cbi.2025.111715_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jsb.2011.09.006","article-title":"UCSF Chimera, MODELLER, and IMP: an integrated modeling system","volume":"179","author":"Yang","year":"2012","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.cbi.2025.111715_bib34","series-title":"Discovery Studio Visualizer, v24.1.0.23298","year":"2024"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972500345X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972500345X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:05:36Z","timestamp":1780722336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927972500345X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"alternative-id":["S000927972500345X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111715","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel aryloxy-hydrazone-thiazoles: Design, synthesis, ADMET prediction and antifungal activity against Sporothrix spp.","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111715","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111715"}}