{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:10:15Z","timestamp":1790971815434,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cbi.2025.111840","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:34:27Z","timestamp":1763645667000},"page":"111840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Investigating penthiopyrad's potential toxicity on male reproductive health via in vitro models and computational network toxicology and docking studies"],"prefix":"10.1016","volume":"423","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5850-1578","authenticated-orcid":false,"given":"Merve","family":"Arici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7672-9127","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Bilgehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-9493","authenticated-orcid":false,"given":"Mohammed T.","family":"Qaoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6926-5723","authenticated-orcid":false,"given":"G\u00fcl","family":"\u00d6zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2025.111840_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.166969","article-title":"Rational understanding of chiral fungicide penthiopyrad stereoselectivity: bioactivity, aquatic toxicity and cytotoxicity","volume":"905","author":"Guo","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2025.111840_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135560","article-title":"Cadmium stress alleviates lipid accumulation caused by chiral penthiopyrad through regulating endoplasmic reticulum stress and mitochondrial dysfunction in zebrafish liver","volume":"478","author":"Wang","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"10","key":"10.1016\/j.cbi.2025.111840_bib3","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1094\/PDIS-10-19-2253-RE","article-title":"Activity of the succinate dehydrogenase inhibitor fungicide penthiopyrad against Sclerotinia sclerotiorum","volume":"104","author":"Mao","year":"2020","journal-title":"Plant Dis."},{"key":"10.1016\/j.cbi.2025.111840_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110680","article-title":"Stereoselective degradation behavior of the novel chiral antifungal agrochemical penthiopyrad in soil","volume":"194","author":"Liu","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.cbi.2025.111840_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136476","article-title":"Assessing the stereoselective bioactivity and biotoxicity of penthiopyrad in soil environment for efficacy improvement and hazard reduction","volume":"480","author":"Fang","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"7","key":"10.1016\/j.cbi.2025.111840_bib6","first-page":"1220","article-title":"Potential enantioselectivity of the hydrolysation and photolysation of the chiral agrochemical penthiopyrad in aquatic environments","volume":"7","author":"Yang","year":"2021","journal-title":"Environ. Sci. J. Integr. Environ. Res.: Water Res. Technol."},{"key":"10.1016\/j.cbi.2025.111840_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110252","article-title":"Enantioselective toxic effects of the novel chiral antifungal agrochemical penthiopyrad in the early life stage of zebrafish (Danio rerio)","volume":"369","author":"Ren","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2025.111840_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122012","article-title":"Development of S-penthiopyrad for bioactivity improvement and risk reduction from the systemic evaluation at the enantiomeric level","volume":"333","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111840_bib9","series-title":"Penthiopyrad: Drinking Water Exposure Assessment for New Chemical Uses","year":"2011"},{"issue":"3","key":"10.1016\/j.cbi.2025.111840_bib10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00244-021-00909-0","article-title":"Effectiveness of a constructed wetland with carbon filtration in reducing pesticides associated with agricultural runoff","volume":"82","author":"McCalla","year":"2022","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbi.2025.111840_bib11","article-title":"Personal air sampling for pesticides in the California San Joaquin Valley","volume":"1\u20137","author":"Bennett","year":"2024","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"47","key":"10.1016\/j.cbi.2025.111840_bib12","first-page":"14291","article-title":"Penthiopyrad; pesticide tolerances","volume":"77","year":"2012","journal-title":"United States Environmental Protection Agency"},{"key":"10.1016\/j.cbi.2025.111840_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.envpol.2018.06.055","article-title":"Toxic effects of boscalid on the growth, photosynthesis, antioxidant system and metabolism of Chlorella vulgaris","volume":"242","author":"Qian","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111840_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113010","article-title":"Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)","volume":"228","author":"Ren","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2025.111840_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.105961","article-title":"Effects of penthiopyrad on the hypothalamic-pituitary-thyroid (HPT) axis in zebrafish","volume":"202","author":"Qian","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbi.2025.111840_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116261","article-title":"Induction of human hepatic cytochrome P-450 3A4 expression by antifungal succinate dehydrogenase inhibitors","volume":"276","author":"Kerhoas","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2025.111840_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115721","article-title":"Assessment of reproductive toxicity in adult zebrafish (Danio rerio) following sublethal exposure to penthiopyrad","volume":"268","author":"Qian","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2025.111840_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2020.108830","article-title":"Evaluation of boscalid toxicity on Daphnia magna by using antioxidant enzyme activities, the expression of genes related to antioxidant and detoxification systems, and life-history