{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:51:23Z","timestamp":1794369083861,"version":"4.9.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007924","name":"Bengbu Medical University","doi-asserted-by":"publisher","award":["Byycxz24029"],"award-info":[{"award-number":["Byycxz24029"]}],"id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH040196"],"award-info":[{"award-number":["2024AH040196"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.cbi.2025.111765","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T02:08:37Z","timestamp":1759198117000},"page":"111765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["HFPO-TA exposure triggers hepatomegaly and lipid peroxidation via Nrf2\/keap1 antioxidant dysregulation and ferroptosis activation in the liver"],"prefix":"10.1016","volume":"421","author":[{"given":"Xu","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-0007","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-9162","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cbi.2025.111765_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2025.111765_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119246","article-title":"PFAS in drinking water and serum of the people of a southeast Alaska community: a pilot study","volume":"305","author":"Babayev","year":"2022","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.cbi.2025.111765_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integrated Environ. Assess. Manag."},{"issue":"14","key":"10.1016\/j.cbi.2025.111765_bib4","doi-asserted-by":"crossref","first-page":"8005","DOI":"10.1021\/acs.est.8b01714","article-title":"Hepatotoxic effects of hexafluoropropylene oxide trimer acid (HFPO-TA), A novel perfluorooctanoic acid (PFOA) alternative, on mice","volume":"52","author":"Sheng","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"12","key":"10.1016\/j.cbi.2025.111765_bib5","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/acs.est.9b07384","article-title":"Evidence of air dispersion: HFPO-DA and PFOA in Ohio and West Virginia surface water and soil near a fluoropolymer production facility","volume":"54","author":"Galloway","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"14","key":"10.1016\/j.cbi.2025.111765_bib6","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.1021\/acs.est.8b00829","article-title":"Worldwide distribution of novel perfluoroether carboxylic and sulfonic acids in surface water","volume":"52","author":"Pan","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2025.111765_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.115145","article-title":"Occurrence and source apportionment of novel and legacy poly\/perfluoroalkyl substances in Hai River basin in China using receptor models and isomeric fingerprints","volume":"168","author":"Li","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.cbi.2025.111765_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109402","article-title":"A review of sources, multimedia distribution and health risks of novel fluorinated alternatives","volume":"182","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"17","key":"10.1016\/j.cbi.2025.111765_bib9","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1021\/acs.est.7b02259","article-title":"First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: an emerging concern","volume":"51","author":"Pan","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2025.111765_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128376","article-title":"Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice","volume":"430","author":"Xie","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2025.111765_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113706","article-title":"Hexafluoropropylene oxide trimer acid causes fibrosis in mice liver via mitochondrial ROS\/cGAS-STING\/NLRP3-mediated pyroptosis","volume":"174","author":"Zhang","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2025.111765_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jes.2021.08.012","article-title":"Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays","volume":"116","author":"Liang","year":"2022","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.cbi.2025.111765_bib13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbi.2025.111765_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/112_2018_10","article-title":"Targeting oxidative stress for the treatment of liver fibrosis","volume":"175","author":"Luangmonkong","year":"2018","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"issue":"26","key":"10.1016\/j.cbi.2025.111765_bib15","doi-asserted-by":"crossref","first-page":"11976","DOI":"10.7150\/thno.50663","article-title":"Novel insights into ferroptosis: implications for age-related diseases","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.cbi.2025.111765_bib16","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41419-022-04927-1","article-title":"Regulatory pathways and drugs associated with ferroptosis in tumors","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.cbi.2025.111765_bib17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.cbi.2025.111765_bib18","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/hep.26749","article-title":"Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH","volume":"59","author":"Sutti","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2025.111765_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8810785","article-title":"The molecular mechanisms of regulating oxidative stress-induced ferroptosis and therapeutic strategy in tumors","volume":"2020","author":"Zhu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cbi.2025.111765_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114632","article-title":"Transcriptome and metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway","volume":"188","author":"Zhang","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.cbi.2025.111765_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2025.111765_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2025.111765_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121683","article-title":"The toxicological effects of perfluorooctanoic acid (PFOA) exposure in large yellow croaker (Larimichthys crocea): exploring the relationship between liver damage and gut microbiota dysbiosis","volume":"278","author":"Han","year":"2025","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.cbi.2025.111765_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"21","key":"10.1016\/j.cbi.2025.111765_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cbi.2025.111765_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158372","article-title":"Uptake, distribution, and depuration of emerging per- and polyfluoroalkyl substances in mice: role of gut microbiota","volume":"853","author":"Wen","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2025.111765_bib27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.04.001","article-title":"Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling","volume":"100","author":"Brand","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.cbi.2025.111765_bib28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/tox.22049","article-title":"Dichlorodiphenyldichloroethylene exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells","volume":"31","author":"Jin","year":"2016","journal-title":"Environ. Toxicol."},{"issue":"2","key":"10.1016\/j.cbi.2025.111765_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/apha.12162","article-title":"Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload","volume":"210","author":"Sripetchwandee","year":"2014","journal-title":"Acta Physiol."},{"key":"10.1016\/j.cbi.2025.111765_bib30","doi-asserted-by":"crossref","first-page":"14577","DOI":"10.1038\/ncomms14577","article-title":"Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus","volume":"8","author":"Suzuki","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.cbi.2025.111765_bib31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ccell.2016.04.006","article-title":"p62, upregulated during Preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-Initiating cells","volume":"29","author":"Umemura","year":"2016","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.cbi.2025.111765_bib32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2025.111765_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117094","article-title":"Penfluridol regulates p62\/Keap1\/Nrf2 signaling pathway to induce ferroptosis in osteosarcoma cells","volume":"177","author":"Zeng","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.cbi.2025.111765_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of Mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.cbi.2025.111765_bib35","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","article-title":"Regulation of ferritin genes and protein","volume":"99","author":"Torti","year":"2002","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.cbi.2025.111765_bib36","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.cbi.2025.111765_bib37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cbi.2025.111765_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.cbi.2025.111765_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"3","key":"10.1016\/j.cbi.2025.111765_bib40","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"18","key":"10.1016\/j.cbi.2025.111765_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.cbi.2025.111765_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.cbi.2025.111765_bib43","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725003953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725003953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:03:59Z","timestamp":1780722239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725003953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":43,"alternative-id":["S0009279725003953"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111765","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HFPO-TA exposure triggers hepatomegaly and lipid peroxidation via Nrf2\/keap1 antioxidant dysregulation and ferroptosis activation in the liver","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111765"}}