{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:40:11Z","timestamp":1792978811829,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["2020-I78"],"award-info":[{"award-number":["2020-I78"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010129","name":"Maud Kuistila Memorial Foundation","doi-asserted-by":"publisher","award":["2024-0147B"],"award-info":[{"award-number":["2024-0147B"]}],"id":[{"id":"10.13039\/100010129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Finnish Cultural Foundation","doi-asserted-by":"publisher","award":["00251048"],"award-info":[{"award-number":["00251048"]}],"id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009067","name":"K Albin Johansson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010125","name":"Jalmari and Rauha Ahokkaan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"The Paulo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cbi.2025.111825","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:36:04Z","timestamp":1762958164000},"page":"111825","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Selective cytotoxicity of anhydroicaritin in ER-positive breast cancer via ESR1-mediated MAPK and apoptotic signaling"],"prefix":"10.1016","volume":"423","author":[{"given":"Huiyan","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jujia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1666-106X","authenticated-orcid":false,"given":"Mingxiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-4303","authenticated-orcid":false,"given":"Xiangwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111825_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41416-021-01328-7","article-title":"Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression","volume":"125","author":"L\u00fc\u00f6nd","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cbi.2025.111825_bib2","doi-asserted-by":"crossref","first-page":"R319","DOI":"10.1530\/ERC-18-0063","article-title":"The challenges of modeling hormone receptor-positive breast cancer in mice","volume":"25","author":"\u00d6zdemir","year":"2018","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.cbi.2025.111825_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40164-022-00363-1","article-title":"Breast cancer heterogeneity and its implication in personalized precision therapy","volume":"12","author":"Guo","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.cbi.2025.111825_bib4","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/annonc\/mdr304","article-title":"Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011","volume":"22","author":"Goldhirsch","year":"2011","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cbi.2025.111825_bib5","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.1158\/0008-5472.CAN-09-1355","article-title":"Adjuvant hormonal therapy for breast cancer and risk of hormone receptor-specific subtypes of contralateral breast cancer","volume":"69","author":"Li","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2025.111825_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.cbi.2025.111825_bib7","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ccell.2020.03.009","article-title":"Overcoming endocrine resistance in breast cancer","volume":"37","author":"Hanker","year":"2020","journal-title":"Cancer Cell"},{"issue":"Suppl 1","key":"10.1016\/j.cbi.2025.111825_bib8","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/S0960-9776(19)31118-X","article-title":"Endocrine therapy resistance: new insights","volume":"48","author":"Lei","year":"2019","journal-title":"Breast"},{"key":"10.1016\/j.cbi.2025.111825_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jtcms.2024.03.005","article-title":"Exploring the molecular mechanism of Epimedium brevicornu maxim. in treating breast cancer via network pharmacology and in vitro experiments","volume":"11","author":"Wang","year":"2024","journal-title":"Journal of Traditional Chinese Medical Sciences"},{"key":"10.1016\/j.cbi.2025.111825_bib10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-2005-837776","article-title":"New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells","volume":"71","author":"Yap","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2025.111825_bib11","article-title":"Anhydroicaritin Inhibits EMT in breast cancer by enhancing GPX1 expression: a research based on sequencing technologies and bioinformatics analysis","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cbi.2025.111825_bib12","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1271\/bbb.120077","article-title":"Induction of apoptosis by Icariside II through extrinsic and intrinsic signaling pathways in human breast cancer MCF7 cells","volume":"76","author":"Huang","year":"2012","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.cbi.2025.111825_bib13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fphar.2016.00191","article-title":"Anti-Cancer properties of the naturally occurring aphrodisiacs: icariin and its derivatives","volume":"7","author":"Tan","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111825_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1566524020666200530212440","article-title":"The Antitumor effects of icaritin against breast cancer is related to estrogen receptors","volume":"21","author":"Tao","year":"2021","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.cbi.2025.111825_bib15","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/s41598-017-03039-7","article-title":"TCM-Mesh: the database and analytical system for network pharmacology analysis for TCM preparations","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2025.111825_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.cbi.2025.111825_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13059-019-1689-0","article-title":"Machine learning and complex biological data","volume":"20","author":"Xu","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.cbi.2025.111825_bib18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s10038-024-01231-y","article-title":"Advances in AI and machine learning for predictive