parameters","volume":"237","author":"Aksakal","year":"2020","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2025.111840_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131830","article-title":"Oxidative stress, intestinal damage, and cell apoptosis: toxicity induced by fluopyram in Caenorhabditis elegans","volume":"286","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2025.111840_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169096","article-title":"Reproductive toxicity in birds predicted by physiologically-based kinetics and bioenergetics modelling","volume":"912","author":"Martin","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2025.111840_bib21","series-title":"Agriculture & Environment Research Unit (AERU)","year":"2025"},{"issue":"32","key":"10.1016\/j.cbi.2025.111840_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202400389","article-title":"A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes","volume":"11","author":"Del Giudice","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.cbi.2025.111840_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2025.106514","article-title":"Reproductive toxicity potential of Fluazifop-butyl: in vitro, network toxicology, and molecular docking insights","author":"Bilgehan","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"issue":"4s","key":"10.1016\/j.cbi.2025.111840_bib24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5530\/ctbp.2024.4s.11","article-title":"A study on toxicity mechanisms of xenobiotics using network pharmacology approach","volume":"18","author":"Shreenidhi","year":"2024","journal-title":"Curr. Trends Biotechnol. Pharm."},{"issue":"1","key":"10.1016\/j.cbi.2025.111840_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1674-6384(15)60016-8","article-title":"Development and application of network toxicology in safety research of Chinese Materia Medica","volume":"7","author":"Zhang","year":"2015","journal-title":"Chinese Herbal Med."},{"issue":"8","key":"10.1016\/j.cbi.2025.111840_bib26","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/acs.chemrestox.2c00375","article-title":"A review on the recent applications of deep learning in predictive drug toxicological studies","volume":"36","author":"Sinha","year":"2023","journal-title":"Chem. Res. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.cbi.2025.111840_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"12","key":"10.1016\/j.cbi.2025.111840_bib28","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1111\/j.1600-6143.2004.00610.x","article-title":"Mycophenolic acid inhibits platelet-derived growth factor-induced reactive oxygen species and mitogen-activated protein kinase activation in rat vascular smooth muscle cells","volume":"4","author":"Park","year":"2004","journal-title":"Am. J. Transplant."},{"issue":"5","key":"10.1016\/j.cbi.2025.111840_bib29","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3390\/nu17050764","article-title":"Camellia tea saponin ameliorates 5\u2013fluorouracil-induced damage of HaCaT cells by regulating ferroptosis and inflammation","volume":"17","author":"Likitsatian","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.cbi.2025.111840_bib30","series-title":"DNA Electrophoresis: Methods and Protocols","first-page":"209","article-title":"Analysis of DNA damage via single-cell electrophoresis","author":"Anderson","year":"2013"},{"key":"10.1016\/j.cbi.2025.111840_bib31","series-title":"DNA Repair Protocols: Eukaryotic Systems","first-page":"203","article-title":"The comet assay (Single-Cell Gel Test) a sensitive genotoxicity test for the detection of DNA damage and repair","author":"Speit","year":"1999"},{"issue":"1","key":"10.1016\/j.cbi.2025.111840_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/0471142956.cy0914s13","article-title":"Flow cytometric analysis of mitochondrial membrane potential using JC\u20101","volume":"13","author":"Cossarizza","year":"2000","journal-title":"Curr. Protoc. Cytometry"},{"issue":"5","key":"10.1016\/j.cbi.2025.111840_bib33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0748233718763517","article-title":"Cadmium telluride quantum dots induce apoptosis in human breast cancer cell lines","volume":"34","author":"Naderi","year":"2018","journal-title":"Toxicol. Ind. Health"},{"issue":"1","key":"10.1016\/j.cbi.2025.111840_bib34","article-title":"Techniques to study autophagy in plants","volume":"2009","author":"Mitou","year":"2009","journal-title":"Int. J. Plant Genom."},{"key":"10.1016\/j.cbi.2025.111840_bib35","series-title":"H\u00fccre \u00d6l\u00fcm\u00fc Ara\u015ft\u0131rma Teknikleri","first-page":"129","article-title":"Otofaji analiz y\u00f6ntemleri ve uygulama a\u015famalar\u0131 (autophagy analysis techniques and applications)","author":"G\u00f6z\u00fca\u00e7\u0131k","year":"2011"},{"key":"10.1016\/j.cbi.2025.111840_bib36","series-title":"PubChem: a large\u2010scale public chemical database for drug discovery. Open Access Databases and Datasets for Drug Discovery","first-page":"39","author":"Kim","year":"2024"},{"issue":"3","key":"10.1016\/j.cbi.2025.111840_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.53388\/PMR202000031","article-title":"Screening key target genes for coronavirus disease 2019 based on bioinformatics and gene network","volume":"2","author":"Yang","year":"2020","journal-title":"Precis. Med. Res."},{"key":"10.1016\/j.cbi.2025.111840_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-15-293","article-title":"Jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinf."},{"issue":"1","key":"10.1016\/j.cbi.2025.111840_bib39","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1021\/acsomega.4c07896","article-title":"Next-Generation carbazole-linked 1, 2, 4-Triazole-Thione derivatives: strategic design, synthesis, molecular docking, and evaluation of antidiabetic potential","volume":"10","author":"\u00c7apan","year":"2024","journal-title":"ACS Omega"},{"issue":"3","key":"10.1016\/j.cbi.2025.111840_bib40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1107\/S2052252524002604","article-title":"RCSB protein data bank: supporting research and education worldwide through explorations of experimentally determined and computationally predicted atomic level 3D biostructures","volume":"11","author":"Burley","year":"2024","journal-title":"Int. Union Crystallogr."