{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:10:52Z","timestamp":1791573052617,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013285","name":"Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972889"],"award-info":[{"award-number":["31972889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.cbi.2026.111972","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:04:58Z","timestamp":1770998698000},"page":"111972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inhibiting NAT10 suppresses hepatocellular carcinoma progression by reducing Nrf2 mRNA stability and increasing oxidative stress"],"prefix":"10.1016","volume":"429","author":[{"given":"Wei","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luanqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunpeng (Craig)","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiang","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingdong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cbi.2026.111972_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib2","first-page":"47","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"issue":"3","key":"10.1016\/j.cbi.2026.111972_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41571-021-00573-2","article-title":"Immunotherapies for hepatocellular carcinoma","volume":"19","author":"Llovet","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.cbi.2026.111972_bib4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2217\/fon-2020-0986","article-title":"Immune-based combinations for advanced hepatocellular carcinoma: shaping the direction of first-line therapy","volume":"17","author":"Rizzo","year":"2021","journal-title":"Future Oncol."},{"issue":"36","key":"10.1016\/j.cbi.2026.111972_bib5","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1200\/JCO.20.02672","article-title":"Systemic therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline","volume":"38","author":"Gordan","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.cbi.2026.111972_bib6","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1093\/nar\/gkv075","article-title":"Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1\/THUMPD1","volume":"43","author":"Sharma","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2026.111972_bib7","article-title":"Prognostic and immunological role of mRNA ac4C regulator NAT10 in Pan-Cancer: new territory for cancer research?","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.cbi.2026.111972_bib8","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.cell.2018.10.030","article-title":"Acetylation of cytidine in mRNA promotes translation efficiency","volume":"175","author":"Arango","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2026.111972_bib9","article-title":"NAT10 promotes osteogenic differentiation of mesenchymal stem cells by mediating N4-Acetylcytidine modification of Gremlin 1","volume":"2021","author":"Zhu","year":"2021","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.cbi.2026.111972_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.omtn.2021.06.022","article-title":"ac4C acetylation of RUNX2 catalyzed by NAT10 spurs osteogenesis of BMSCs and prevents ovariectomy-induced bone loss","volume":"26","author":"Yang","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"16","key":"10.1016\/j.cbi.2026.111972_bib11","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1093\/nar\/gkad628","article-title":"NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells","volume":"51","author":"Liu","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"6183","key":"10.1016\/j.cbi.2026.111972_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1126\/science.1252651","article-title":"Chemical inhibition of NAT10 corrects defects of laminopathic cells","volume":"344","author":"Larrieu","year":"2014","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.cbi.2026.111972_bib13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.scib.2024.09.020","article-title":"NAT10-mediated mRNA N4-acetylcytidine modifications in mouse oocytes constitute a checkpoint of ovarian follicle development","volume":"70","author":"Wang","year":"2025","journal-title":"Science bulletin"},{"key":"10.1016\/j.cbi.2026.111972_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.907286","article-title":"NAT10 maintains OGA mRNA stability through ac4C modification in regulating oocyte maturation","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41392-021-00489-4","article-title":"NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1","volume":"6","author":"Zhang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13046-022-02586-w","article-title":"Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression","volume":"42","author":"Deng","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.cbi.2026.111972_bib17","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1016\/j.apsb.2022.01.015","article-title":"NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma","volume":"12","author":"Wei","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"10.1016\/j.cbi.2026.111972_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.738","article-title":"NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression","volume":"12","author":"Wang","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"10","key":"10.1016\/j.cbi.2026.111972_bib19","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1158\/0008-5472.CAN-22-2233","article-title":"NAT10 drives Cisplatin chemoresistance by enhancing ac4C-Associated DNA repair in bladder cancer","volume":"83","author":"Xie","year":"2023","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s13046-022-02551-7","article-title":"Acetyltransferase NAT10 regulates the Wnt\/beta-catenin signaling pathway to promote colorectal cancer progression via ac(4)C acetylation of KIF23 mRNA","volume":"41","author":"Jin","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.cbi.2026.111972_bib21","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/cac2.12363","article-title":"N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA","volume":"42","author":"Zheng","year":"2022","journal-title":"Cancer Commun."