{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:10:17Z","timestamp":1793243417979,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000572"],"award-info":[{"award-number":["82000572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374124"],"award-info":[{"award-number":["82374124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274185"],"award-info":[{"award-number":["82274185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["20KJB310003"],"award-info":[{"award-number":["20KJB310003"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016798","name":"Natural Science Foundation of Yangzhou Municipality","doi-asserted-by":"publisher","award":["YZ2023165"],"award-info":[{"award-number":["YZ2023165"]}],"id":[{"id":"10.13039\/100016798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20200840"],"award-info":[{"award-number":["BK20200840"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.cbi.2026.111950","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:02:46Z","timestamp":1769792566000},"page":"111950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["m6A methylation dependent autophagy activation is required for anti-tumor effects of artesunate through ferroptosis in hepatocellular carcinoma"],"prefix":"10.1016","volume":"427","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6816-614X","authenticated-orcid":false,"given":"Yujia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangling","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangjuan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cbi.2026.111950_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cbi.2026.111950_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: an overview","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"issue":"5","key":"10.1016\/j.cbi.2026.111950_bib3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1053\/j.gastro.2023.01.033","article-title":"Global epidemiology and genetics of hepatocellular carcinoma","volume":"164","author":"Toh","year":"2023","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.cbi.2026.111950_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41575-022-00704-9","article-title":"Evolving therapeutic landscape of advanced hepatocellular carcinoma","volume":"20","author":"Yang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"10360","key":"10.1016\/j.cbi.2026.111950_bib5","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cbi.2026.111950_bib6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/HEP.0000000000000390","article-title":"Ferroptosis in hepatocellular carcinoma: from bench to bedside","volume":"80","author":"Tang","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2026.111950_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154259","article-title":"Artesunate: a review of its therapeutic insights in respiratory diseases","volume":"104","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.cbi.2026.111950_bib8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41401-020-0478-3","article-title":"Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma","volume":"42","author":"Li","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2026.111950_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103867","article-title":"Artesunate induces ferroptosis in gastric cancer by targeting the TFRC-HSPA9 axis for iron homeostasis regulation","volume":"87","author":"Liu","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.cbi.2026.111950_bib10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41419-025-07822-7","article-title":"Artesunate induces ferroptosis in diffuse large B-cell lymphoma cells by targeting PRDX1 and PRDX2","volume":"16","author":"Liu","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cbi.2026.111950_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12943-022-01508-w","article-title":"Insights into N6-methyladenosine and programmed cell death in cancer","volume":"21","author":"Liu","year":"2022","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.cbi.2026.111950_bib12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41419-024-07148-w","article-title":"Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cbi.2026.111950_bib13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","author":"Murphy","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cbi.2026.111950_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101126","article-title":"crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer","volume":"77","author":"Zou","year":"2024","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.cbi.2026.111950_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102971","article-title":"Autophagy activation is required for N6-methyladenosine modification to regulate ferroptosis in hepatocellular carcinoma","volume":"69","author":"Li","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbi.2026.111950_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102151","article-title":"N-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells","volume":"47","author":"Shen","year":"2021","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.cbi.2026.111950_bib17","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1080\/15548627.2019.1687985","article-title":"RNA-binding protein ZFP36\/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells","volume":"16","author":"Zhang","year":"2020","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.cbi.2026.111950_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12943-024-01999-9","article-title":"Ferroptotic therapy in cancer: benefits, side effects, and risks","volume":"23","author":"Diao","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cbi.2026.111950_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107526","article-title":"Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma","volume":"210","author":"Liu","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.cbi.2026.111950_bib20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/15548627.2023.2261758","article-title":"Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy","volume":"20","author":"Ma","year":"2023","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.cbi.2026.111950_bib21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.2022.12366","article-title":"Diagnosis, treatment, and prevention of malaria in the US: a review","volume":"328","author":"Daily","year":"2022","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.cbi.2026.111950_bib22","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1093\/cid\/ciab570","article-title":"Safety and effectiveness of intravenous artesunate for treatment of severe malaria in the United States-April 2019 through December 2020","volume":"73","author":"Abanyie","year":"2021","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cbi.2026.111950_bib23","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41467-024-45452-3","article-title":"Artesunate treats obesity in male mice and non-human primates through GDF15\/GFRAL signalling axis","volume":"15","author":"Guo","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972600058X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972600058X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:08:17Z","timestamp":1773997697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927972600058X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":23,"alternative-id":["S000927972600058X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.111950","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"m6A methylation dependent autophagy activation is required for anti-tumor effects of artesunate through ferroptosis in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.111950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111950"}}