},{"issue":"8","key":"10.1016\/j.cbi.2025.111840_bib41","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1021\/ct300203w","article-title":"Improving the prediction of absolute solvation free energies using the next generation OPLS force field","volume":"8","author":"Shivakumar","year":"2012","journal-title":"J. Chem. Theor. Comput."},{"issue":"21","key":"10.1016\/j.cbi.2025.111840_bib42","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein\u2212 ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2025.111840_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2024.102793","article-title":"A comprehensive survey on protein-ligand binding site prediction","volume":"86","author":"Xia","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"19","key":"10.1016\/j.cbi.2025.111840_bib44","doi-asserted-by":"crossref","first-page":"10737","DOI":"10.1039\/C9NR10638C","article-title":"An accurate free energy estimator: based on MM\/PBSA combined with interaction entropy for protein\u2013ligand binding affinity","volume":"12","author":"Huang","year":"2020","journal-title":"Nanoscale"},{"issue":"4","key":"10.1016\/j.cbi.2025.111840_bib45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/toxics11040330","article-title":"Contaminants of emerging concern (CECs) and male reproductive health: challenging the future with a double-edged sword","volume":"11","author":"Marcu","year":"2023","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.cbi.2025.111840_bib46","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1530\/REP-17-0064","article-title":"Steroidogenesis in Leydig cells: effects of aging and environmental factors","volume":"154","author":"Wang","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.cbi.2025.111840_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2021.104773","article-title":"Flufenoxuron suppresses the proliferation of testicular cells by targeting mitochondria in mice","volume":"173","author":"Ham","year":"2021","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbi.2025.111840_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106175","article-title":"Resmethrin disrupts mitochondria-associated membranes and activates endoplasmic reticulum stress, leading to proliferation inhibition in cultured mouse Leydig and Sertoli cells","volume":"205","author":"Ham","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"issue":"19","key":"10.1016\/j.cbi.2025.111840_bib49","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.3390\/molecules26195842","article-title":"The short-term exposure to sdhi fungicides boscalid and bixafen induces a mitochondrial dysfunction in selective human cell lines","volume":"26","author":"d'Hose","year":"2021","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.cbi.2025.111840_bib50","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/etc.5847","article-title":"Assessment of mitochondrial function in the AmE\u2010711 honey bee cell line: boscalid and pyraclostrobin effects","volume":"43","author":"Martinovi\u0107\u2010Weigelt","year":"2024","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbi.2025.111840_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2025.104675","article-title":"Reliability of pesticide toxicity evaluation: effects of pesticides on cellular respiration under conventional versus physiological growth conditions","volume":"115","author":"Tepp","year":"2025","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"11","key":"10.1016\/j.cbi.2025.111840_bib52","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1161\/hs1101.098328","article-title":"Mitochondrial disease and stroke","volume":"32","author":"Martinez-Fernandez","year":"2001","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.cbi.2025.111840_bib53","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/cvr\/cvm005","article-title":"Heart mitochondria: gates of life and death","volume":"77","author":"Gustafsson","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.cbi.2025.111840_bib54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.taap.2009.11.028","article-title":"Oxidative stress and oxidative damage in chemical carcinogenesis","volume":"254","author":"Klaunig","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"8\u20139","key":"10.1016\/j.cbi.2025.111840_bib55","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.dnarep.2004.03.002","article-title":"DNA damage responses to oxidative stress","volume":"3","author":"Barzilai","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.cbi.2025.111840_bib56","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cbi.2014.10.016","article-title":"Free radicals, reactive oxygen species, oxidative stress and its classification","volume":"224","author":"Lushchak","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.cbi.2025.111840_bib57","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1478-3231.2006.01324.x","article-title":"Apoptosis in liver disease","volume":"26","author":"Schattenberg","year":"2006","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.cbi.2025.111840_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2009.16","article-title":"Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria","volume":"1","author":"Wirawan","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2025.111840_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144519","article-title":"Toxic effects and potential mechanisms of Fluxapyroxad to zebrafish (Danio rerio) embryos","volume":"769","author":"Lin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2025.111840_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127037","article-title":"Fluxapyroxad induces developmental delay in zebrafish (Danio rerio)","volume":"256","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2025.111840_bib61","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.chemosphere.2018.01.046","article-title":"The embryonic developmental effect of sedaxane on zebrafish (Danio