},{"issue":"32","key":"10.1016\/j.cbi.2026.111972_bib22","article-title":"NAT10 promotes prostate cancer growth and metastasis by acetylating mRNAs of HMGA1 and KRT8","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"32","key":"10.1016\/j.cbi.2026.111972_bib23","article-title":"NAT10\/ac4C\/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer","volume":"10","author":"Chen","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"23","key":"10.1016\/j.cbi.2026.111972_bib24","article-title":"N4-Acetylcytidine drives glycolysis addiction in gastric cancer via NAT10\/SEPT9\/HIF-1alpha positive feedback loop","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"7","key":"10.1016\/j.cbi.2026.111972_bib25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41419-024-06951-9","article-title":"Chemotherapy-induced acetylation of ACLY by NAT10 promotes its nuclear accumulation and acetyl-CoA production to drive chemoresistance in hepatocellular carcinoma","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.cbi.2026.111972_bib26","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.bbrc.2018.04.047","article-title":"Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma","volume":"499","author":"Tan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2026.111972_bib27","article-title":"N-Acetyltransferase 10 enhances doxorubicin resistance in Human hepatocellular carcinoma cell lines by promoting the epithelial-to-mesenchymal transition","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1186\/s12885-017-3570-4","article-title":"NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity","volume":"17","author":"Li","year":"2017","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41420-023-01355-8","article-title":"Role of NAT10-mediated ac4C-modified HSP90AA1 RNA acetylation in ER stress-mediated metastasis and lenvatinib resistance in hepatocellular carcinoma","volume":"9","author":"Pan","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cbi.2026.111972_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/cac2.12595","article-title":"Targeting N4-acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2-mediated HMGB2 mRNA translation","author":"Liu","year":"2024","journal-title":"Cancer Commun."},{"key":"10.1016\/j.cbi.2026.111972_bib31","article-title":"Uncovering N4-Acetylcytidine-Related mRNA modification pattern and landscape of stemness and immunity in hepatocellular carcinoma","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.cbi.2026.111972_bib32","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","article-title":"NRF2 and the hallmarks of cancer","volume":"34","author":"Rojo de la Vega","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cbi.2026.111972_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120111","article-title":"Nrf2\/Keap1\/ARE signaling: towards specific regulation","volume":"291","author":"Ulasov","year":"2022","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib35","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1038\/s41467-019-12606-7","article-title":"Genome-wide CRISPR\/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC","volume":"10","author":"Wei","year":"2019","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.cbi.2026.111972_bib36","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1007\/s11427-021-2067-7","article-title":"CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 pathway","volume":"65","author":"Chen","year":"2022","journal-title":"Sci. China Life Sci."},{"issue":"1","key":"10.1016\/j.cbi.2026.111972_bib37","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/s41467-021-21828-7","article-title":"RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-beta2","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.cbi.2026.111972_bib38","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbi.2026.111972_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121948","article-title":"Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS\/NLRP3","volume":"330","author":"Wang","year":"2023","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.cbi.2026.111972_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119521","article-title":"NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-kappaB pathway in macrophages","volume":"1870","author":"Zhang","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"5","key":"10.1016\/j.cbi.2026.111972_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12051116","article-title":"NAT10, an RNA cytidine acetyltransferase, regulates ferroptosis in cancer cells","volume":"12","author":"Dalhat","year":"2023","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.cbi.2026.111972_bib42","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1111\/cas.16249","article-title":"NAT10 inhibition promotes ac4C-dependent ferroptosis to counteract sorafenib resistance in nasopharyngeal carcinoma","volume":"115","author":"Xue","year":"2024","journal-title":"Cancer Sci."},{"issue":"16","key":"10.1016\/j.cbi.2026.111972_bib43","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1093\/nar\/gkz545","article-title":"MORC2 regulates DNA damage response through a PARP1-dependent pathway","volume":"47","author":"Zhang","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726000803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726000803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:39:46Z","timestamp":1777415986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726000803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S0009279726000803"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.111972","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibiting NAT10 suppresses hepatocellular carcinoma progression by reducing Nrf2 mRNA stability and increasing oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.111972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111972"}}