{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:43:05Z","timestamp":1774003385326,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230157"],"award-info":[{"award-number":["BK20230157"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230459"],"award-info":[{"award-number":["BK20230459"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017547","name":"Jiangsu Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404662"],"award-info":[{"award-number":["82404662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016966","name":"Bethune Charitable Foundation","doi-asserted-by":"publisher","award":["Z04J2023E095"],"award-info":[{"award-number":["Z04J2023E095"]}],"id":[{"id":"10.13039\/100016966","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.cbi.2026.111932","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:40:42Z","timestamp":1768981242000},"page":"111932","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function"],"prefix":"10.1016","volume":"427","author":[{"given":"Yingjie","family":"Qing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbi.2026.111932_bib1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s41591-024-02826-w","article-title":"T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy","volume":"30","author":"Ghilardi","year":"2024","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13045-020-01006-w","article-title":"Novel targeted therapies of T cell lymphomas","volume":"13","author":"I\u017cykowska","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"25","key":"10.1016\/j.cbi.2026.111932_bib3","first-page":"3019","article-title":"How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults","volume":"141","author":"Si Lim","year":"2023","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.cbi.2026.111932_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/bjh.18901","article-title":"Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL","volume":"202","author":"Lahera","year":"2023","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.cbi.2026.111932_bib5","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/s41375-021-01191-8","article-title":"Targeted based therapy in nodal T-cell lymphomas","volume":"35","author":"Chihara","year":"2021","journal-title":"Leukemia"},{"issue":"14","key":"10.1016\/j.cbi.2026.111932_bib6","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1182\/blood.2023021423","article-title":"Whole-genome CRISPR screening identifies molecular mechanisms of PD-L1 expression in adult T-cell leukemia\/lymphoma","volume":"143","author":"Chiba","year":"2024","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.cbi.2026.111932_bib7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41388-023-02913-1","article-title":"Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia","volume":"43","author":"Noura","year":"2024","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.cbi.2026.111932_bib8","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s11864-023-01111-1","article-title":"Treatment of adult T-Cell Leukemia\/Lymphoma: established paradigms and emerging directions","volume":"24","author":"Stuver","year":"2023","journal-title":"Curr. Treat. Options Oncol."},{"issue":"18","key":"10.1016\/j.cbi.2026.111932_bib9","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/0006-2952(74)90174-9","article-title":"Commentary. Lysosomotropic agents","volume":"23","author":"de Duve","year":"1974","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.111932_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.ph.28.030166.002251","article-title":"Functions of lysosomes","volume":"28","author":"De Duve","year":"1966","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cbi.2026.111932_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.phrs.2016.12.021","article-title":"Effect of lysosomotropic molecules on cellular homeostasis","volume":"117","author":"Kuzu","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.cbi.2026.111932_bib12","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2174\/1389200218666170925125940","article-title":"Lysosomotropic drugs: pharmacological tools to Study lysosomal function","volume":"18","author":"Pisonero-Vaquero","year":"2017","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.cbi.2026.111932_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178082","article-title":"Ridaifen derivatives function as potent lysosomotropic agents, depending on their basic side chains","volume":"1005","author":"Semba","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13045-021-01087-1","article-title":"Role of lysosomes in physiological activities, diseases, and therapy","volume":"14","author":"Zhang","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cbi.2026.111932_bib15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-pharmtox-010715-103101","article-title":"Critical functions of the lysosome in cancer biology","volume":"57","author":"Davidson","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.cbi.2026.111932_bib16","first-page":"2143","article-title":"Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells","volume":"119","author":"Ivanov","year":"2009","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.cbi.2026.111932_bib17","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/leu.2016.4","article-title":"Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism","volume":"30","author":"Dielschneider","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.cbi.2026.111932_bib18","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.2147\/IJN.S321343","article-title":"Novel approaches of dysregulating lysosome functions in cancer cells by specific drugs and its nanoformulations: a smart approach of modern therapeutics","volume":"16","author":"Allemailem","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"5","key":"10.1016\/j.cbi.2026.111932_bib19","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1042\/BST20140145","article-title":"Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death","volume":"42","author":"Villamil Giraldo","year":"2014","journal-title":"Biochem. Soc. Trans."},{"issue":"3","key":"10.1016\/j.cbi.2026.111932_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032176","article-title":"Lysosomes as a target of anticancer therapy","volume":"24","author":"Trybus","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41419-020-03324-w","article-title":"Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response","volume":"12","author":"Tian","year":"2021","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.cbi.2026.111932_bib22","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s44318-025-00396-2","article-title":"A one-two punch against cancer: combining CDK4 inhibitors with lysosomotropic agents","volume":"44","author":"Ferbeyre","year":"2025","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.cbi.2026.111932_bib23","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500599R","article-title":"Therapeutic effect of V8 affecting mitophagy and endoplasmic reticulum stress in Acute Myeloid leukemia mediated by ROS and CHOP signaling","volume":"39","author":"Guo","year":"2025","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.cbi.2026.111932_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1229","article-title":"Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies","volume":"13","author":"Qing","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"10.1016\/j.cbi.2026.111932_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.154","article-title":"Natural HDAC-1\/8 inhibitor baicalein exerts therapeutic effect in CBF-AML","volume":"10","author":"Yu","year":"2020","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12964-021-00764-5","article-title":"Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia","volume":"19","author":"Qing","year":"2021","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib27","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41401-025-01636-1","article-title":"Isoliensinine inhibits mitophagy and sensitizes T cell malignancies for STING-mediated NK clearance","volume":"47","author":"Ge","year":"2026","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.cbi.2026.111932_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10565-014-9274-5","article-title":"Characterization of V-ATPase inhibitor-induced secretion of cysteine-rich with EGF-like domains 