{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:02:10Z","timestamp":1790856130760,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016323","name":"Fujian Provincial Maternity and Children's Hospital","doi-asserted-by":"publisher","award":["2022QNA092"],"award-info":[{"award-number":["2022QNA092"]}],"id":[{"id":"10.13039\/501100016323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003815","name":"Huaqiao University","doi-asserted-by":"publisher","award":["2022YX002"],"award-info":[{"award-number":["2022YX002"]}],"id":[{"id":"10.13039\/501100003815","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cbi.2025.111791","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T20:22:07Z","timestamp":1763324527000},"page":"111791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["F\u201353B triggers ovarian granulosa cell senescence and ovarian dysfunction by triggering mitochondrial dysfunction"],"prefix":"10.1016","volume":"423","author":[{"given":"Zhiyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MengQin","family":"wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbi.2025.111791_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integrated Environ. Assess. Manag."},{"issue":"21","key":"10.1016\/j.cbi.2025.111791_bib2","doi-asserted-by":"crossref","first-page":"8020","DOI":"10.3390\/ijerph17218020","article-title":"PFAS environmental pollution and antioxidant responses: an overview of the impact on human field","volume":"17","author":"Bonato","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"7","key":"10.1016\/j.cbi.2025.111791_bib3","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1021\/es001834k","article-title":"Global distribution of perfluorooctane sulfonate in wildlife","volume":"35","author":"Giesy","year":"2001","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2025.111791_bib4","first-page":"1302","article-title":"Emerging per- and polyfluoroalkyl substances (PFASs) in surface water and sediment of the North and Baltic Seas","volume":"571","author":"Shi","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.cbi.2025.111791_bib5","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1021\/acs.est.6b06049","article-title":"Chlorinated polyfluoroalkyl ether sulfonic acids in matched maternal, cord, and placenta samples: a study of transplacental transfer","volume":"51","author":"Chen","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2025.111791_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107108","article-title":"Human exposure to F-53B in China and the evaluation of its potential toxicity: an overview","volume":"161","author":"He","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2025.111791_bib7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ecoenv.2019.01.010","article-title":"Toxicokinetics and toxic effects of a Chinese PFOS alternative F-53B in adult zebrafish","volume":"171","author":"Wu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2025.111791_bib8","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.chemosphere.2019.07.016","article-title":"Acute exposure to environmentally relevant concentrations of Chinese PFOS alternative F-53B induces oxidative stress in early development zebrafish","volume":"235","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2025.111791_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175609","article-title":"Adolescent F-53B exposure induces ovarian toxicity in rats: Autophagy-apoptosis interplay","volume":"951","author":"Lan","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.cbi.2025.111791_bib10","first-page":"37","article-title":"Worldwide trend analysis of primary and secondary infertility rates over past decades: a cross-sectional study","volume":"20","author":"Borumandnia","year":"2022","journal-title":"Int. J. Reprod. Biomed."},{"issue":"12","key":"10.1016\/j.cbi.2025.111791_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001356","article-title":"National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys","volume":"9","author":"Mascarenhas","year":"2012","journal-title":"PLoS Med."},{"issue":"7973","key":"10.1016\/j.cbi.2025.111791_bib12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS\u2013STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"issue":"7747","key":"10.1016\/j.cbi.2025.111791_bib13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41586-019-1006-9","article-title":"Autophagy induction via STING trafficking is a primordial function of the cGAS pathway","volume":"567","author":"Gui","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cbi.2025.111791_bib14","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/jcb.23053","article-title":"Regulation of AMP\u2010activated protein kinase by LKB1 and CaMKK in adipocytes","volume":"112","author":"Gormand","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cbi.2025.111791_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123544","article-title":"Hepatotoxicity induced in rats by chronic exposure to F\u201353B, an emerging replacement of perfluorooctane sulfonate (PFOS)","volume":"346","author":"Li","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111791_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123333","article-title":"Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K\/AKT\/mTOR pathway in human granulosa cell line KGN","volume":"344","author":"Gao","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111791_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.998424","article-title":"Epigenetic regulation in premature ovarian failure: a literature review","volume":"13","author":"Wang","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbi.2025.111791_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119269","article-title":"Endocrine disrupting chemicals impact on ovarian aging: evidence from epidemiological and experimental evidence","volume":"305","author":"Ding","year":"2022","journal-title":"Environ. Pollut."},{"issue":"7","key":"10.1016\/j.cbi.2025.111791_bib19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/ncb1001","article-title":"Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice","volume":"5","author":"Wikonkal","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"Supplement_1","key":"10.1016\/j.cbi.2025.111791_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvae088.002","article-title":"CDK4\/6 inhibitor ribociclib induces cardiotoxicity in dynamic engineered heart tissues, mitigated by E2F1 overexpression","volume":"120","author":"Linders","year":"2024","journal-title":"Cardiovasc. Res."},{"issue":"8","key":"10.1016\/j.cbi.2025.111791_bib21","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"issue":"1","key":"10.1016\/j.cbi.2025.111791_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13753","article-title":"Role of autophagy in aging: the good, the bad, and the ugly","volume":"22","author":"Tabibzadeh","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.cbi.2025.111791_bib23","unstructured":"6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induced Nephrotoxicity Associated with Oxidative Stress, Inflammation and Fibrosis in Mice."},{"key":"10.1016\/j.cbi.2025.111791_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111535","article-title":"Maternal co-exposure to Cd and PS-NPLs induces offspring ovarian inflammatory aging via promoting M1 macrophage polarization","author":"Zhang","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111791_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111426","article-title":"Knockout of TRPM2 protects against cyclophosphamide-induced premature ovarian failure via inhibiting AMPK\/p53 signaling pathway","volume":"409","author":"Nie","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111791_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111737","article-title":"Celecoxib blocks AKT\/mTOR in AKT\/YapS127A-driven intrahepatic cholangiocarcinoma, activating p21\/p27 for cycle arrest and suppressing Mcl-1 for apoptosis","author":"Tan","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111791_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111757","article-title":"Benzophenone-3 drives osteoarthritis pathogenesis by regulating chondrocyte senescence","author":"Zhu","year":"2025","journal-title":"Chem. Biol. Interact."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725004211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725004211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:57:42Z","timestamp":1773842262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725004211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"alternative-id":["S0009279725004211"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111791","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"F\u201353B triggers ovarian granulosa cell senescence and ovarian dysfunction by triggering mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111791"}}