rerio)","volume":"197","author":"Yao","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2025.111840_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109880","article-title":"Toxicity of thifluzamide in earthworm (Eisenia fetida)","volume":"188","author":"Yao","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2025.111840_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121131","article-title":"Honeybee queen exposure to a widely used fungicide disrupts reproduction and colony dynamic","volume":"322","author":"Pineaux","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111840_bib64","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"issue":"10","key":"10.1016\/j.cbi.2025.111840_bib65","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","article-title":"Oxidative DNA damage: mechanisms, mutation, and disease","volume":"17","author":"Cooke","year":"2003","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.cbi.2025.111840_bib66","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100067R","article-title":"Mitochondrial fusion and fission: the fine\u2010tune balance for cellular homeostasis","volume":"35","author":"Adebayo","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2025.111840_bib67","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0076-6879(08)01415-8","article-title":"Chapter fifteen detection of autophagy in cell death","volume":"442","author":"Zakeri","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbi.2025.111840_bib68","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.envpol.2018.09.041","article-title":"Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio)","volume":"243","author":"Yang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2025.111840_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108749","article-title":"Assessing male reproductive toxicity of environmental pollutant di-ethylhexyl phthalate with network toxicology and molecular docking strategy","volume":"130","author":"Hong","year":"2024","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.cbi.2025.111840_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002013","article-title":"Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation","volume":"3","author":"Van Raam","year":"2008","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cbi.2025.111840_bib71","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.3390\/ijms10041911","article-title":"Heterogeneity of mitochondria and mitochondrial function within cells as another level of mitochondrial complexity","volume":"10","author":"Kuznetsov","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2025.111840_bib72","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbi.2025.111840_bib73","first-page":"135","article-title":"Mitochondrial complex I (NADH-ubiquinone oxidoreductase)","volume":"60","author":"Miki","year":"2002","journal-title":"Nihon rinsho. Japanese Journal of Clinical Medicine"},{"issue":"1","key":"10.1016\/j.cbi.2025.111840_bib74","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev-biochem-070511-103700","article-title":"Mitochondrial complex I","volume":"82","author":"Hirst","year":"2013","journal-title":"Annu. Rev. Biochem."},{"issue":"6","key":"10.1016\/j.cbi.2025.111840_bib75","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1667\/RR1617.1","article-title":"Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation","volume":"172","author":"Dayal","year":"2009","journal-title":"Radiat. Res."},{"key":"10.1016\/j.cbi.2025.111840_bib76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jtemb.2018.06.009","article-title":"Respiratory complex II in mitochondrial dysfunction-mediated cytotoxicity: insight from cadmium","volume":"50","author":"Belyaeva","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"38","key":"10.1016\/j.cbi.2025.111840_bib77","doi-asserted-by":"crossref","first-page":"36027","DOI":"10.1074\/jbc.M304854200","article-title":"Production of reactive oxygen species by mitochondria: central role of complex III","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.cbi.2025.111840_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012801","article-title":"Impact of the mitochondrial genetic background in complex III deficiency","volume":"5","author":"Gil Borlado","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.cbi.2025.111840_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/sj.cdd.4401225","article-title":"Mitochondrial functions during cell death, a complex (IV) dilemma","volume":"10","author":"Ricci","year":"2003","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.cbi.2025.111840_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22934","article-title":"Celecoxib decreases mitochondrial complex IV activity and induces oxidative stress in isolated rat heart mitochondria: an analysis for its cardiotoxic adverse effect","volume":"36","author":"Atashbar","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"14","key":"10.1016\/j.cbi.2025.111840_bib81","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/00002030-199814000-00004","article-title":"Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway","volume":"12","author":"Brinkman","year":"1998","journal-title":"Aids"},{"issue":"16","key":"10.1016\/j.cbi.2025.111840_bib82","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.2174\/0929867054546663","article-title":"Drug-associated mitochondrial toxicity and its detection","volume":"12","author":"Amacher","year":"2005","journal-title":"Curr. Med. Chem."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725004703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279725004703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T09:26:56Z","timestamp":1765186016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279725004703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":82,"alternative-id":["S0009279725004703"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111840","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating penthiopyrad's potential toxicity on male reproductive health via in vitro models and computational network toxicology and docking studies","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2025.111840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111840"}}