2","volume":"30","author":"Oh-hashi","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.cbi.2026.111932_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.216049","article-title":"A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer","volume":"555","author":"Wang","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cbi.2026.111932_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.toxlet.2022.07.814","article-title":"Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo","volume":"367","author":"Tao","year":"2022","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41419-021-03394-4","article-title":"FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.cbi.2026.111932_bib32","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/jcb.29437","article-title":"Lys05 induces lysosomal membrane permeabilization and increases radiosensitivity in glioblastoma","volume":"121","author":"Zhou","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cbi.2026.111932_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145017","article-title":"LZ-106, a potent lysosomotropic agent, causing TFEB-dependent cytoplasmic vacuolization","volume":"760","author":"Zou","year":"2020","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.cbi.2026.111932_bib34","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1080\/15548627.2024.2440842","article-title":"Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death","volume":"21","author":"Alvarez-Valadez","year":"2025","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.cbi.2026.111932_bib35","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/j.apsb.2021.02.004","article-title":"Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: dynamic analysis on cytotoxic effects of LW-218","volume":"11","author":"Hu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"13","key":"10.1016\/j.cbi.2026.111932_bib36","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1158\/0008-5472.CAN-24-0749","article-title":"Ammonia suppresses the Antitumor activity of natural killer cells and T cells by decreasing mature perforin","volume":"85","author":"Domagala","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2026.111932_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2017.12.021","article-title":"Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - a comparison with lysosomotropic drugs","volume":"281","author":"Sanchez Garcia","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.111932_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.627639","article-title":"Overcoming chemoresistance: altering pH of cellular compartments by chloroquine and hydroxychloroquine","volume":"9","author":"Halcrow","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.cbi.2026.111932_bib39","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1194\/jlr.M055152","article-title":"Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity","volume":"56","author":"Jaishy","year":"2015","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib40","first-page":"245","article-title":"RCE-4, a potential anti-cervical cancer drug isolated from Reineckia carnea, induces autophagy via the dual blockade of PI3K and ERK pathways in cervical cancer CaSki cells","volume":"45","author":"Xiang","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.cbi.2026.111932_bib41","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.cbi.2026.111932_bib42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41419-023-05786-0","article-title":"Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways","volume":"14","author":"Xie","year":"2023","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.cbi.2026.111932_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071679","article-title":"The ins and outs of cathepsins: physiological function and role in disease management","volume":"9","author":"Yadati","year":"2020","journal-title":"Cells"},{"issue":"7795","key":"10.1016\/j.cbi.2026.111932_bib44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41586-020-1968-7","article-title":"ATP13A2 deficiency disrupts lysosomal polyamine export","volume":"578","author":"van Veen","year":"2020","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.cbi.2026.111932_bib45","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1080\/15548627.2021.1995150","article-title":"LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization","volume":"18","author":"Tanaka","year":"2022","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41418-023-01237-7","article-title":"MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis","volume":"31","author":"Liu","year":"2024","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.cbi.2026.111932_bib47","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrm2745","article-title":"Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function","volume":"10","author":"Saftig","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6036","key":"10.1016\/j.cbi.2026.111932_bib48","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cbi.2026.111932_bib49","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1016\/j.csbj.2024.05.049","article-title":"Acidic sphingomyelinase interactions with lysosomal membranes and cation amphiphilic drugs: a molecular dynamics investigation","volume":"23","author":"Scrima","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"11","key":"10.1016\/j.cbi.2026.111932_bib50","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1080\/15548627.2021.1874208","article-title":"Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death","volume":"17","author":"Meyer","year":"2021","journal-title":"Autophagy"},{"issue":"7280","key":"10.1016\/j.cbi.2026.111932_bib51","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature08710","article-title":"Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology","volume":"463","author":"Kirkegaard","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2026.111932_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154689","article-title":"Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis","volume":"113","author":"Nandi","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2026.111932_bib53","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.redox.2018.06.010","article-title":"ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells","volume":"18","author":"Cai","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbi.2026.111932_bib54","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2024.10.311","article-title":"The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death","volume":"225","author":"Baldensperger","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2026.111932_bib55","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.bios.2016.10.004","article-title":"An artemisinin-mediated ROS evolving and dual protease light-up nanocapsule for real-time imaging of lysosomal tumor cell death","volume":"92","author":"Huang","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"6","key":"10.1016\/j.cbi.2026.111932_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202150","article-title":"Boosting ROS-Mediated lysosomal membrane permeabilization for cancer ferroptosis therapy","volume":"12","author":"Chen","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"12","key":"10.1016\/j.cbi.2026.111932_bib57","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.tibs.2021.07.003","article-title":"The lysosome as a master regulator of iron metabolism","volume":"46","author":"Rizzollo","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cbi.2026.111932_bib58","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fphar.2020.00444","article-title":"Iron promotes dihydroartemisinin cytotoxicity via ROS production and blockade of Autophagic Flux via lysosomal damage in Osteosarcoma","volume":"11","author":"Shen","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2026.111932_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/nyas.12953","article-title":"Targeting the lysosome in cancer","volume":"1371","author":"Piao","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726000402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726000402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:23:10Z","timestamp":1773994990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726000402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":59,"alternative-id":["S0009279726000402"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.111932","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.111932","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111932"}}