medicine","volume":"69","author":"Sharma","year":"2024","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.cbi.2025.111825_bib19","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/ije\/dyw088","article-title":"Selecting instruments for Mendelian randomization in the wake of genome-wide association studies","volume":"45","author":"Swerdlow","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.cbi.2025.111825_bib20","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cbi.2025.111825_bib21","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1038\/s41598-023-35868-0","article-title":"Identification of molecular mechanisms causing skin lesions of cutaneous leishmaniasis using weighted gene coexpression network analysis (WGCNA)","volume":"13","author":"Momeni","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2025.111825_bib22","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2025.111825_bib23","first-page":"D330","article-title":"The Gene Ontology Resource: 20 years and still GOing strong","volume":"47","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2025.111825_bib24","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2025.111825_bib25","series-title":"Elife Sciences Publications","article-title":"A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning","author":"Li","year":"2024"},{"key":"10.1016\/j.cbi.2025.111825_bib26","doi-asserted-by":"crossref","first-page":"20332","DOI":"10.18632\/aging.103807","article-title":"Identification of long-term survival-associated gene in breast cancer","volume":"12","author":"Ning","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.cbi.2025.111825_bib27","article-title":"Identification of a central network hub of key prognostic genes based on correlation between transcriptomics and survival in patients with metastatic solid tumors","volume":"17","author":"Lazar","year":"2024","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.cbi.2025.111825_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2021.681721","article-title":"Prognostic Nomogram of prognosis-related genes and clinicopathological characteristics to predict the 5-Year survival rate of Colon cancer patients","volume":"8","author":"Huang","year":"2021","journal-title":"Front. Surg."},{"key":"10.1016\/j.cbi.2025.111825_bib29","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2025.111825_bib30","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cbi.2025.111825_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5455\/OVJ.2021.v11.i2.9","article-title":"The MTT assay application to measure the viability of spermatozoa: a variety of the assay protocols","volume":"11","author":"Buranaamnuay","year":"2021","journal-title":"Open Vet. J."},{"key":"10.1016\/j.cbi.2025.111825_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115516","article-title":"Integrating network pharmacology and experimental models to investigate the efficacy of QYHJ on pancreatic cancer","volume":"297","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2025.111825_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s42003-019-0361-2","article-title":"Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease","volume":"2","author":"Marouli","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cbi.2025.111825_bib34","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.csbj.2024.05.024","article-title":"Addressing docking pose selection with structure-based deep learning: recent advances, challenges and opportunities","volume":"23","author":"Vittorio","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.cbi.2025.111825_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106899","article-title":"Assessment of palmitic acid toxicity to animal hearts and other major organs based on acute toxicity, network pharmacology, and molecular docking","volume":"158","author":"Lv","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cbi.2025.111825_bib36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2025.111825_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/cells8040362","article-title":"The Cytoskeleton-A complex interacting meshwork","volume":"8","author":"Hohmann","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2025.111825_bib38","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1186\/s12885-021-08511-2","article-title":"Molecular and cellular characterization of two patient-derived ductal carcinoma in situ (DCIS) cell lines, ETCC-006 and ETCC-010","volume":"21","author":"Samson","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cbi.2025.111825_bib39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-4598-12-9","article-title":"Epigenetic reactivation of estrogen receptor-\u03b1 (ER\u03b1) by genistein enhances hormonal therapy sensitivity in ER\u03b1-negative breast cancer","volume":"12","author":"Li","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cbi.2025.111825_bib40","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1126\/science.1068537","article-title":"Molecular determinants for the tissue specificity of SERMs","volume":"295","author":"Shang","year":"2002","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.cbi.2025.111825_bib41","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.270.5241.1491","article-title":"Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase","volume":"270","author":"Kato","year":"1995","journal-title":"Science (New York, N.Y.)"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725004557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725004557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:00:12Z","timestamp":1773813612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725004557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"alternative-id":["S0009279725004557"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111825","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective cytotoxicity of anhydroicaritin in ER-positive breast cancer via ESR1-mediated MAPK and apoptotic signaling","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111825","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111825"}}